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1 rt, the acute appetite-stimulating effect of orexin A.
2 hen intracerebroventricularely injected with orexin A.
3 reboxetine, they were by exogenously applied orexin A.
4 A-A receptor agonist) were injected prior to orexin A.
5  of food-evoked dopamine spikes by intra-VTA orexin-A.
6  the infected hypothalamic neurons contained orexin-A.
7 metabolic activity (CMRglc) than intravenous orexin-A.
8                                              Orexin A (0, 100, 500, and 1000 pmol, in 0.5 microl arti
9  single intracerebroventricular injection of orexin A (1 and 3 nmol) or orexin B (3 nmol), during the
10                                              Orexin A (1 micromol/l) caused a 500% increase (P < 0.01
11                           Fourth ventricular orexin-A (1 nmol) activated Fos expression in the raphe
12                             Nanoinjection of orexin-A (12 pmol) into the rostral raphe pallidus (rRPa
13  rank order of potency orexin A > orexin B > orexin A 16-33, that it bound antagonist ligands with af
14 ng 20 h (4-24 h postinjection period) in the orexin A 3 nmol injected group whilst the frequency of i
15                    Central administration of orexin-A acutely suppressed cataplectic behavioral arres
16 ntly dropped during the first hour following orexin A administration, coinciding with orexin A-induce
17 ve behavior and autonomic functions of local orexin-A administration in nonanesthetized rats.
18                                              Orexin-A administration to the fourth ventricle induced
19                                              Orexin A altered the intrinsic neuronal properties of GS
20 mic (LH) orexin neurons, increases levels of orexin A and 2-arachidonoylglycerol (2-AG) in the ventra
21                 The neuromodulatory peptides orexin A and B are important central nervous system regu
22                            The neuropeptides orexin A and B are synthesised by perifornical and later
23                                              Orexin A and B fibers were visible across the brain, wit
24                                              Orexin A and B neurons were located in a single populati
25 dentify the specific sites of orexin action, orexin A and B were microinjected into a number of hypot
26      Orexins (hypocretins) are two peptides (orexin A and B) produced from the pre-pro-orexin precurs
27                                              Orexin A and B, a recently identified pair of neuropepti
28            It is concluded that the peptides orexin A and B, acting on orexin receptors, which are GT
29 n-like peptide 1, oxyntomodulin, peptide YY, orexin A and ghrelin.
30 e-controlling neuropeptides such as ghrelin, orexin A and neuropeptide Y is also discussed.
31                                              Orexin A and Orexin B (also known as hypocretins) are ne
32                                              Orexin A and orexin B stimulate feeding when administere
33                                              Orexin A and orexin B were microinjected into the perifo
34 tured primary hypothalamic neurons expressed orexin A and orexin receptor 1.
35 de that GSNs are specific target neurons for orexin A and suggest that they may mediate, at least in
36                                              Orexin-A and -B are brain-gut peptides that stimulate fo
37                  It has long been known that orexin-A and -B excite basal forebrain cholinergic neuro
38                       These peptides, termed orexin-A and -B, have no significant structural similari
39 the conduits of a negative crosstalk between orexin-A and CRF as demonstrated in transfected cells an
40 le-label immunohistochemistry confirmed that orexin-A and dynorphin-A peptides were highly colocalize
41 pounds including the native agonist peptides orexin-A and orexin-B and the potent therapeutic inhibit
42                                              Orexin-A and orexin-B are neuropeptides originally ident
43  Melanin concentrating hormone (MCH) and the orexins (A and B) have been identified as neuropeptides
44 s inhibition of the excitatory neuropeptides orexins A and B by design of orexin receptor antagonists
45 orexin system consists of two neuropeptides (orexins A and B) and two receptors (OX1 and OX2).
46 xins 1 and 2, and two neuropeptide agonists, orexins A and B, has captured the attention of the scien
47             Hypocretins 1 and 2 (also called orexins A and B, respectively) are hypothalamic neuropep
48      The hypothalamic peptides hypocretin-1 (orexin A) and hypocretin-2 (Hcrt-2; orexin B) are import
49 el, MD led to increased hypothalamic CRH and orexin A, and frontal cortical orexin 1 receptors (OX1R)
50 letely blocked by prior administration of an orexin A antagonist.
51        prepro-orexin mRNA and immunoreactive orexin-A are localized in neurons within and around the
52                                              Orexin A augmented feeding in the 0-1 h and 1-2 h post-i
53  greatly reduced the binding and function of orexin A but not antagonist ligands.
54 estingly, ISO neurons responded to light and orexin A, but did not respond to the other food intake-r
55 ons, which are inhibited by low glucose, but orexin A caused smaller depolarization than on GSNs and
56 using both calcium mobilization and [(125)I]-orexin-A competition binding.
