ライフサイエンスコーパス: optic cup

1 folds, caudal branchial arch, hindbrain, and optic cup.

2 ls (RPCs) residing in the inner layer of the optic cup.

3 ing (cVax) within the ventral but not dorsal optic cup.

4 bdividing dorsal and ventral portions of the optic cup.

5 trols tissue specification in the developing optic cup.

6 retinal neuroepithelium (RNE), a part of the optic cup.

7 steps before the formation of the definitive optic cup.

8 of the eye arrests prior to formation of an optic cup.

9 tating cell rearrangement to form a complete optic cup.

10 f the bimetallic strip, the curvature of the optic cup.

11 pithelial flow around the distal rims of the optic cup.

12 ayered cortical neuroepithelium or an entire optic cup.

13 s that originate from the inner layer of the optic cup.

14 thereby suppress apoptosis in the developing optic cup.

15 involute around the rim of the invaginating optic cup.

16 expressed in the mesenchyme surrounding the optic cup.

17 o regulate the morphogenesis of the lens and optic cup.

18 the transition of the optic vesicle into the optic cup.

19 nted epithelium are not contained within the optic cup.

20 nts that lead to ventral invagination of the optic cup.

21 in timing and apposition of two poles of the optic cup.

22 y close, giving rise to a healthy, spherical optic cup.

23 lens ectoderm is not sufficient to create an optic cup.

24 s that underwent invagination and formed the optic cup.

25 rm that induces the optic vesicle to form an optic cup.

26 Optic vesicles formed but lacked the optic cups.

27 the formation of small and abnormally shaped optic cups.

28 ntified in the anterior portion of lens-less optic cups.

29 11 resulted in structurally normal lens and optic cup, although the latter showed abnormal expressio

30 that is derived from the anterior rim of the optic cup, an extension of the neural tube.

31 Ventral closure of the optic cup and choroid fissure does not occur.

32 Pax6 may promote cell surface changes in the optic cup and control the fate of the ectoderm from whic

33 ic vesicle formation, transformation into an optic cup and integration with neighboring tissues are e

34 h placodes invaginate to form the definitive optic cup and lens, respectively.

35 acting directly and cell autonomously in the optic cup and lens.

36 embryonic fissure as it forms in the ventral optic cup and optic stalk.

37 ural tube, urogenital system, optic vesicle, optic cup and optic tract.

38 rogenital system, neural tube, otic vesicle, optic cup and optic tract.

39 ive Wnt receptor expressed in the eye field, optic cup and retina - causes all of these defects with

40 her sex and found that the morphology of the optic cup and stalk and the closure of the optic fissure

41 of Wnt/beta-catenin target molecules in the optic cup and stalk may underlie the molecular and morph

42 expression in the intermediate mesoderm, the optic cup and stalk, and the otic vesicle, Pax2, a membe

43 h signals persist after the formation of the optic cup and suggest that the early vertebrate optic pr

44 differentiation begins in the dorso-central optic cup and sweeps peripherally and ventrally.

45 Krd/+ embryos, Pax2+ cells in the posterior optic cup and the optic stalk undergo abnormal morphogen

46 iameter and perimeter of each optic disc and optic cup and the width of the neuroretinal rim were dra

47 A larger optic cup and/or a more damaged visual field are predict

48 vel approaches for detecting optic discs and optic cups and calculating VCDR, offers clinicians a pro

49 entiated photoreceptors in three-dimensional optic cups and retinal pigment epithelium (RPE) from iPS

50 rying a null allele of this gene do not form optic cups and so do not develop eyes.

51 ing membrane within the temporal area of the optic cup, and ODVD reduction was determined when there

52 the development of the renal epithelia, the optic cup, and the inner ear.

53 ere higher for vertical optic disc, vertical optic cup, and vertical cup-to-disc ratio than for intra

54 tion, cNCC migration and localization in the optic cup are perturbed.

