ライフサイエンスコーパス: on (its|their) own

1 On its own, computational "inside-out" design can lead t

2 On its own, pol beta fails to copy TNRs during DNA synth

3 On its own, SA-4-1BBL outperformed MPL in this setting.

4 On its own, small t antigen controls cell survival and d

5 On its own, the Pol2 catalytic subunit of Pol epsilon is

6 On its own, this moderate, short-lived warming was unlik

7 On their own, HDPDL1 exhibited no antitumor effect and C

8 On their own, miRNA-AGO2 complexes displayed little if a

9 On their own, the metrics proposed here explain a larger

10 On their own, these single SNPs explained from 1.15% to

11 IL-6 or IL-12 on its own did not induce PD-1.

12 active RyR2 channels eager to release Ca(2+) on their own appear as essential components of this arrh

13 -regulating p21 expression, whereas Nutlin-3 on its own had no effect, consistent with its mechanism

14 A calculated FLR between 28% and 30% on its own should not represent a formal contraindicatio

15 Intra-AcbSh AC187 on its own disrupted PPI in a haloperidol-reversible man

16 By accreting on their own accumulated peat, these desert mangroves st

17 goal, which neither discipline could achieve on its own; (ii) finding common ground in shared methodo

18 Moreover, IFN-1s do not act on their own, and clearly there is much cross-talk betwe

19 To what extent MLL fusion proteins act on their own during tumor initiation, or if they collabo

20 onvert glucose-phosphates, as well as acting on their own definitive substrates.

21 iciently potent to be therapeutically active on their own.

22 esponse and had no overt anticancer activity on its own, it dramatically impaired the emergence of re

23 However, ExoU does not exhibit activity on its own but instead requires eukaryotic cell cofactor

24 tive prodrug or has pharmacological activity on its own remains unclear.

25 MEDI5117 also displayed robust activity on its own against trastuzumab-resistant HER2(+) tumor c

26 ibody mimetics that have no agonist activity on their own can be transformed into potent agonists thr

27 nds were found to have little redox activity on their own as measured by the DTT assay, but they enha

28 ch of them which of the CDRs may bind the Ag on its own as a peptide.

29 ls which fragments of the Ab may bind the Ag on their own.

30 use they appear incapable of recognizing Ags on their own and are perceived as nonreactive.

31 r researchers to easily use these algorithms on their own datasets.

32 olving CBFs are not sufficient to induce AML on its own and the full spectrum of mutations coexisting

33 While amodiaquine on its own failed to demonstrate efficacy, we cannot exc

34 thermal stimuli following hypnotic analgesia on their own hand, but also when they viewed pictures of

35 to conduct a voxel-based asymmetry analysis on their own, it may also be useful to experienced users

36 pe of social evidence that they received and on their own ongoing experience with the task.

37 Dexamethasone or 8-Br-cAMP applied on their own produced cysts predominantly arising in pro

38 ibitory negative feedback regulation of ARF2 on its own transcription and thereby further promote GA

39 Although most of the filaments assemble on their own to form higher order structures, growing ev

40 CRMP-1 does not nucleate actin assembly on its own, nor does it directly activate the Arp2/3 com

41 xpressed construct, is a fully active ATPase on its own.

42 s not convey approach motivation or aversion on its own.

43 The influence of postharvest UV-B on its own and in combination with fermentation (e.g. sa

44 ; in both cases, the decision could be based on their own wishes or what they think the deceased woul

45 d MT neurons cannot overturn this bias based on their own feature selectivity.

46 n groups balance personal information (based on their own past experiences) with social information (

47 events should be prioritized in memory based on their own significance, as well as the significance o

48 ace that allows users to modify models based on their own experimental conditions.

49 es full advantage of limited resources based on their own performance features.

50 mucosal projection toward the lumen, bending on its own axis, and increased numbers of projections to

51 reductase could provide a selectable benefit on its own, and therefore, reduction of nitrate to dinit

52 is amino acid residues that, although benign on their own, could rescue the human mutations in vivo.

53 Each accession grew best on its own soil.

54 Here, we demonstrate that BIN1, on its own, is able to form complex interconnected tubul

55 elevate apoCaM, we find that apoCaM binding on its own markedly upregulates opening, rivaling the st

56 , as in vivo and in vitro anti-PD-1 blockade on its own only modestly improved T cell function.

57 armacological effect of Br-PBTC depends both on its own and agonists' occupancy of primary and access

58 what effect this topographic change has both on its own and in concert with the flux of freshwater fr

59 abidopsis Rubisco large subunits (AtL), both on their own (producing tob(AtL) plants) and with a cogn

60 d in hormone replacement therapy (HRT), both on their own and in combination with EE2.

