ライフサイエンスコーパス: organ of Corti

1 d for the successful formation of a complete organ of Corti.

2 the human and mouse spiral ganglia (SG) and organ of Corti.

3 ed by hair cells and supporting cells of the organ of Corti.

4 ituent hair cells or cytoarchitecture of the organ of Corti.

5 p63 (TAp63) protein is normally found in the organ of Corti.

6 s migrating from the outermost region of the organ of Corti.

7 constituent of the hair cell tip link in the organ of Corti.

8 s hair cell formation in the differentiating organ of Corti.

9 by loss or damage to outer hair cells in the organ of Corti.

10 ) and lateral compartments in the developing organ of Corti.

11 spiral ligament, and supporting cells of the organ of Corti.

12 f the prosensory domain destined to form the organ of Corti.

13 induction to cellular differentiation in the organ of Corti.

14 ear growth, cell fate, and patterning of the organ of Corti.

15 eafness, and progressive degeneration of the organ of Corti.

16 d damage or death of outer hair cells in the organ of Corti.

17 normal mechanical stimulation, or an intact organ of Corti.

18 n cells affects efferent fiber growth to the organ of Corti.

19 o the hair cells and supporting cells of the organ of Corti.

20 maintain normal innervation patterns to the organ of Corti.

21 s (IPCs)] in whole-mount preparations of rat organ of Corti.

22 mmalian cochlea that constitutes the nascent organ of Corti.

23 pt, afferent fibers are disoriented near the organ of Corti.

24 loss due to progressive degeneration of the organ of Corti.

25 ) molecules are clearly expressed within the organ of Corti.

26 rcular canals and auditory hair cells in the organ of Corti.

27 he supporting cells and Schwann cells of the organ of Corti.

28 olarized subcellular localization across the organ of Corti.

29 ferentially affected supporting cells in the organ of Corti.

30 hlear epithelium encompassing the primordial organ of Corti.

31 nd ligament, and supporting cells within the organ of Corti.

32 entally for continued function of the mature organ of Corti.

33 s the predominantly expressed isoform in the organ of Corti.

34 iters' cells, a non-sensory cell type of the organ of Corti.

35 expression in the sensory epithelium of the organ of Corti.

36 's, Claudius, and inner sulcus cells) in the organ of Corti.

37 f the sensory epithelium in the cochlea, the organ of Corti.

38 ls that act like force generators within the organ of Corti.

39 stibular system as well as to the developing organ of Corti.

40 ia vascularis, spiral ganglion cells and the organ of Corti.

41 tility in OHCs of the apical turn of the rat organ of Corti.

42 iral ganglion and were projecting toward the organ of Corti.

43 necessary for the normal development of the organ of Corti.

44 rase staining of surface preparations of the organ of Corti.

45 s and a disruption in the development of the organ of Corti.

46 ifferentiated supporting cells of the mature organ of Corti.

47 respond to noise damage by infiltrating the organ of Corti.

48 in an ex vivo preparation of the adult mouse organ of Corti.

49 nical properties of the basilar membrane and organ of Corti.

50 n either amplify or reduce vibrations in the organ of Corti.

51 ssed precisely at the neural boundary of the organ of Corti.

52 naptic terminal segments beneath IHCs in the organ of Corti.

53 table in >85% of supporting cells within the organ of Corti.

54 ying the hearing organ of the inner ear, the organ of Corti.

55 as well as optical nanoscopy of apical turn organs of Corti.

56 its mechanical effect via deformation of the organ of Corti, a complex assembly of sensory and suppor

57 ong the length of the cochlear spiral is the organ of Corti, a highly derived and rigorously patterne

58 lian hearing requires the development of the organ of Corti, a sensory epithelium comprising unique c

59 afness that include surgical ablation of the organ of Corti, acoustic trauma, ototoxic drugs, and her

60 acid signaling during the development of the organ of Corti, activation of retinoid receptors was blo

61 olds that three different cochlear elements (organ of Corti, afferent neurons, and stria vascularis)

62 l ganglion, lateral wall of the cochlea, and organ of Corti, all targets for acoustic trauma.