55 ONH parameters (including optic disc area, optic cup area, neuroretinal rim area, cup volume, rim v

56 g the specification of cells along the inner optic cup as retinal tissue, polarity of the retinal neu

57 e inner and outer segments of the developing optic cup at embryonic days 10.5 to 11.5.

58 tly its expression becomes restricted to the optic cup by reciprocal transcriptional repression of pa

59 undergo optic cup morphogenesis; and (2) the optic cup can form in the absence of lens formation.

60 surface fish embryonic lens into a cavefish optic cup can restore a complete eye.

61 2alpha mutants also exhibited defects in the optic cup consisting of transdifferentiation of the dors

62 or abnormal development leading to defective optic cup, cornea, and eyelid morphogenesis.

63 and induced pluripotent stem cell (iPSC) 3D optic cups derived from a patient carrying an RP2 nonsen

64 iPSCs differentiated normally into RPE and optic cups, despite abnormal CEP290 splicing and cilia d

65 RA signaling in the optic cup, detected by using a RARE-lacZ transgene, is n

66 us demonstrate a role for Bcor during normal optic cup development in preventing colobomata.

67 enetic proteins (BMPs) also regulate ventral optic cup development.

68 l (RPE) compartment during optic vesicle and optic cup development.

69 d in the smaller optic discs controlling for optic cup diameter as well as age, systolic and diastoli

70 55, 0.57, and 0.48 for intraocular pressure, optic cup diameter, optic disc diameter, and cup-to-disc

71 Absolute (anterior or posterior) optic cup displacement (OCD) averaged 41 +/- 7 mum in 30

72 e is overproliferation of the outer layer of optic cup (E10.5) immediately after the initial specific

73 cation of the eye anlage, growth rate of the optic cup, establishment of retinal stratification, spec

74 splicing and cilia defects were observed in optic cups, explaining the retinal-specific manifestatio

75 mc1 function impairs basal contractility and optic cup folding.

76 Later aspects of distal optic cup formation (i.e. retina development) are normal

77 f Vax1 and Vax2, known regulators of ventral optic cup formation and choroid fissure closure, and tha

78 de evidence that Tbx2 is required for proper optic cup formation and plays a critical early role in r

79 rocedure quantifies eye field specification, optic cup formation and retinal differentiation in 3D cu

80 sis needs to be tightly regulated for normal optic cup formation and that Bcl6a, Bcor, Rnf2 and Hdac1

81 We investigated the role of Tbx2 in optic cup formation by analysing mice with a targeted ho

82 esis occur, but development arrests prior to optic cup formation in both the optic neuroepithelium an

83 icle to optic cup transition and after early optic cup formation in chick embryos.

84 mburger Hamilton (HH) stage 10, there was no optic cup formation, and lens development was abortive d

85 orebrain hemisphere fusion, ventricle shape, optic cup formation, neural tube closure, and layering o

86 by fast-developing species to enable timely optic cup formation.

87 optic vesicle position but caused arrest of optic cup formation.

88 or, is required to prevent colobomata during optic cup formation.

89 coordinates the multiple pathways leading to optic cup formation.

90 Gli3 into the Ftm (-/-) background restored optic cup formation.

91 nation of RNE cells and consequently impairs optic cup formation.

92 The hemispheric, bi-layered optic cup forms from an oval optic vesicle during early

93 nsgene is expressed within the domain of the optic cup from which RPE arises, and Yap immunoreactivit

94 inarily that the most anterior layers of the optic cup have a retained retinal and neuroglial differe

95 tecture, for the detection of optic disc and optic cup in fundus images and the subsequent calculatio

96 The neuroepithelium forms an optic cup in which the spatial separation of three domai

97 Fundus examination showed glaucomatous optic cupping in the right eye, while the left fundus co

98 n of all lines resulted in the generation of optic cups in a self-organising manner after 100 days in

99 ification of normal ciliary body, we created optic cups in which the lens had been removed while stil

100 essed in the non-neuronal derivatives of the optic cup, including the pigment epithelium, optic stalk

101 ce fish lens is transplanted into a cavefish optic cup, indicating that cavefish optic tissues have c

102 e lens tissue in inducing and/or maintaining optic cup invagination in ovo.