61 for 24 hours to see whether they can breathe on their own.

62 e it is composed of two subunits, each built on its own ribosomal RNA (rRNA) scaffold.

63 maintenance, whereas expression of cadherins on their own could only transiently support adhesion and

64 Caffeine on its own induced no phase shifts.

65 Nevertheless, because cAMP on its own does not activate these chimeric channels, cA

66 Although students can, on their own, discover the increased value of being acti

67 It concludes that PrEP cannot on its own eliminate the risk of secondary transmission

68 EfaCas1-Cas2 on its own is not able to find the CRISPR repeat in the

69 ited capacity to translocate a peptide chain on its own.

70 tocene-Holocene boundary, but climate change on its own may not explain the disappearance of the mega

71 mutant does not generate functional channels on its own, large C-terminal truncations of KCNQ3 (inclu

72 nnel proteolysis do not form active channels on their own but, when properly paired, produce currents

73 s (HSPH1 and HSPH2) are bona fide chaperones on their own that collaborate with Hsp40 (DNAJA1 and DNA

74 o arachidonic acid without being chemotactic on its own.

75 ing but are not required for nuclear closure on their own.

76 um can elaborate gaze reorientation commands on its own, rather than merely acting as a relay from up

77 provide a pathway for cellular communication on their own independent of their role as structural pre

78 who need to conduct whole-genome comparisons on their own computers.

79 Moreover, if each bar is a composite on its own, multiple resonant band gaps appear in the co

80 ein remains in an autoinhibited conformation on its own, and processive motility is activated when it

81 Each lobe was allowed to switch conformation on its own.

82 who cannot reduce their alcohol consumption on their own, despite substantial harm to themselves and

83 es both by making a significant contribution on their own and by synergistically enhancing the effect

84 ds identifying when network structure could, on its own, drive the resilience, sustainability, and ev

85 s that rarely cause midline craniosynostosis on their own make the development of the disorder a cert

86 ea isolates underwent extensive crosslinking on their own, but heteropolymers were not observed in mu

87 of Cxcl10 was observed on microglia cultured on their own.

88 se results we conclude that APLP1 deficiency on its own does not lead to defects in synaptic plastici

89 ergy density as well as a high power density on their own.

90 mational changes in VWF, but also may depend on its own conformational activation.

91 re outcomes of individuals and groups depend on their own choices and on those of other (groups of) i

92 Since they encode no proteins, they depend on their own RNA and on host proteins for replication an

93 ure, none has proven accurate and dependable on its own under all scenarios where mutation analysis i

94 ffect in a manner that was largely dependent on its own modulatory function.

95 st in vivo as a monomer or a dimer depending on its own activity.

96 s, '2 up 1 down' or '2 down 1 up', depending on its own polarization.

97 m their preferred habitat by drift depending on their own traveling speed in relation to that of the

98 er ribonucleic acid (mRNA) anchoring depends on its own locally translated protein product.

99 osteoblasts, had no effect on thymine dimers on its own but prevented the 1,25(OH)(2)D(3)-induced pro

100 id not influence grey matter volume directly on its own but in mutation carriers it modulated the slo

101 ch these forces; either by pressing directly on their own finger or by operating a robot that pressed

102 ed the force required when pressing directly on their own finger than when operating a robot.

103 ng enough to support stimulus discrimination on their own.

104 ariants may be insufficient to cause disease on their own but may modify phenotype in a genetically s

105 Anatomical variations are not diseases on their own and may be present as incidental findings i

106 nterestingly, despite not affecting division on its own, Arp2/3 inhibition potentiated the effect of

107 transcription factor TFIIB and can bind DNA on its own.

108 of peptidomimetic drugs, and potential drugs on their own.

109 ion, which does not influence actin dynamics on its own.

110 oly(I:C), and TSG-6 did not exert any effect on its own.

111 and exhibited a significant cytotoxic effect on its own.

112 c receptors, although nicotine had no effect on its own.

113 eas the substances had no significant effect on their own.

114 a mutation in BGLC1 had significant effects on its own, lack of BGLC3 had only minor effects.

115 nt and sol-gel immobilization were efficient on their own, their combination can ensure additional op

116 In contrast, eIF4A on its own has little RNA substrate specificity.

117 In the soil, Se was applied either on its own (selenate only) or as a granular, Se-enriched

118 step in protein structure predictions either on its own or complemented by NMR restraints.

