ライフサイエンスコーパス: outbred

1 that some blind individuals were relatively outbred.

2 lso increased the lifespan of inbred but not outbred adults, suggesting that the beneficial buffering

3 n extreme quantitative trait locus GWA on an outbred advanced intercross population derived from extr

4 r Genetic Reference Panel (DGRP) and a large outbred, advanced intercross population derived from 40

5 tion analyses in the DGRP and a DGRP-derived outbred, advanced intercross population identified candi

6 urden of ROHs among patients with AD from an outbred African American population, which could reflect

7 dy using a well-characterized model in which outbred, aged, male Long-Evans rats exhibit a spectrum o

8 NIH:Swiss outbred and Apc(Min/+) mice were infected with CR (10(8)

9 tgb8 deletion (Itgb8(-/-)) were generated on outbred and C57BL/6 congenic backgrounds.

10 autosomal and X-linked haplotypes from both outbred and consanguineous pedigrees.

11 TS intragenic mutations, and TP53 status in outbred and experimental cancer cell lines did not predi

12 te the study of immune control, we sought an outbred and immunocompetent laboratory mouse strain in w

13 nd converged to a mortality plateau for both outbred and inbred beetles.

14 nflammatory cytokines and chemokines in both outbred and inbred mice.

15 ght rats appear equivalent to those found in outbred and inbred rat strains, except for lower inciden

16 ted for identifying SNPs in polyploids, both outbred and inbred, but would tend to be conservative fo

17 substitution, Collaborative Cross, Diversity Outbred and other mapping populations.

18 s than strangers, in marked contrast to both outbred and rederived wild mice.

19 eptible vs -resistant populations using both outbred and selectively bred models of susceptibility.

20 t on the donor, and not the recipient, being outbred and that it is characterized by hemorrhagic necr

21 e transgene to their offspring with both the outbred and the inbred EIII/JC genetic background.

22 turally existing polymorphisms among inbred, outbred and wild rats.

23 strains of mice, in males and females: CD1 (outbred) and C57BL/6 (inbred).

24 ges in the T cell compartment of long-lived, outbred, and pathogen-exposed organisms, their relevance

25 ss Ib loci and their polymorphism in inbred, outbred, and wild-derived mice.

26 ivo response to miHA vaccination in a large, outbred animal model without using recipient cells to se

27 ays a role in graft rejection and GVHD in an outbred animal model, and ICOS blockade may be an approa

28 y compared to experimental designs involving outbred animal populations.

29 Gene expression in pig BMDM from outbred animals responding to LPS was profiled using Aff

30 types and facilitates extinction learning in outbred animals, therefore we examined the effects of ea

31 deemed acute, in 54% of Hyal2 KO mice on an outbred background; Hyal2 KO mice without the severe car

32 were approximately 5% shorter than those of outbred beetles, and there was no difference in inbreedi

33 mmobility events that were highly similar to outbred BN rats in terms of spike-wave morphology, frequ

34 t and of shorter duration in wild-caught and outbred BN rats than the outbred Long-Evans and inbred W

35 way [BN]) rats to recordings from laboratory outbred BN, outbred Long-Evans, and inbred WAG/Rij rats

36 ion of chickens was created by crossing four outbred broiler sires to dams of two highly inbred lines

37 ncrease in larval survival in inbred than in outbred broods.

38 ne pancreata of RD-fed Grp78(+/-) mice in an outbred C57BL/6 x 129/sv genetic background exhibited ER

39 most effective in inbred BALB/c followed by outbred CD-1 and inbred B6J mice.

40 validates a simple breeding strategy between outbred CD-1 mice and inbred C57-based Cre lines that ca

41 d Drd1-Cre and Drd2-Cre transgenic mice with outbred CD-1 mice and used cell-type-specific Cre-DREADD

42 rant aggression and reported that adult male outbred CD-1 mice lever-press for the opportunity to att

43 d DsRed, respectively), into the footpads of outbred CD-1 mice to simulate transmission by a mosquito

44 Outbred CD-1 mice were immunized twice with the antigens

45 In this study, we examined whether groups of outbred CD-1 virgin female mice housed in a large vivari

46 6, C57BL/10, DBA/2, SJL, SWR, 129P3) and one outbred (CD-1) mouse strains following treatment with ve

47 J, DBA/2J, SJL/J, SWR/J and 129P3/J) and one outbred (CD-1) mouse strains previously tested with nalt

48 /10J, DBA/2J, SJL/J, SWR/J, 129P3/J) and one outbred (CD-1) mouse strains.

