ライフサイエンスコーパス: organ-specific

1 gnals controlling mesothelial cell entry are organ specific.

2 m imaging reveals sparse, taste-specific and organ-specific activation in the Kenyon cell dendrites o

3 porter to screen for mutants affected in the organ-specific activation of jasmonate (JA) signaling in

4 I diabetes, such as strong HLA association, organ-specific adaptive immune responses, viral involvem

5 ate postembryonic development, especially in organ-specific adult stem cells, is unclear.

6 A large number of transcripts show organ-specific, age-dependent or sex-specific differenti

7 ransplants, as they are not part of Canadian organ-specific allocation models at present.

8 cells in newly invaded microenvironments are organ specific and consequently demand distinct mechanis

9 DY-780 and DY-654 showed organ specific and determined elimination routes in both

10 body alterations in glucose transport may be organ specific and facilitate nutrient partitioning duri

11 and effector(s) of complement in IRI may be organ specific and remain to be fully characterized.

12 ranscriptome across six organs revealed 4154 organ-specific and 7704 differentially expressed (DE) ge

13 ulation pattern of the hcn RNA degradants is organ-specific and can be affected by various endogenous

14 We defined organ-specific and common immune alterations and identif

15 re used to identify proteins associated with organ-specific and composite disease activity.

16 cells in newly invaded microenvironments are organ-specific and consequently demand distinct mechanis

17 We found distinct organ-specific and developmental stage-specific miRNA ex

18 etes mellitus is increased across a range of organ-specific and multisystem chronic inflammatory diso

19 cular disease are elevated across a range of organ-specific and multisystem chronic inflammatory diso

20 dered off-target, including anaphylaxis, and organ-specific and severe cutaneous adverse reactions.

21 61 additional inbred lines were enriched in organ-specific and stress-induced DE genes suggesting th

22 transplantation from 2003 to 2016, including organ-specific and system-wide factors that may affect o

23 y a unique role for ICER, which affects both organ-specific and systemic autoimmunity in a Th17-depen

24 (MI) into relevant biologic signatures at an organ-specific and systemic level are not achievable wit

25 isms of miRNA production or modification are organ-specific and the extent of their evolutionary cons

26 Organ-specific and whole-body dosimetries for (68)Ga-DOT

27 major congenital malformations (overall and organ specific) and spontaneous abortions and during the

28 d to elucidate the mechanisms that determine organ-specific anemia tolerance.

29 Notably, we demonstrate that organ-specific angiocrine signaling is essential not onl

30 cently, Bmp2 has been identified by us as an organ-specific angiokine derived from LSECs.

31 autoimmune hepatitis is associated with non-organ-specific antibodies in the context of hepatic auto

32 ivers than WT mice, indicating that distinct organ-specific antiparasitic mechanisms were involved in

33 ighlight the emerging question of whether an organ-specific approach toward lupus trials and treatmen

34 h focused on one of the following general or organ-specific areas: death determination using neurolog

35 We provide an organ-specific atlas of both systemic and local changes

36 , thymoma, or both for clinical features and organ-specific autoantibodies characteristic of APS-I pa

37 flammation but is not required for effective organ-specific autoimmune attack.

38 gers of systemic autoimmunity, but a role in organ-specific autoimmune disease has not been demonstra

39 eg accumulation and function during an acute organ-specific autoimmune disease in vivo.

40 We now recognize that MN is an organ-specific autoimmune disease in which circulating a

41 ysis bullosa acquisita (EBA) is a prototypic organ-specific autoimmune disease induced by autoantibod

42 lerance have not been studied in spontaneous organ-specific autoimmune disease.

43 uction and skin blistering in a prototypical organ-specific autoimmune disease.

44 A-deficient mice did not develop systemic or organ-specific autoimmune disease.

45 ommon among patients with Down syndrome, but organ-specific autoimmune diseases are common.

46 ffecting the skin, is one of the most common organ-specific autoimmune diseases in humans.

