ライフサイエンスコーパス: olfactory

1 ere processes were observed close to primary olfactory afferents and projection neurons.

2 ood pressure, demographic, cognitive, motor, olfactory and affective information enabling the assessm

3 a great deal of research has focused on the olfactory and gustatory system over the years, it is onl

4 ccurring zinc nanoparticles were detected in olfactory and nasal respiratory epithelia and cilia in a

5 from the lACA, while most receive additional olfactory and thermo- and/or hygrosensory PN inputs.

6 Aquatic and amphibious mammals face olfactory and thermoregulatory challenges not generally

7 halamus) that lie in the trajectories of the olfactory and trigeminal nerves.

8 Drosophila and presented directional visual, olfactory, and airflow cues known to elicit orienting be

9 s) covered with thousands of mechanosensory, olfactory, and gustatory sensilla.

10 connections, the potential for another early olfactory area, the anterior olfactory nucleus (AON), to

11 g the specific functions of different higher olfactory areas given their extensive recurrence, and of

12 ogenesis (e.g., dentate gyrus, hypothalamus, olfactory areas, cerebellum) in the whole-brain datasets

13 hest densities of synapses in the isocortex, olfactory areas, hippocampal formation and cortical subp

14 ns (OW) (e.g. "banana") or with little or no olfactory associations (CW) (e.g. "chair") were used as

15 Words with strong olfactory associations (OW) (e.g. "banana") or with litt

16 al prefrontal cortex (mPFC), as mice learned olfactory associations.

17 nally, we demonstrate that the regulation of olfactory associative learning by serotonin is mediated

18 m neuropils, such as odorant recognition and olfactory associative learning.

19 Here, we show for the first time that olfactory associative memory in Drosophila requires sign

20 s, and we discovered that it is required for olfactory aversive learning.

21 to the training odorants to generate learned olfactory behavior.

22 rm to OFC can be entrained to elicit learned olfactory behavior.

23 l roles in the state-dependent processing of olfactory behaviors.

24 correct glomeruli formation in the accessory olfactory bulb (AOB) and survival.

25 MENT Information processing in the accessory olfactory bulb (AOB) plays a central role in conspecific

26 The accessory olfactory bulb (AOB), the first neural circuit in the mo

27 ive ranges (MRRs) of glomeruli in the dorsal olfactory bulb (dOB) innervated by the MOR18-2 olfactory

28 ctions (two to three synapses) onto the main olfactory bulb (MOB).

29 s (OSNs) project their axons directly to the olfactory bulb (OB) glomeruli, where their synaptic rele

30 Neuronal morphology and organization in the olfactory bulb (OB) have been extensively studied, howev

31 ated by short axon cells (SACs) in the mouse olfactory bulb (OB) might shape odor representations as

32 In this study, we examined how the olfactory bulb (OB) performs 'whitening', a fundamental

33 tion of glutamatergic AON projections to the olfactory bulb (OB) transiently inhibited the excitabili

34 naptic projections onto granule cells in the olfactory bulb (OB), express the synaptogenic molecule C

35 We investigated this question in the mouse olfactory bulb (OB), where mitral and tufted cells (MTCs

36 vity in all areas of the human brain but the olfactory bulb (OB).

37 al bridge represent responses from the human olfactory bulb - recordings we term Electrobulbogram (EB

38 l motor nucleus of the vagus, as well as the olfactory bulb and anterior olfactory nucleus, and then

39 nucleus (AON) receives direct input from the olfactory bulb and sends an associative projection to pi

40 the functional organization of the accessory olfactory bulb circuitry remain unclear.

41 ow that the presence of noradrenaline in the olfactory bulb during acquisition renders olfactory memo

42 e, simple network effect of noradrenaline on olfactory bulb dynamics can underlie these seemingly dif

43 By imaging OSN axon terminals in olfactory bulb glomeruli as well as OSN cell bodies with

44 ricular zone neural stem cells that generate olfactory bulb granule cell neurons were electroporated

45 The olfactory bulb had higher (210)Po levels than either olf

46 are key elements in organizing the accessory olfactory bulb into functional microcircuits, each chara

47 raphic two-photon optogenetic stimulation of olfactory bulb neurons with cellular and single-action-p

48 , protein carbonylation was increased in the olfactory bulb of aged Carns1-deficient mice.