119 n cell therapy of autoimmune diseases either on their own or as graft complement in autologous stem c

120 n each generate a large pulse of barbed ends on their own, but have little synergy; high synergy occu

121 Improving the built environment on its own might be insufficient to increase physical ac

122 It can also act as an enzyme on its own in the presence of Eu(II)DTPA, displaying a s

123 r Anks1a is specifically localized to the ER on its own serine phosphorylation.

124 encouraging Whites to anchor their estimates on their own circumstances increased their tendency to o

125 monstrate that this simple gene fusion event on its own is sufficient to confer functional allostery

126 ients were encouraged to continue exercising on their own.

127 populations were initially unable to expand on their own, and were dependent on long-distance disper

128 enomena that neither perspective can explain on its own.

129 developed countries and they cannot explain on their own the strong underrepresentation of women in

130 and prolonged plasma exposure, but exposure on its own did not explain the presence or absence of ei

131 g, agency, and ability to avoid SHS exposure on their own volition; they also have physiological or b

132 rm nanotubule-like structures when expressed on its own in the cytoplasm of Escherichia coli.

133 When expressed on its own, this sequence targeted to microvilli in the

134 ironment have been identified, yet no factor on its own is known to stimulate overt myocardial hyperp

135 positive feedback of a transcription factor on its own synthesis - and assess its response to extrin

136 up to a point where cooperation is favoured on its own.

137 agic process, Tax exerts a positive feedback on its own stability.

138 their partner's, rather than simply focusing on their own contribution.

139 's discovery that purified proteins can fold on their own after removal from denaturant.

140 s are so poor that they cannot be formulated on their own, so new methods for increasing drug solubil

141 ciate and the helicase does not move forward on its own.

142 tam, the resultant dihydrothiazine fragments on its own or is assisted by an adjacent nucleophilic at

143 oes not adequately predict 12-month function on its own, our findings do not support changing the def

144 teolytically cleaved form, does not function on its own.

145 specific transcription factors and functions on its own in vitro to activate promoter transcription.

146 omeric partner of CFD1 in metazoa, functions on its own in plants.

147 E-decorated proteoliposomes that cannot fuse on their own, we now demonstrate that full fusion activi

148 sed the question of whether loss of Siglec G on its own affects disease severity in animal models of

149 s the gel; that is, no component forms a gel on its own.

150 ce of directional motion or force generation on its own.

151 etic effects (DGEs) of an individual's genes on its own phenotype and the indirect genetic effects (I

152 and keep pace with sea-level rise by growing on their own root remains.

153 pared, none yet are capable of activating H2 on their own.

154 that sNASP makes a specific complex with H3 on its own in vitro, but not with H4, suggesting that it

155 The regulatory effect auxin has on its own transport is critical in numerous self-organi

156 rst demonstration that the amphipathic helix on its own is capable of this effect.

157 eriencing distress are unlikely to seek help on their own initiative.

158 e1, but can non-specifically modify histones on its own.

159 rarely renew, manage to preserve homeostasis on their own.

160 However, HOXA9 on its own is not sufficient to confer in vivo long-term

161 vation step, we found that full-length Hsp70 on its own could activate the Hsp104 hexamer by promotin

162 Crystal structures were determined for hXK, on its own and in complexes with Xu, ADP, and a fluorina

163 a phosphine being able to hydrodefluorinate on its own.

164 , were sufficient to induce mild hyperplasia on their own.

165 R antagonist, WAY-100635, which was inactive on its own.

166 in is split into fragments that are inactive on their own, but can be reconstituted after dimerizatio

167 VL incidence on its own is not a reliable indicator of the performanc

168 ollect telephone metadata in bulk, including on their own citizens.

169 ly selecting and mating the best individuals on their own or relatives' performance.

170 rn vaccines which are relatively ineffective on their own.

171 eral independent processes, each ineffectual on its own, can reinforce to ultimately develop the patt

172 on should be able to eradicate the infection on its own.

173 hypothesized that VPA does not cause injury on its own, but it predisposes patients to pancreatitis

174 Second, theta-modulated inhibitory input on its own generates membrane potential peaks that are i

175 , explaining why polyQ domains are insoluble on their own.

176 Therefore, provided that sound intensity on its own can cue newborns' sound distance perception,

177 Although the lobes do not interact on their own, the sgRNA recruits them into a ternary com

178 scene than they could make if they viewed it on their own.

179 ncy of a pre-mRNA therefore depends not just on its own concentration and affinity for limiting splic

180 However, CeA ChR2 laser on its own lacked any reinforcement value: laser by itse

181 d the opportunities for individuals to learn on their own outside of formal classroom settings have g

182 or NRAS(G12D), does not cause acute leukemia on its own, and leukemia virus insertion frequencies pre

183 neys where they spent months or years living on their own in socially isolated environments that excl

184 MD on its own potentiated VEPs contralateral to the NDE dur

185 e guest, are able to cross the cell membrane on their own.

