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1 rge at the inner leaflet exceeds that at the outer leaflet.
2 end into the hydrocarbon chain region of the outer leaflet.
3 n the inner leaflet and a single site in the outer leaflet.
4 ing a majority of lipopolysaccharides in its outer leaflet.
5 d GM3 (monosialodihexosylganglioside) in the outer leaflet.
6 dylcholine (PC) family from the inner to the outer leaflet.
7 formation of nano-clusters of GM3 within the outer leaflet.
8 y to alter the surface electrostatics of the outer leaflet.
9 inner leaflet and sphingomyelin (SM) in the outer leaflet.
10 phipathic LPS molecules across the OM to the outer leaflet.
11 the extracted lipids were from the membrane outer leaflet.
12 r translocation of MPD from the inner to the outer leaflet.
13 nd defective redistribution of sterol to the outer leaflet.
14 LPS) comprise the hydrophobic portion of the outer leaflet.
15 he induction of inner leaflet domains by the outer leaflet.
16 ria contains lipopolysaccharide (LPS) in the outer leaflet.
17 x glycolipid lipopolysaccharide (LPS) in the outer leaflet.
18 ation of ceramide within the plasma membrane outer leaflet.
19 f diblock copolymer and an independent lipid outer leaflet.
20 ation of phospholipids from the inner to the outer leaflet.
21 ted galactosylceramide from the inner to the outer leaflet.
22 l asymmetry of 0.63 +/- 0.04 in favor of the outer leaflet.
23 the inner leaflet but not of the IMPs of the outer leaflet.
24 ts the longitudinal diffusion of IMPs of the outer leaflet.
25 inner leaflet and lipopolysaccharides in the outer leaflet.
26 a unique lipid bilayer containing LPS in its outer leaflet.
27 lipid bilayer with lipopolysaccharide in the outer leaflet.
28 the delivery of exogenous lipids to the cell outer leaflet.
29 cellular envelope and is assembled at the OM outer leaflet.
30 leaflet and lipopolysaccharides (LPS) in the outer leaflet.
31 osition mimics the mammalian plasma membrane outer leaflet.
32 between the physical states of the inner and outer leaflets.
33 ral perturbation moved through the inner and outer leaflets.
35 observe an enrichment of cholesterol in the outer leaflet and a general non-ideal lateral mixing of
36 line (POPC) as the predominant lipids in the outer leaflet and dioleoylphosphatidylcholine (DOPC), PO
37 tive pressure in the headgroup region of the outer leaflet and increasing the positive pressure throu
38 distribution with lipopolysaccharides at the outer leaflet and phospholipids (PLs) at the inner leafl
39 th lipopolysaccharides (LPS) residing in the outer leaflet and phospholipids (PLs) in the inner leafl
40 composed of lipopolysaccharide (LPS) in the outer leaflet and phospholipids in the inner leaflet.
41 ne, with lipopolysaccharide molecules in the outer leaflet and phospholipids in the inner leaflet.
42 FFA into vesicles containing both FPE in the outer leaflet and pyranine trapped in the inside aqueous
43 species including the glycolipid GM3 in the outer leaflet and the anionic lipid, phosphatidylinosito
49 ght to pass through hemifusion, in which the outer leaflets are fused while the inner leaflets engage
50 and thereby stress small unilamellar vesicle outer leaflets as well as the periphery of intermediate
52 only the outer leaflet of the bilayer, this outer leaflet becomes more ordered, and thus more solid-
57 mbrane of gram-negative bacteria contains an outer leaflet composed of lipopolysaccharide (LPS) that
58 mentioned nonextractable cardiolipin and its outer leaflet composed of trehalose dimycolates, phospha
62 UVs, lateral diffusion in the bSM-containing outer leaflet decreased, whereas that in the DOPC-contai
68 distinct waves, presumably hemifusion of the outer leaflet followed by inner leaflet (core) fusion.