49 2 gene in all backgrounds examined including outbred CD1 and inbred C3H and C57BL/6J.

50 We exposed pregnant outbred CD1 female mice and the male progeny was crossed

51 in human ascites fluid, and the survival of outbred CD1 mice challenged subcutaneously or intraperit

52 th survival and competition experiments with outbred CD1 mice demonstrated that PEG344 was required f

53 Outbred CD1 neonatal mice were orally gavaged with one o

54 and electroolfactogram defects were found in outbred (CD1) and inbred (C57/bl6) mouse genetic backgro

55 n, with large and robust differences in both outbred (CD1) and inbred (C57bl/6) mouse strains without

56 its ability to persist in the intestines of outbred chickens relative to the parent strain.

57 We show that in an outbred cohort (n = 2,093) of HIV C-clade-infected indiv

58 complex statistical methods as in studies of outbred cohorts.

59 nd we included Wistar rats as an additional, outbred control strain.

60 8- to 12-week-old inbred C57BL/6JCrl (B6J), outbred Crl:CD1(ICR) (CD-1), and inbred BALB/cAnNCrl (BA

61 ats (inbred: LEW, WKY, F344/ICO and F344/DU, outbred: Crl:SD) were exposed to Spared Nerve Injury (SN

62 Here, a QTL analysis using an outbred cross was initiated to determine the molecular b

63 difier; and Mom3, which was discovered in an outbred cross.

64 population structures, including inbred and outbred crosses as well as natural populations, and can

65 o discuss the suitability of this design for outbred crosses in organisms with large genomes and for

66 mmune response was investigated in Diversity Outbred (DO) F1 mice that express human HER2.

67 We sought to evaluate Diversity Outbred (DO) mice as a tool for exposure threshold asses

68 e isolated 233,447 islets from 483 Diversity Outbred (DO) mice maintained on a Western-style diet, an

69 e the Collaborative Cross (CC) and Diversity Outbred (DO) models.

70 ultiparent populations such as the Diversity Outbred (DO) mouse stock accumulate large numbers of cro

71 Collaborative Cross (CC) strains, Diversity Outbred (DO) stock, and their isogenic founder strains.

72 gh-diversity mouse population, the Diversity Outbred (DO), we found substantial sex and genetic effec

73 % homozygous compared to the genomes of the outbred domestic cat (24.08 % homozygous), Virunga Mount

74 ransplants were successfully performed in 22 outbred domestic ferrets in the absence of immunosuppres

75 d the potential for purging using inbred and outbred Drosophila melanogaster larvae exposed to biotic

76 brid method for a low input sample, a single outbred Drosophila melanogaster.

77 ouring outbred offspring, but rather because outbred embryos exert a rescuing effect on inbred half-s

78 resent in one-third of familial ALS cases of outbred European descent, making it the most common gene

79 R19X is rare (<0.05% frequency) in outbred European populations.

80 11 well-described population isolates and an outbred European-derived sample, using SNP markers space

81 d results were confirmed in three additional outbred F(2) families (n=96 per family).

82 ome-wide mapping was initiated using a large outbred F(2) rainbow trout family (n=480) and results we

83 ally-induced skin cancer in NIH/Ola by SPRET/Outbred F1 backcrosses.

84 Second, via tracking survival in inbred and outbred families, we demonstrate that inbred families ha

85 This was applied to wild-stock outbred female house mice, which nest socially and often

86 We also found that both inbred and outbred females had higher immunity than males in PO act

87 ales was 9-13% shorter than the life span of outbred females, whereas the life span of inbred males d

88 water temperature in inbred fish but not in outbred fish.

89 inbred lines with that of crickets from the outbred founder population.

