ライフサイエンスコーパス: organelle

1 peckles (specific type of non-membrane-bound organelles).

2 le stress-responsive processes in this quasi-organelle.

3 bolism and preventing osmotic stress of this organelle.

4 erminal presequences that direct them to the organelle.

5 tein translation in the essential apicoplast organelle.

6 nd action of proteins on the surface of this organelle.

7 the plethora of functions performed by this organelle.

8 role in the morphology and function of this organelle.

9 and organizes cristae positioning within the organelle.

10 asm by hitchhiking on motor-driven "carrier" organelles.

11 eorganization of microtubules and associated organelles.

12 ccumulation of misfolded proteins or damaged organelles.

13 anding diseases associated with membraneless organelles.

14 f phase separation in cells and membraneless organelles.

15 -inducible recruitment of motors to specific organelles.

16 nd may also link to the dysfunction of other organelles.

17 y that clears the cytoplasm of dysfunctional organelles.

18 our understanding of these complex cellular organelles.

19 the assembly and disassembly of membraneless organelles.

20 f6 were also concentrated on the replication organelles.

21 ng cell membranes and eukaryotic subcellular organelles.

22 A surveillance and processing encounter both organelles.

23 cell by degradation of damaged proteins and organelles.

24 their molecules, to molecular complexes, to organelles.

25 ins underlies the formation of membrane-less organelles.

26 in various subcellular compartments known as organelles.

27 of distinct membrane-bound and membraneless organelles.

28 dation of membrane, proteins, pathogens, and organelles.

29 subcellular compartments termed membraneless organelles.

30 nents into viral replication compartments or organelles.

31 n behavior between closely related endocytic organelles.

32 r 2C in recruiting STING to RV-A replication organelles.

33 ing viral replication complexes, replication organelles.

34 ane repair and autophagic removal of damaged organelles.

35 ganizing RNAs and proteins into membraneless organelles.

36 cal systems, including cells and subcellular organelles.

37 production, activity, and movement of these organelles.

38 etime imaging of live cells and sub-cellular organelles.

39 Because biogenesis of lysosomal related organelle-2 (BLOC-2) functions in the biogenesis of plat

40 imulate mitochondrial movements, and promote organelle accumulation at the cortical cytoskeleton in n

41 smic reticulum (ER) and other membrane-bound organelles allow for efficient transfer of ions and/or m

42 anism level, our results show its use at the organelle and cellular level.

43 hninae initially occurred via an increase in organelle and GLDP content in MS cells, which generated

44 which expressed a diverse set of fluorescent organelle and pathway markers in three distinct cell lin

45 utophagy" hereinafter) is a process by which organelles and aggregated proteins are delivered to lyso

46 ton serves as both a supportive scaffold for organelles and an arborized system of tracks for intrace

47 onized elimination of damaged or unnecessary organelles and cells is a prerequisite of health.

48 deposits of glycogen but without any kind of organelles and delimiting membrane (type2).

49 clear membrane, containing degenerative cell organelles and heterolysosomes (type1) and inclusions wi

50 e, cell size determines the spatial scale of organelles and intracellular transport and thereby affec

51 e apical complex to organize their secretory organelles and invasion machinery.

52 se the overall transport rate of hitchhiking organelles and lead to greater efficiency in organelle d

53 The best-known organelles and major protein families of this system are

54 Within neurons, it helps to remove damaged organelles and misfolded or aggregated proteins and has

55 on of specific cargos, such as dysfunctional organelles and protein aggregates.

56 In situ molecular architecture analysis of organelles and protein assemblies is essential to unders

57 Within a tissue, different organelles and protein functions were enriched with diff

58 ostatic program for the turnover of cellular organelles and proteins, in which double-membraned vesic

59 (dHL-60) labeled with fluorescent markers of organelles and stimulated with bacterial toxins or Candi

60 s may regulate the formation of membraneless organelles and subcellular localization of numerous prot

61 a membrane, are recruited to the replication organelles and that Arf1 appears to be the most importan

62 ct of disrupting retrograde transport on the organelles and the axon was unknown.