57 ior or superior colliculi, a large number of orexin-A-containing neuronal processes and terminal arbo
58 pressing excitatory vs. inhibitory inputs to orexin-A-containing neurons in the lateral hypothalamus
59 active neurons were not colocalized with the orexin-A-containing neurons.
60 mplex promotes a long-term disruption of the orexin-A-CRF negative crosstalk.
61 nal amyloid load was not associated with CSF orexin-A, CSF AD biomarkers, or neuropsychological profi
62                          Results showed that orexin-A delivered via the intravenous and nasal routes
63             We find that, as with yohimbine, orexin A depression of excitatory transmission in BNST i
64         While the effects of dynorphin-A and orexin-A desensitize over multiple applications, co-appl
65     The responses both to dynorphin-A and to orexin-A desensitize, but co-application of dynorphin-A
66                                              Orexin-A elicits arousal EEG during anesthetic burst-sup
67  of the hypothalamus as an area important to orexin A feeding regulation.
68 ucleus possessed little or no immunoreactive orexin A fibres in its core, but had fibres at its perip
69 leaflet contained a plexus of immunoreactive orexin A fibres throughout its rostro-caudal extent.
70                      Immunoreactive varicose orexin A fibres were found throughout the hypothalamus.
71 and all were found to contain immunoreactive orexin A fibres.
72 S score (mean+/-SD) at 4 h was higher in the orexin-A group compared to controls (57.3+/-5.8 vs. 40.7
73 frequency was similar in both groups but the orexin-A group demonstrated higher IQ values compared to
74  values remained significantly higher in the orexin-A group for the first 120 min (p=0.008) and subse
75  it was activated with rank order of potency orexin A &gt; orexin B > orexin A 16-33, that it bound anta
76                                              Orexin A (&gt;/=500 pmol) stimulated feeding in the PFH and
77                                              Orexin-A had no effect on the resting discharge of affer
78 Concentrations of CSF hypocretin-1 (formerly orexin A) have been measured in many patients with sleep
79  alcohol via stimulation of the hypocretin-1/orexin-A (Hcrt-1/Ox-A) system.
80                                              Orexin A/hypocretin-1 (oxA/hcrt-1) is known to be a modu
81  of this study show that MTN neurons receive orexin A hypothalamic innervation with a somatotopic arr
82 esencephalic trigeminal nucleus (MTN), using orexin A immunohistochemistry.
83 dbrain-pontine junction part of the nucleus, orexin-A-immunopositive varicosities were relatively mor
84                              The presence of orexin A-immunoreactive fibres in the neural architectur
85 tween TRH-immunoreactive nerve terminals and orexin-A-immunoreactive cell bodies.
86    In the caudal pontine MTN, only scattered orexin-A-immunoreactive fibers were found, while more ro
87 lamic orexinergic input, the distribution of orexin A immunoreactivity was examined in the rat mesenc
88                                              Orexin-A-immunostained nerve fibers and terminals were f
89 cadian system suggests an important role for orexin A in circadian timekeeping processes.
90 s were used to determine the distribution of orexin A in the structures of the hypothalamus and thala
91 evidence for the effectiveness of intranasal orexin-A in alleviating cognitive deficits produced by l
92     Here, we show that NAc microinjection of orexin-A in medial shell amplifies the hedonic impact of
93                                  The role of orexin-A in recovery of arousal after CA deserves furthe
94 des corticotropin-releasing factor (CRF) and orexin-A in the ventral tegmental area (VTA) play an imp
95  lacked any electrophysiological response to orexin-A in the wake-promoting neurons of the tuberomamm
96                                 Injection of orexin-A increased vital signs to baseline levels.
97  resistance, and in voltage-clamp recordings orexin-A induced an inward current that reversed near th
98  orexin 1 receptor antagonist (SB334867A) on orexin A-induced feeding and locomotor activity was asse
99                                              Orexin A-induced feeding was significantly attenuated by
100 A antagonists failed to significantly affect orexin A-induced feeding, but muscimol significantly and
101 significantly and dose dependently inhibited orexin A-induced feeding.
102 ing orexin A administration, coinciding with orexin A-induced feeding.
103                                              Orexin A-induced locomotor activity was not affected by
104 ent study shows that in vitro application of orexin A induces potentiation of N-methyl-D-aspartate re
105  neurons express OX-R1 and OX-R2 and whether orexin-A inhibits responses to CCK.
