ライフサイエンスコーパス: orthovanadate

1 osine and dual-specific phosphatases, sodium orthovanadate.

2 y ligands such as MgATP, MgADP, or inorganic orthovanadate.

3 ts in its apparent affinity for ATP, H+, and orthovanadate.

4 UV-C, gamma radiation, TNF-alpha, and sodium orthovanadate.

5 ), with optimal effects seen at 25 microg/ml orthovanadate.

6 aration containing vanadyl ribonucleoside or orthovanadate.

7 were reversed by pertussis toxin and sodium orthovanadate.

8 htened sensitivity to brefeldin A and sodium orthovanadate.

9 in surface AMPAR clusters was unaffected by orthovanadate.

10 eptor (AMPAR) subunits, an effect blocked by orthovanadate.

11 opiperazines and the ATPase inhibitor sodium orthovanadate.

12 more sensitive to beryllium fluoride than to orthovanadate.

13 state at NBD2 by the gamma-phosphate analog orthovanadate.

14 ited by TNF, and this was reversed by sodium orthovanadate.

15 presence of the phosphatase inhibitor sodium orthovanadate.

16 ase inhibitors phenylarsine oxide and sodium orthovanadate.

17 n cells pretreated with the PTPase inhibitor orthovanadate.

18 e in either apoptosis or survival induced by orthovanadate.

19 otein-tyrosine phosphatase inhibitor, sodium orthovanadate.

20 PP inhibition with sodium orthovanadate (100 microM), okadaic acid (10 nM), or Ro

21 D98,059 (20 microM) or phosphatase inhibitor orthovanadate (30 microM) completely blocked the potenti

22 However, treatment with orthovanadate (50 microM), a widely used tyrosine phosph

23 n of phosphatase inhibitors (5 mmol/l sodium orthovanadate, 50 mmol/l sodium fluoride, or 5 mmol/l ED

24 ysis with the tyrosine phosphatase inhibitor orthovanadate (500 microM) prevented the actions of both

25 r cells treated with interleukin-6 (IL-6) or orthovanadate (a general activator of STATs) were fracti

26 er preincubation of oocytes with 1 mM sodium orthovanadate (a protein tyrosine phosphatase inhibitor)

27 red insulin's effect on MAPK activity, while orthovanadate (a tyrosine phosphatase inhibitor), inhibi

28 Sodium orthovanadate, a known inhibitor of TDP2, inhibits produ

29 Indeed, infusion of sodium orthovanadate, a nonspecific MKP inhibitor, attenuated M

30 hat the inhibitory form is usually monomeric orthovanadate, a particularly good inhibitor of phosphat

31 nt HCD57 murine cell line with 70 micromol/L orthovanadate, a tyrosine phosphatase inhibitor, resulte

32 The tyrosine phosphatase inhibitor sodium orthovanadate ablated the inhibitory effects of roscovit

33 Orthovanadate activated JAK2, STAT1, STAT5, the phosphat

34 ally, we show that the phosphatase inhibitor orthovanadate acts as does CHI to render cells susceptib

35 Orthovanadate also delayed apoptosis in primary human er

36 rthermore, the well studied PTPase inhibitor orthovanadate also induced protein tyrosine phosphorylat

37 (Sp)-cAMP, cells were pretreated with sodium orthovanadate, an inhibitor of phosphotyrosine phosphata

38 Culture of normal erythroid progenitors with orthovanadate, an inhibitor of protein tyrosine phosphat

39 zes ATP (Km, 0.62 mm), which is inhibited by orthovanadate and beryllium fluoride.

40 tion, and two general PTP inhibitors, sodium orthovanadate and bpV(pic), dramatically rescued the cel

41 otein-tyrosine-phosphatase inhibitors sodium orthovanadate and dephostatin prevented PPARgamma ligand

42 It was inhibited by orthovanadate and fluoride compounds.

43 that was abolished in the presence of sodium orthovanadate and inhibited significantly by the sulfhyd

44 ibited by the tyrosine phosphatase inhibitor orthovanadate and is particularly sensitive to inhibitio

45 Other PTP inhibitors--orthovanadate and phenylarsine oxide (PAO)-inhibited PTP

46 otein tyrosine phosphatase (PTP) inhibitors, orthovanadate and phenylarsine oxide, selectively block

47 he Camnn9Delta strain is resistant to sodium orthovanadate and sensitive to hygromycin B.

48 nd the protein phosphatase inhibitors sodium orthovanadate and sodium fluoride.