63 s and lipid droplets, and also between these organelles and the ER and mitochondria, controls their m

64 to the assembly mechanism of these bacterial organelles and will aid downstream engineering efforts.

65 terfaces with membranes, macromolecules, and organelles, and its buildup appears to be vital for func

66 confers label-free recognition of cells and organelles, and quantifies their number-density that, th

67 in acidification of intracellular vesicles, organelles, and the extracellular milieu in eukaryotes.

68 Importantly, we also showed that these organelles are able to capture important innate immune t

69 in coordination between these two essential organelles are associated with metabolic disorders, neur

70 While the organelles are distinct, many of them make intimate cont

71 has been recognized for some time that these organelles are of key importance for normal cellular fun

72 Organelles are physically connected in membrane contact

73 arboxylesterases that localize to intestinal organelles are required for the assembly of both modular

74 Membraneless organelles are sites for RNA biology including small non

75 t three-dimensional characterizations of the organelles are still lacking.

76 ce of aggregation-prone proteins and damaged organelles are vital for post-mitotic neurons.

77 ted alterations of Ca(2+) fluxes at specific organelles as we identify novel candidates for the devel

78 tribution of cytoskeletal tracks and carrier organelles, as well as the number, length, and flexibili

79 pid droplets (LDs) are neutral lipid storage organelles assembled at the endoplasmic reticulum (ER).

80 ) is one proposed mechanism for membraneless organelle assembly.

81 are then typically employed to make protein-organelle assignments.

82 It recruits organelle-associated reads using a modified "baiting and

83 nctional imaging of cellular and subcellular organelles at <=50 nm resolution.

84 logic of ER-phagy, reveal parallels between organelle autophagies, and provide an entry point to the

85 ignal propagation induced by the presence of organelle barriers, leading to arrival times at the nucl

86 tortuous environment involving a variety of organelle barriers.

87 Mitochondria are subcellular organelles best known for their central role in energeti

88 structures were phase-separated membraneless organelles ("biomolecular condensates").

89 They make sperm-specific membranous organelles but fail to assemble their major sperm protei

90 lls requires Inp1, which is recruited to the organelle by the peroxisomal membrane protein Pex3.

91 ses that replicate in cytoplasmic membranous organelles called viral inclusions (VIs) where progeny v

92 Here, we investigated whether cytoplasmic organelles-called intracellular vesicle clusters (IVCs)-

93 s are responsible for movement of molecules, organelles, cells, and whole animals.

94 ure red blood cell (RBC) lacks a nucleus and organelles characteristic of most cells, but it is elega

95 ls with biochemicals to plant photosynthetic organelles (chloroplasts) using a guiding peptide recogn

96 One way in which organelles communicate and integrate their activities is

97 hts for understanding and manipulating inter-organelle communication in cells.

98 Lipid droplets (LDs) are energy storage organelles composed of neutral lipids, such as triacylgl

99 Membraneless organelles, comprising dozens to hundreds of macromolecu

100 mount of heterologous protein than wild-type organelles, confirming efficient usage in plastid engine

101 in Drosophila have an additional specialized organelle connecting the cells called the fusome.

102 These membrane-surrounded acidic organelles contain around 70 hydrolases, 200 membrane pr

103 in the paraquat-exposed heart especially in organelle-containing subcellular fractions.

104 cargo of lipid droplets suggests that these organelles could be connected to C. neoformans melanin s

105 Lipid droplets are cellular organelles critical for the replication of many viral an

106 skeletal and/or membrane maintenance in post-organelle degradation maturation stage fiber cells.

107 oopted for a function in the chloroplast, an organelle derived from endosymbiosis of a cyanobacterium

108 ith dynamic actin tracks to drive long-range organelle dispersion in opposition to microtubules.