90 ween genetic diversity and macroparasites in outbred, free-ranging populations of raccoons (Procyon l

91 hasing and imputing genome-wide genotypes in outbred full-sib families from single nucleotide polymor

92 encing forking defects were identified in an outbred full-sibling family of loblolly pine, using sing

93 In an outbred genetic background, Dnaaf2 homozygotes die after

94 sposed to asthma), only partially evident in outbred germ-free Swiss Webster mice, and marginal in co

95 trophil depletion prevented early failure of outbred grafts, whereas transplanting CD73-deficient inb

96 ng 1184 STR/indel markers, were found in the outbred group (P < 0.0001) and were associated with lowe

97 cell-mediated and protective immunity in the outbred guinea pig model of pulmonary tuberculosis.

98 These findings suggest that the outbred guinea pig model recapitulates ZEBOV infection o

99 Uniformly lethal outbred guinea pig models of MARV-Angola (MARV-Ang) and

100 Thirty-six outbred guinea pigs were infected with guinea pig-adapte

101 Features of disease in ZEBOV-infected outbred guinea pigs were largely consistent with disease

102 duction of allergen-specific blocking IgG in outbred guinea pigs which had been immunized with recomb

103 ong tracts of homozygosity in the apparently outbred HapMap populations.

104 MARV-, ZEBOV-, and SEBOV-induced disease in outbred Hartley guinea pigs where we observed protection

105 -gamma production was observed in inbred and outbred hosts and controlled by extrinsic (but not cell-

106 ed memory CD8 T cell responses in inbred and outbred hosts generated in response to different types o

107 tude and kinetics of CD8 T cell responses in outbred hosts.

108 ferences between inbred mouse models and the outbred human population and allelic receptor variants n

109 echanisms and are directly applicable to the outbred human population.

110 ikely essential for maximum protection in an outbred human population.

111 gabase-scale ancestral haplotypes persist in outbred human populations in broad genomic regions which

112 rect relevance to development of vaccines in outbred humans.

113 small-molecule MIF antagonist, CPSI-1306, to outbred ICR mice following induction of NIDDM significan

114 mids were next introduced into the livers of outbred ICR mice via hydrodynamic tail vein injection.

115 lity, which was overcome by crossing them to outbred ICR mice.

116 MIP-2 (a CXC chemokine) levels after CLP in outbred (ICR/CD-1) mice.

117 We used the outbred, immune-competent Skh-1 hairless mouse model of

118 We show that MmuPV1 challenge of the outbred immunocompetent SKH1 strain produces both transi

119 ome, but not other, wild mice that were kept outbred in the laboratory.

120 n the absence of an independent set of known outbred individuals from which to estimate allele freque

121 ovel immunogenic T4SS proteins recognized by outbred individuals with common MHC haplotypes further j

122 he phenotypic variance present in ostensibly outbred individuals.

123 more resources to this form of immunity than outbred individuals.

124 s in protective memory CD8 T cell numbers in outbred individuals.

125 suring up to 4 Mb are common in demonstrably outbred individuals.

126 requencies can be estimated from a subset of outbred individuals.

127 ully inbred genotype will exceed the mean of outbred individuals.

128 us coding variation in a worldwide sample of outbred individuals.

129 Adult, female, outbred Institute of Cancer Research mice.

130 als from three genetic backgrounds (inbred - outbred) into a novel environment at three founding size

131 n SNPs at a mean r(2) value of 0.98 in 2,073 outbred laboratory mice (0.15x sequencing coverage).

132 ents, a conclusion that logically extends to outbred laboratory rats and possibly to those that have

133 acteristics, however, are routinely found in outbred laboratory rats, leading to debate on whether SW

134 However, these events are also common in outbred laboratory rats, raising concerns about whether

135 ed immobility, are also prevalent in healthy outbred laboratory rats.

136 In contrast, Drosophila oocytes from outbred laboratory stocks develop fully regardless of ma

137 ximately equal, averaging a 42% reduction in outbred larval survival relative to controls.

138 a cross between C57BL/6J and an ICR-derived outbred line (HR).

139 assembled and phased genomes, termed Phased Outbred Lines (POLs).

140 Here, we studied an F2 intercross of two outbred lines of rats selected for tame and aggressive b

141 To circumvent this, we used two outbred lines of rats, which are genetically similar exc

142 s domestication has produced many inbred and outbred lines that are used for different purposes, incl

143 air design," for use with F2 crosses between outbred lines.

144 in wild-caught and outbred BN rats than the outbred Long-Evans and inbred WAG/Rij strains.