49 nced high gamma and beta power (PRP), in the olfactory bulb of mice learning to discriminate odorants

50 indeed, reflect the idle state of accessory olfactory bulb output in awake male and female mice.

51 his study shows that AON activation inhibits olfactory bulb output neurons in both anesthetized as we

52 iform cortex and its sensory inputs from the olfactory bulb represent chemical odour relationships th

53 Other findings included olfactory bulb signal abnormalities (seven of 37; 19%),

54 ermined circuit-extending from the accessory olfactory bulb to the posterior medial amygdala-that is

55 zation of the deeper layers of the accessory olfactory bulb was indistinct, perhaps as a consequence

56 n is transmitted from olfactory receptors to olfactory bulb, and then to piriform cortex, where ensem

57 le cells, the most common interneuron in the olfactory bulb, are known to broadly integrate sensory i

58 immunoreactive soma in cave Astyanax in the olfactory bulb, basal telencephalon, preoptic nuclei, ve

59 t of Pcdh-gammaC4 mRNA, being highest in the olfactory bulb, dentate gyrus, and cerebellum.

60 In the mouse olfactory bulb, inhalation of different odors leads to c

61 In the mouse accessory olfactory bulb, the first central stage of information p

62 Within the accessory olfactory bulb, the glomeruli did not appear distinct, r

63 of the sub-ependymal zone NSC niche and the olfactory bulb, the region to which newly generated neur

64 Within the main olfactory bulb, the size of the glomeruli, at approximat

65 nal lobe, the insect analog of the mammalian olfactory bulb, to higher-order brain regions in an adul

66 (V-SVZ), in which neural stem cells generate olfactory bulb-destined interneurons.

67 resolved transcriptomics data from the mouse olfactory bulb.

68 r to transmission of odor information to the olfactory bulb.

69 Cs compared with analogous cells in the main olfactory bulb.

70 leus of the diagonal band of Broca, and main olfactory bulb.

71 t of adult-born granule cells (abGCs) in the olfactory bulb.

72 ely 3,500 glomeruli are present in each main olfactory bulb.

73 C and DeltaOMP-eGFP strains of uninjured and olfactory bulbectomized transgenic mice that correspond

74 n infected cell populations connected to the olfactory bulbs following intranasal instillation of H1N

75 d alpha-synuclein preformed fibrils into the olfactory bulbs of wild type male and female mice.

76 o controls, most women with uRPL had smaller olfactory bulbs, yet increased hypothalamic response in

77 he human brain via the respiratory tract and olfactory bulbs.

78 We identified rapid and repeated loss of olfactory capacities synchronously associated with gains

79 regenerate odor-detecting neurons and other olfactory cell types after loss due to injury, infection

80 arrier by generating airway cells instead of olfactory cells.

81 which is synthesized and degraded locally by olfactory cells; (2) old age as well as repeated injurie

82 cells and exhaust their potential to produce olfactory cells; and (3) exhausted stem cells alter the

83 we revealed compartmental ACh signals in the olfactory center of transgenic flies in response to exte

84 lar fashion to flies, i.e., through a single olfactory channel with a high degree of sensitivity for

85 hypotheses regarding the functional role of olfactory circuit activity at both single neuronal and p

86 into a computational model of the mammalian olfactory circuit.

87 ive learning in distinct neural sites of the olfactory circuit.

88 In particular, it is not clear how olfactory circuits achieve rapid, data efficient learnin

89 een glomeruli, the functional units of early olfactory coding and processing.

90 IGNIFICANCE STATEMENT A key area of study in olfactory coding involves understanding the transformati

91 ciently, revealing fundamental principles of olfactory coding.