47 IL-15 disorders play pathogenetic roles in organ-specific autoimmune diseases including celiac dise

48 Recovery from organ-specific autoimmune diseases largely relies on the

49 The target autoantigens in several organ-specific autoimmune diseases, including type 1 dia

50 in almost all of the animal models of human organ-specific autoimmune diseases, transplant rejection

51 ential role in resistance or pathogenesis of organ-specific autoimmune diseases.

52 ered as a model for an autoantibody-mediated organ-specific autoimmune disorder.

53 r for both systemic autoimmune disorders and organ-specific autoimmune disorders probably involves th

54 treatments that target adaptive immunity in organ-specific autoimmune disorders.

55 al importance during the priming phase of an organ-specific autoimmune response remains unclear.

56 Systemic organ-specific autoimmunities (type 1 diabetes mellitus

57 ting, particularly in patients with systemic organ-specific autoimmunities.

58 nding how commensal microbiota contribute to organ-specific autoimmunity and for developing novel muc

59 nd deficiency in LYN spontaneously developed organ-specific autoimmunity in the eye.

60 ry immunodeficiency disorder associated with organ-specific autoimmunity linked to NFAT5 deficiency.

61 1 had Hashimoto thyroiditis, suggesting that organ-specific autoimmunity might be linked to nonhemato

62 le in regulating autoreactive Th17 cells and organ-specific autoimmunity remains largely unknown.

63 IL-15 is a potent cytokine that can promote organ-specific autoimmunity when up-regulated on tissue

64 technology offers a new approach to monitor organ-specific autoimmunity, and represents a platform t

65 p to answer important lingering questions in organ-specific autoimmunity, as to what factors initiate

66 onomous role in central T cell tolerance and organ-specific autoimmunity, but play a redundant role i

67 ith increased susceptibility to systemic and organ-specific autoimmunity, but the mechanism by which

68 how vitiligo, an underappreciated example of organ-specific autoimmunity, helps to answer them.

69 can present as an inflammatory disease with organ-specific autoimmunity, suggesting a role for DNA-P

70 germinal center formation in the absence of organ-specific autoimmunity.

71 uld combine with an Aire mutation to provoke organ-specific autoimmunity.

72 imaging was performed at 6, 12, and 24 h and organ-specific biodistribution at 24 h after probe injec

73 erentially expressed genes reflect the known organ-specific biological activities.

74 rved mechanism emerges whereby epithelia use organ-specific BTNL/Btnl genes to shape local T cell com

75 Development of organ-specific calcium and calmodulin-dependent protein

76 High carrier potency was leveraged to create organ-specific cancer models in livers and lungs of mice

77 cer (NSSC), who are not eligible to enter an organ-specific cancer program.

78 in cancer mortality, or in the incidence of organ-specific cancers.

79 Consistent with a role for GlcCer in organ-specific cell differentiation, calli from gcs-1 mu

80 ves as a foundational scaffold that supports organ-specific cell types and enables normal organ funct

81 to cover the energy demands of the different organ-specific cell types.

82 show that tumour-derived exosomes uptaken by organ-specific cells prepare the pre-metastatic niche.

83 s and be further differentiated into desired organ-specific cells.

84 OR=5.9, P=0.04) ii/ a more severe global and organ-specific cGvHD scoring (P<0.05), iii/ the presence

85 These organ-specific changes in manganese were recently recapi

86 Occurrence of organ-specific CHCs, instead of transplant receipt, was

87 irculate through most human tissues and that organ-specific chemokine expression patterns might affec

88 re, using 3C, Hi-C, and Capture Hi-C (CHi-C) organ-specific chromosome conformation capture technique

89 ations of accumulation patterns arising from organ-specific clearance mechanisms, particle size, and

90 tastatic action of platelets was found to be organ specific, clearly enhancing lung metastasis but no

91 anistic insight into the developing field of organ-specific clocks.

92 s observed between distinct CSC subtypes and organ-specific colonization.

93 r involvement is rarely reported, suggesting organ-specific compensatory mechanisms.

94 am responsible for surveillance of major and organ-specific complications (for example, arterial aneu

95 esponse to malignancy is highly dependent on organ-specific conditions and is modifiable.

96 or viral ITAM-mediated signaling with likely organ-specific consequences in the host.

