ライフサイエンスコーパス: organizer

1 s initiates at the site of the morphogenetic organizer.

2 al cells, which subsequently emerge from the organizer.

3 try of the body in the vertebrate left-right organizer.

4 1 (beta-NRX1) via Cbln1, a C1q-like synaptic organizer.

5 al portal (AIP) endoderm as a putative heart organizer.

6 ins oskar mRNA, which encodes the germ plasm organizer.

7 a large battery of target genes in the head organizer.

8 s essential for proper positioning of the DV organizer.

9 fluid flow inside the vertebrate left-right organizer.

10 motile and immotile cilia at the left-right organizer.

11 in-2 and not neuroligin-1 excitatory synapse organizer.

12 3K27 methylation in the embryonic left-right organizer.

13 competence and on Shh signaling from the ZLI organizer.

14 est a role for U-STAT3 as a chromatin/genome organizer.

15 wo pools of microtubules with AKAP6 as a key organizer.

16 s intrathalamica (ZLI), the mid-diencephalic organizer.

17 degradation, which is also expressed in the organizer.

18 maximum is sufficient to specify a stem-cell organizer.

19 giving rise to the formation of the Spemann organizer.

20 us, these xylem-identity cells constitute an organizer.

21 r and suggest similarity with other metazoan organizers.

22 performed by the participants and challenge organizers.

23 Centrosomes are important cell organizers.

24 mendations from these past events for future organizers.

25 d Ccdc151 expressed in vertebrate left-right organizers.

26 omplement the overall assessment by the CAFA organizers.

27 nisms orchestrated by regional morphogenetic organizers.

28 patterning is controlled by several discrete organizers.

29 rior and posterior poles, which are putative organizers.

30 identifying infusions when using line labels/organizers (0:31) than in the baseline (1:20), smart pum

31 ficantly fewer errors when using line labels/organizers (0; 0%) than in the baseline (12; 7.7%) and s

32 NOXO1beta [NOXO1 (Nox organizer 1) beta] is a cytosolic protein that, in conju

33 al side of the embryo and induces the dorsal organizer, a BMP signaling gradient patterns tissues alo

34 l interpretation of these data to aid future organizers achieve improved equity among the limited num

35 ds promise as a tool to discover other novel organizers acting during development.

36 whether the subcellular distribution of the organizer/adapter NOX p47(phox) subunit is altered in PV

37 Here, we asked whether the synaptic organizer agrin might regulate the metabolic stability a

38 and mouse to maintain Gsc expression in the organizer and along the axial midline, neural tube closu

39 erochronies during gastrulation that produce organizer and axial mesoderm tissues with different prop

40 rosstalk between mesenchymal lymphoid tissue organizer and hematopoietic lymphoid tissue inducer cell

41 After Spemann's organizer and its derivatives have endowed the neural pl

42 n the dorsal side, in cells of the embryonic organizer and its neighbors.

43 ter, MZdchs1b mutants exhibit altered dorsal organizer and mesendodermal gene expression, due to impa

44 tubules in wild-type embryos impaired dorsal organizer and mesodermal gene expression without percept

45 Ce-Punctin as a previously unknown synaptic organizer and show that presynaptic and postsynaptic dom

46 2-4 signaling is a key part of the spiralian organizer and suggest similarity with other metazoan org

47 brafish Ccr7 or Ccl19.1 expands the blastula organizer and the dorsoanterior tissues at the expense o

48 Wnt inactivation by the Tiki protease in the Organizer and the Notum deacylase in presumptive neuroec

49 ate consists of two outgrowths with distinct organizers and growth trajectories; a lower median fin t

50 ncreasing our understanding of how extrinsic organizers and intracellular mechanisms contribute to pr

51 ate that replication origins are fundamental organizers and regulators of gene activity through embry

52 rough online search or directly from meeting organizers and were reviewed and analyzed.

53 irect interaction between MDC1, a master DDR organizer, and a marker of DNA damage, histone gammaH2AX

54 HSV-1) localizes to ND10s, degrades the ND10 organizer, and disperses ND10 components in order to all

55 including a catalogue of trainers and course organizers, and an announcement service for training eve

56 Although signals from the isthmic organizer are known to specify cerebellar territory alon

57 Organizers are regions of the embryo that can both induc

58 performed a method designed by the challenge organizers as well as predictions by ALS clinicians.