145 ts to recordings from laboratory outbred BN, outbred Long-Evans, and inbred WAG/Rij rats (i.e., a mod

146 ll samples, but here a large sample of 1,598 outbred male and female heterogeneous stock rats were sc

147 In Experiment 1, outbred male Wistar rats self-administered sweetened alc

148 d males did not differ from the life span of outbred males.

149 17 degrees of latitude in a four-grandparent outbred mapping population in outcrossing switchgrass (P

150 n, time post infection) and was validated in outbred mice (AUC>0.97).

151 The use of outbred mice allows for the exploration of gestational m

152 In outbred mice and rats, familiarity determined willingnes

153 one BALB/c mice and weak in asthma-resistant outbred mice and requires germ-free conditions before co

154 on density in early generations of Diversity Outbred mice are consistent with expectations based on s

155 an estimated human dose injected into young outbred mice as a saline solution, were bactericidal aga

156 IgG antibody levels induced in young outbred mice by the S. sonnei O-SPC conjugates were sign

157 e, we demonstrate that adult immunocompetent outbred mice can be effectively colonized with the proto

158 Therefore, outbred mice could provide broader insight into donor an

159 ne expression profiles of multi-tissues from outbred mice fed with a high-fat diet (HFD) or regular c

160 e rAls1p-N vaccine also improves survival of outbred mice from disseminated candidiasis and that it i

161 y (6-16 days posttransplantation), untreated outbred mice had heterogeneous outcomes, with grafts fai

162 everity was dependent on genetic background: outbred mice or those on a CD1 background are highly sus

163 For the present study, an outbred mice population containing 1,904 individuals and

164 n this study, we demonstrate that inbred and outbred mice recovering from a septic event are more sus

165 nd hyperglycemia were divergent in diversity outbred mice that model human genetic variation.

166 Outbred mice were exposed to cockroach allergens on Days

167 Immunizations in outbred mice with rMSP1-IO achieved 100% responsiveness

168 holangiocarcinoma growth in vivo in hairless outbred mice with severe combined immunodeficiency (SHO-

169 n LS in virgin and postpartum mice, 2) using outbred mice, and 3) evaluating the role of sensory inpu

170 responses to both antigens, particularly in outbred mice, and most importantly, the efficacy was equ

171 ong-term graft acceptance in both inbred and outbred mice, but did not prevent the early graft failur

172 w here, in a survey of 97 traits measured in outbred mice, that most phenotypes display parent-of-ori

173 tein expression in livers from 192 Diversity outbred mice, we identify 2,866 protein quantitative tra

174 re immunogenic than their parental strain in outbred mice, while MVvac2-H2 additionally proved more i

175 gave high antibody titers in both inbred and outbred mice.

176 , NOD2(-/-), ob/ob, and Rag1(-/-)), and >200 outbred mice.

177 from Collaborative Cross lines and Diversity Outbred mice.

178 ly with exploratory tendencies in individual outbred mice.

179 ty of silicosis was determined in inbred and outbred mice.

180 and puncture model of sepsis in adult female outbred mice.

181 ogenicities of new peptides were assessed in outbred mice.

182 lotype space in 1,887 commercially available outbred mice.

183 aque offers an intriguing, non-human primate outbred model organism with which hypotheses concerning

184 e of other isoform (GR(wt)), is found in two outbred mouse lines that were produced by selection for

185 for protein quantification with an emerging outbred mouse model containing extensive genetic variati

186 hite (CFW) mice are a commercially available outbred mouse population that exhibit rapid LD decay in

187 In an application to data from an outbred mouse population, we find that mixed random fore

188 had genetic variations not present in other outbred mouse populations.

189 rs located on 39 pairs of chromosomes for an outbred multigenerational pedigree, initiated with a lim

190 ells (iPSCs) and hESC-derived progenitors in outbred murine recipients.

191 nt of chronic CVB3-induced myocarditis in an outbred NMRI mouse model.

192 5 receptor blockade using Mut-IL-15/Fc in an outbred non-human primate model of renal allotransplanta

193 The linear peptide was also immunogenic in outbred nonhuman primates (Aotus nancymaae), eliciting a

194 rough paternity-biasing mechanisms favouring outbred offspring, but rather because outbred embryos ex

195 rmance of inbred offspring more than that of outbred offspring.

196 during larval development and (ii) inbred or outbred offspring.

