ライフサイエンスコーパス: opt

1 Using data from over 100 opted-in users, we replicate key findings from previous

2 ong 26 982 patients who were randomized, 154 opted out, and 26 828 were analyzed (mean [SD] age, 58 [

3 The remaining 27 (7%) opted for surgery without Class I or II indications.

4 (n=126) chose "Focus on comfort;" 20% (n=75) opted for "Live as long as possible;" and 12% (n=47) sel

5 AAV8G9-opt-IDUA administered to human corneas via intrastromal

6 We adopted an opt-in prescription system for patients undergoing ambul

7 rds' defeat the free-riding encouraged by an opt-in default.

8 dermine initial cooperation encouraged by an opt-out default, while 'good shepherds' defeat the free-

9 setting cooperation as the default (i.e., an opt-out default).

10 We initiated an opt-out VH and HIV testing and linkage-to-care program w

11 and draw implications for the adoption of an opt-out organ donation policy.

12 physicians consented to participate with an opt-in or opt-out mechanism; patient consent was waived

13 ased relative, support the transition to an "opt-out" policy, or donate a kidney while alive.

14 sed relative, or support a transition to an "opt-out" policy.

15 Implementing risk-based and opt-out screening could diagnose 41,900 to 122,700 new H

16 needed in addition to provider-initiated and opt-out HIV testing in adolescents, Sheri Weiser and col

17 ventures that are not in their interest and opt for ones that are.

18 transmission network, reinfection rate, and opt-out HCV screening rate are lacking.

19 self-registered on the Lumosity platform and opted in to participate in research.

20 ot meeting eligibility criteria (30-35%) and opting out (23%), and these did not differ by sex.

21 ot meeting eligibility criteria (30-35%) and opting-out (23%), and these did not differ by sex.

22 ing to be addressed, many municipalities are opting for selective testing of samples within a kit, wh

23 ultaneous liver-kidney transplant (SLKT) are opting to accept donation after circulatory death (DCD)

24 A multidisciplinary board opted for a second endovascular attempt, this time with

25 don optimized idua cDNA expression cassette (opt-IDUA) was validated for IDUA production and function

26 Centers opted for one dose (70, 74, or 78 Gy).

27 Resistant cells also co-opt developmental pathways and display stem-like propert

28 Tumors routinely attract and co-opt macrophages to promote their growth, angiogenesis, a

29 encode ethologically relevant stimuli and co-opt midbrain reward circuits to promote prosocial behavi

30 focus on the hypothesis that anesthetics co-opt the neural mechanisms regulating sleep.

31 pport to the following scenario: bacteria co-opt the host transporter SLC35D2 to import UDP-glucose i

32 io where kin- and other indirect benefits co-opt strategies originally evolved for mind-reading, and

33 studies suggest that squirrels and camels co-opt a common molecular strategy to adapt to hot environm

34 n and demonstrate that an oncoprotein can co-opt HA biosynthesis to drive malignancy.

35 demonstrate that general anesthetics can co-opt the neural circuits regulating arousal to produce un

36 chitinase A is a unique way an insect can co-opt the plant's defense proteins for its own benefit.

37 e concept that tumor-initiating cells can co-opt the self-renewal program of endogenous stem cells as

38 Here we show that B2BM cells co-opt a neuronal signalling pathway that was recently impl

39 Thus, cancer cells co-opt innate RNA sensing to induce a chemotactic signallin

40 et al., (2017) demonstrate how host cells co-opt sequential action of autophagy proteins and IFN-indu

41 e beginning to reveal the ways that cells co-opt the structures of the nuclear periphery for nuclear

42 How cancer cells co-opt this process to promote tumorigenesis remains unclea

43 Thus, commensal-specific T cells co-opt tissue residency and cell-intrinsic flexibility as a

44 liovirus (PV), and enterovirus 71 (EV71), co-opt the host cell secretory pathway, which controls the

45 How EVs co-opt cellular functions to promote replication and spread

46 Our findings suggest that host genomes co-opt retroelement activity in the germline to create new

47 Glioblastomas co-opt stem cell regulatory pathways to maintain brain tumo

48 ow that chemotherapy-resistant CD36+ LSCs co-opt gonadal adipose tissue to support their metabolism a