59 Atg11, the preautophagosomal structure (PAS) organizer, as a downstream effector of Ypt1 and show tha

60 ing molecule (RIM) is a critical active zone organizer, as it recruits Ca(2+) channels and activates

61 The expression patterns of the organizer-associated gene HyWnt3 and the hypostome-speci

62 ignals originated from the so-called isthmic organizer at the mid/hindbrain junction; however, the un

63 w approach, using chick embryos, to discover organizers based on a common gene expression signature,

64 dence shows that these cells act as a tissue organizer by positioning the domain of oriented cell div

65 leus downregulates the glutamatergic synapse organizer Cbln1, which is needed for sociability in mice

66 important LTbetaR-dependent lymphoid tissue organizer cell population and indicates that continuous

67 enesis in plants is typically coordinated by organizer cells that direct the adjacent stem cells to u

68 ies a subset of murine fetal lymphoid tissue organizer cells that gives rise exclusively to adult mar

69 Consistent with this dual function of the organizer cells, xylem and phloem originate from a singl

70 on of mesenchymal cells into lymphoid tissue organizer cells.

71 ylem identity and cellular quiescence of the organizer cells.

72 e processes are orchestrated by the synaptic organizer CePunctin/MADD-4, which controls the localizat

73 ive imaging technique for Xenopus left-right organizer cilia and show that Galnt11-mediated Notch1 si

74 and characterized CPTX, a synthetic synaptic organizer combining structural elements from cerebellin-

75 uded several previously unrecognized Spemann organizer components.

76 This was tested in mosaic organizers composed of motile and immotile cilia generat

77 vascular cambium stem cells and whether the organizer concept applies to the cambium are currently u

78 Here we argue that the vertebrate genome organizer CTCF (CCCTC-binding factor) played an importan

79 regulator and three-dimensional (3D) genome organizer CTCF at cryptic binding sites, in conjunction

80 ling pathways, thus establishing the Spemann organizer domain.

81 unctional motile monocilia of the left-right organizer during early embryonic development can lead to

82 has a well-established role as a microtubule organizer during mitosis and cytokinesis.

83 a functions as a potent endogenous circadian organizer (ECO), which rewires the pathophysiological di

84 ng, leading to reduced expression of Spemann organizer effector genes and inducing head and axial def

85 Embryonic organizers establish gradients of diffusible signaling m

86 tives of this first phase, the Pre-B Project organizers established 4 working groups (WGs) to address

87 As organizers explore new ways of sharing knowledge globall

88 rchin embryo relies on a ventrally-localized organizer expressing Nodal, a pivotal regulator of the D

89 Loss of the elastogenic organizer, fibulin-5 (FBLN5), leads to pelvic organ prol

90 expressing prechordal cells, which leave the organizer first, migrate and do not undergo CE like the

91 Thus, RA acts as a central organizer for coordinated homeostatic plasticity in both

92 ere it binds Rapsyn and serves as a synaptic organizer for MT-associated proteins, EB1 and MAP1b, and

93 ting molecular scaffold involving MreD as an organizer for optimal cell function and growth based on

94 then serves as a stalk-specific topological organizer for PG synthesis activity, including its recru

95 dorsomedial telencephalon, is the embryonic organizer for the hippocampus.

96 eractions, implying that it functions as the organizer for the local three-dimensional architecture.

97 hat normally differentiated HCs act as 'self-organizers' for OC development and that Atoh1 plays a cr

98 Although roles of Wnt signaling during organizer formation have been studied extensively, it is

99 als high evolutionary conservation of dorsal organizer formation in the chordate lineage.

100 c activation of Wnt signaling and subsequent organizer formation on the future dorsal side of the emb

101 terminants, the initiation of Wnt signaling, organizer formation, and ultimately results in ventraliz

102 s required for relocation of the microtubule organizer function from centromeres to the nuclear rim d

103 A hallmark of Spemann organizer function is its expression of Wnt antagonists

104 , to which current models assign a stem cell organizer function.

105 We encourage all conference organizers, funders and institutions who are able to do

106 iption initiation that involves mesoderm and organizer gene expression.