97 t not in nonpulmonary, LCH cases, suggesting organ-specific contribution of oncogenic RAS to LCH path

98 The relative organ-specific contributions to the levels and effects o

99 uced in liver, but not muscle, suggesting an organ-specific defect.

100 entiated cells, the HGPS mutation results in organ-specific defects.

101 ic chromatin loop formation, with consequent organ-specific deficiency of PMM2 leading to the restric

102 zes available murine models with systemic or organ-specific deletion of ACE2, or with overexpression

103 destruction has become a promising tool for organ specific delivery of bioactive substance.

104 cent imaging provides spatially resolved and organ-specific detection of lymphoid cell death during p

105 trictions do not lead to the same changes in organ-specific DFA metabolism as those associated with w

106 Organ-specific DFA partitioning and cardiac and hepatic

107 ovide starting points for the development of organ-specific diagnostics and therapies.

108 The organ-specific difference in cancer prevalence has been

109 d that NLR expression patterns could reflect organ-specific differences in effector challenge and tes

110 ts dynamic spatiotemporal expression, ensure organ-specific differentiation and proportional growth,

111 (i.e., arteries, veins, and lymphatics) and organ-specific differentiation.

112 sinusoids, and their application to modeling organ-specific diseases.

113 Hazards were increased in organ-specific disorders, including severe psoriasis (1.

114 analysis of the Hoxa3 null mutant shows that organ-specific domains did undergo initial patterning, b

115 nstrates for the first time that TPP enables organ-specific drug target engagement and identification

116 esponse is truly localised in the context of organ-specific drug toxicity.

117 Organ-specific ECs control their tissue microenvironment

118 date modifier genes that could influence the organ-specific ectopic mineralization phenotypes.

119 nucleotide changes in the seed sequence with organ specific editing rates, highest in the brain.

120 h signaling in the endothelium has opposing, organ-specific effects on metastasis to the lung and the

121 ognition, and decreased physical fitness, to organ-specific effects such as severe hepatosplenism, pe

122 In addition to organ-specific effects, the absence of CXCL10 during inf

123 s whose differential expression may underlie organ-specific elongation.

124 ding of the role of GA biosynthetic genes in organ-specific elongation.

125 The interaction of tumor cells with organ-specific endothelial cells (EC) is an important st

126 ella Variation within this intron affects an organ-specific enhancer that regulates the level of STER

127 r distributions could allow new insight into organ-specific enrichment and possible transportation pr

128 erspecies blastocyst complementation enables organ-specific enrichment of xenogenic pluripotent stem

129 ntified suites of mature miRNAs that display organ-specific enrichment, many of which are evolutionar

130 ypes that develop in close register with the organ-specific epithelium.

131 elements in pleiotropic genes contribute to organ-specific evolution.

132 Inclusion and organ-specific exclusion criteria were the most common r

133 Organ-specific exposures were associated with increased

134 ed at low levels and characterized by tissue/organ specific expression profiles.

135 MicroRNAs (miRNAs) can have organ-specific expression and functions; they can origin

136 sters, with an overall pattern of increasing organ-specific expression as embryonic development proce

137 genes with low network connectivity and with organ-specific expression patterns.

138 Hence, growing demand by cell biologists for organ-specific extracellular mimics has led to the devel

139 cy varies depending on pathogen-, cell-, and organ-specific factors.

140 induced skin damage; (iii) reinfection; (iv) organ specific failure of memory T cell responses; and (

141 burn patients to determine the incidence of organ-specific failure and outcome.

142 firmed the expected chronologic incidence of organ-specific failure and yield the long-term mortality

143 oups on the basis of the incidence of single-organ-specific failure, MOF, and non-MOF.

144 tions in developing treatment strategies for organ-specific fatal malaria.

145 d by Plasmodium falciparum manifests in many organ-specific fatal pathologies, including cerebral mal

146 (urinary symptoms, psychosocial dysfunction, organ specific findings, infection, neurologic/systemic

147 First, a series of organ-specific focus groups of kidney, liver, heart, and

148 ned by endothelial cells engaged in distinct organ-specific functions but little is known about their

149 uniquely differentiated to fulfill important organ-specific functions in development, under homeostat

150 ic interrogator maintained the viability and organ-specific functions of eight vascularized, two-chan

151 Understanding the stage and organ-specific functions of HvCEN and downstream molecul

152 We review recent findings on the tissue- and organ-specific functions of SPs and KLFs in the digestiv

153 Organ-specific functions of tissue-resident macrophages

154 Many body surfaces harbor organ-specific gammadelta T cell compartments that contr

155 l cells (ECs) are increasingly recognized as organ-specific gatekeepers of their microenvironment.