63 In neonatal rat organ of Corti, ALMS1 was localized to the basal bodies

64 e mammalian inner ear detects sound with the organ of Corti, an intricately patterned region of the c

65 hysical interaction of these two proteins in organ of Corti and brain.

66 The signals that induce the organ of Corti and define its boundaries in the cochlea

67 l limbus may promote pathology of the medial organ of Corti and eventual loss of afferent neurons, wi

68 for establishing the cytoarchitecture of the organ of Corti and for hearing.

69 These hair cell receptors reside in the organ of Corti and function to transduce mechanical stim

70 of Math1 protein in supporting cells of the organ of Corti and in adjacent nonsensory epithelial cel

71 egins in the epithelial support cells of the organ of Corti and is accompanied by changes in cellular

72 results from damage to the hair cells of the organ of Corti and is irreversible in mammals.

73 signaling that first set the boundary of the organ of Corti and later regulate hair cell development.

74 ities in the patterning of hair cells in the organ of Corti and missing ampullae, structures that hou

75 ttenuated by (+)-MK-801 and PD 174494 in the organ of Corti and modiolar core, by L-NAME in the later

76 owed thinning and receding hair cells in the organ of Corti and much lower expression of F-actin cyto

77 the appearance of immature hair cells in the organ of Corti and new hair cells adjacent to the organ

78 rane vibration, the internal workings of the organ of Corti and of the tectorial membrane have resist

79 tional regulation are observed in the mature organ of Corti and retina, suggesting that this mechanis

80 )-permeable CNGA3 expressed in the mammalian organ of Corti and saccular hair cells was found to inte

81 ssion patterns along the length of the mouse organ of Corti and spiral ganglion neurons.

82 ame transcripts were found in microdissected organ of Corti and spiral ganglion samples.

83 uditory system in particular in the cochlear organ of Corti and stria vascularis.

84 by BDNF, in promoting SGN axon growth in the organ of Corti and synaptogenesis on IHCs.

85 tional deformation in a cross section of the organ of Corti and tectorial membrane in the mammalian c

86 e development of our hearing epithelium, the organ of Corti and the acquisition of hearing.

87 The micromechanics of the organ of Corti and the tectorial membrane is then analyz

88 In both the organ of Corti and the vestibular organ, impaired termin

89 re coupled to a micromechanical model of the organ of Corti and to electrical potentials in the cochl

90 ng in the auditory inner hair cells from the organ of Corti and to investigate molecular differences

91 ally to the death of outer hair cells in the organ of Corti and ultimately to deafness.

92 chanism based on the cytoarchitecture of the organ of Corti and using the time-averaged Lagrangian me

93 it is found in the sensory epithelium of the organ of Corti and vestibular end organs as well as in c

94 the sensory and non-sensory epithelia in the organ of Corti and vestibular end organs.

95 3 and CAMSAP3/Marshalin are expressed in the organ of Corti, and carry several protein-protein intera

96 IBC/IPhC regeneration is lost in the mature organ of Corti, and consequently IHC survival and hearin

97 hair/supporting cell damage in the mammalian organ of Corti, and emphasize the importance of transcri

98 tochastic events; and 5) Independent strial, organ of Corti, and neural pathology.

99 rise to both the auditory sensory organ, the organ of Corti, and SG neurons.

100 motile, sensorimotor outer hair cells of the organ of Corti, and that the amplification and frequency

101 cells (OHCs) in amplifying the motion of the organ of Corti, and thereby contributing to the sensitiv

102 of an ex vivo preparation of the adult mouse organ of Corti, and these waves were found to propagate

103 he sensory and supporting cells (SCs) of the organ of Corti are derived from a limited number of prog

104 f spiral ganglion neurons (SGN) close to the organ of Corti are disorganized and abnormally swollen.

105 lacement by cells from the outer side of the organ of Corti are factors that may need to be considere

106 nsory hair cells and supporting cells of the organ of Corti are generated by a precise program of coo

107 heral hearing function and morphology of the organ of Corti are normal.

108 Unique specializations in the organ of Corti are required to make this conversion, suc

109 r cells, most likely supporting cells of the organ of Corti, are the main source of SGN survival fact

110 nsory primordium from which the cells of the organ of Corti arise, but instead is limited to a role i

111 d and demonstrate altered innervation to the organ of Corti, as well as fewer sensory hair cells.