107 This suggests that, at organizer gene promoters, a stable transcriptional compl

108 nism for spatial and temporal restriction of organizer gene transcription by the integration of two m

109 sum, we provide evidence that fetal stromal organizers give rise to adult marginal reticular cells a

110 We propose that in the organizer Gsc represses CE as well: Gsc-expressing prech

111 later embryogenesis, the role of Gsc in the organizer has remained enigmatic.

112 So far, surprisingly few organizers have been discovered, considering the number

113 li and particularly the five human nucleolus organizers have not been well characterized.

114 ance and to be expressed in apical meristem "organizers." Here, we focus on the role of the WOX5 tran

115 B1 is an important T-cell specific chromatin organizer in cutaneous T-cell lymphoma, whereas its expr

116 t3 activity, a central component of the head organizer in Hydra.

117 lts in acquiring characteristics of the head organizer in the body column.

118 tor 22 (FGF22), a target-derived presynaptic organizer in the mouse hippocampus, induces the expressi

119 y, was identified as an anterograde synaptic organizer in the nematode Caenorhabditis elegans.

120 s, guidance signals emanating from a central organizer in the specific target tissue may act as an im

121 ptic scaffold protein liprin-alpha2 as a key organizer in this process.

122 (Gsc) expression marks the primary embryonic organizer in vertebrates and beyond.

123 (NL-NRX) complexes are fundamental synaptic organizers in the central nervous system.

124 Tetraspanins are master organizers in the plasma membrane, forming tetraspanin-e

125 unctional experiments manipulating secondary organizers in zebrafish and mice.

126 culus in the absence of Fgf8 and the isthmic organizer, indicating that FGF and Mek1(DD) initiate qua

127 n by anti-sense morpholinos causes defective organizer induction, patterning and differentiation of m

128 In Hydra, formation of the head organizer involves the canonical Wnt pathway.

129 An organizer is a portion of the embryo producing signals t

130 Ontology Term Organizer is a user-friendly, web-based, consensus-promo

131 o, we show that fluid flow in the left-right organizer is asymmetric and provides a good predictor of

132 The thalamic organizer is the zona limitans intrathalamica (ZLI), a t

133 The concept of an "organizer" is basic to embryology.

134 C-binding factor (CTCF), a crucial chromatin organizer, is essential for Schwann cell myelination and

135 rate development is broken at the left-right organizer (LRO) by ciliary motility and the resultant di

136 We found that despite all left-right organizer (LRO) cells express foxj1a and the ciliary axo

137 ocess: monocilia at the embryonic left-right organizer (LRO) facilitate both the generation and sensi

138 The left-right organizer (LRO) in the mouse consists of pit cells withi

139 ymmetry originates at a transient left-right organizer (LRO), a ciliated structure where cilia play a

140 ty of a ciliated organ functioning as the LR Organizer (LRO).

141 Here we identify two synaptic organizers, Lrrtm1 and Lrrtm2, as targets of nuclear cal

142 lymphoid tissue inducer and lymphoid tissue organizer (LTo) cells.

143 Additionally, the organizer maintains phloem identity in a non-cell-autono

144 A key premise is that project organizers may be able to draw on underused human resour

145 The results suggest that line labels/organizers may increase infusion identification accuracy

146 g they are early mesenchymal lymphoid tissue organizer (mLTo) cells.

147 ption factor combination is a novel synaptic organizer molecule, the single immunoglobulin domain pro

148 Furthermore, addition of the synaptic organizers, neuroligins, induces presynaptic differentia

149 ired for the localization of the microtubule organizer NOCA-1/Ninein, and defects in a noca-1 mutant

150 and highlights the role of flow as a central organizer of actomyosin network architecture.

151 Reward seeking is a major motivator and organizer of behavior, and animals readily learn to modi

152 sphatidylserine-binding protein and critical organizer of caveolae (small microdomains in the plasma

153 reB based on evidence implicating MreB as an organizer of cell wall synthesis.

154 These data implicate FGF14 as an organizer of channel localization in the AIS and provide

155 dent LARG-RhoA signaling module as a central organizer of directed cell migration and invasion.

156 tranded DNA binding protein (SSB) acts as an organizer of DNA repair complexes.

157 in transcription factor Lhx2 is an essential organizer of early eye development and is subsequently e

158 Fibronectin is a master organizer of extracellular matrices (ECMs) and promotes

159 g protein beta (mAKAPbeta) serves as a nodal organizer of hypertrophic signaling.