49 Bacteria masterfully co-opt and subvert host signal transduction.

50 MM cells may co-opt the IRE1alpha-XBP1s pathway; however, the validity o

51 MCs co-opt their secretory granules for antigen processing and

52 peutics, small hairpin RNAs (shRNAs) must co-opt sufficient quantities of the endogenous microRNA mac

53 Viruses must co-opt the cellular translation machinery to produce progen

54 At the molecular level, TBL1XR1 mutants co-opt SMRT/HDAC3 repressor complexes toward binding the MB

55 rationally design degrader molecules that co-opt CRL4s, much about the organization and regulation of

56 ed exquisite virus-host interactions that co-opt or evade a number of host pathways to enable the vir

57 Our results reveal that tissues co-opt neutrophils en route for elimination to induce progr

58 host specialization can enable aphids to co-opt both the phytohormonal responses and defensive compo

59 nd have therefore developed strategies to co-opt cellular processes to optimize infection and counter

60 ons expressing a photoactivatable Rac1 to co-opt endogenous growth cone guidance machinery to precise

61 results establish RSV's unique ability to co-opt host cell mitochondria to facilitate viral infection

62 w retroviruses coevolved with the host to co-opt innate immune sensing pathways designed to fight vir

63 fic transcription factor is sufficient to co-opt somatic transcriptional machinery to drive a pro-tum

64 One solution to this problem would be to co-opt the "temporal" guidance mechanisms that control the

65 and Neospora use a conserved mechanism to co-opt these host organelles, which suggests that lipid dro

66 roteins, E1B55K and E4orf6, that together co-opt a cellular ubiquitin ligase complex to overcome host

67 erscores why eukaryotic viruses typically co-opt eukaryotic genes and bacteriophages commonly harbour

68 In addition, viruses co-opt exosome biogenesis pathways both for assembling infe

69 s in regulating RNA function, and viruses co-opt these pathways for their own benefit.

70 environmental inputs are consolidated and co-opted by a latent virus to balance lifelong infection wi

71 he help of viral replication proteins and co-opted host proteins within large viral replication compa

72 involved in immune cell homeostasis, are co-opted by cancer cells to thwart the development of effec

73 trophils and neutrophil-derived IL-10 are co-opted by nematode parasites and other pathogens to atten

74 egulatory functions of UTRs, how they are co-opted in cancer, new technologies to interrogate cancero

75 ctivation, identifying functions that are co-opted or abated to drive human cancers and developmental

76 uppression, or mutualistic, where TEs are co-opted to benefit their host.

77 is whether host cytosolic components are co-opted to transport the viral particle into the cytosol.

78 ng and receptor trafficking, which can be co-opted and amplified in mutant p53-driven cancer cells to

79 he distributions of sequences that can be co-opted are biased with respect to codons, and phasing of

80 n mechanisms enabling regeneration may be co-opted by cancer to promote growth at primary and metasta

81 Therefore, OPCs may be co-opted by the immune system in MS to perpetuate the autoi

82 pose that larger BS in C3 lineages may be co-opted for C3 -C4 and C4 biochemistry requirements.

83 modulatory mechanisms may potentially be co-opted or interfered with for therapeutic benefits.

84 by which the innate immune system may be co-opted to drive tumor progression.

85 sic growth cone guidance machinery can be co-opted to non-invasively build new connectivity, allowing

86 d shell has another function and has been co-opted as a defense system to encase and kill parasitic n

87 y example of an exoskeleton that has been co-opted as an immune system.

88 hese transcription units, which have been co-opted as gene regulatory mechanisms.

89 ll puncturing nanomachines that have been co-opted by bacteria for self-defense against both bacteria

90 cutes and demonstrate that they have been co-opted by hosts as "anti-anti-CRISPRs," repressing phage

91 most are silenced, certain TEs have been co-opted by the host.

92 d reactive oxygen species (ROS) have been co-opted during evolution into the regulation of plant grow

93 ution of swordtails a brain gene has been co-opted for an additional novel function in establishing a

94 ures in vertebrate evolution, having been co-opted for an enormous array of functions.

95 vent in which a toxic phage gene has been co-opted for core cellular function at the root of a large

96 that nuclear import mechanisms have been co-opted for independent roles in ciliary import.

97 response to ultrasonic bat calls has been co-opted for mate location.

98 es whose RNA-directed nucleases have been co-opted for various technologies.

