ライフサイエンスコーパス: outer segment

1 accumulates either in the cone cell body or outer segment.

2 on surrounding the base of the photoreceptor outer segment.

3 d inner retina but an abnormal photoreceptor outer segment.

4 ostasis in the vicinity of the photoreceptor outer segment.

5 lding and trafficking to the photoreceptor's outer segment.

6 pansion leads to an axial contraction of the outer segment.

7 ing their transport to the rod photoreceptor outer segment.

8 ble for blocking the movement of PDE6 to the outer segment.

9 but had little efficacy when applied to the outer segment.

10 e sensory cilium of photoreceptor cells, the outer segment.

11 y can be sorted for specific delivery to the outer segment.

12 t and GDP-locked mutants concentrated in the outer segment.

13 or cells shed approximately a tenth of their outer segment.

14 glycan 2 (IMPG2), rapidly accumulated in the outer segment.

15 scence was concentrated predominantly in the outer segment.

16 ensitive disc membranes of the photoreceptor outer segment.

17 ide of the inner segment, directly below the outer segment.

18 itating rhodopsin transport to photoreceptor outer segments.

19 glycolytic pathway impacted the size of the outer segments.

20 nal defects in phagocytosis of photoreceptor outer segments.

21 increased structural instability of the rod outer segments.

22 e for the ABCA4 transporter in photoreceptor outer segments.

23 function and abnormally shaped photoreceptor outer segments.

24 interface between the RPE and photoreceptor outer segments.

25 for normal trafficking of cone opsins to the outer segments.

26 ly through phagocytosis of the photoreceptor outer segments.

27 s responsible for removing Ca(2+) from their outer segments.

28 did not prevent rhodopsin trafficking to rod outer segments.

29 iated proteasomal degradation at the base of outer segments.

30 necessary for the formation of rod and cone outer segments.

31 ncodes a protein localizing to photoreceptor outer segments.

32 able to traffic effectively to the Rp2h(-/-) outer segments.

33 GRK1 to their destination, the photoreceptor outer segments.

34 under some circumstances, of generating new outer segments.

35 eptor cell death, and reduced lengths of rod outer segments.

36 hyporeflective spaces at the level of absent outer segments.

37 n addition to its normal localization to the outer segments.

38 rotein confinement between the inner and the outer segments.

39 age, displaying either very short or absent outer segments.

40 ansion of Abca4(-/-)Rdh8(-/-) mouse rod cell outer segments accompanied by macrophage infiltration af

41 h length have been observed in photoreceptor outer segments after a flash stimulus via phase-resolved

42 on of inner segment membrane proteins in the outer segment, along with insufficient RHO delivery, is

43 ween RPE apical microvilli and photoreceptor outer segments also declined during peak adhesion in all

44 al abnormalities, for example, inner segment-outer segment alterations were found in 60.4% of eyes tr

45 AOSLO imaging showed repopulation of cone outer segments, although their density remained below no

46 that acts as a diffusion barrier between the outer segment and cell body.

47 ever, S-opsin trafficked normally to the rod outer segment and produced functional S-pigment upon sub

48 uanylyl cyclase (RetGC) in the photoreceptor outer segment and suppresses RetGC activation by guanyly

49 geting information that excludes it from the outer segment and that this information is overridden by

50 acute vision loss to the cone photoreceptor outer segment and will refocus the search for the cause

51 structures that distorted rod photoreceptor outer segments and became more prominent with age.

52 Rpgrip1homozygous mutants do not form rod outer segments and display mislocalization of rhodopsin,

53 -one match between sites of formerly missing outer segments and new outer segments that had appeared

54 prompted the loss of adjacent photoreceptor outer segments and photoreceptor death, which eventually

55 ssion of the mutant causes shortening of the outer segments and photoreceptor death.

56 knockdown of rab11a in rods led to shortened outer segments and retinal degeneration.