160 n of neuroligin NLG-1, itself a postsynaptic organizer of inhibitory synapses.

161 t increase in the expression of gephyrin, an organizer of ligand-gated ion channels at inhibitory syn

162 ub for complex sphingolipids, but also as an organizer of membrane domains segregating receptors and

163 Caveolin-1 (Cav-1) is a key organizer of membrane specializations and a scaffold pro

164 While cell polarity is an intrinsic organizer of morphogenic events, environmental cues in t

165 PML, the organizer of NBs, is expressed as a number of splice var

166 he degradation and dissociation of the major organizer of ND10, a promyelocytic leukemia (PML) and ND

167 e role of the nucleolus as a determinant and organizer of nuclear architecture and other epigenetic s

168 ase, thereby revealing a function of Rif1 as organizer of nuclear architecture.

169 cytic leukemia protein (PML) is an essential organizer of PML nuclear bodies (NBs), which carry out a

170 us on the actin regulator Cortactin, a major organizer of protrusion, membrane mobility, and invasive

171 The small GTPase Rab7 is a key organizer of receptor sorting and lysosomal degradation

172 Our findings demonstrate that NG2 is a core organizer of Rho GTPase activity and localization in the

173 Our work reveals LLPS as a principal organizer of signaling compartments and highlights the p

174 ndomesodermal lineage represent an embryonic organizer of subsequent development and are causally inv

175 rylation of Munc18-1 (Stxbp1), a presynaptic organizer of synaptic vesicle fusion, is a powerful mech

176 r protein (CDC42EP) signaling pathway, a key organizer of the actin cytoskeleton, was previously repo

177 scaffolding protein ankyrin-G is the master-organizer of the AIS.

178 ily, protein survivin (Sur), a ubiquitous re-organizer of the cell life cycle with the ability to inh

179 evious studies showed that the male-specific organizer of the complex, MSL2, and the ubiquitous DNA-b

180 enchymal cells (the cumulus) functions as an organizer of the dorsoventral axis.

181 lated protein Rab-7a (Rab7a) serves as a key organizer of the endosomal-lysosomal system.

182 Thus, the Dg-Dys complex works as a crucial organizer of the epithelial basal domain, regulating bot

183 ociation of ERAD machinery components, a key organizer of the ERAD complex.

184 urce in the rostromedial telencephalon as an organizer of the neocortical area map.

185 ch transcript-Z+Agrin-known to be a critical organizer of the NMJ.

186 spermatogenesis-associated 7 (SPATA7), a key organizer of the photoreceptor-specific distal CC, was d

187 unction among plant meristems, the stem-cell organizer of this tissue shares features with the organi

188 We show that Arp2/3 complex is an essential organizer of treadmilling actin filament arrays but has

189 anchor cell (AC) of the gonad, the critical organizer of uterine and vulval development.

190 Angptl4 is expressed in the Spemann organizer of Xenopus embryos and acts as a Wnt antagonis

191 tor in human cancer cells and in the Spemann organizer of Xenopus embryos.

192 nt and demonstrates a role for astrocytes as organizers of active synaptic connections by coordinatin

193 ad hoc formats for data science, we surveyed organizers of ad hoc data science education efforts to u

194 rin-alpha have been identified as two master organizers of AZ assembly.

195 e of chromosomes (SMC) complexes are central organizers of chromatin architecture throughout the cell

196 tenance of chromosome (SMC) proteins are key organizers of chromosome architecture and are essential

197 nance of chromosomes (SMC) complexes are key organizers of chromosome architecture in all kingdoms of

198 complex as essential RAB3/SEC4 effectors and organizers of DCV fusion sites by recruiting DCVs via RA

199 e plasma membrane of most cells serve as key organizers of intracellular signalling and tethering poi

200 lgeranyl isoprenoids to Rab GTPases, the key organizers of intracellular vesicular transport, is esse

201 ther as a unit, with interneurons serving as organizers of linked pyramidal ensemble activity.

202 uncover a novel function for neutrophils as organizers of lymphangiogenesis during inflammation.

