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1 a were inhibited with antimycin A, there was only a modest (1.3-fold) increase in the rate of lactic
2 the AMViap gene from the AmEPV genome led to only a modest (10-fold) loss of virion production in inf
3 traplantar formalin-evoked pain response but only a modest (20-30%) and nonsignificant reduction of m
4 mase for more detailed analysis, we observed only a modest 25% increase in k(cat)/K(m) for ceftazidim
5 alysis of the purified Y82F protein revealed only a modest (3.5-fold) decrease in binding affinity fo
6 he transmembrane domain of synaptobrevin has only a modest ability to self-associate, whereas the tra
8 like L. pneumophila, L. longbeachae triggers only a modest activation of caspase 3 and low levels of
9 or the enzyme-CoA-ribostamycin complex, with only a modest adjustment to accommodate the "linker".
11 virtually eliminated the Cl(-) currents with only a modest affect on nCl(-)-HCO(3)(-) exchange activi
13 h a single double bond in the 3-position had only a modest affinity for alpha-syn and no selectivity
14 cing CD8 T cells in T-bet-deficient mice and only a modest, although significant, reduction in the nu
16 ility over the course of infection explained only a modest amount of the variation in model results.
18 , phenotypic and genotypic factors explained only a modest amount of variability in insulin-like grow
21 he selected Zn(2+)-dependent DNAzymes showed only a modest (approximately 3-fold) activity enhancemen
22 he majority of patients (14/19 patients) had only a modest area (<25%) of endocardial abnormality.
25 platin-based chemotherapy typically produces only a modest benefit (eg, stabilization or 0.2 logMAR i
26 me, a recent placebo-controlled trial showed only a modest benefit for BoNT-A over placebo with a res
27 us bone marrow mononuclear cells, have found only a modest benefit in patients receiving stem cell th
31 e with a high prevalence of risk factors but only a modest burden of known coronary or cerebrovascula
34 tivation by acetylated H4 tail peptides, but only a modest change by unmodified H4 tail peptides.
35 nificant loss of affinity for VMAT2, whereas only a modest change in affinity was obtained in the tra
36 The overall early death rate was 17.3%, and only a modest change in early death rate was observed ov
38 ctors, and hormones, because they have shown only a modest clinical effect, and are often used in com
40 the corepressor function of Cyc8-Tup1 makes only a modest contribution to expression of target genes
46 rtile range: 85% to 96%), respectively, with only a modest correlation between hospital performance o
52 rameshift transplant" mutants transpose with only a modest decrease in efficiency, suggesting that th
54 activated T cells with rapamycin resulted in only a modest decrease in IL-4-induced S phase entry, bu
56 rlier observation that HSD is accompanied by only a modest decrease in release probability, as indica
57 lin receptor substrate-2 phosphorylation and only a modest decrease in Stat6 activation and insulin r
58 ase in tetraloop-receptor folding rate, with only a modest decrease in the corresponding unfolding ra
59 rements collected from the EMT data revealed only a modest decrease in the DAT KO group (n=3 mice) co
61 Moreover, for the reinfection experiments, only a modest decrease in the growth of a secondary M. t
62 ubstitution of Lys265 with Met or Arg causes only a modest decrease in the rate of sarcosine oxidatio
63 virus possessing Glu at 627 of PB2 exhibited only a modest decrease in virulence in mice and was high
67 E133V v-cyclin CDK-binding mutant exhibited only a modest defect in virus reactivation from splenocy
73 n cells are grown in minimal media, it shows only a modest dependence on sigma(S) when cells are grow
74 (2+), a cation not pumped by Ca(2+)-ATPases, only a modest difference between CCh- and BK-stimulated
78 supporting the hypothesis that fructose has only a modest effect in relieving repression of frtA by
80 e does not have any effect; TL2 mutation has only a modest effect in translation, but translation is
81 interface in the presence of added NaCl, and only a modest effect is seen on kcat at the anionic inte
84 hat enhanced substrate thermal stability has only a modest effect on activity, regardless of sequence
86 reatment of uninfected endothelial cells had only a modest effect on CD1d expression, suggesting that
90 majority expected that such RD&D would have only a modest effect on cost, but would improve performa
95 We show here that although T790M alone has only a modest effect on EGFR function, when combined wit
98 establishment of the silenced state but had only a modest effect on expression of some proviral inte
99 ither PD98059 or SB203580, respectively, had only a modest effect on fMLP-elicited superoxide product
102 osophila species pairs, the X chromosome has only a modest effect on hybrid male sterility between D.