112 The sensory cells of the mammalian organ of Corti assume a precise mosaic arrangement durin

113 logical and pharmacological methods in mouse organs of Corti at postnatal day 11 (P11)-P13, hearing o

114 OHCs are situated within the organ of Corti atop the basilar membrane (BM), which sup

115 ip1) expression is induced in the primordial organ of Corti between E12 and E14, correlating with the

116 Others neglect viscous dissipation in the organ of Corti but consider fluid viscosity.

117 form, and remains in close proximity to the organ of Corti, but is detached from the limbal surface.

118 t expressed in all support cell types in the organ of Corti, but is restricted to developing Deiters'

119 and the level of 8-isoprostane formed in the organ of Corti, but not in the lateral wall tissues.

120 bohydrate on CTL2 and presumably damages the organ of Corti by blocking the transporter function of t

121 ional model to illustrate deformation of the organ of Corti by the two active processes.

122 indings indicate that the quiescent neonatal organ of Corti can replenish specific supporting cells c

123 of birds, unlike hair cells in the mammalian organ of Corti, can regenerate following sound-induced l

124 els in the inner and outer hair cells of the organ of Corti, cells lining the inner sulcus, and suppo

125 12, the prosaposin KO mice showed histologic organ of Corti changes including cellular hypertrophy in

126 Early models considered the organ of Corti complex (OCC) as a succession of spring-m

127 Second, the local stiffness of the organ of Corti complex felt by individual outer hair cel

128 dissipation of the cochlea occurs within the organ of Corti complex, not in the scalar fluids.

129 ioned by a viscoelastic structure called the organ of Corti complex.

130 pex of the cochlea through vibrations of the organ of Corti complex.

131 ative changes in outer hair cells and in the organ of Corti, conforming to human sensory ARHL.

132 The mammalian organ of Corti consists of a highly organized array of h

133 The mammalian auditory sensory organ, the organ of Corti, consists of sensory hair cells with unif

134 Critical for sound detection, the mammalian organ of Corti contains functional units arranged tonoto

135 e mammalian auditory sensory epithelium (the organ of Corti) contains a number of unique cell types t

136 ory epithelium in the mammalian cochlea (the organ of Corti) contains four rows of mechanosensory hai

137 e mammalian auditory sensory epithelium, the organ of Corti, contains sensory hair cells and nonsenso

138 feed-backward approximation representing the organ of Corti cytoarchitecture.

139 f SPRY2 results in dramatic perturbations in organ of Corti cytoarchitecture: instead of two pillar c

140 ion; second, outer hair cell motility causes organ of Corti deformations that alter the cross-section

141 2(-/-) mice, stria vascularis abnormalities, organ of Corti degeneration, and profound hearing loss w

142 In the organ of Corti, deletion of Atoh1 at E15.5 led to the de

143 The organ of Corti derives from a prosensory domain that run

144 pression gradient in supporting cells of the organ of Corti deserves attention, given the role of sup

145 of N-Myc (using Pax2-Cre), hair cells in the organ of Corti develop and remain until at least seven d

146 g hair cell differentiation during embryonic organ of Corti development ex vivo.

147 Outer hair cells (OHCs) in the mammalian organ of Corti display electromotility, which is thought

148 lear microphonic potentials suggest that the organ of Corti does continue to move after the end of a

149 (outer hair and supporting cells) within the organ of Corti during a specific developmental time.

150 vation and enabled diagnostic imaging of the organ of Corti, even 30 hours after death.

151 ACAM16 are consistent with the idea that the organ of Corti evolved to maximize the gain of the cochl

152 Dexamethasone treatment of organ of Corti explants challenged with an ototoxic leve

153 iral ganglion neuron (SGN) cell cultures and organ of Corti explants from P3 rats were used to test t

154 This study examines the response of naive organ of Corti explants to treatment with dexamethasone.

155 Three-day-old rat organ of Corti explants were cultured for 1, 2, or 4 day

156 It is not known if naive organ of Corti explants will respond in a similar manner

157 o 2.03 times greater than untreated, hypoxic organ of Corti explants.