203 Primary cilia have pivotal roles as organizers of many different signaling pathways, includi

204 In animals, they are known to act as central organizers of membrane complexes and thought to facilita

205 s by interacting with tetraspanins, critical organizers of membranous organelles.

206 pericentromeric heterochromatin clusters as organizers of nuclear microenvironment required for prop

207 izer of this tissue shares features with the organizers of root and shoot meristems.

208 ce provides a list of outstanding women whom organizers of scientific meetings, scientific review pan

209 ular condensates are proposed to be critical organizers of subcellular biochemistry and to control th

210 Neurexins are considered central organizers of synapse architecture that are implicated i

211 Neurexins are recognized as key organizers of synapses that are essential for normal bra

212 ich presynaptic Ca(v) channels serve both as organizers of synaptic building blocks and as sources of

213 in-binding protein filamins (FLNs) are major organizers of the actin cytoskeleton.

214 CD4 Th cells are organizers of the immune response, directing other immun

215 CASPs are known to be the organizers of the lignin-based Casparian strip, which fu

216 eLRRon proteins as important components and organizers of the pre-cuticular and cuticular apical ECM

217 nd June; Rino (RR) was one of the scientific organizers of the Transforming Vaccinology Keystone, whi

218 CSPGs, acting as central organizers of the tumor microenvironment, dramatically i

219 o whether AnkG functions as an initial nodal organizer or whether it functions as a nodal stabilizer

220 of invited speakers, assembled by conference organizers or committees, is key to achieving these goal

221 l modeling, we find that the vertebrate tail organizer orchestrates morphogenesis over distances beyo

222 ndent transcription factor for NADPH oxidase organizer p47phox, thereby increasing ROS-NFkappaB-VCAM-

223 The meeting organizers, Patricia Ernst, Hanna Mikkola and Timm Schro

224 atory factor (NHERF1) is a molecular pathway organizer, PDZ-domain protein that recruits membrane, cy

225 science education efforts to understand how organizers perceived the events to have gone-including a

226 Organizers play important roles during the embryonic dev

227 e E3 ubiquitin ligase that degrades the ND10 organizer PML and disperses ND10 to alleviate the repres

228 is article grew out of contributions made by organizers, presenters, panelists, and other participant

229 stone acetyltransferase p300 is recruited to organizer promoters in a Wnt and Nodal effector-dependen

230 We found that the genome organizer protein Satb1 is highly expressed in mature ne

231 NCC ubiquitination and ERAD, the Hsp70/Hsp90 organizer protein stabilized NCC turnover, indicating th

232 teracting protein (CHIP) and the Hsp70/Hsp90 organizer protein, were associated with NCC.

233 bout WNT interaction with mitotic structural organizer proteins.

234 d rRNA gene subtypes mapped to the nucleolus organizer region (NOR) on chromosome 2 (NOR2).

235 to be a determinant at the Xenopus gastrula organizer region and a segment-polarity determinant in D

236 f 45S rDNA and their corresponding nucleolus organizer regions (NOR).

237 Nucleolus organizer regions (NORs) are chromosomal loci where hund

238 tures in human nuclei, form around nucleolar organizer regions (NORs) comprising ribosomal DNA (rDNA)

239 curred in both the centromeres and nucleolar organizer regions (NORs) in D- and AD-genome species, ye

240 f 45S rRNA gene copies localize in Nucleolus Organizer Regions (NORs), and the activation or repressi

241 localizes with the 45S rDNA at the nucleolar organizer regions (NORs).

242 Dorsoventral patterning is mediated by two organizer regions that extend along the dorsal and ventr

243 ed with altered silver staining of nucleolar organizer regions, coupled to a modest decrease in H3K9

244 The Satb1 genome organizer regulates multiple cellular and developmental

245 The organizer regulates the rate and coherence of cell motio

246 regulating cellular dynamics in the Spemann organizer, regulates delamination of neuroblasts in the

247 ctor, has been shown to act as a presynaptic organizer released from the postsynaptic site, it seems

248 Here we show that the cytoskeletal organizer RhoA suppresses neutrophil priming via formins

249 ng the DR loci, we applied a novel recursive organizer (ROR) to discover disease-associated amino aci

250 proposed more than a decade ago explain the organizer's region-specific inductions (i.e., head and t

251 T cell-specific deficiency of the genome organizer Satb1 impaired Treg-SE activation and the subs

252 al. (2017) uncover a key role for the genome organizer Satb1 in restraining PD1 expression and promot

253 The chromatin organizer SATB1 is highly enriched in thymocytes and is

254 In March 2016, meeting organizers Sebastian Jessberger and Hongjun Song brought

255 Our findings implicate FGF8 as an organizer signal, and its source in the rostromedial tel

256 e development of all structures that require organizer signaling and ventralizes the embryo.