71 y flipped across the liposome bilayer to the outer leaflet in the presence of Mg(2+)-ATP, whereas no
72 The presence of phosphatidylcholine in the outer leaflet increased the cholesterol concentration re
73 At room temperature, SM exchange into the outer leaflet increased the inner leaflet lipid order, s
74 veral assays showed that the ordering of the outer leaflet induced by the presence of SM was not refl
75 osphatidylserine (PS) to the plasma membrane outer leaflet is a nearly universal marker of apoptosis
76 unique asymmetric lipid bilayer in which the outer leaflet is composed of lipopolysaccharide (LPS) an
79 Analysis of the lipid composition of the outer leaflet is important for understanding cell membra
80 ular the exclusion of phospholipids from the outer leaflet, is key to creating an almost impenetrable
83 e outer leaflet of brain SM, which decreased outer-leaflet lateral diffusion, had little effect upon
85 ously defined for erythrocytes, as judged by outer leaflet lipid composition; and plasma membrane out
88 le neutral or cationic lipid was used as the outer leaflet lipid to form an asymmetric lipid bilayer
89 on of lipid asymmetry by partial exchange of outer-leaflet lipid, 4) verification of lipid asymmetry
90 envelope protein induced mixing of membrane outer leaflet lipids but did not lead to content mixing,
92 stant rafts exhibited a balance of inner and outer leaflet lipids, whereas the Triton X-100 rafts con
100 For asymmetric vesicles containing egg SM, outer-leaflet Lo domains were also depleted in a saturat
101 on-enhanced coupling resulting in inner- and outer-leaflet Lo domains with similar physical propertie
103 t the two populations of cells have distinct outer leaflet membrane compositions with the membranes o
105 nes, communication between inner leaflet and outer leaflet, membrane adhesion, and raft mobility.
106 ted at the cell surface mediated hemifusion (outer leaflet merger) upon low-pH treatment, but only th
107 outer-leaflet diffusion upon introduction of outer-leaflet milk SM or a synthetic C24:0 SM, both of w
108 contrast, in asymmetric vesicles containing outer-leaflet milk SM, which has long acyl chains capabl
110 the wedging of its long alpha-helix into the outer leaflet of a membrane may cause curvature and an a
111 ping and to redistribute lipids added to the outer leaflet of ATG9 vesicles, thereby enabling growth
112 sequesters cell wall precursors found in the outer leaflet of bacterial plasma membranes, Lipid II an
114 aberrant lipid composition presented on the outer leaflet of cancer cell membranes, which makes the
115 bined enrichment of both these lipids in the outer leaflet of cancer cells is highly significant for
117 1% of the human proteome is anchored to the outer leaflet of cell membranes via a class of glycolipi
118 amine, two aminophospholipids exposed on the outer leaflet of dead and activated cells, has shed new
119 hosphatidylcholine, which is enriched in the outer leaflet of eukaryotic cells, are not well understo
125 tained probe, Pro12A, stains exclusively the outer leaflet of lipid bilayers of liposomes, as evidenc
126 phiphile that spontaneously inserts into the outer leaflet of lipid bilayers to bury its hydrophobic
127 atidylethanolamine (FPE) introduced into the outer leaflet of lipid vesicles was used to monitor FFA
130 A(2) rapidly hydrolyzed phospholipids in the outer leaflet of liposomes and proteoliposomes with a ha
132 n, glucose 6-phosphate releases HKI from the outer leaflet of mitochondria; however, the site of gluc
134 eaflet showed that PS already existed in the outer leaflet of null spermatozoa before sperm capacitat
136 nction in preventing appearance of PS in the outer leaflet of plasma membrane, and ectopic exposure o
137 th lipid compositions typically found in the outer leaflet of plasma membranes induce liquid-ordered
138 containing glycosphingolipids present in the outer leaflet of plasma membranes, are produced at high
139 cyanine lipid analogs in the plasma membrane outer leaflet of RBL mast cells was used to investigate
140 nge to characterize the phospholipids in the outer leaflet of red blood cells (RBCs) is reported.
143 This glycolipid is found exclusively in the outer leaflet of the asymmetric outer membrane (OM), whe
146 g of wt20, which is known to affect only the outer leaflet of the bilayer, this outer leaflet becomes
147 ile daunorubicin is stably inserted into the outer leaflet of the bilayer, verapamil dynamically flip
148 syn penetrates approximately 9-14 A into the outer leaflet of the bilayer, with a substantial portion
151 nzyme from intracellular compartments to the outer leaflet of the cell membrane, where hydrolysis of
152 osphocholine and DiI have been imaged on the outer leaflet of the cell membrane, while phosphocholine
157 ught to power the extraction of LPS from the outer leaflet of the cytoplasmic membrane and its transp
158 d within a coiled-coil domain of Rz near the outer leaflet of the cytoplasmic membrane and were not a
161 l wall dd-carboxypeptidase, localized in the outer leaflet of the cytosolic membrane of this Gram-neg
162 ermore, phospholipid synthesis "refills" the outer leaflet of the endoplasmic reticulum (ER) membrane
164 Kdo) is an essential component of LPS in the outer leaflet of the Gram-negative bacterial outer membr
166 huttling hopanoid virulence factors from the outer leaflet of the inner membrane to the periplasm.