186 2 fails to translocate across cell membranes on its own, addition of the palladium reagent induces an

187 itivity more accurately than each metabolite on its own or other published metabolic signatures.

188 x cannot erase H2B-Ub or histone methylation on its own.

189 higher prediction accuracy than either model on its own.

190 unleash the power of computational modeling on their own data.

191 Unexpectedly, use of MPL on its own was associated with unfavorable intratumoral

192 ID93-specific TH1 responses, whereas neither on their own are effective adjuvants for generation of I

193 1p, forms a GTP-hydrolysis-dependent network on its own, serving as both a fusion and curvature-stabi

194 rom one modality, which activates the neuron on its own, should suppress the response to a preferred

195 , but which cannot mediate neurotransmission on its own.

196 The viral fusion protein gB is nonfusogenic on its own and requires glycoproteins H (gH) and L (gL)

197 uman and yeast Exo1 are processive nucleases on their own.

198 C to centromeres, failed to bind nucleosomes on its own and requires Borealin and INCENP for its bind

199 hat are distinct and discriminable may occur on their own, or in groups such as a stack of books.

200 types of spreading dynamics, each occurring on its own layer, by focusing on the two fundamental qua

201 of which is known to form a simple oligomer on its own (e.g., a dimer or trimer).

202 e not been observed to form stable oligomers on their own or with DNA, suggesting that important dete

203 ant to interact and thus induce TolC opening on its own.

204 effect than was treatment with either BA or on its own.

205 and sense of meaning by phone, in person, or on their own.

206 transmission and cannot sustain an outbreak on their own, they play an important role in establishin

207 Closed loop was started by participants on their own volition on 866 (89%) of 978 nights.

208 r by a heart failure nurse or by the patient on their own.

209 We show that these payloads on their own induced an immune response that prevented t

210 s but did not induce macrophage phagocytosis on their own.

211 fers only an extremely weak Cit(+) phenotype on its own.

212 ver, it is unclear why dynein-1 moves poorly on its own or how it is activated by dynactin.

213 sexual eukaryotes, sweep through populations on their own.

214 upport a time-dependent dilation of the pore on its own but rather reveal that the open pore of P2X r

215 identified, each of which has the potential on its own to drive the Earth system into a new state sh

216 f which can produce the paclitaxel precursor on their own.

217 ency that elicits no response when presented on its own as a signal.

218 judging visual or tactile stimuli presented on their own body surface, or pictures of hands and feet

219 ne analogs do not induce cytokine production on their own.

220 not access fibroblast chromatin productively on their own; instead, Ascl1 recruits Brn2 to Ascl1 site

221 Furthermore, activation of the EMT program on its own, as orchestrated by Zeb1, is sufficient to in

222 specialist nurse who followed the programme on their own.

223 Also, when Treg cells highly proliferated on their own, there was no additional Treg cell boost by

224 medicinal plants with antioxidant properties on their own, but that can be improved when mixed.

225 ity and ferroelectricity are rare properties on their own, combining them in one crystalline organic

226 ypically considered beneficial or protective on their own, to the basal media or feed stream may caus

227 the CVSC is not formed from pUL17 and pUL25 on their own but requires a contribution from pUL36.

228 beyond a level that individuals could reach on their own - is a topic of increasing interest.

229 ranular metrics such as precision and recall on their own specialized datasets.

230 igh recanalization rates, but recanalization on its own does not predict outcome.

231 ng through potential outcomes and reflecting on their own preferences.

232 r, they do not directly induce reinstatement on their own.

233 nt, infectious diseases clinicians must rely on their own ingenuity to effectively treat infections w

234 fy pressure ulcer risk, and that nurses rely on their own knowledge and experience rather than resear

235 public policies, decision makers often rely on their own behavioral preferences.

236 tions in their genomes and fail to replicate on their own.

237 cells can undergo inflammatory reprogramming on their own.

238 culosis CM, which has no allosteric response on its own, acquires allosteric behavior to facilitate i

239 dylethanolamines (LPEs), elicits no response on its own but synergizes with activating sulfonolipid r

240 ng extinction of conditioned motor responses on its own.

241 estingly, IFNs exert a negative retrocontrol on their own signaling by enhancing STAT1 SUMOylation.