92 on on territorial dominance, indicating that olfactory communication involving apical VNO receptors l

93 as our primary sensory modality, research on olfactory communication is hampered by a lack of tractab

94 (yuzunone) is reported to be one of the main olfactory contributors of the specific fruity-green-bals

95 inting to a potential mechanism by which the olfactory cortex can actively and dynamically gate senso

96 We found that neural activity in olfactory cortex largely reflects sensory coding, with v

97 for reward prediction does not occur within olfactory cortex, but rather in circuits involving the o

98 our space have not yet been described in the olfactory cortex, it remains unclear how odour relations

99 ions rely upon dance information rather than olfactory cues that could otherwise guide them to the sa

100 ntext in which the interaction occurs (i.e., olfactory cues), or it may be influenced by local signal

101 ished nests with fresh wormwood leaves using olfactory cues, that nests containing wormwood leaves ha

102 speed and accuracy of performance of rats on olfactory decision tasks could be best explained by a Ba

103 Olfactory decisions that were not context-dependent were

104 Whether these pathologies induce functional olfactory deficits, and the mechanistic role of Th17 lym

105 We studied this problem using an olfactory delayed match to sample task whereby a sample

106 ranscription factor Gli3 is known to disrupt olfactory development, however, if Gli3 plays a role in

107 he identification of allosteric modifiers of olfactory-driven behaviors capable of providing enhanced

108 t throughout the life cycle of lampreys, but olfactory-driven behaviors differ according to the devel

109 After the remission of MDD, the olfactory dysfunction was improved, which might be regar

110 data suggest that correct development of the olfactory ensheathing cells (OEC) is imperative for norm

111 l-1(+) vomeronasal progenitors, formation of olfactory ensheathing cells in the nasal mucosa, and imp

112 efects observed in Gli3 mutants from lack of olfactory ensheathing cells in the nasal mucosa, moreove

113 iling of ACE2 suggests tongue keratinocytes, olfactory epithelial cells, airway club cells and respir

114 y bulb had higher (210)Po levels than either olfactory epithelium (p = 0.071), frontal lobe (p < 0.00

115 th embryonic development and turnover of the olfactory epithelium in adult mice, and rosette-bearing

116 meruli as well as OSN cell bodies within the olfactory epithelium in freely breathing mice, we find w

117 Pathological analysis of olfactory epithelium obtained from human COVID-19 autops

118 mixture information appears to occur in the olfactory epithelium prior to transmission of odor infor

119 Neurogenesis in the zebrafish olfactory epithelium requires the bHLH proneural transcr

120 Chemical ablation of the olfactory epithelium with dichlobenil or physical separa

121 Here, we considered this in the main olfactory epithelium, a chemosensory structure with over

122 OSNs differentiate from stem cells in the olfactory epithelium, and how the epithelium generates c

123 xcitation (SCAPE) microscopy of intact mouse olfactory epithelium, imaging ~10,000 olfactory sensory

124 ust sexually dimorphic phenotype in the main olfactory epithelium.

125 can be acquired (patients with a history of olfactory experiences), or inborn (patients without olfa

126 ry experiences), or inborn (patients without olfactory experiences/life-long inability to smell).

127 identify that expression of many genes with olfactory function is a unique feature of mammalian Peye

128 The olfactory function of MDD appears to be correlated negat

129 dy infiltration into the CNS, and have their olfactory function partially restored.

130 ent sniffing, we gain a sensitive measure of olfactory function(10-15).

131 lammation, cell cycle, circadian rhythm, and olfactory functions.

132 icularly large number (about 460) of primary olfactory glomeruli, suggesting an advanced sense of sme

133 Three sensory systems, the olfactory, gustatory, and solitary chemosensory cell (SC

134 Thus, a critical period for long-term olfactory habituation in Drosophila, which closes early

135 ction that link and interact with gustatory, olfactory, homeostatic, visceral, and cognitive systems;

136 he pangolins were able to find the food with olfactory information alone (N = 2), but not with visual

137 ntially because simultaneous transmission of olfactory information also plays a major role in foragin

138 rtical amygdala, is the main target for this olfactory information and has been shown to guide innate

139 Processing of olfactory information is modulated by centrifugal projec

140 T The anterior olfactory nucleus (AON) as an olfactory information processing area sends extensive pr

141 include projection neurons (PNs), providing olfactory information to higher-order neuropils via para

142 utions of dance communication and hive-based olfactory information transfer to honeybee recruitment e

143 able to insect mushroom bodies in processing olfactory information.

144 portant, as foragers are primarily guided by olfactory information.

145 Before this processing, olfactory input is refined through the feedback provided

146 ity of mitral/tufted cells (MTCs) that relay olfactory input to the cortex.