167 e faces, RS is associated primarily with the outer leaflet of the inner segment plasma membrane throu
168 ng conformation with two portals open to the outer leaflet of the membrane and a unique topology of t
170 of phosphatidylserine from the inner to the outer leaflet of the membrane bilayer during platelet ac
171 PS) externalization has been observed on the outer leaflet of the membrane shortly after nsPEF exposu
172 bstrates, phosphatidylserine exposure on the outer leaflet of the membrane, and loss of viability.
173 lipooligosaccharide (LOS) exclusively in the outer leaflet of the membrane, establishes an impermeabl
176 lipid droplets are thought to form from the outer leaflet of the microsomal membrane, the reduction
178 t mislocalized glycerophospholipids from the outer leaflet of the OM and return them to the inner mem
179 sh chemical treatments accumulate PLs in the outer leaflet of the OM and this disrupts lipopolysaccha
180 oprotein that removes phospholipids from the outer leaflet of the OM of Escherichia coli, increases O
181 ert LPS from the periplasm directly into the outer leaflet of the OM to establish the asymmetry of th
182 assembled with divalent metal cations in the outer leaflet of the OM to form an impervious layer that
183 ransport of misplaced phospholipids from the outer leaflet of the OM to the cytoplasmic membrane (4)
189 Lipid A species comprise the bulk of the outer leaflet of the outer membrane and are produced thr
191 s of lipopolysaccharides that constitute the outer leaflet of the outer membrane in Gram-negative bac
192 e (LPS), a glycolipid that forms most of the outer leaflet of the outer membrane in Gram-negative bac
193 highly acylated saccharolipid located on the outer leaflet of the outer membrane of Gram-negative bac
194 endotoxin) is an essential component of the outer leaflet of the outer membrane of gram-negative bac
196 lipid anchor of a lipopolysaccharide in the outer leaflet of the outer membrane of Gram-negative bac
198 Similar to most Gram-negative bacteria, the outer leaflet of the outer membrane of Vibrio cholerae i
199 lipid A of the LPS may be inserted into the outer leaflet of the outer membrane through a lateral op
200 ase subunits reveals that they reside on the outer leaflet of the outer membrane under anaerobic cond
201 slocated lipoprotein that is anchored in the outer leaflet of the outer membrane, with its C-terminal
204 lucosamine-based phospholipids that form the outer leaflet of the outer membranes of Gram-negative ba
206 t LPS induced translocation of ASMase to the outer leaflet of the plasma membrane and reduced SM leve
207 lasma membrane induced exposure of PS on the outer leaflet of the plasma membrane at sites of egress,
208 X2 or tNOX), associated exclusively with the outer leaflet of the plasma membrane at the surface of c
209 ect traversing of CPPs through the uncharged outer leaflet of the plasma membrane bilayer is unlikely
210 ion, we show that coupling may extend to the outer leaflet of the plasma membrane by examining the fl
211 ion with the GM1 ganglioside receptor in the outer leaflet of the plasma membrane in intestinal (HT-2
212 quid disorder heterogeneity of lipids in the outer leaflet of the plasma membrane in live cells.
213 imited exposure of aminophospholipids on the outer leaflet of the plasma membrane is a fundamental fe
214 ystems showed that sphingomyelin (SM) in the outer leaflet of the plasma membrane is responsible for
215 monstrated that the lipid composition of the outer leaflet of the plasma membrane is sufficient for t
216 hatidylethanolamine, that are exposed on the outer leaflet of the plasma membrane of dead and activat
217 PS), 2 phospholipids that translocate to the outer leaflet of the plasma membrane of dead cells, as t
218 agged annexin V to phosphatidylserine in the outer leaflet of the plasma membrane of degranulated mas
219 e the sphingolipids and phospholipids in the outer leaflet of the plasma membrane of living mammalian
221 d signaling molecules typically float in the outer leaflet of the plasma membrane or freely diffuse a
223 and phosphatidylserine (PS) exposure on the outer leaflet of the plasma membrane preceded loss of PM
224 of unknown function that is retained on the outer leaflet of the plasma membrane when MCs are activa
225 by this flippase causing PS exposure on the outer leaflet of the plasma membrane without disrupting
226 livery of acid sphingomyelinase (ASM) to the outer leaflet of the plasma membrane, and a rapid form o
227 which is a glycosphingolipid residing on the outer leaflet of the plasma membrane, and acetylcholine
228 id not interact with liposomes mimicking the outer leaflet of the plasma membrane, but it did induce
229 from the inner (cytoplasmic) leaflet to the outer leaflet of the plasma membrane, delivering Glc2-DA
231 membranes and, most interestingly, with the outer leaflet of the plasma membrane, suggesting a role
240 to selectively oxidize MPD molecules in the outer leaflet of the reconstituted vesicles, we demonstr
241 used to anchor a synthetic transducer in the outer leaflet of the vesicles, and when the protein was
243 n of the midspan Arg (694) "snorkels" to the outer leaflet of the viral membrane, the MSD assumes a m
244 ed viruses display phosphatidylserine on the outer leaflet of their membranes, enabling TAM receptor
246 phosphatidylserine (PtdSer) exposure on the outer leaflet of transduced cells triggers their engulfm
247 l-phosphatidylcholine was exchanged into the outer leaflet of vesicles composed of 1,2-dioleoyl-phosp
248 ich the physical properties of the inner and outer leaflets of a bilayer are coupled to one another.