49 inhibitors of tyrosine phosphatases (sodium orthovanadate and sodium molybdate) but not by inhibitor

50 ith a tyrosine phosphatase inhibitor (sodium orthovanadate) and T-cell activation signals (phorbol 12

51 rotein kinase (MAPK) was poorly activated by orthovanadate, and inhibition of MAPK with PD98059 block

52 The PTP inhibitors ALN, orthovanadate, and PAO suppressed in vitro formation of

53 vely high Km for ATP (1.9 mM), inhibition by orthovanadate, and the ability to specifically bind an a

54 ptimal at pH 7; 2) potently inhibited by F-, orthovanadate, and Zn2+ > Co2+ > Mn2+ but unaffected by

55 Vanadyl ribonucleoside and orthovanadate are commonly employed as inhibitors of rib

56 Orthovanadate, BeFx, and AlFx effectively inhibited ABCG

57 Pertussis toxin and orthovanadate blocked AT2 receptor-mediated ceramide pro

58 Finally, in dissociated hippocampal neurons, orthovanadate blocked the ability of DHPG to reduce the

59 Pretreatment of neurons with sodium orthovanadate blocked the ability of insulin to inhibit

60 Additionally, orthovanadate blunted the effect of sarcomere length on

61 The enzyme is inhibited by sodium orthovanadate but not by sodium fluoride or okadaic acid

62 The activity is inhibited by orthovanadate, but not by N-ethylmaleimide, bafilomycin

63 (B44) and a tyrosine phosphatase inhibitor (orthovanadate), changes in both CCK- and TPA-stimulated

64 te is due to formation of a pentacoordinated orthovanadate complex at the phosphorylation site, corre

65 sing trivalent ytterbium-171 ions in yttrium orthovanadate coupled to a nanophotonic waveguide and a

66 qubit doped into a nuclear-spin-rich yttrium orthovanadate crystal(15), we develop a robust quantum c

67 The ATPase inhibitor sodium orthovanadate demonstrated dose-dependent inhibition of

68 Sodium orthovanadate had a slight but significant inhibitory ef

69 -1 cells with either cycloheximide or sodium orthovanadate had little effect on the early peak of ERK

70 nanophotonic cavity fabricated in an yttrium orthovanadate host crystal.

71 eral other ABC proteins and was inhibited by orthovanadate in a profile diagnostic of ABC transporter

72 Inactivation of PTPs with sodium orthovanadate in human and rodent islets and beta-cells

73 cal for the survival of erythroid cells, and orthovanadate in the absence of EPO both maintained expr

74 ells with the tyrosine phosphatase inhibitor orthovanadate in the presence of insulin or okadaic acid

75 promotion of pro-MMP-2 activation by sodium orthovanadate in the presence of suboptimal concentratio

76 posure to the tyrosine phosphatase inhibitor orthovanadate increases tyrosine phosphorylation of beta

77 otein tyrosine phosphatase inhibitor, sodium orthovanadate, increases eNOS tyrosine phosphorylation.

78 Both showed orthovanadate-independent retention of ATP and ADP.

79 Furthermore, sodium orthovanadate-induced phosphorylation of ASC Y144, neces

80 plete inhibition of ATPase activity, whereas orthovanadate inhibited exclusively the PC-stimulated AT

81 A phosphatase inhibitor, sodium orthovanadate, inhibited endothelial cell apoptosis and

82 rotein tyrosine phosphatase inhibitor sodium orthovanadate inhibits fertilization suggest that protei

83 dimer is most prominent upon the addition of orthovanadate (K(i) = 0.70 +/- 0.20 microM) and PhAH, in

84 Thus, orthovanadate likely acts to greatly increase JAK/STAT a

85 In the presence of orthovanadate, Lys-174 at the boundary between M2 and th

86 ts or T-cells with the phosphatase inhibitor orthovanadate markedly abolished MIP1beta-induced chemot

87 tase (PTP), because the PTP inhibitor sodium orthovanadate mimicked the effects of Go6976.

88 rt that the addition of BeF(3)(-) and sodium orthovanadate (Na(3)VO(4)) to medium containing digitoni

89 Sodium orthovanadate (Na3VO4), sodium oxodiperoxo(1,10-phenanth

90 n via the patch pipette of 200 microM sodium orthovanadate (Na3VO4), which inhibits tyrosine phosphat

91 yrosine phosphatases (PTPs) inhibitor sodium orthovanadate (Na3VO4).