147 social cue produces long-term learning of an olfactory input, however, remains unknown.

148 nvergence of different inputs, including non-olfactory inputs and memory-related feedback onto third-

149 that aversive learning increases peripheral olfactory inputs at the first synapse, which may contrib

150 gy, they deviate strongly in both visual and olfactory investment.

151 , yet there remains a prevailing belief that olfactory language is deficient.

152 We show that it is required for aversive olfactory learning after pairing diacetyl with the absen

153 entations of odor thought to be essential to olfactory learning and behaviors.

154 Here, we formulate olfactory learning as a Bayesian optimization process, t

155 While the role of dopamine in olfactory learning in Drosophila is well described, the

156 the absence of food, but not for appetitive olfactory learning in response to butanone.

157 n and its downstream receptors on Drosophila olfactory learning remain largely unexplored.

158 modulation of the gap junctions facilitates olfactory learning.

159 de a rationale for the previously described "olfactory lens," an increase in pheromone reception at t

160 Olfactory loss can be acquired (patients with a history

161 Inborn olfactory loss, or congenital anosmia (CA), is relativel

162 Studies in Drosophila suggest aversive olfactory LTM is optimal after spaced training, multiple

163 amers, suggest that we have obtained a valid olfactory measure, one that may enable the digitization

164 he olfactory bulb during acquisition renders olfactory memories more stable.

165 nitric oxide to increase the flexibility of olfactory memories.

166 several developmental milestones and spatial olfactory memory in Ts1Cje neonates.

167 tual similarity, and the ensuing creation of olfactory metamers, suggest that we have obtained a vali

168 Using this cut-off, we were able to design olfactory metamers-pairs of non-overlapping molecular co

169 Electrical stimulation of the olfactory nerve in an in vitro whole-brain preparation e

170 is reveals basic new features of GGN and the olfactory network surrounding it.

171 d that FLP-1 neuropeptide released from this olfactory neural circuit signals through peripheral NPR-

172 ultured neural progenitor cells derived from olfactory neuroepithelium (CNON cells) as a genetically

173 These data from the olfactory neuroepithelium niche provide evidence that ne

174 etical analysis of AWC(ON), a well-described olfactory neuron in C. elegans, here we derive a general

175 hypothesis by using two independent sets of olfactory neuronal cells biopsied from patients and heal

176 characterized high-quality population data, olfactory neuronal cells biopsied from patients with SZ

177 Olfactory neurons send their axons through the leg nerve

178 and memory-related feedback onto third-order olfactory neurons.

179 -tubulin peptides in the background of human olfactory neurosphere-derived stem (ONS) cell matrix.

180 , amygdala, suprachiasmatic nuclei, anterior olfactory nuclei, and spinal cord gray matter.

181 e cortex.SIGNIFICANCE STATEMENT The anterior olfactory nucleus (AON) as an olfactory information proc

182 The anterior olfactory nucleus (AON) receives direct input from the o

183 r another early olfactory area, the anterior olfactory nucleus (AON), to contribute to piriform activ

184 ere we show that the neurons of the anterior olfactory nucleus (AON), which form abundant synaptic pr

185 Six months after injection, the anterior olfactory nucleus and piriform cortex displayed a high a

186 , as well as the olfactory bulb and anterior olfactory nucleus, and then later affects other intercon

187 sues and sensory organs implicated in either olfactory or thermoregulatory functions.

188 nary implications of the loss of a dedicated olfactory organ in spiders and its effects on the mushro

189 r chemosensory specialization (proteomics of olfactory organs).

190 constrains on their motion and impairs their olfactory orientation.

191 f information processing along the accessory olfactory pathway, projection neurons (mitral cells) dis

192 Using calcium imaging, we identify olfactory pathways in D. sechellia that detect volatiles

193 A wide range of evidence indicates that olfactory perception is strongly involved in food intake

194 synapse loss, defective climbing ability and olfactory perception, as well as lifespan reduction.

195 These findings combine to suggest altered olfactory perceptual and brain responses in women experi

196 We evaluated olfactory perceptual function by monitoring odor-evoked

197 d to fully recapitulate the reproductive and olfactory phenotypes observed in patients harboring PROK

198 In this work, we evaluated the olfactory physiology of the screwworm fly and compared i

199 ograms offered insights into the comparative olfactory physiology of the two fly species.