156 targets were mapped onto human organs using organ-specific gene expression data.

157 Given that ECs possess organ-specific gene expression, morphology, and function

158 xA transcription factors play major roles in organ-specific gene expression, regulating, for example,

159 f the posterior spiracles by coordinating an organ-specific gene network.

160 Organ-specific gene regulation by FoxA proteins is achie

161 he importance of DNA binding specificity for organ-specific gene regulation by modulating promoter ac

162 ura-seq revealed hundreds of unique, dynamic organ-specific gene signatures depending on the microenv

163 expression ratios within species, suggesting organ-specific hardwiring of NLR expression patterns in

164 he lymphatic system and emerging evidence of organ-specific heterogeneity of lymphatic vessels in the

165 a microfluidic 3D in vitro model to analyze organ-specific human breast cancer cell extravasation in

166 ing pathway of NKG2D and the pathogenesis of organ-specific immune disorders.

167 by DCs, implicating DCs as key mediators of organ-specific immune tolerance.

168 astritis (AIG) is an increasingly prevalent, organ-specific, immune-mediated disorder characterized b

169 Organ-specific immunity is a feature of many infectious

170 e systemically administered TLR5 agonists as organ-specific immunoadjuvants, enabling efficient antit

171 key immune cells, the cause of lymphopenia, organ-specific immunology, the dynamics of sepsis-associ

172 We have previously reported on a novel organ-specific immunomodifying therapy that provides pro

173 ent, and we put forth the concept of focused organ-specific immunotherapy as an alternative option.

174 Cell-, tissue- or organ-specific inducible expression systems are powerful

175 tion including fever, rashes, arthritis, and organ-specific inflammation and are caused by defects in

176 This study was designed to elucidate organ-specific inflammation by identifying proteins that

177 erized by recurrent episodes of systemic and organ-specific inflammation, known as periodic fever syn

178 e innate immunity, thus connecting stress to organ-specific inflammation.

179 ndings support the hypothesis that T1D is an organ-specific inflammatory disease.

180 > damage --> inflammation that manifests via organ-specific inflammatory switching networks.

181 es in CT, current management implications of organ-specific injuries depicted at multidetector CT are

182 veal that plant clocks can be set locally by organ-specific inputs but coordinated globally via spati

183 as to quantify the changes in whole-body and organ-specific insulin sensitivities 12 weeks after perm

184 or 9 or 30 days, and changes in systemic and organ-specific insulin sensitivity and inflammation were

185 our understanding of neutrophil recruitment, organ-specific intravital microscopy methods are needed.

186 efore, we show that thrombosis develops with organ-specific kinetics and challenge the universality o

187 mportant to examine rejection pathways at an organ-specific level.

188 and root clocks can largely be explained by organ-specific light inputs.

189 n the specification of neural and non-neural organ-specific lineages, as well as cell survival during

190 s modulate neuronal activity to give rise to organ-specific, long-lasting changes in vascular archite

191 vessels during embryogenesis is critical for organ-specific lymphatic function.

192 esults indicate that the lacteal is a unique organ-specific lymphatic system and does not merely serv

193 recent findings highlight the importance of organ-specific lymphatics, the functional anatomy of liv

194 eport on phosphatase dysregulation linked to organ-specific malignancies.

195 tative RT-PCR analysis to be expressed in an organ-specific manner in M. truncatula.

196 cardiac energy demand, AMPK functions in an organ-specific manner to maintain cardiac energy homeost

197 pression of SAA proteins and cytokines in an organ-specific manner.

198 d with the photomorphogenic transition in an organ-specific manner.

199 e B and kill target cells in an epitope- and organ-specific manner.

200 ription somewhere in the body, largely in an organ-specific manner.