109 organelles and lead to greater efficiency in organelle dispersion.

110 t levels within the apicoplast that preceded organelle disruption, suggesting that PyrKII is required

111 ocation of the sarcoplasmic reticulum, inter-organelle distances, and differential distribution of re

112 To explore how intracellular organelle distributions affect cellular functions, sever

113 olymerisation domain substitution raised the organelle DNA polymerase error rate by 140-fold relative

114 The error prone organelle DNA polymerase introduced mutations at multipl

115 tested the fidelities of error prone tobacco organelle DNA polymerases using a novel positive selecti

116 Membrane tension pores determine organelle dynamics and functions, giving rise to physica

117 ll and transient actin structures regulating organelle dynamics are challenging to detect with fluore

118 -permeant molecules, they can visualize dual organelle dynamics in hard-to-transfect cell lines by su

119 d actions of membrane-bound and membraneless organelles ensure spatiotemporal control of various cell

120 However, the impact of DRP1 on other organelles, especially its direct influence on ER functi

121 This enigmatic organelle extrudes in extracellular invasive parasites a

122 plasmic reticulum (ER), mitochondria, acidic organelles, F-actin, keratin, and soluble fluorescein.

123 The isolation of organelles facilitates the focused analysis of subcellul

124 stinal stem cell biology, cell type-specific organelle features, the roles of new transcription facto

125 or macromolecules and provide a platform for organelle fission.

126 end of the flagellum, which is an important organelle for endo/exocytosis.

127 s and recycles proteins, macromolecules, and organelles for cells to survive starvation.

128 oronavirus-induced exploitation of lysosomal organelles for egress provides insights into the cellula

129 ze of lysosomes and modifies the pH of these organelles from ~4.5-5 to ~6.1 after recruitment to VIs

130 ctions with other intracellular vesicles and organelles generate the final content of the exosomes.

131 te-of-the-art toolkit to accurately assemble organelle genomes from whole genome sequencing data.

132 A novel family of DNA polymerases replicates organelle genomes in a wide distribution of taxa encompa

133 uces all possible configurations of circular organelle genomes.

134 h-resolution reconstructions of cellular and organelle geometries.

135 Retrograde transport of this organelle has been implicated in turnover of aged organe

136 nsfer of metabolites or ions between the two organelles has not been elucidated.

137 elles (specifically nuclear speckles) and of organelle heterogeneity on splicing particle biogenesis

138 Thus, cholesterol-mTORC1 signaling controls organelle homeostasis and is a targetable pathway in NPC

139 ng both morphology and physiology of a major organelle, identify a lacking loop during innate RNA sen

140 y are key components in the establishment of organelle identity and dynamics.

141 Organelle identity depends on protein composition.

142 endoplasmic reticulum (ER) is a fundamental organelle in cellular metabolism and signal transduction

143 Mitochondria are an essential organelle in most eukaryotes.

144 ic reticulum (SR), the major calcium storage organelle in striated muscle.

145 on, and enlarged and annular LAMP-1-positive organelles in AMD RPE.

146 late previously observed behavior of pigment organelles in amphibian melanophores.

147 hodologies used in the study of membraneless organelles in bacteria, highlights the limitations in de

148 ge about the functional role of membraneless organelles in bacteria.

149 g effective turnover of proteins and damaged organelles in cells.

150 Mitochondria are essential organelles in eukaryotes.

151 terest due to the importance of membraneless organelles in facilitating various biological processes

152 vant to the hitchhiking motion of peroxisome organelles in fungal hyphae.

153 nd the identification of small molecules and organelles in mammalian cells.

154 harges of the cytosolic membranes of various organelles in situ in intact cells.

155 measure the membrane potential of different organelles in situ in live cells.

156 om stable isotope labeling within individual organelles in situ.

157 replication, segregate mtDNA into individual organelles in the Drosophila early germarium.