92 we detected the specific effects of ATP and orthovanadate on the thermal stability of ATP-binding ca

93 SHP1 overrecruitment, treatment with sodium orthovanadate or a novel inhibitor with micromolar activ

94 sing either the phosphatase inhibitor sodium orthovanadate or antisense oligonucleotides prevents the

95 Global phosphatase inhibition by orthovanadate or depletion of protein tyrosine phosphata

96 hibition of phosphoprotein phosphatases with orthovanadate or fluoride yielded a global protein phosp

97 otactic activity in HAEC treated with sodium orthovanadate or MKP-1 antisense oligonucleotides is due

98 tion of the intracellular stores with either orthovanadate or thapsigargin.

99 presence of a phosphatase inhibitor, sodium orthovanadate, or antisense oligonucleotides, suggesting

100 tyrosine phosphatase (PTPase) inhibition by orthovanadate (OVA) showed that this Src activity is hig

101 Three such compounds, sodium orthovanadate, peroxovanadate, and bpV(phen), had no eff

102 Inclusion of 2 mM orthovanadate, polymerized primarily to decavanadate, in

103 of the tyrosine phosphatase inhibitor sodium orthovanadate prior to ethanol restored tyrosine phospho

104 splayed a 40-fold decrease in sensitivity to orthovanadate, reflecting a shift in equilibrium from th

105 a mixture of hydrogen peroxidase and sodium orthovanadate, respectively.

106 ld type or mutant forms of PECAM-1 to sodium orthovanadate resulted in high levels of cytoplasmic tyr

107 mutant cells with the phosphatase inhibitor orthovanadate resulted in strong coordinate elevation of

108 Orthovanadate-sensitive (45)Ca(2+) transport into vesicl

109 ct, like S1P-mediated ERK1/2 inhibition, was orthovanadate-sensitive and pertussis toxin-insensitive.

110 via an ATP-driven, protonophore-insensitive, orthovanadate-sensitive mechanism, equating with export

111 These results suggest that a TPA-inducible, orthovanadate-sensitive protein-tyrosine phosphatase may

112 ase activity by phenylarsine oxide or sodium orthovanadate shifted ventricular hyperpolarization-acti

113 d the reversal and phosphatase inhibition by orthovanadate significantly accelerated the recovery.

114 suggesting a critical role of PI-3 kinase in orthovanadate-stimulated survival.

115 ocytes also displayed GTP gamma S and sodium orthovanadate stimulation of actin comet tails on GLUT4

116 a-thio]triphosphate (GTP gamma S) and sodium orthovanadate stimulation of actin comet tails.

117 imulated KDR activity was impaired by sodium orthovanadate, suggesting that the inhibitory activity o

118 1/2 activity was abolished by treatment with orthovanadate, suggesting the involvement of a tyrosine

119 Inhibition of dephosphorylation with sodium orthovanadate suggests that this effect is at least part

120 Upon activation of signaling by IL-6 or orthovanadate the respective Tyr-phosphorylated STAT spe

121 one in the presence of 100 micromol/L sodium orthovanadate to prevent enzymatic redistribution of lip

122 sence and presence of the phosphate analogue orthovanadate, to determine the roles the nucleoside moi

123 Orthovanadate-trapping experiments showed that mutation

124 PI-3 kinase activity, triggered apoptosis in orthovanadate-treated cells, suggesting a critical role

125 ated what survival signals were activated by orthovanadate treatment.

126 Orthophosphate and the oxoanion analogues orthovanadate, tungstate, molybdate, arsenate, and sulfa

127 ormation in the presence of Mg(2+), ADP, and orthovanadate (V(i)), a photoreactive phosphate analog w

128 of the stable myosin subfragment 1(S1).MgADP.orthovanadate (Vi) complex results in oxidation of an ac

129 The loss of coupling in the presence of orthovanadate (Vi) suggests that the gamma-phosphate of

130 his reason, we have carried out studies with orthovanadate (Vi), a phosphate analog which has the pot

131 can hydrolyze ATP simultaneously, we used an orthovanadate (Vi)-induced ADP-trapping technique (P-gp.

132 Sensitivity toward orthovanadate was increased when Asn-106 was substituted

133 Mg(2+)-ADP and orthovanadate were used to examine the structural effect

134 Orthovanadate, which inhibits dynein activity, specifica

135 ructure of AcpA complexed with the inhibitor orthovanadate, which is the first structure of any F. tu

136 h Gly-371 were highly resistant to inorganic orthovanadate, with IC(50) values at least 10-fold above

137 Application of orthovanadate, Zn(2+), or poly(Glu, Tyr) (4:1), each of