201 re metastatic than non-CSC populations in an organ-specific manner.

202 n many dysregulated genes on autosomes in an organ-specific manner.

203 any of the miRNAs were regulated in a tissue/organ-specific manner.

204 . sojae infection as well as expressed in an organ-specific manner.

205 expressed at all anatomical sites and in an organ-specific manner; highly expressed genes were shown

206 s, the thymus and parathyroids by E18.5, and organ-specific markers are absent or downregulated durin

207 This is partly due to a lack of targetable, organ-specific markers for in vivo studies of two critic

208 In this study, we show that CXCL12 is an organ-specific maturation factor of particular relevance

209 he hypothesis that evolutionarily-conserved, organ-specific mechanisms may regulate post-transcriptio

210 We investigated organ-specific metabolic roles of Drosophila PDGF/VEGF-l

211 Thus, irrespective of cancer types, organ-specific metastases may share common genomic aberr

212 tality; however, specific features mediating organ-specific metastasis remain unexplored.

213 ssociated with cancer, but their function in organ-specific metastasis remains unclear.

214 was linked to elevated PTHLH expression and organ-specific metastasis to bone.

215 ential role for 3q genes in the mechanism of organ-specific metastasis.

216 exosomal integrins could be used to predict organ-specific metastasis.

217 res of host organs, which together determine organ-specific metastatic behaviors.

218 tic CSCs and their metabolomic signatures in organ-specific metastatic colonization.

219 PET and computed tomography (CT) in terms of organ-specific metastatic lesion detection and radiation

220 How organ-specific metastatic traits arise in primary tumors

221 However, the molecular regulators that drive organ-specific microvascular transcriptional programs an

222 n exposure was projected by using a separate organ-specific model that accounted for anatomic coverag

223 approach was applied that integrates static organ-specific models with a whole-plant dynamic model.

224 Mammaglobin A (MGA) is an organ specific molecular biomarker for metastatic breast

225 This study provides organ-specific molecular resolution of genetic variation

226 n the context of the eventual development of organ-specific molecular signatures from peripheral flui

227 PET/MR imaging is to study how stand-alone, organ-specific MR imaging can be improved by PET/MR imag

228 ing a whole-body PET scan with whole-body or organ-specific MR imaging.

229 thematosus and rheumatoid arthritis) and two organ-specific (multiple sclerosis and type 1 diabetes)

230 In mammals, most organ-specific N-glycosylation events occur in the brain

231 Regulation of organ-specific neutrophil entry occurs at two levels.

232 Notch signaling in organ-specific niches has been implicated in mediating o

233 onstrate that autophagy acts as an endocrine organ-specific, nutritionally regulated gating mechanism

234 self-antigens (autoantibodies), resulting in organ-specific or systemic autoimmune diseases.

235 al homeostasis, and they provide evidence of organ-specific pathobiology resulting from different mut

236 ffer new insights into organ homeostasis and organ specific pathology.

237 Here we review the extrapulmonary organ-specific pathophysiology, presentations and manage

238 e to interpret the most important metric for organ-specific patient mortality.

239 a common regulatory mechanism exists and how organ-specific patterns can emerge.

240 eration metastasis map (MetMap) that reveals organ-specific patterns of metastasis, enabling these pa

241 rmal development, when they are expressed in organ-specific patterns.

242 organ hormone sensitivity might explain this organ-specific penetrance.

243 ), an activating ligand of CX3CR1, regulates organ-specific peritoneal colonization.

244 rapy regimens and may also enable imaging of organ-specific processes such as spleen activation.

245 We show that the organ-specific processing of these compounds was consist

246 Three compounds were evaluated for organ-specific processing: terfenadine for pharmacokinet

247 We identify an ampullary organ-specific proneural transcription factor, and candi

248 Accumulating evidence points to organ-specific properties of systemic inflammation and N

249 detection of PLCPs by identifying common and organ-specific protease activities and identify previous

250 l matrices throughout the body, the internal organ-specific radiation dose due to inhaled radioactive

251 pecific, autoimmune Th1 cells fostered their organ-specific reactivity, as confirmed in an autoimmune

252 ruitment and highlight recent discoveries in organ-specific recruitment patterns.