197 rast, swine derived by nuclear transfer into outbred oocytes differed in the HV1 region sequence from

198 identical knockout counterparts derived from outbred oocytes were rejected within 2 weeks, whereas tr

199 , we performed heart transplantation between outbred or inbred mice.

200 llular immune response induced by AS01 in an outbred ovine model, 2) to develop a lymphatic cannulati

201 knockout of HAO1 (expected ~1 in 30 million outbred people).

202 gh-dose intrarectal SIV(mac251) challenge in outbred pigtail macaques.

203 ence Panel (DGRP) and an advanced intercross outbred population derived from a subset of DGRP lines.

204 The JAX Diversity Outbred population is a new mouse resource derived from

205 cted a significant association at MC22 in an outbred population maintained under laboratory condition

206 time in the accessions and genotyped in the outbred population were replicated in both mapping popul

207 ed by the natural genetic polymorphism in an outbred population.

208 s of an anti-self HER2 response in a healthy outbred population.

209 tion ability compared with crickets from the outbred population.

210 components method to model complex traits in outbred populations (e.g., humans).

211 gosity (ROH) in the genome are detectable in outbred populations and can be associated with an increa

212 f homozygosity in coronary artery disease in outbred populations and suggest the potential biological

213 ions of low amounts of epistatic variance in outbred populations are concordant.

214 terious recessive alleles that are masked in outbred populations are predicted to be expressed in sma

215 extended beyond experimental intercrosses to outbred populations by exploiting long-range linkage dis

216 vealed by changing allele frequencies in the outbred populations derived from extreme DGRP lines.

217 The standard model for outbred populations is based on premises of genetic equi

218 Our results suggest that in outbred populations multi-locus diversity might be impor

219 s of disease together with genetic data from outbred populations represents a promising strategy to u

220 ied experimentally with greater ease than in outbred populations such as humans.

221 htly controlled, their large variation among outbred populations suggests genetic factors.

222 e distance at which r2=0.2 extends <10 kb in outbred populations to >1.7 Mb in populations that have

223 Linkage disequilibrium (LD) analysis in outbred populations uses historical recombinations to de

224 Even among outbred populations, autozygosity can occur to varying d

225 mmetry (FA) in inbred compared to relatively outbred populations, but many studies have failed to fin

226 hough statistical methods for QTL mapping in outbred populations, e.g., humans, can be applied for su

227 ge of population sizes, including inbred and outbred populations, monogamous and polygamous mating pa

228 s, such as Collaborative Cross and Diversity Outbred populations, offer the opportunity for parallel

229 tification in genetic association studies of outbred populations, such as in the United States.

230 However, for outbred populations, very large sample sizes may be requ

231 ions exhibit a greater range of kinship than outbred populations, which helps in fitting the epistati

232 or role in defining HL risk in predominantly outbred populations.

233 ations occurred at lower male skews than for outbred populations.

234 teractions, which is difficult to measure in outbred populations.

235 s in recombination rate between the sexes in outbred populations.

236 homozygous polymorphisms in individuals from outbred populations.

237 ot be utilized through methods developed for outbred populations.

238 equencing to species with highly recombinant outbred populations.

239 from distant common ancestors in apparently "outbred" populations.

240 The 597-626 epitope was immunogenic in outbred rabbits eliciting Abs which recognized HER-2, co

241 antagonism potently reduce sucrose intake in outbred rat and mouse strains, the present study examine

242 rt the development and application of an RHV outbred rat model for HCV vaccine development.

243 To address this issue, we used a unique outbred rat population (heterogeneous stock) that better

244 o identify impulsive action phenotypes in an outbred rat population before cocaine self-administratio

245 whether this is due to the use of different outbred rat strains.

246 We showed two real examples in outbred rat where ADDO identified significant dominant Q

247 Their equal occurrence in outbred rats also implies a major potential confound for

248 directly influences social dominance in male outbred rats and identify an important mediating role fo

249 ed immobility may be nonepileptic in healthy outbred rats and reflect instead voluntary rodent behavi

250 nce and voluntary control of SWDs in healthy outbred rats could indicate that these phenomena do not

251 We discovered that both inbred and outbred rats could shorten the duration of SWDs to obtai

252 method for classifying addiction severity in outbred rats following intermittent-access heroin self-a

253 CANCE STATEMENT Our evidence that inbred and outbred rats learn to control the duration of spike-wave

254 and saccharin preference tests) behaviors in outbred rats relate to mitochondrial morphology (electro

255 ned sequence and genetic mapping analysis in outbred rats that maps 355 quantitative trait loci for 1

256 Here, we use outbred rats to investigate if cAMP response element-bin

257 g NFkappaB-mediated luciferase expression in outbred rats.