158 Prosaposin demonstrates diffuse organ of Corti expression at birth, with gradual localiz

159 helia shows numerous fibers overshooting the organ of Corti, followed by a reduction of those fibers

160 on of both outer and inner hair cells in the organ of Corti, following two reciprocal longitudinal gr

161 point deflection, and the deformation of the organ of Corti for current injection, as well as display

162 pling; and 3), the Y-shaped structure in the organ of Corti formed by the outer hair cell, the Deiter

163 or ablating the hair bundles in the cultured organ of Corti from neonatal gerbils.

164 he sensory primordium that gives rise to the organ of Corti from within the cochlear epithelium is pa

165 ion were decreased in hair cells in cultured organs of Corti from Va(J)/+ and Va(J)/Va(J) mice.

166 In organ of Corti hair cell cultures (UB/OC-1 cells), cispl

167 ns of DT resulted in nearly complete loss of organ of Corti hair cells within 1 week of injection reg

168 ess and the complex cyto-architecture of the organ of Corti has made interrogating the individual met

169 We demonstrate that the organ of Corti has the intrinsic capacity to replenish I

170 Motions of the BM and organ of Corti have been studied at the cochlear base in

171 how that Ca(2+)-dependent interaction of the organ of Corti HCN1 and protocadherin 15 CD3 is mediated

172 t hair cell model, the amino terminus of rat organ of Corti HCN1 was found by yeast two-hybrid analys

173 cular type of fiber did not project into the organ of Corti; however, the nonperivascular type could

174 In vitro studies in UB/OC-1 cells, an organ of Corti immortalized cell line, showed that R-PIA

175 fibers, as seen in confocal analysis of the organ of Corti immunostained for presynaptic and postsyn

176 In the organ of Corti, immunostaining was restricted to the sec

177 hair cell formation and morphogenesis of the organ of Corti in developing mammals, the changing statu

178 Here we measured the 2-D motion of the organ of Corti in mice and found that the structures tha

179 The organ of Corti in the excised cochlea was subjected to m

180 he spiral ganglia or supporting cells of the Organ of Corti in the human cochlea.

181 Sensory hair cells of the mammalian organ of Corti in the inner ear do not regenerate when l

182 of Corti and new hair cells adjacent to the organ of Corti in the interdental cell, inner sulcus, an

183 g and analyzed the cellular integrity of the organ of Corti in two mouse models of this disease with

184 ound-induced 2-D vibrations within the mouse organ of Corti in vivo Our goal was to determine the tra

185 te loss of the cochlear neuroepithelium (the organ of Corti) in adult mutant mice.

186 cx30 colocalised in supporting cells of the organ of Corti, in the basal cell region of the stria va

187 rotein, Fbx2 is also highly expressed in the organ of Corti, in which it has been called organ of Cor

188 n the cochlear ganglion, cochlear nerve, and organ of Corti, including the type I and type II ganglio

189 ial transcriptional events in the developing organ of Corti, including those involving Atoh1, has bee

190 n made in identifying the signals regulating organ of Corti induction and differentiation, less is kn

191 e data indicate that supporting cells in the organ of Corti initiate electrical activity in auditory

192 Here we show that the organ of Corti is formed from a thicker and shorter post

193 The organ of Corti is highly structured for transmitting vib

194 After P15, GFAP expression in the organ of Corti is mostly restricted to supporting cells

195 Our analysis demonstrates that the organ of Corti is nearly optimized to receive maximum so

196 he existence of periodic Ca(2+) waves in the organ of Corti is not restricted to the prehearing perio

197 n jc mutants, the cellular patterning of the organ of Corti is severely disrupted, exhibiting supernu

198 The organ of Corti is the mechanosensory transducing apparat

199 e mammalian auditory sensory epithelium, the organ of Corti, is a highly ordered cellular structure t

200 The organ of Corti, located within the mammalian cochlea, co

201 space, extracellular fluid space within the organ of Corti, looks like a slender micro-tube.