103 The formation of the vertebrate optic cup is a morphogenetic event initiated after the o

104 The driving element within the optic cup is almost certainly the retinal pigmented epit

105 per dorsal--ventral pattern formation of the optic cup is essential for vertebrate eye morphogenesis

106 Later, in the optic cup, it is restricted to the prospective dorsal ci

107 Optic cup morphogenesis (OCM) generates the basic struct

108 ior and actomyosin dynamics during zebrafish optic cup morphogenesis by live imaging.

109 added, a neural retina does not develop and optic cup morphogenesis fails, although lens formation a

110 m line Pax6 inactivation, and the failure of optic cup morphogenesis indicates the importance of ecto

111 Our work shows that optic cup morphogenesis is driven by a constriction mech

112 re or in some instances, more severe ventral optic cup morphogenesis phenotypes.

113 inding transcription factors govern lens and optic cup morphogenesis.

114 e absence of neural crest partially restores optic cup morphogenesis.

115 n with pre-lens ectoderm in order to undergo optic cup morphogenesis; and (2) the optic cup can form

116 gs of this cohort study suggest that smaller optic cup morphology may be associated with optic disc e

117 nd scleral canal opening, and alterations in optic cup morphology, including shallow or deep excavati

118 In the dorsal RPE of the optic cup, Nf2 inactivation leads to a robust increase i

119 riptional changes that spatially pattern the optic cup (OC) and control the initiation and progressio

120 ris, two tissues derived from the peripheral optic cup (OC).

121 tion of a surface fish lens into a cave fish optic cup or lens extirpation.

122 ectopic Pax2 expression in the chick ventral optic cup past the normal developmental period when Pax2

123 entral retinal pigment epithelium, defective optic cup periphery, and closure defects of the eyelid,

124 rise to four basic tissues in the vertebrate optic cup: pigmented epithelium, sensory neural retina,

125 ormation and highlight the key role that the optic cup plays in this process.

126 ablish that cell movements in the developing optic cup require neural crest.

127 pressed in the anterior optic vesicle and/or optic cup, respectively, did not affect the rod pattern.

128 ent after transplantation into the cave fish optic cup, restoring optic tissues lost during cave fish

129 We show that genetic ablation of SOX2 in the optic cup results in complete loss of neural competence

130 ectroporation of Pax2 into the chick ventral optic cup results in the formation of colobomas, a condi

131 igment epithelium (RPE) progenitors near the optic cup rim.

132 ess consistent and not significant for small optic cup sizes.

133 At the optic cup stage, Pax6, Tbx5 and Bmp4 are ectopically exp

134 At optic cup stages, however, noggin overexpression caused

135 ficant effects on the development of ventral optic cup structures.

136 genes is lost following early removal of the optic cup, suggesting a role for this tissue in inducing

137 e show by genetic ablation in the developing optic cup that Meis1 and Meis2 homeobox genes function r

138 e (CF), a transient structure in the ventral optic cup through which vasculature enters the eye and g

139 tiation protocol, allowing three-dimensional optic cups to form.

140 In the POAG group, optic cup-to-disc ratio (CDR) was positively correlated

141 irements for Shh during the optic vesicle to optic cup transition and after early optic cup formation

142 The ventral region of the chick embryo optic cup undergoes a complex process of differentiation

143 c consequences that included a saucer-shaped optic cup, ventral coloboma, and a deficiency of periocu

144 Changes in minimum rim width, optic cup volume, Bruch membrane opening height, peripap

145 total retinal thickness, minimum rim width, optic cup volume, mean cup depth, mean cup width, cup-di

146 The morphology of the optic cup was also severely affected in these chimeras;

147 Human 3D organoid optic cups were used to investigate REEP6 expression and

148 during development with the formation of the optic cup, which contains the neural retina, retinal pig

149 Treating optic cups with an antisense morpholino effectively bloc