99 nes for insect pathogenesis may have been co-opted from genes involved in endophytic colonization.

100 This process has been co-opted into a range of developmental events, and it also

101 be ancient bacteriophages that have been co-opted into serving their host and can now transfer any g

102 suggest that TE proteins have often been co-opted or 'domesticated' by their host as adaptations to

103 suggest that a lamin derivative has been co-opted to enhance tissue stability in tardigrades, a func

104 st that different HPAT homologs have been co-opted to function in diverse species-specific developmen

105 ue chemistry that cyanobacteria have been co-opted to perform.

106 in the earliest seed plants before being co-opted to control transpiration and CO2 exchange in deriv

107 supplemental mechanism of immune evasion co-opted by tumors to evade antitumor immunity and offers a

108 nts, which might have been evolutionarily co-opted as an essential part of the adaptive genetic reper

109 Viral pathogens have also extensively co-opted the OTU fold to subvert host signaling, but the ex

110 Inhibition of host factors co-opted during active infection is a strategy hosts use to

111 Our results uncover a novel role for co-opted viral genes, demonstrating that they are used to m

112 Frequently co-opted to pattern new structures, the pathway is conserve

113 ERV elements (ERVs) has been functionally co-opted via a stress-induced SUMO switch to augment antivi

114 -microRNA regulatory circuits are further co-opted by plants to regulate both beneficial and pathogen

115 Drosophila, the nuclear piRNA pathway has co-opted a conserved mechanism of SUMO-dependent recruitmen

116 We propose that Caulobacter has co-opted a nucleoid-associated protein with high AT recogni

117 udy reveals how the human spliceosome has co-opted additional proteins to modulate a conserved RNA-ba

118 We show that the spot enhancer has co-opted the sequences of the wing blade enhancer.

119 s as a transcriptional activator that has co-opted XPB to specifically target 15 EBV promoters that h

120 Primates have co-opted a viral gene to produce an envelope protein that p

121 species that have a fully folded H2 have co-opted an alternative mechanism for promoting p150(Glued)

122 ion of the somatic nucleus, and they have co-opted different DNA recombination mechanisms-some previo

123 Therefore, we have co-opted IL-8 release from tumors to enhance intratumoral T

124 which bacterial Tn7-like transposons have co-opted nuclease-deficient CRISPR-Cas systems to catalyse

125 s1-2, whereas the prespacer processing is co-opted by cellular non-Cas exonucleases, thereby offsetti

126 Furthermore, this allosteric mechanism is co-opted by pathway branchpoint enzyme chorismate mutase up

127 tial mediator of the ALT mechanism and is co-opted by post-translational mechanisms to maintain telom

128 ibility is that this feedback response is co-opted by the learning system and used as a template to i

129 llular ancestor when an ancestral gene is co-opted for cell adhesion.

130 The other splice site is co-opted from the gene sequence that is duplicated upon tra

131 We suggest this system is co-opted in the brain to counteract and regulate aberrant n

132 mulation in most cells that express it is co-opted to negatively regulate pDC IFN-I production and li

133 inhibition as in existing treatments, is co-opted to trigger therapeutic programs.

134 volved in a non-sexual context, and later co-opted for sexual signalling when sound producing organs

135 e ancestor and that smooth myocytes later co-opted the striated contractile module repeatedly - for e

136 However, a subgroup of genes was likely co-opted de novo early in the Pooideae.

137 Endogenous viruses are occasionally co-opted by their hosts to combat other viruses.

138 this study, we dissected the functions of co-opted cellular ESCRT-I (endosomal sorting complexes requ

139 ealed intriguing and complex functions of co-opted cellular translation factors, heat shock proteins,

140 Although the important roles of co-opted host proteins in RNA virus replication have been a

141 iga, suggesting a pathway that was partly co-opted during the evolution of the haustorium.

142 P32A represents an essential host partner co-opted to support influenza virus replication and is a ca

143 The cellular host factors and pathways co-opted during SARS-CoV-2 and related coronavirus life cyc

144 idea that these elements are pervasively co-opted for the regulation of host genes.

145 tation of the CRISPR/Cas editing platform co-opted from bacteria has provided a mechanism for a means

146 r chromatin states, representing putative co-opted LAVA enhancers.