104 -25/6 or mHS-3.5 in embryonic stem cells has only a modest effect on in vitro erythroid differentiati
105 Surprisingly, absence of palmitoylation has only a modest effect on in vitro or in vivo signaling.
106 ion by virus produced in fibroblasts but had only a modest effect on infection by virus from epitheli
107 he two rapid-mix reaction sequences revealed only a modest effect on k(burst) ((D)k(burst) approximat
108 ore, our results may explain why climate has only a modest effect on leaf economic traits in general.
109 ling, is sufficient to activate Akt, but has only a modest effect on lymphomagenesis in the same mode
115 vere reduction in resection tract length has only a modest effect on repair of multiple, dirty DSBs i
116 exception of the eye, ablation of Stra6 has only a modest effect on retinoid homeostasis and does no
120 e seven positions separating the two REs had only a modest effect on SoxS binding, AT basepairs were
121 e or decreasing it by hyperosmotic shock has only a modest effect on stiffness, whereas defects in th
123 generation of regulatory T cells (day 7) and only a modest effect on T-cell proliferation (48 to 96 h
124 a severe decrement in 5'-kinase activity and only a modest effect on the 3'-phosphatase; the nearby N
125 PK and to migrate in response to EGF but had only a modest effect on the ability of the cells to indu
126 ypertension was induced with norepinephrine, only a modest effect on the atherosclerotic lesion area
127 mouse prostate model is demonstrated to have only a modest effect on the characteristics of primary p
129 se opposing influences, ovule oversupply has only a modest effect on the degree to which lifetime see
130 lain why binding of ligands to exosite I has only a modest effect on the E*-E equilibrium for this mu
131 duction of both RANKL and OPG, and IL-17 had only a modest effect on the expression of RANKL or OPG.
133 ated pathogen-induced ROI production but had only a modest effect on the hypersensitive response.
134 ene, homozygous deletion of Gab2 in mice had only a modest effect on the initiation of Neu-induced ma
135 brium binding constant for RNAP while having only a modest effect on the isomerization rate constant.
137 cation of HAdV-C5 in the liver, while it has only a modest effect on the replication of HAdV-C6.
140 ered by percutaneous injections at S1-S2 had only a modest effect on thermal escape, even at higher d
142 e or double deletions of RAD17 or RAD24 have only a modest effect on TNR fragility, indicating that s
144 Zta-induced lytic replication of EBV but had only a modest effect on transcription activation functio
145 stitution of a consensus TATA box at -29 had only a modest effect on transcription, and deletion or s
147 strongly inhibited viral morphogenesis, with only a modest effect on viral gene expression, recapitul
148 irmed loci from the GWA studies, that confer only a modest effect size, could harbour a significantly
150 summary, maternal HIV infection probably has only a modest effect, if any, on maximal expiratory flow
162 nt excision circle analysis reveals there is only a modest fall in recent CD4(+) thymic emigrants in
164 suggest that common genetic variants explain only a modest fraction of heritable risk for common dise
165 ve genetic and environmental origins, yet in only a modest fraction of individuals can specific cause
168 e-wide association studies generally explain only a modest fraction of the total estimated heritabili
174 parasites, loss of TgPOFUT2 in T. gondii had only a modest impact on MIC2 levels and the wider parasi
175 f methane and black carbon would likely have only a modest impact on near-term global climate warming
176 r adjustment for number of comorbidities had only a modest impact on the association between insuranc
178 e demonstrate that MyD88-deficient mice have only a modest impairment in their LM-specific CD4 T cell
179 espite marked reductions of BDNF expression, only a modest impairment of epileptogenesis and increase
181 arning, feature characterization contributed only a modest improvement to relevance vector machine-ba
183 the levels of 5-HmdC, 5-FodC and 5-CadC, but only a modest increase in 5-HmdU, in genomic DNA of HEK2
185 contrast with many protein kinases, ACK1 has only a modest increase in activity upon phosphorylation.