158 so report the presence of lamellar body-like organelles in tumor cells accumulating glucose-derived b

159 at contact sites between the ER and several organelles, including late endosomes.

160 ssociates externally with membranes of other organelles, including the endoplasmic reticulum, via N-t

161 multiple signals are integrated to terminate organelle inheritance.

162 including TWIK-1 retention in intracellular organelles, inhibition by posttranslational sumoylation,

163 nctions including maintenance of protein and organelle integrity and regulation of metabolism(4).

164 hifts rapidly to manage cellular metabolism, organelle integrity, and cell fate.

165 le and transient protein-protein and protein-organelle interactions.

166 teins that segregate the duplicated cellular organelles into two daughter cells during cell division,

167 sembly of paraspeckles, membraneless nuclear organelles involved in gene regulation.

168 How cells position their organelles is a fundamental biological question.

169 Affinity purification of organelles is a powerful tool for reaching higher spatia

170 How the distinct lipid composition of organelles is determined and maintained is still poorly

171 Communication between organelles is essential for their cellular homeostasis.

172 w cells achieve proper localization of their organelles is still not well-understood, especially in l

173 cking target biomolecules and/or subcellular organelles labeled with imaging probes.

174 vations support selective inheritance at the organelle level through a series of developmentally orch

175 ift have not been fully characterized at the organelle level.

176 elayed in the cells lacking F-actin; as this organelle lies directly in the path of the cleavage furr

177 mic systems is vital for the construction of organelle-like architectures in living cells, but has pr

178 compacting the bacterial DNA into a distinct organelle-like entity, the nucleoid.

179 logical transformation from nanoparticles to organelle-like hydrogel architecture in living cells.

180 embraneless regions of cytoplasm with liquid organelle-like properties.

181 ing formation of intestinal lysosome-related organelles (LROs) is required for biosynthesis of most m

182 ccur in a manner similar to lysosome-related organelles (LROs).

183 d IL-2(+) vesicles can tether with endocytic organelles (lysosomes/late endosomes) by forming membran

184 tion, suggesting that PyrKII is required for organelle maintenance due to its role in nucleotide trip

185 quired for blood-stage parasite survival and organelle maintenance.

186 ing motor and track assembly activity at the organelle membrane.

187 rmed 'actin chromobodies' (ACs), targeted to organelle membranes to enable high-resolution imaging of

188 nsates are often referred to as membraneless organelles (MLOs), which have roles in cellular processe

189 ucleoprotein (RNP) granules are membraneless organelles (MLOs), which majorly consist of RNA and RNA-

190 ariety of both synthetic planar networks and organelle morphologies extracted from living cells.

191 rheostat that relates metabolic function and organelle morphology.

192 More robust control over organelle motility will aid in dissecting spatial cell b

193 by functioning as a scaffold to link axonal organelles, motors and membranes, establishing important

194 microtubules in eukaryotic cells, including organelles, mRNA and viruses.

195 enomes and evolved into mitochondria-related organelles (MROs).

196 sma membrane, and intracellular proteins and organelles, myosins can generate contractility, directly

197 rch on planar networks, motivated by tubular organelle networks in cell biology that contain molecule

198 bdomere, the microvilli-based photosensitive organelle of Drosophila photoreceptor cells.

199 The light-sensitive outer segment organelle of the vertebrate photoreceptor cell is a modi

200 Motile cilia are highly complex hair-like organelles of epithelial cells lining the surface of var

201 Organelles of the endomembrane system maintain their ide

202 -motile primary cilium is a critical sensory organelle on the cell surface.

203 ytoplasm and the intracellular matrix of the organelles (only in eukaryotes).

204 nals are relayed between tissues, cells, and organelles opens up new avenues to target metabolic regu

205 economic, and potentially applicable to any organelle or to organelle subpopulations.