200 ygdala (BLA), dorsomedial striatum (DMS) and olfactory piriform cortex (PIR).

201 individual Drosophila exhibit idiosyncratic olfactory preferences and idiosyncratic neural responses

202 rated important roles of the CCKergic TCs in olfactory processing by orchestrating OB inhibitory acti

203 may play a primary role in the modulation of olfactory processing by sampling behavior.

204 omputational model to simulate this chain of olfactory processing from the receptor neurons to MBONs.

205 The study aimed to investigate the top-down olfactory processing in patients with CA or idiopathic a

206 rcuits determines the level of complexity of olfactory processing in the downstream neuropils, such a

207 reconstruct the first complete inventory of olfactory projections connecting the antennal lobe, the

208 y unobserved pathways, including non-sensory olfactory receptor activity.

209 We identify 814 associated loci, including olfactory receptor associations with fruit and tea intak

210 d transcription factor (Acj6) only regulates olfactory receptor expression in one ORN type and only w

211 eceptor heteromers, may allosterically alter olfactory receptor function and profoundly affect subseq

212 set of 166 dispensable genes was enriched in olfactory receptor genes (41 genes).

213 The 41 dispensable olfactory receptor genes displayed a relaxation of selec

214 ptation in the functional diversification of olfactory receptor genes in a bird lineage that relies e

215 nstraints similar to that observed for other olfactory receptor genes.

216 As flies explore a circular arena, their olfactory receptor neuron (ORNs) are optogenetically act

217 The Drosophila olfactory receptor neurons (ORNs) provide an excellent s

218 t studies have identified a subpopulation of olfactory receptor neurons (ORNs) that consist of intrin

219 ction, and we find that a specific subset of olfactory receptor neurons encodes absolute salinity con

220 channel defined by inputs from one class of olfactory receptor neurons.

221 an age-dependent reduction in the number of olfactory receptor neurons.

222 factory bulb (dOB) innervated by the MOR18-2 olfactory receptor, also known as Olfr78, with human ort

223 Each ORN type expresses a unique olfactory receptor, or a combination thereof, and sends

224 The family of olfactory receptors (ORs) subserves the sense of smell a

225 Olfactory receptors (ORs), encoded by the largest verteb

226 7 candidate genes significantly clustered in olfactory receptors activity (GO:0004984, p = 4 x 10(- 1

227 h PME and valeric acid traits, as well as 17 olfactory receptors activity genes for PME traits relate

228 The identification of the olfactory receptors as the largest family of GPCRs catap

229 t - unlike in Drosophila and as in mammals - olfactory receptors may play a role, providing new insig

230 ATEMENT Odor information is transmitted from olfactory receptors to olfactory bulb, and then to pirif

231 ands to the variable subunits of heteromeric olfactory receptors.

232 onergic neuron (the CSDn) that spans several olfactory regions.

233 Progress in olfactory research is currently hampered by incomplete k

234 lay critical roles in regulating and shaping olfactory responses in vertebrates and invertebrates.

235 altered olfaction, and particularly altered olfactory responses to body-odor.

236 iscope-sniff' presumed to be used to enhance olfactory sampling by an elephant in circumstances of al

237 ll Identification Test (CSIT), Self-reported Olfactory Scale (SROS), 17-item Hamilton Depression Rati

238 4-month-old) Carns1-deficient mice exhibited olfactory sensitivity impairments that correlated with a

239 Starvation enhances olfactory sensitivity that encourage animals to search f

240 candidates for decoding reward category from olfactory sensory input and relaying this information to

241 ood preference (STFP), the combination of an olfactory sensory input with a social cue induces long-t

242 s demonstrated considerable heterogeneity of olfactory sensory neuron (OSN) cell populations in wild-

243 naling in starvation-dependent modulation of olfactory sensory neuron (OSN) function in the Drosophil

244 irst synapses of the olfactory system, where olfactory sensory neurons (OSNs) contact second-order pr

245 nd the axon hillock spiking mechanism of the olfactory sensory neurons (OSNs) have yet to be fully de

246 Olfactory sensory neurons (OSNs) in chordates usually ha

247 Primary olfactory sensory neurons (OSNs) project their axons dir

248 , CCKergic TCs receive direct input from the olfactory sensory neurons (OSNs).