188 -maximal saturation of 19.6 +/- 2.2 nm, with only a modest increase in affinity in the absence of mag
189 nd phenyl alpha-D-galactopyranoside exhibits only a modest increase in binding affinity (K(D) = 0.15
190 tion of the monocytes in women who displayed only a modest increase in circulating triacylglycerols i
191 studies have shown that exogenous FA causes only a modest increase in DNA adduct formation compared
192 finity, but the Fur(2) Zn(2) :Me(2) form has only a modest increase in DNA binding affinity (approxim
194 logous and collagen protein (SHC) and caused only a modest increase in ERK1/2 phosphorylation similar
195 cells remained metabolically quiescent, with only a modest increase in glycolysis and oxygen consumpt
197 ever, elevation of Sam68 expression achieved only a modest increase in HIV-1 production, further supp
198 detection power at markers distant from QTL, only a modest increase in marker density is needed to ob
199 s deficient in the four exonucleases display only a modest increase in mutation rate, raising questio
200 Exaggerated peritonitis was accompanied by only a modest increase in neutrophil viability, and tran
201 ars of age, subjects with 1 FDR with CRC had only a modest increase in risk for CRC incidence and dea
203 robust mt-cpYFP flashes were accompanied by only a modest increase in SNARF-1 ratio (corresponding t
205 ession of Ato within the ectoderm results in only a modest increase in SOP formation, suggesting many
206 ive cytotoxic chemotherapy, which results in only a modest increase in survival and causes significan
207 models of bubonic and pneumonic plague found only a modest increase in survival in low-dose infection
208 most frequent TERT promoter mutations showed only a modest increase in TERT transcription with no imp
209 eakly conjugated central acceptors exhibited only a modest increase in the 2PA cross section relative
213 urden better than the older guidelines, with only a modest increase in the number of patients who wer
214 t forebrain neurons contain NR1, we obtained only a modest increase in the specificity of gene transf
216 , the Pro(473) --> Leu mutant protein showed only a modest increase in Top2-mediated double strand br
218 is feasible and achieves rapid cooling with only a modest increase in treatment times in the setting
219 tion increased by >4,000-fold, but there was only a modest increase in viral production from CEM cell
220 sicular pH was approximately 6.5, supporting only a modest increase of vglut1-pHluorin fluorescence d
225 n this study, host genetic factors exhibited only a modest influence on the S. aureus carrier state o
226 bunit interactions formed by Tyr42alpha have only a modest influence on the structural properties and
227 phenylethyl bromide and methyl tosylate show only a modest influence upon introduction of the carbony
228 the radiosensitivity to killing and produced only a modest inhibition in DNA DSB rejoining in M059-J
230 nce of general toxicity while Combo Free had only a modest inhibitory effect at 16mg/kg GMP and 1.6mg
233 terestingly, we find that mismatches present only a modest kinetic barrier to nucleotide incorporatio
234 the cells infected with the mutant, there is only a modest lag in the initial accumulation of IE1 72
236 cells that more closely resembled cDC, with only a modest level of L. monocytogenes replication.