147 of the early mouse embryo have seemingly co-opted TEs as enhancers, but there is little evidence tha

148 tein that acts as a "don't eat me" signal co-opted by cancers to evade innate immune surveillance, is

149 othesise that WIP genes were subsequently co-opted in the control of morphogenesis of novel multicell

150 target in stem chordates and subsequently co-opted into the development of many novel traits in verte

151 R-associated Rossman fold (CARF) subunits co-opted from type III CRISPR immunity.

152 independently evolved fungal complex that co-opted useful activities from bacterial neighbours within

153 The emerging picture is that many of the co-opted host factors are from highly expressed and conserv

154 The co-opted PK generates high levels of ATP within the viral r

155 The ATP generated by the co-opted PK is used to promote the helicase activity of rec

156 or VRCs, likely in collaboration with the co-opted the syntaxin18-like Ufe1 SNARE protein within the

157 , demonstrating the requirement for these co-opted cellular factors in tombusvirus replicase formatio

158 ome editing to determine the roles of two co-opted transcription factors that are expressed during ea

159 can be controlled by the activity of two co-opted transcription factors.

160 trunk myogenic patterning and how it was co-opted during tail evolution to generate similar muscle b

161 We conclude that (1) ABA was co-opted early in plant evolution to regulate functionally

162 chitecture of inactive kinase domains was co-opted in the activated dimer but the network hub shifted

163 We report that the HoxC gene cluster was co-opted to be transcribed in the distal limb ectoderm, whe

164 We co-opted Escherichia coli for biomolecular synthesis and as

165 We co-opted the aberrant reproductive process of haploid induc

166 f lateral openings that subsequently were co-opted as pharyngeal gills.

167 ant ARABIDILLO germination functions were co-opted early into both gametophyte and sporophyte, with a

168 volved as chromosomal scaffolds that were co-opted for a similar purpose in striated muscles.

169 fish kank genes suggested KANK genes were co-opted for vertebrate vascular development.

170 ormation and that NOG2-related genes were co-opted into the lignin biosynthesis pathway after the div

171 own, however, about how, or even whether, co-opted genes function in eyespot development.

172 Co-opting cellular factors for viral translation and viral

173 Co-opting Cullin4 RING ubiquitin ligases (CRL4s) to inducib

174 nerate phenotypic novelty: exaptation and co-opting of the ancestral bauplan, the quasi-independence

175 These viruses make sfRNAs by co-opting a cellular exonuclease via structured RNAs called

176 two tissues to promote tumorigenesis, by co-opting a normal regulatory mechanism that prevents the m

177 suggesting that this syndrome evolved by co-opting a preexisting age-dependent program.

178 ual deception, pollination is achieved by co-opting and regulating two independent biosynthetic pathw

179 ceptor impinges on a signaling pathway by co-opting protein kinase docking sites to constitutively ac

180 tion factors, and nontranscriptionally by co-opting redox oscillations.

181 st enhancing and integrative functions by co-opting the capacities of the two cerebral hemispheres.

182 that have evolved dosage compensation by co-opting the dosage-compensation male-specific lethal (MSL

183 ago (Mya), whereas Cf-2 evolved <6Mya by co-opting the pre-existing Rcr3 in the Solanum genus.

184 trations at a post-translational level by co-opting the ubiquitin-proteasome system.

185 s of phage genes for their own benefit by co-opting them as toxins for functions related to bacterial

186 and to present CMV antigen to TH1 cells, co-opting MC secretory granules for antigen processing and

187 Despite co-opting STING to promote its replication, interferon sign

188 he hypothesis that EVs may be critical in co-opting tissues by tumours to generate distant metastatic

189 eals that, contrary to the expectation of co-opting regulatory mechanisms readily in place, the evolu

190 oach to targeted therapy that is based on co-opting the cellular quality-control machinery-the ubiqui

191 viral genome packing and in host-protein co-opting necessary for viral replication and infectivity.

192 The evolution of a receptor co-opting a conserved pathogen target contrasts with other

193 ti-tumoral immunity and escape, revealing co-opting of tissue-specific immune development in the tumo

194 rculating proteins to their own surfaces, co-opting the host protein functions as a mechanism of viru

195 Moreover, we show that co-opting this circuit by chemogenetic activation can creat

196 n complexes and provide an example of the co-opting of cellular processes by CMV.