106       We examined whether microinjections of orexin-A into the VP hotspot enhance the hedonic impact
107  the treatment group received 0.1 mL of 1 nM orexin-A intraventricularly, while controls received sal
108                                              Orexin A is a neuropeptide located exclusively in neuron
109 ed changes in expression and distribution of orexin A (its precursor is also known as hypocretin-HCRT
110 cent studies which suggest that hypocretin 1/orexin A may be involved in modulating arousal states an
111           Together, these data indicate that orexin A may influence food intake by decreasing GABAerg
112 ities within the AccSh, we hypothesized that orexin A may partly regulate feeding behavior and locomo
113 t the hypothesis that the AccSh is a site of orexin A modulation of feeding behavior and locomotor ac
114 here was a strong trend towards an increased orexin-A mRNA expression in the rostral ventrolateral me
115         To test this hypothesis, we measured orexin-A mRNA expression in the rostral ventrolateral me
116  propose that enhanced inhibitory control of orexin-A neurons, and their CB1-mediated disinhibition,
117                                  Hypocretin (orexin), a neuropeptide synthesized exclusively in the p
118                                              Orexin A or B (10-1000 nM) directly and reversibly depol
119                               Superfusion of orexin A or B (10-300 nM) caused a slow depolarization i
120 he diaphragm, were immunopositive for either orexin-A or MCH.
121                          Bath application of orexin-A or orexin-B (30-300 nM) produced a slow depolar
122 the patch solution significantly reduced the orexin A- or B-induced depolarizations.
123   The method was demonstrated by determining orexin A, orexin B, and a novel isoform of rat beta-endo
124  but not the smaller ingestive peptides NPY, orexin A, orexin B, CART (55-102[Met(O)(67)]), MCH, or A
125 ent increased gene and protein expression of orexin A, orexin receptor 1, and orexin receptor 2 in th
126 behavior had lower hippocampal expression of Orexin A (OrxA).
127                         POMC neurons receive orexin-A (OX-A)-expressing inputs and express both OX-A
128                                              Orexin A (OXA) and neuropeptide Y (NPY) are two hypothal
129 gical signals, with Neuropeptide Y (NPY) and Orexin A (OXA) offering diagnostic information on stress
130  many NPY cells in the grass rat IGL exhibit orexin-A (OXA) fiber appositions.
131                                              Orexin-A (OXA) increases food intake in rodents, and fas
132              Moreover, administration of the orexin A peptide directly into the ventral tegmental are
133 d oxyntomodulin) and orexigenic (ghrelin and orexin A) peptides.
134       In dopaminergic neurons of VTA slices, orexin A presynaptically inhibits GABAergic transmission
135 whereas at -70 mV the excitatory response to orexin-A prevails.
136 whereas at -70 mV the excitatory response to orexin-A prevails.
137 tial effects on performance, nasal delivered orexin-A produced a more pronounced reversal of sleep de
138 lications, co-application of dynorphin-A and orexin-A produces a sustained response that reverses dep
139 itize, but co-application of dynorphin-A and orexin-A produces a sustained response.
140              These findings demonstrate that orexin A receptive sites for stimulation of food intake
141 in sleep-deprived animals was accompanied by orexin-A related alterations in local cerebral glucose m
142 s behavioral studies with antagonists at the orexin A-selective receptor, OX(1), have demonstrated it
143 armacological inhibitors, we showed that, in orexin-A-stimulated cells, the AA-derived radioactivity
144 B(1) receptor antagonists on the function of orexin A suggest an interplay between these two systems
145 e highest dose (10 microg/kg) of intravenous orexin-A tested.
146 lly significant interactions between CRF and orexin-A that depend on oligomerization of CRF1 receptor
147 ls to the excitatory effects of both CRF and orexin-A, thus providing a mechanism by which stress ind
148                                  Addition of orexin A to individual cells expressing an OX(1) sensor
149                     Moreover, the ability of orexin A to internalize the CB(1) receptor was also bloc
150            The higher potency of the agonist orexin A to regulate the CB(1)-OX(1) heteromer compared
151 ect of intravenous administration of Hcrt-1 (orexin-A) to anaesthetized rats on glutamate and GABA re
152                In rats resuscitated from CA, orexin-A transiently increased arousal and EEG entropy w
153                             The synthesis of orexin A undergoes diurnal variation in certain areas of
154                               This effect of orexin A was concentration-dependent and blocked by OX(1
155                                              Orexin A was found to enhance food intake when injected
156                              The response to orexin A was significantly reduced in the presence of th
157 , response of the OX(1) and OX(2) sensors to orexin A was slow, consistent with a multistep binding a
158                                  Remarkably, orexin A was substantially more potent in producing inte
159 and1 microL of saline with or without 3 nmol orexin-A was infused.
160 he fraction of infected cells that contained orexin-A was lower.
161            The improvement in performance by orexin-A was specific to trials classified as high versu
162                                Hypocretin-1 (orexin-A) was administered to sleep-deprived (30-36 h) r
163                     Cells immunoreactive for orexin A were noted in the lateral hypothalamic area.
164  but given rAAV-orexin, detectable levels of orexin-A were evident in the CSF, indicating release of
165             Two methods of administration of orexin-A were tested, intravenous injections (2.5-10.0 m
166                                              Orexin A, which depolarizes thalamocortical neurons loca
167  These were also internalized by the peptide orexin A, which has no direct affinity for the cannabino
168                         We hypothesized that orexin-A would improve arousal and EEG entropy after CA.

 
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