237 putative B. burgdorferi Hfq protein revealed only a modest level of similarity with the Hfq from Esch
238 or Sle3/5 (B6.Sle3/5), strains that express only a modest lupus-related phenotype, the bicongenic B6
239 anscription elongation factor b (P-TEFb) had only a modest negative effect on cleavage, as long as tr
240 ation of E2A and HEB in pre-B cell lines has only a modest negative impact on B lineage gene expressi
241 , a simple formula is proposed that requires only a modest number of inputs that are readily obtainab
243 etic markers for studying LOH, but typically only a modest number of microsatellites are tested in LO
244 liable genetic markers for studying LOH, but only a modest number of SSLPs are used in LOH studies be
246 contrast, paclitaxel-induced DEGs displayed only a modest overlap between daytime and nighttime (Zei
247 d substitution of generic drugs would affect only a modest percentage of drug expenditures, it could
248 of less than 70 mg/dL in most patients, with only a modest percentage requiring a PCSK9 inhibitor.
250 ogenic Ptx-deficient B. pertussis strain had only a modest phenotype in wild-type mice but was comple
251 d several trait-associated loci, but explain only a modest portion of the phenotypic variability.
252 n in sexually selected traits often explains only a modest portion of the variation in mating success
253 a strong activation of JNK1 and p38alpha but only a modest potentiation of serum-stimulated ERK1/2 ac
254 and 3mC with comparable efficiencies and has only a modest preference for a single-stranded DNA subst
256 d by genome-wide association studies explain only a modest proportion of heritability, suggesting tha
260 ver, the pan-caspase inhibitor Z-VAD-fmk had only a modest protective effect against the drug, sugges
261 of micronutrient-supplementation RCTs showed only a modest protective effect for multimicronutrient i
265 exposure leads to increased glycolysis, with only a modest reduction in ATP level and cell number.
267 h, myocardial infarction, or stroke, despite only a modest reduction in blood pressure (23.3 mm Hg sy
268 the absence of TRAF2 in B cells resulted in only a modest reduction in CTAR1-mediated signals and no
269 ion in mast cells, RasGRP4 deficiency led to only a modest reduction in FcepsilonRI-mediated degranul
271 stitution for the 15-hydroxyl group produced only a modest reduction in FP receptor binding, but elim
272 in provided no overall mortality benefit and only a modest reduction in hospitalizations among patien
273 ompared to MMR screening alone, but produced only a modest reduction in MDR-TB prevalence (from 0.74%
275 Furthermore, AZD1480 treatment resulted in only a modest reduction in the proportion of HPCs that w
276 in PDBu binding in the presence of lipid but only a modest reduction in the weaker binding of PDBu ob
277 igh RNA-dependent ATPase activity and causes only a modest reduction in translation and RNA splicing
278 ly, this therapeutic effect could occur with only a modest reduction observed in anti-dsDNA titers, i
279 an intervention would be cost-saving even if only a modest reduction of 1 g per day were achieved gra
280 of plasma membrane PtdIns4P but surprisingly only a modest reduction of PtdIns(4,5)P(2) because of ro
284 by Delta20, Delta20R, and KOS, and there was only a modest reduction of vhs packaging in Delta20.
285 tween the K(D) and IC(50) of a compound, but only a modest relationship between k(off) and IC(50) was
286 tation-free survival over the long term with only a modest relative increased risk of subsequent inte
288 acid intake from diet and supplements showed only a modest risk reduction for intakes of > or = 1.0 m
293 most positions in these model loops produced only a modest stabilization or destabilization except fo
294 ing agents are found, paradoxically, to have only a modest stabilizing effect, of the order of 1 kcal
297 , and lipoprotein particles, yet interrogate only a modest subset of pathways relevant to cardiovascu
298 kers between a suspect and a sample excludes only a modest subset of the population unless a very lar
299 lthough generally the materials appear to be only a modest supplier: this applies even to iron, a min
300 terestingly, disease suppression occurs with only a modest, transient increase in serum 25(OH)D(3) le