258 usceptible and stress-resilient subgroups in outbred rats.

259 sive (LI) phenotypes were identified from an outbred rodent population with the 1-choice serial react

260 t the intestine of social wasps hosts highly outbred S. cerevisiae strains as well as a rare S. cerev

261 w substantially higher levels of LD than the outbred sample and many fewer regions of very low LD (te

262 l likelihood-based method for QTL mapping in outbred segregating populations of autotetraploid specie

263 These are outbred species exhibiting substantial levels of genetic

264 play levels of diversity comparable to other outbred species, except for those populations impacted b

265 Meiotic crossovers in outbred species, such as oil palm (Elaeis guineensis Jac

266 requent inbreeding, the number of inbred and outbred sporophytes was balanced, resulting in an averag

267 inction learning and retention compared with outbred Sprague Dawley rats, whereas bLRs show reduced e

268 resent study compared SHR, WKY and standard, outbred Sprague-Dawley (SD) rats on a delay discounting

269 Both selectively bred Crl:OP[CD] rats and outbred Sprague-Dawley rats fed an HE diet showing high

270 omotor activity in a novel environment among outbred Sprague-Dawley rats.

271 elements mapping to the peak linkage area in outbred spretus, Spret/EiJ, FVB/NJ, and NIH/Ola.

272 All inbred strains and outbred stocks of laboratory mice studied to date have b

273 2 on the C57BL/6 background) strain, and one outbred strain (CD1) of mice.

274 s in the genetically heterogeneous Diversity Outbred strain as well as greater alveolar inflammation

275 e was investigated in two mouse strains, the outbred strain CD1 and the inbred strain C57BL/6.

276 possess more translational value than common outbred strains for modeling neuropathic pain.

277 de (ODN) and was observed in both inbred and outbred strains of mice.

278 d intake of sucrose varies across inbred and outbred strains of mice.

279 lets was normal in Cc1(-/-) mice (inbred and outbred strains).

280 nditioning in male rats to determine whether outbred strains, Sprague Dawley and Long-Evans, and/or t

281 sensitivity when compared to other inbred or outbred strains.

282 iduals under consideration come from a large outbred subpopulation of the population for which allele

283 One to 2 billion hepatocytes from outbred swine were transplanted into the spleens of cyno

284 is murine pathogen has been characterized in outbred Swiss Webster (SW) mice but not in the cognate i

285 ng study relied upon mice backcrossed on the outbred Swiss Webster (SW) strain that were homozygous f

286 We report here that outbred Swiss Webster mice infected with P. chabaudi cha

287 n liver, kidney and monocyte cell lines, and outbred Swiss Webster mice tolerate high doses of the co

288 tion (H268Q) in Jag1 (Jag1(+/Ndr) mice) were outbred to a C3H/C57bl6 background to generate a mouse m

289 differing ancestral histories (ranging from outbred to inbred) from the Dalmatian islands in Croatia

290 or mice; this may be the result of examining outbred versus captive populations.

291 information for rare, recent variants in the outbred Wellcome Trust Case-Control Consortium (WTCCC) d

292 ivation of sharp vision (DSV) was induced in outbred White Leghorn chicks aged 4 days.

293 Outbred Wistar rats experienced extended access methamph

294 the first study to examine simultaneously in outbred WT Drosophila pseudoobscura the lifetime costs a

295 However, five lines of outbred XY(d) females with Y chromosome deletions Y(Del(

296 ly documented for C57BL/6 inbred XY females, outbred XY(Sry-) and XO,Zfy2 females showed frequent fai

297 Outbred XY(Sry-) female mice that lack Sry due to the 11

298 mes, we studied the induction of LTP in male outbred young and aged rats behaviorally characterized i

299 pment and population viability of inbred and outbred zebrafish (Danio rerio).

300 Eggs were obtained from WT outbred zebrafish and exposed to 0%, 0.1%, 0.2%, 0.4%, 0