197 Thus, HSV-1 co-opts an innate immune pathway resulting from IL-1 stimul

198 We have shown that C. albicans co-opts amino acid catabolism to generate and excrete ammon

199 NPM-ALK co-opts several intracellular signal transduction pathways,

200 The viral polymerase complex co-opts the nuclear RNA exosome complex and cellular RNAs e

201 n an unusual twist, human cytomegalovirus co-opts the antiviral radical SAM enzyme viperin (virus-inh

202 intracellular parasite Toxoplasma gondii co-opts critical functions of its host cell to avoid immune

203 We show that budding yeast Ty3/Gypsy co-opts binding sites of the essential meiotic transcriptio

204 ere, we show that hepatitis C virus (HCV) co-opts the host protein CypA to aid evasion of antiviral r

205 This study examined whether HIV co-opts the normal T cell activation process through the so

206 s, we found that the type III-B machinery co-opts type I-F CRISPR-RNAs.

207 These results suggest Mtb co-opts an evolutionary recent IFN-IL6-CEBP feed-forward lo

208 its association with MAL and Rab11b, Nef co-opts Lck switchlike function driving the formation Ca(2+

209 f evidence suggests that cancer mimics or co-opts developmental processes to facilitate tumor initiat

210 This research co-opts this crosslinking-mediated internalization for effi

211 The system co-opts the orthogonal autoinducer AI-1 and AI-2 cell-cell

212 We find that TBSV co-opts the cellular glycolytic ATP-generating pyruvate kin

213 paper, the authors demonstrate that TBSV co-opts the guanosine triphosphate (GTP)-bound active form

214 Tomato bushy stunt virus (TBSV) co-opts cellular ESCRT (endosomal sorting complexes require

215 GEF within the multifunctional OtDUB that co-opts host Rac1 signaling to induce changes in cytoskelet

216 The MR1 antigen-presentation pathway thus co-opts ER chaperones to fulfill its unique ability to pres

217 One route by which Toxoplasma co-opts its host cell is through hijacking host organelles,

218 ness along remaining blood vessels, which co-opts vessels in a VEGF-independent and neoangiogenesis-i

219 cooperation under defaults for cooperation (opt-out) and defection (opt-in).

220 The current "opt-in" strategy for anti-EGFR therapy in all patients w

221 lts for cooperation (opt-out) and defection (opt-in).

222 We develop opt-SNE, an automated toolkit for t-SNE parameter select

223 e reasons why potential living kidney donors opt out of the donor evaluation process for nonmedical r

224 absorption between 600 and 940 nm with an Eg(opt) of 1.32 eV.

225 fidence in their choices, and refrained from opting out of objectively difficult trials.

226 minal propensities across population groups, opting for a facultative view of life history evolution

227 d over, suffered from chronic back pain, had opted in to the clinic and had sufficient ability to rea

228 Unique to this review, we have opted to highlight research efforts undertaking meticulo

229 Should he opt out of the care of these patients or does his duty t

230 could potentially increase registrations in opt-in donation systems.

231 In opting for perceptual realism over social constructivism

232 tion than ever before, with many individuals opting to consume content through social channels rather

233 tandard of care included health information, opt-out HIV testing, infant feeding counselling, referra

234 ert committees, the National Heart Institute opted against an explanatory diet trial and for a pragma

235 ert committees, the National Heart Institute opted against an explanatory diet trial and for a pragma

236 V case-finding (achieved through introducing opt-out HCV testing in UK pilot prisons) and increasing

237 nimizer-based tools (e.g. Minimap2, Mashmap) opt to discard the most frequently occurring minimizers

238 etween July 2017 and June 2018 in a narcotic opt-in program.

239 we randomly assigned practices that did not opt out to an implementation package targeting either di

240 ted number of centers have reported rates of opting out between 0.2% and 22%; the reasons for declini

241 However, if one opts to use the term COVID-19 in the incidental setting,

242 n southwestern Harare implemented optimised, opt-out PITC for all attendees aged 6-15 years.

243 an email with the active choice to opt in or opt out (active choice), or the active choice email plus

244 s consented to participate with an opt-in or opt-out mechanism; patient consent was waived with IRB a

245 Fourteen participants opted for a 16 week moderate intensity supervised exerci

246 rcise intervention, while seven participants opted for control.