202 Since no regeneration occurs in the mature organ of Corti, loss of hair cells leads to deafness.

203 that GJs connecting supporting cells in the organ of Corti mainly provide ionic pathways for rapid r

204 from P6 rat pups consisting of a portion of organ of Corti maintained intact with the corresponding

205 Thus, location-dependent signals within the organ of Corti may set the "address" of neurons within t

206 ating as a wave through support cells in the organ of Corti, may constitute a fundamental mechanism t

207 An underlying assumption was that organ of Corti mechanics are governed by rigid body kine

208 ibration measurement techniques reveals that organ of Corti mechanics are too complicated to be fully

209 We show that the organ of Corti mechanics dictate the longitudinal trend

210 el without alteration to outer hair cell and organ of Corti mechanics or to mechanoelectric transduct

211 he active feedback are considered explicitly-organ of Corti mechanics, and outer hair cell electro-me

212 ea that incorporates viscous fluid dynamics, organ of Corti microstructural mechanics, and electrophy

213 back of outer hair cells, facilitated by the organ of Corti microstructure, can control the tuning an

214 In the mouse organ of Corti MOR was expressed in inner and outer hair

215 r-vibrations are driven by energy added into organ of Corti motion after the end of an acoustic stimu

216 In the organ of Corti, Nav1.6 was localized in the short segmen

217 ochlea showed that Nhe6 was localized in the organ of Corti (OC), spiral ganglion (SG), stria vascula

218 ost vestibular hair-cell model and mammalian organ of Corti (OC).

219 voked motion of hundreds of cells within the organ of Corti (OC).

220 sed sequence tag (EST) database of the mouse organ of Corti (OC).

221 ch afferent dendrites must pass to reach the organ of Corti (OC).

222 sound into auditory signals in the mammalian organ of Corti (OC).

223 d from hair cells or supporting cells in the organ of Corti (OC).

224 ion of cellular and functional repair in the organ of Corti of a mature deaf mammal.

225 ction of the HA tag on either subunit in the organ of Corti of adult mice revealed immunopuncta clust

226 Histological observations made in the organ of Corti of homozygous Cx26 and Cx30 gene knockout

227 cally active cells are still observed in the organ of Corti of postnatal day 6 animals, suggesting th

228 ctural analysis of sensory hair cells in the organ of Corti of the inner ear indicates that the whirl

229 In the organ of Corti of the inner ear, TJs of the reticular la

230 talized cell line UB/OC-2 developed from the organ of Corti of the transgenic H-2Kb-tsA58 mouse (the

231 model incorporates cochlear fluid dynamics, organ of Corti (OoC) mechanics and outer hair cell elect

232 tly from age-related pathology of either the organ of Corti or cochlear neurons.

233 of selected populations of cells within the organ of Corti or spiral ganglion cells rather than a mi

234 ve relied upon either microdissection of the organ of Corti or the generation of serial sections of t

235 The only sensory neurons innervating the organ of Corti originate from the spiral ganglion, rough

236 In the organ of Corti, Panx1 labeling was found in supporting c

237 Intense noise damages the cochlear organ of Corti, particularly the outer hair cells (OHCs)

238 We used electrical stimulation in an excised organ of Corti preparation to examine evoked release of

239 sified as exemplifying sensory (referring to organ of Corti), "primary" neural (loss of afferent neur

240 egulator of the self-renewal gene network in organ of Corti progenitor cells.

241 In the auditory sensory epithelium-the organ of Corti-progenitor cells exit the cell cycle in a

242 dentified to travel longitudinally along the organ of Corti propagated at a lower velocity of 1-3 mum

243 organ of Corti, in which it has been called organ of Corti protein 1.

244 Here, we provide evidence for organ of Corti proteins, of Ca(2+)-dependent binding of

245 al modes due to the complex structure of the organ of Corti provide optimal phases for outer hair cel

246 thway, is crucial for the development of the organ of Corti, providing a molecular explanation for th

247 The development of the organ of Corti requires a series of inductive events tha

248 g of cell cycle withdrawal in the developing organ of Corti requires p27(Kip1), a cyclin-dependent ki

249 edge to the spiral limbus and lies over the organ of Corti, retains its general form, and remains in

250 Immunostaining of adult mouse organ of Corti revealed that myosin XV protein is concen

251 This partition, comprising the organ of Corti sandwiched between the basilar and tector

252 The sensory epithelium called the organ of Corti separates the two fluids.

253 data argue that passive mechanics within the organ of Corti sharpen frequency selectivity by defining

254 ed nitration of cellular proteins within the organ of Corti, spiral ganglion, and stria vascularis, w

255 f cells from the various functional domains (organ of Corti, spiral ganglion, etc.) by LCM.