252 proximately 1:1 if only the PG lipids in the outer leaflets of membranes are accessible to daptomycin
254 through hemifusion, a condition in which the outer leaflets of the bilayers are mixed, but the inner
255 differences in tension between the inner and outer leaflets of the membrane contribute to this proces
256 nthesizing major components of the inner and outer leaflets of the mycobacterial outer membrane.
257 species are segregated between the inner and outer leaflets of the plasma membrane by ATP-dependent l
258 the context of lipid rafts at the inner and outer leaflets of the plasma membrane, respectively, for
262 ried as glycoproteins and glycolipids on the outer leaflets of their plasma membranes and constitute
263 usion intermediate, a condition in which the outer leaflets of two bilayers are combined and the inne
264 ially binds to mammalian cell membranes, the outer leaflets of which are enriched in sphingomyelin, c
265 oyl-sn-glycero-3-phospho-rac-glycerol in the outer leaflet only was quantified by zeta-potential meas
266 a cholesterol analogue was localized to the outer leaflet only, the fast diffusion of cholesterol di
267 s also significantly lower than the D in the outer leaflet or in giant unilamellar vesicles and the d
268 ster, indicative of coupling between SM-rich outer-leaflet-ordered domains and inner-leaflet-ordered
269 aflet lipid composition; and plasma membrane outer leaflet phosphatidylcholine had a significantly lo
270 Furthermore, in all raft preparations, the outer leaflet phospholipid species were significantly di
271 eaflet phospholipids to the pore, but allows outer leaflet phospholipids to bind to a pronounced ridg
272 d transport protein that selectively removes outer leaflet phospholipids to help maintain the essenti
275 oon as FPE detects adsorption of FA into the outer leaflet, pyranine detects its movement to the inne
276 red domain formation in the SM+PC-containing outer leaflet relative to ordered domain stability in ch
278 ol POPE:POPS inside (SMo/2:1 POPE:POPSi) the outer leaflet SM formed an ordered state with a thermal
279 In other words, ordered state formation by outer-leaflet SM in asymmetric vesicles was not destabil
280 anoparticles was held at a distance from the outer leaflet-solution interface of bilayers containing
283 within the TMD region spanning the vesicle's outer leaflet strongly impairs exocytosis and decelerate
284 characteristic time of lipid mixing between outer leaflets (tau approximately equal to 24 s) was com
285 redistributes lysosomal-derived PS to the PM outer leaflet that leads to membrane expansion and the f
286 ect phospholipid packing modification in the outer leaflet, that is promoted by protonation of cardio
287 morphology and surface electrostatics of the outer leaflet, the insertion of ACs, in particular their
288 e bilayer: upon hemifusion and mixing of the outer leaflets, the DNA-lipid is free to diffuse into th
289 sphingomyelin resided in the plasma membrane outer leaflet; the asymmetry of metabolically active cel
290 ethanolamine and phosphatidylserine from the outer leaflet to the cytosolic leaflet of the plasma mem
291 luorescent PtdIns(3,4)P(2) can flip from the outer leaflet to the inner leaflet of the membrane.
292 diffusion of annular lipids in the inner and outer leaflets was observed and correlated with an asymm
293 (asymmetric) compositions in their inner and outer leaflets were deposited at surface pressures of 20
294 the sum of the molar ratios of the inner and outer leaflets), were characterized before and after bet
295 aflet of the PM, but PS redistributes to the outer leaflet when the cell is damaged or at the onset o
296 osis, these phospholipids move to the cell's outer leaflet where they are recognized by so-called PS
298 d to extract phospholipids from the membrane outer leaflet, while delivering lipids to the cell to ma
299 the most abundant phospholipids in the RBCs outer leaflet with PC 34:1 and SM 34:1 being the most ab
300 ich show restricted diffusion of IMPs of the outer leaflet, with our simulations, we conjectured the