242 nsonian rats: (1) it produced intense reward on its own and in parallel (2) decreased interest in oth

243 ogy, rotation resembles the Earth's rotation on its own axis, while revolving resembles the Earth's r

244 ins compared to the application of foliar Se on its own, the majority of which was in the highly bioa

245 a chemical message that E. coli cannot sense on its own to a molecule that activates a natural cellul

246 Compared with SF on its own, SF (at concentrations of 0.09-25%) in combin

247 The ability of SLAMF2 to signal on its own after it is engaged and the functional conseq

248 tion-competent human IL-27alpha that signals on its own and can regulate immune cell function.

249 Although significant on their own, the incorporation of genetic data in the c

250 elevant siRNA carriers is needed since siRNA on its own is an incompetent silencing agent.

251 act by forming phosphotyrosine-docking sites on their own endodomains that propagate signals through

252 nge, 1.02-1.03; P < .01), this was too small on its own to counterbalance the reduced fitness of affe

253 es and liposomes we now show that alpha-SNAP on its own interferes with the zippering of membrane-anc

254 Clinicians frequently rely solely on their own clinical judgement for risk prediction rath

255 GTP can exist in active and inactive states; on its own, GTP binding may not compel K-Ras4B activatio

256 control transmission if local ITN strategies on their own are insufficiently effective.

257 ultrapure LPS chemotypes used in this study on their own except under certain conditions.

258 The D207H substitution on its own in the monomer did not result in fluorescence

259 evious study, we showed that the OrX subunit on its own in liposomes could detect volatile organic co

260 Can plasma technology be successful on its own, or can synergies be achieved by combining it

261 esults establish that Igf2 LOI is sufficient on its own to increase rates of neoplastic development i

262 neither sorting nor plasticity is sufficient on its own to sharpen transition regions between differe

263 n and silencing, this site is not sufficient on its own to physically recruit miRISC.

264 immune protection, as neither was sufficient on their own.

265 No metazoan cell survives on its own, absent the signals and support of its milieu

266 These mutants cannot swarm on their own because they lack production of the biosurf

267 ish that SAS-6 can impose cartwheel symmetry on its own and indicate how this process might occur mec

268 Exogenous T on its own did not modulate aggressive behavior.

269 , they outperform Mfps or curli fibres taken on their own and exhibit better tolerance to auto-oxidat

270 h alignments is a complex computational task on its own; application of coevolutionary modeling has,

271 NTD and apoNGAL suggests that the N terminus on its own cannot account for the internalization of NGA

272 ch patient whether to manage genomic testing on their own, refer the patient for such testing, or ini

273 cellular module is inactivated when tethered on its own to the plasma membrane, and fluorescence cros

274 owth inhibitory activity in combination than on their own, supporting a combined delivery of PfCyRPA

275 results from each of the two techniques that on their own would appear to be contradictory.

276 inal conserved amphipathic helix (APH) that, on its own, interacts strongly with negatively charged m

277 -resolution shape and size information that, on its own, cannot lead to unique 3-D structures of biol

278 They also suggest that, on its own, the R-SNARE enters an anomalous binding mode

279 by mass action of copy number changes that, on their own, are benign.

280 many nurses highlighting the impact of this on their own wellbeing.

281 with cooperators than they would be able to on their own or by invading cooperators.

282 e" hydroperoxide photoproducts are not toxic on their own, but they become toxic after the bacteria a

283 chool closures cannot interrupt transmission on their own, they can reduce peak incidence by 40 to 60

284 ole in leaf blade outgrowth in M. truncatula on its own or in combination with STF.

285 hat a positive or negative result is unable, on its own, to confirm or exclude a suspected infection.

286 n which the individual subunits are unstable on their own.

287 We show that our method may be used on its own to make accurate identification of specific,

288 ays where each antibody preparation was used on its own.

289 al optical density (OD) measurements if used on their own without more sophisticated complementary me

290 ), but had also significant predictive value on its own (AUC=0.65, 95% CI 0.52-0.79).

291 n the population and that no gene or variant on its own has been shown to be fully deterministic of s

292 in vivo that is unable to support viability on its own.

293 t mRNAs in the cell and act in distinct ways on their own and each other's transcripts to create a ne

294 imers confirms that the lateral bond is weak on its own, with a mean lifetime of ~0.1 mus, implying t

295 itory and tactile stimuli that were too weak on their own to bias binocular rivalry were combined, th

296 an NPF that activates Arp2/3 complex weakly on its own, but with WASP/N-WASP, another class of NPFs,

297 lication-associated genome regions that were on their own "lethally recombinant." Surprisingly, mixed

298 Mutations in these two genes, whether on their own or combined with mutations in other exoglyc

299 These insertions, which on their own shift the equilibrium distribution of ISP-H

300 rganelles, but none of these organelles work on their own.