256 rogressive hair cell loss in the base of the organ of Corti, starting between 6 and 13 weeks of age,

257 not reach hair cells and remain outside the organ of Corti, suggesting a chemotactic role for neurot

258 bB3 are expressed by supporting cells of the organ of Corti, suggesting that these molecules mediate

259 ferent innervation of these cells within the organ of Corti suggests that regulation of outer hair ce

260 In the organ of Corti, tenascin-C lines the neural pathways alo

261 ic motor was more effective in deforming the organ of Corti than in displacing the basilar membrane.

262 rough mechanosensitive cells of the cochlear organ of Corti that rest on the basilar membrane (BM).

263 The organ of Corti, the auditory mammalian sensory epitheliu

264 The organ of Corti, the auditory neuroepithelium of the inne

265 The organ of Corti, the auditory organ of the inner ear, con

266 n-induced hearing loss and cell death in the organ of Corti, the auditory sensory epithelium of mamma

267 ring loss and sensory hair cell death in the organ of Corti, the mammalian auditory sensory epitheliu

268 In the organ of Corti, the pattern of noise-induced lipid perox

269 veling waves along the apical surface of the organ of Corti, the reticular lamina (RL), are amplified

270 MYH9 was immunolocalized in the organ of Corti, the subcentral region of the spiral liga

271 ect micromechanical interactions between the organ of Corti, the tectorial membrane and the subtector

272 ndolymphatic and perilymphatic spaces of the organ of Corti; the separation from one another by epith

273 fness functionally uncouples the TM from the organ of Corti, thereby minimizing energy losses during

274 ions regulate cellular patterning within the organ of Corti through the induction of one cell fate (P

275 s limited by the extensive remodeling of the organ of Corti throughout postnatal development and asso

276 forces amplify traveling-wave motion on the organ of Corti throughout the wave's extent, but that th

277 The morphological study of the Odontocete organ of Corti, together with possible alterations assoc

278 that the mechanical properties of the BM and organ of Corti tune how OHC forces accumulate spatially.

279 not assembled in the supporting cells of the organ of Corti until 3 days after birth in mice and then

280 voked OHC somatic motility within the gerbil organ of Corti using an excised cochlear preparation.

281 rations of different layers in the cochlea's organ of Corti using optical coherence tomography.

282 Understanding how the organ of Corti vibrates because of acoustic pressure and

283 The cochlear sensory epithelium, the organ of Corti, vibrates because of external and interna

284 that distinct low-frequency forward waves of organ of Corti vibration are launched simultaneously at

285 The intra-organ of Corti vibrations measured in the region of the

286 Organ of Corti vibrations, including those of individual

287 cell specification, the radial patterning of organ of Corti was disrupted, revealed by aberrant expre

288 In contrast, Nav1.2 in the organ of Corti was localized to the unmyelinated efferen

289 The organ of Corti was microdissected, and indirect immunohi

290 l imaging of FM1-43 in excised strips of the organ of Corti, we show that the time constants of fluor

291 h specification and radial patterning of the organ of Corti were intact.

292 All cells in the middle turn organ of Corti were lost 1 month after birth, and degene

293 The auditory sensory epithelium (organ of Corti), where sound waves are converted to elec

294 tic equilibration in epithelial cells in the organ of Corti, which are subject to large K(+) fluxes d

295 ory inner and outer hair cells (OHCs) of the organ of Corti, which convert mechanical deflections of

296 her constitute the sensory epithelium of the organ of Corti, which is the hearing apparatus of the ea

297 structure was characterized in immunolabeled organ of Corti whole mounts using confocal microscopy to

298 ctal cells and inner border cells of the rat organ of Corti with a tonotopic expression gradient.

299 null mice show morphological defects of the organ of Corti, with supernumerary hair cells, as also r

300 sduction of sound by hair cells (HCs) in the organ of Corti within the cochlea of the inner ear.