206 Mutations in components of these organelles or those involved in their assembly may resul

207 signalling assemblies represent membraneless organelles, or condensates, that form via liquid-liquid

208 In many cases, this coupling involves organelle- or adaptor-induced activation of the microtub

209 didate genes were significantly clustered in organelle organization (GO:0004984, p = 3.9 x 10(- 2)) f

210 Not much is known about how organelles organize into patterns.

211 piRNA) pathway engages with the membraneless organelle P granule in Caenorhabditis elegans.

212 cytokine-containing vesicle (CytV)-endocytic organelle pairs are released sequentially.

213 cholesterol-mTORC1 signaling contribution to organelle pathogenesis are not understood.

214 ing cellular homeostasis by clearing damaged organelles, pathogens, and unwanted protein aggregates.

215 suppressor screens to identify the oxidative organelles peroxisomes as critical contributors to ferro

216 Cilia are dynamic microtubule-based organelles present on the surface of many eukaryotic cel

217 faster timescales than for membrane-enclosed organelles, presenting a possible mechanism to control s

218 monstration of tissue-specific regulation of organelle protein import and suggest that it operates by

219 ing from hemoglobin degradation to secretory organelle protein processing for egress, invasion, and e

220 Here, we combine vesicle relocalisation with organelle proteomics and Bayesian analysis to define the

221 quently re-routed vesicles was determined by organelle proteomics.

222 c-protease (Clp) system and how it regulates organelle proteostasis.

223 Primary cilia, organelles protruding from the surface of eukaryotic cel

224 that regulate signaling, nutrient status and organelle quality by specifying whether material enterin

225 HSV induces host organelle rearrangement and forms multiple, dispersed as

226 The function of cellular organelles relates not only to their molecular compositi

227 lies a relationship between insolubility and organelle remodeling.

228 s, lipid metabolism, membrane biogenesis and organelle remodelling.

229 tions, several optogenetic approaches enable organelle repositioning through light-inducible recruitm

230 While two members of the family are found in organelle ribosomes, we show here that two uL18-type pro

231 that the inner centromere is a membraneless organelle scaffolded by the CPC.

232 uantify analytes in live cells at the single-organelle, single-cell, tissue section, and whole organi

233 luorescent timer and flow cytometry-assisted organelle sorting, Yau et al. develop an elegant approac

234 to an essential protein that is required for organelle-specific trafficking and brain development.

235 ect of spatial organization of membrane-less organelles (specifically nuclear speckles) and of organe

236 ygen or nutrient starvation, proteotoxic and organelle stress, and elevation of reactive oxygen speci

237 otentially applicable to any organelle or to organelle subpopulations.

238 Smaller organelles such as mitochondria as well as cytoplasmic c

239 ins multiple dynamic and electrically active organelles such as mitochondria, chloroplasts, lysosomes

240 lation initiation in bacteria and eukaryotic organelles such as mitochondria.

241 -organisation and dynamics of membrane-bound organelles such as the Golgi apparatus, remain elusive.

242 Organelle surfaces within human B cells are reconstructe

243 Raman signals that locate in this region for organelle-targeting live-cell Raman imaging.

244 osperm-wide conservation of AEF1 and its two organelle targets.

245 Mesoscale macromolecular complexes and organelles, tens to hundreds of nanometers in size, crow

246 Only endocytic organelle-tethered CytVs are preferentially transported

247 the Golgi outpost has emerged as a satellite organelle that can function as an acentrosomal microtubu

248 The lysosome is an essential catabolic organelle that consumes cellular biomass to regenerate b

249 The carboxysome is a specialized bacterial organelle that encapsulates enzymes into a virus-like pr

250 chondria is a double membrane-bound cellular organelle that generates energy to maintain the homeosta

251 tment (Pdu MCP), a specialised proteinaceous organelle that is essential for 1,2-propanediol degradat

252 re proliferative signals conveyed through an organelle that is present for only part of the cell cycl

253 are morphologically and functionally diverse organelles that are dependent on nuclear-encoded, plasti

254 Primary cilia are sensory organelles that are essential for eukaryotic development

255 Mitochondria are dynamic organelles that can change shape and size depending on t

256 Mitochondria are highly dynamic organelles that can exhibit a wide range of morphologies

257 exit route of flaviviruses in LC3+ secretory organelles that enables them to evade circulating antibo

258 Primary cilia are vital signaling organelles that extend from most types of cells, includi

259 it information in subcellular structures and organelles that have rotational symmetry.