249 mouse olfactory epithelium, imaging ~10,000 olfactory sensory neurons in parallel.

250 This subpopulation of olfactory sensory neurons was over-represented in sex-se

251 We identified a subpopulation of olfactory sensory neurons, defined by receptor expressio

252 in antennal sensilla to receptors present in olfactory sensory neurons.

253 ly increased the electrical responses of the olfactory sensory receptors.

254 ergic AON projections to the OB impede early olfactory signaling by inhibiting OB output neurons, the

255 ioral responses by enhancing the saliency of olfactory signals.

256 striatum.SIGNIFICANCE STATEMENT Rodents are olfactory specialists and can use odors to learn conting

257 ry experience includes tactile, thermal, and olfactory stimulation delivered to the young via contact

258 cillations were not observed when unilateral olfactory stimulation during sleep followed learning wit

259 -specific sequences of "odor-cells" encoding olfactory stimuli followed by "time-cells" encoding time

260 aracterizing peripheral population codes for olfactory stimuli, of inferring the specific functions o

261 cortex, but rather in circuits involving the olfactory striatum.SIGNIFICANCE STATEMENT Rodents are ol

262 B.SIGNIFICANCE STATEMENT The mouse accessory olfactory system (AOS) interprets social chemosignals, b

263 HCDs were undetectable in the primary olfactory system and skeletal muscle of Carns1-deficient

264 y of the interhemispheric connections in the olfactory system arise from AONpP, the third set examine

265 e calcium imaging techniques to identify the olfactory system as the primary sense used for salt dete

266 lastic, suggesting a means through which the olfactory system can assign related odour cues to common

267 A detailed description of olfactory system development in ants reveals that - unli

268 and odorant response properties of the early olfactory system of Drosophila melanogaster.

269 ction neurons and local neurons in the early olfactory system of insects.

270 The distribution of HA in the olfactory system of S. officinalis is similar to the pre

271 r organization to that of other mammals, the olfactory system of the African wild dog has certain fea

272 ntly described the localization of HA in the olfactory system of the cuttlefish Sepia officinalis.

273 n of responses increases the capacity of the olfactory system to distinguish complex odor mixtures.

274 Here, we use the mammalian olfactory system to investigate such mechanisms.

275 s), some of which are perceived by the human olfactory system, contributing to a myriad flavors.

276 In the mammalian olfactory system, inhibitory interneurons called short a

277 first neural circuit in the mouse accessory olfactory system, is critical for interpreting social ch

278 In the insect olfactory system, odors are initially represented in the

279 In the insect olfactory system, projection neurons of the antennal lob

280 on and glycation end products in the primary olfactory system, protein carbonylation was increased in

281 lobe (AL) contains the first synapses of the olfactory system, where olfactory sensory neurons (OSNs)

282 We are specifically interested in the olfactory system, wherein recent experimental studies ha

283 is necessary for correct development of the olfactory system.

284 three neuronal connections in the Drosophila olfactory system.

285 epresentations in the detection layer of the olfactory system.

286 postsynaptic neurons in the adult Drosophila olfactory system.

287 anges in this initial cortical region of the olfactory system.

288 mble observations from neurons in the insect olfactory system.

289 Here, we examined the role of UPF3B in the olfactory system.

290 l the organization of the main and accessory olfactory systems of the African wild dog.

291 tudy used encoding characteristics of insect olfactory systems to develop a new paradigm for quantify

292 Olfactory tests did not reveal any deterioration in 8-mo

293 y maps of complete populations of neurons in olfactory, thermosensory, hygrosensory, and memory syste

294 mesenchymal stromal cell derived from human olfactory tissue, which has the potential to induce mult

295 Here, we examined DA modulation of olfactory transmission in lampreys.

296 both combat and non-combat odors) to assess olfactory trauma memory and emotional response.

297 Importantly, olfactory trauma memory was identified as a mediator of

298 onnectivity, which were both correlated with olfactory trauma memory.

299 pport decision-making are not known, but the olfactory tubercle (OT) and posterior piriform cortex (p

300 lcium imaging in CA1 while mice performed an olfactory working-memory task, we recorded stimulus-spec