253 ering plants and is often associated with an organ-specific reduction in flower size.

254 its the identification of genes required for organ-specific regeneration and suggests an ancient func

255 Specifically, the natural organ-specific retention of nanotherapeutics following i

256 re often distinct, with disease-specific and organ-specific risk factors, triggers and sites of first

257 These findings identify an organ-specific role for RA in GVHD and provide evidence

258 of the brain to ischemic damage is due to an organ-specific role of NOX4 in blood-brain-barrier endot

259 lture platforms to interact outside of their organ-specific scientific community.

260 The DENVER2 score was used to assess organ-specific scores for lung, liver, kidney, and heart

261 Additionally, an analysis of organ-specific SOFA scores revealed higher scores in thr

262 Human tissues are an important link between organ-specific spatial molecular information, patient pa

263 ription factors (such as POU2F1 in neurons), organ-specific specializations of broadly distributed ce

264 Our analyses focused on organ-specific specializations of broadly distributed ce

265 SI patients, two (10.5%) were diagnosed with organ-specific SSIs, which eventually led to graft loss;

266 for organ maturation and formation of adult organ-specific stem cells during vertebrate postembryoni

267 (Eya1) is a conserved critical regulator of organ-specific stem cells.

268 of human pluripotent stem cells (hPSCs) into organ-specific subtypes offers an exciting avenue for th

269 Secondary clinical outcomes included organ-specific symptoms, medication-free days, rhinitis

270 long wondered how some patients develop this organ-specific syndrome.

271 The autonomic nervous system orchestrates organ-specific, systemic and behavioural responses to in

272 drives the thymic development of a subset of organ-specific T(regs), which are likely coopted by tumo

273 lar photobody dynamics, indicative of tissue/organ-specific temperature signaling circuitry either do

274 e coordinated patterning of these cells into organ-specific territories.

275 s (IFN-gamma, granzyme B, and IL-10) display organ-specific thresholds of maximum activation.

276 ivergent evolution of dio2 paralogs supports organ-specific timing of the TH-dependent events governi

277 l intestine, and skeletal muscle to quantify organ-specific tolerance of different levels of acute an

278 s and not readily predictable off-target and organ-specific toxicities and highlight the need for imp

279 r proposed adjunctive use of age-appropriate organ-specific toxicity criteria for severity grading an

280 tes, metastatic cancer cells need to acquire organ-specific traits.

281 esults have been published regarding whether organ-specific transcriptional patterns dominate over sp

282 The organ-specific transcriptome adjustments reflected the d

283 dopsis (Arabidopsis thaliana) seedlings show organ-specific transcriptome responses to elevated tempe

284 role for dendritic cells (DCs) in regulating organ-specific Treg cell biology.

285 the development and peripheral regulation of organ-specific Treg cells are dependent on antigen prese

286 implications for enhancing the generation of organ-specific Treg cells in autoimmune diseases.

287 migratory DCs coordinated the activation of organ-specific Treg cells in the prostate-draining lymph

288 iver and heart following T/HS, demonstrating organ-specific UPR transcriptome changes.

289 es for Notch signaling in the development of organ-specific vascular beds.

290 crovascular specification and acquisition of organ-specific vascular competence, which are indispensa

291 ndothelial Notch1 (Notch1DeltaEC) share some organ-specific vascular defects with Adam10DeltaEC mice,

292 m17DeltaEC), which survived postnatally with organ-specific vascular defects, resembled Adam10DeltaEC

293 otch signaling, survived into adulthood with organ-specific vascular defects.

294 provides a molecular framework to understand organ-specific vascular disease mechanisms and therapeut

295 ular ECs instruct neighboring cells in their organ-specific vascular niches through angiocrine factor

296 ht molecular asymmetries are translated into organ-specific vascular patterns.

297 Progression of organ-specific vasculopathy often precedes organ dysfunc

298 us as an advantageous model for the study of organ-specific vessel development and provide new insigh

299 l in which to investigate the early steps of organ-specific vessel formation.

300 r benefits in tuberculosis are thought to be organ specific, with clinicians using them routinely to