247 We compared survival of patients opting for an HLAi kidney transplant with that of simila

248 three characteristic pH values (pH(phi1), pH(opt), and pH(phi2)) at which recognizable transitions ta

249 The pH(opt) was recognized at the net charge neutrality or the

250 In Australia's "opt-in" system, people register their donation decision

251 , an informed consent was obtained after she opted for medical termination of pregnancy.

252 An informed consent was obtained after she opted for medical termination of pregnancy.

253 , and even risk-averse individuals sometimes opt for riskier alternatives.

254 In summary, opt-SNE enables superior data resolution in t-SNE space

255 s to predict responses of both AO rate and T(opt) at varying substrate and temperature below the crit

256 the total amount of leaf area displayed at T(opt) and intermediate growth temperatures.

257 Substrate addition elevates T(opt) when ambient substrate is unsaturated.

258 , they do not reduce the risk of exceeding T(opt) (+2% higher).

259 y environments lower the risk of exceeding T(opt) , critical EWL limits are still exceeded during 63%

260 2-2012), we predict that harmful thermal (>T(opt) ) and hydric (>EWL(crit) ) conditions limit the act

261 requency of exceeding the thermal optimum (T(opt) ) or critical evaporative water loss (EWL(crit) ) l

262 inimum (T(min) ) and optimum temperatures (T(opt) ) for growth in water (-17 and +20 degrees C, respe

263 ubstrate co-regulate optimum temperatures (T(opt)), generating distinct thermal response patterns wit

264 ng distinct thermal response patterns with T(opt) varying from <=14 degrees C to >=34 degrees C.

265 Patients were excluded if they opted out this service after the initial assessment, suf

266 d HCV testing in UK prisons (such as through opt-out testing) is borderline cost-effective compared t

267 Policies to remove parents' ability to opt-out from school immunization requirements on the bas

268 control), an email with the active choice to opt in or opt out (active choice), or the active choice

269 sent an introductory letter with 14 days to opt out.

270 rally permissible and a rational decision to opt out.

271 h care providers at high risk, the option to opt out of the care Covid-19 suspected or infected patie

272 lantation, which would encourage programs to opt into splitting more livers.

273 Finally, we offer some guidance on when to opt for scRNA-Seq and when bulk sequencing approaches ma

274 dge, attitudes, and behavior with respect to opting out of NBS or DBS for their child.

275 e-riding under opt-out and cooperation under opt-in.

276 should strategically deter free-riding under opt-out and cooperation under opt-in.

277 Universal opt-out HCV screening in prisons is highly cost-effectiv

278 Risk-based and universal opt-out hepatitis C screening in prisons, followed by tr

279 e of this analysis was to evaluate universal opt-out HIV and HCV screening in two EDs in San Diego.

280 We used 'opt-out' recruitment, and we randomly assigned practices

281 generated from three hundred million users, opted-in to Location History, are used to extract global

282 nsional structures could be controlled using opted processing routes.

283 VvCEB1(opt) -overexpressing lines also showed increased salinit

284 VvCEB1(opt) -overexpressing lines displayed significant increas

285 VvCEB1(opt) -overexpressing lines showed increased instantaneou

286 elix-loop-helix transcription factor (VvCEB1(opt) ) from wine grape involved in the cell expansion ph

287 different examples of a single situation, we opt for model-based learning and adaptive flexibility.

288 background staining of the host nucleus, we opted for developing HIV-1 reverse transcriptase (RT)-sp

289 The negative impact of hiding holds whether opting not to disclose unflattering (drug use, poor grad

290 donations, we find that 21% were made while opting to be anonymous to the public, with survey result

291 ther research on potential living donors who opt out of donation.

292 The experiences of individuals who opt out of donation may reveal avenues for enhancing don

293 tissue expander or the implant for women who opt for a two-stage expander-implant reconstruction.

294 sed the biparametric MRI findings in men who opted for EBRT from January 2018 to June 2019 (n = 79; m

295 Patients who opted for ABR had significantly higher satisfaction with

296 ical correlation was done in 31 patients who opted for surgical treatment.

297 no significant change in VA in patients who opted to have PPV to treat their IMT type 2 and FTMH com

298 ho underwent surgery compared with those who opted for medical management.

299 l of 692 patients were enrolled, 84% of whom opted to receive bevacizumab.

300 ibration of early exaggeration together with opt-SNE adjustment of gradient descent learning rate dra