260 in endosomes, creating engineered artificial organelles that manufacture organic compounds intracellu

261 Lipid droplets (LDs) are fat storage organelles that originate from the endoplasmic reticulum

262 umulate within late endosomes and lysosomes, organelles that participate in the degradation and turno

263 Mitochondria are essential cellular organelles that play critical roles in cancer.

264 Primary cilia are microtubule-based organelles that play important roles in the organ develo

265 demonstrate an accumulation of lysosome-like organelles that precedes neurodegeneration.

266 Melanosomes are melanin-containing organelles that provide pigmentation and protection from

267 Endosomes are compositionally dynamic organelles that regulate signaling, nutrient status and

268 y formed autophagic vesicle to the recycling organelle, the lysosome.

269 finement by using their largest and stiffest organelle, the nucleus.

270 th its host erythrocyte (RBC) using a unique organelle, the parasitophorous vacuole (PV).

271 and Jonikas take a look at an unconventional organelle, the pyrenoid.

272 e the long-standing connection between these organelles, the function(s) of lysosomes required to sus

273 effects the diffusion rate of molecules and organelles, thereby affecting processes such as metaboli

274 elle has been implicated in turnover of aged organelles through lysosomal degradation in the cell bod

275 lved in the removal of unwanted proteins and organelles through lysosomes.

276 se 4-aminoquinoline drugs out of this acidic organelle, thus preventing these drugs from binding heme

277 mtDNA mutations at multiple scales, from the organelle to the human population, and challenge the con

278 s underlies all biological systems, from the organelle to the tissue scale.

279 Furthermore, we demonstrate that attaching organelles to microtubules can result in a substantial e

280 rsity of retrograde signals that travel from organelles to the nucleus in a lineal or classical model

281 teins, protein aggregates, lipid droplets or organelles) to the vacuole (lysosome in mammals) for deg

282 ular activities, including cell division and organelle transport.

283 Emerging evidence shows that these two organelle types interact in many biological processes.

284 have identified myriad pathways and cellular organelles underlying the autophagy process, be it as si

285 Formation of membrane-less organelles via liquid-liquid phase separation is one way

286 The cargo-specific removal of organelles via selective autophagy is important to maint

287 Although this organelle was discovered 120 years ago, such basic quest

288 demonstrated that one of these membraneless organelles was generated by the reversible polymerizatio

289 osomes, which like WPBs are lysosome-related organelles, we hypothesized that BLOC-2-dependent endoly

290 ns are regulated and recruited to autophagic organelles, we performed a nonbiased biochemical screen

291 ous alpha-syn is present in melanosomes, the organelle where melanin polymerization occurs.

292 tiguous inner membrane compartmentalizes the organelle, which is crucial for mitochondrial function.

293 only underlies the formation of membraneless organelles, which compartmentalize molecules intracellul

294 ted control of the structure and function of organelles, which relies on specific changes in their pr

295 The Golgi is a dynamic organelle whose correct assembly is crucial for cellular

296 This work highlights LDs as dynamic organelles with functions beyond lipid storage.

297 cate that the GJ Nexus is a dynamic membrane organelle, with cytoplasmic and membrane-embedded protei

298 n dynactin, is essential to the transport of organelles within cells.

299 sible repositioning of (endogenously tagged) organelles within cellular populations.

300 utophagy-associated proteins and degenerated organelles within type1 NI plays a role in disease progr