257 inhibit or promote formation of the Spemann organizer signaling center.

258 the pathway is active in all lineages during organizer signaling, but activation is strongest on the

259 nduce eyes and external shell, which require organizer signaling.

260 Just as its amphibian counterpart in the organizer signals body plan and cell fate during embryog

261 Organizer signals come from a surprisingly limited set o

262 se extended interactome includes the spindle organizer, silencing factors, the proteasome, and key co

263 ns: baseline (current practice); line labels/organizers; smart pump; and light-linking system.

264 vocative new studies establish the chromatin organizer special AT-rich binding protein 1 (Satb1) as o

265 We found that the chromatin organizer special AT-rich sequence-binding protein-1 (Sa

266 The genome organizer, special AT-rich sequence-binding protein-1 (S

267 dorsal-anterior structures and overexpressed organizer-specific genes, indicating that maternal Bicc1

268 rab5ab is essential for nodal signalling and organizer specification in the developing zebrafish embr

269 stimulated phosphorylation of p47(phox) (an organizer subunit for nicotinamide adenine dinucleotide

270 c architectures without benefit of a central organizer, such as a centrosome, to control the location

271 Using these devices, Otx2 and other head organizer TFs (for example, Lim1/Lhx1 (activator) or Goo

272 r Visceral Endoderm (AVE), an extraembryonic organizer that controls the position of the streak.

273 ts presented argue that E202 acts as a water-organizer that creates a proton conduit connecting intra

274 tra-terminal (ET) domain, is a key chromatin organizer that directs gene activation in chromatin thro

275 CTIP2 appears to serve as a transcriptional organizer that integrates input from multiple signaling

276 between SIDD and SATB1, a crucial chromatin organizer that interacts with SIDD regions.

277 h ERF115 acts as a wound-inducible stem cell organizer that interprets wound-induced auxin maxima.

278 ted set of interactions operating within the organizer that is critical for embryonic patterning.

279 Satb1 is a nuclear organizer that partitions chromatin through the formatio

280 abidopsis thaliana) root meristem acts as an organizer that promotes stem cell fate in adjacent cells

281 Sema3G serves as a vascular-derived synaptic organizer that regulates synaptic plasticity and hippoca

282 The most famous example is the Spemann organizer that sets up embryonic axes in amphibian embry

283 ucidate an additional mechanism of embryonic organizers that is a secondary consequence of morphogen

284 d by a small group of cells, often called an organizer, that signals to other cells to establish the

285 For course organizers, the portal provides opportunities to promote

286 Meeting organizers thus felt the time was right, armed with new

287 Transplantation of Spemann organizer tissue showed that Chordin diffused over long

288 which gives rise to Shh-expressing posterior organizer tissue, caused loss of posterior gene expressi

289 motile and immotile cilia at the left-right organizer to determine laterality, and reveal a novel me

290 rmation, DNA is also an excellent biological organizer to establish well-designed nanostructures in t

291 These results connect the spiralian organizer to this general aspect of secondary axis patte

292 can derepress viral genes by degrading ND10 organizers to disrupt ND10.

293 ql3, produced by MFs, serve as extracellular organizers to recruit functional postsynaptic KAR comple

294 ar to experiments performed with the Spemann organizer, transplantation of the cumulus is able to ind

295 ordin protein secreted by the dorsal Spemann organizer was found to diffuse along a narrow region tha

296 ity is initiated at the embryonic left-right organizer, where motile cilia generate leftward flow tha

297 esent a detailed molecular analysis of these organizers, which occur on the short arms of five human

298 ly characterized as a T cell-specific genome organizer whose aberrant overexpression in breast cancer

299 ssively refined by the activity of secondary organizers within the neuroepithelium that function by r

300 8 is increased at the rostral telencephalic organizer, yet the FGF8 source was unchanged in hem-abla