57 the retinal nerve fiber layer, photoreceptor outer segments and retinal pigment epithelium show promi

58 nerve fiber layer's features, photoreceptor outer segments and retinal pigment epithelium when 23 di

59 usen complex includes the interdigitation of outer segments and RPE apical processes and SDD in eyes

60 rmal retinal histology, normal morphology of outer segments and RPE cells, and no evidence of photore

61 PDE6H in murine eyes was restricted to both outer segments and synaptic terminals of short and long/

62 livered M-opsin localizes in the dorsal cone outer segments, and co-localizes with S-opsin in the ven

63 ing rods and double cones displayed abnormal outer segments, and elevated levels of apoptosis.

64 end transition zones (connecting cilia) with outer segments, and visual pigments mistrafficked.

65 , reduced levels of rhodopsin, disrupted rod outer segments, and widespread accumulation of the typic

66 Outer segments appeared rapidly at postnatal day six and

67 ning only minimally alters the photoreceptor outer segment architecture beyond the site of new disc f

68 the optical path length of the photoreceptor outer segment as a response to an optical stimulus in th

69 to shortening and loss of the photoreceptor outer segments as observed for various inherited blindin

70 s and the phototransduction machinery in the outer segment, as well as acting as a calcium store.

71 in protein trafficking across the CC to the outer segments, as we identified that rhodopsin accumula

72 nstate phagocytosis of labeled photoreceptor outer segments at a reduced, but significant level.

73 nd that tagged KIF17 localized along the rod outer segment axoneme when expressed in mouse and X. lae

74 PRL outer segments became significantly thinner over time in

75 fundamental differences in the structures of outer segments between rod and cone photoreceptor cells

76 ceptors in mice rely on glycolysis for their outer segment biogenesis.

77 vision from being a visual pigment and major outer segment building block to directing trafficking of

78 rinsic instability and long half-life in the outer segment, but also highlights the potential of alte

79 uccessfully enhanced P23H traffic to the rod outer segment, but this led to reduced photoreceptor fun

80 s, all-trans-retinal, is released in the rod outer segment by photoactivated rhodopsin after light ex

81 a fast, millisecond-scale contraction of the outer segments by tens of nanometers, followed by a slow

82 hat the entry of nascent PRPH2 into the cone outer segment can be blocked by either cone dystrophy-ca

83 Ca(2+) ions have distinct roles in the outer segment, cell body, and synaptic terminal of photo

84 tion, leading to the positioning of the cone outer segment closer to the retinal pigment epithelium.

85 ce of CNGB3, CNGA3 was able to travel to the outer segments, co-localize with cone opsin, and form te

86 ptor layer and better targeting of opsins to outer segments compared with sham-treated eyes.

87 Outer segment components are transported from the site o

88 wever, all-trans-retinal can also react with outer segment components, sometimes forming lipofuscin p

89 We observed outer segment debris, hypo/hyperpigmented RPE, abnormal

90 Photoreceptor outer segment degeneration was evident, with a significa

91 es rhodopsin for intracellular stability and outer segment delivery.

92 hat visual pigments transport to the retinal outer segment despite removal of KIF3 and IFT88, and KIF

93 Loss in the photoreceptor outer segment detected by SD-OCT co-localized with an ar

94 r data indicate RPGRIP1 is necessary for rod outer segment development through regulating ciliary pro

95 transduction, the retinoid cycle, cilia, and outer segment development.

96 exhibited minor disruptions of photoreceptor outer segment dimensions without any mislocalization of

97 a prototypical GPCR, embedded in native rod outer segment disc membranes from photoreceptor cells of

98 dvanced maturation, showing the beginning of outer-segment disc formation and photosensitivity.

99 Imaging of rod photoreceptor outer-segment disc membranes by atomic force microscopy

100 t the distal end, with vertically misaligned outer segment discs and membrane whorls.

101 Rod outer-segment discs were not essential and developed aft

102 shape the high-curvature rim domains of the outer segment disk and suggests that the protein's C ter

103 he ciliary membrane at the initiation of new outer segment disk formation.

104 eceptors does not affect the localization of outer segment disk membrane proteins, such as rhodopsin,

105 ization at the high-curvature rim domains of outer segment disk membranes suggests that it may act to

106 letion of NCKX1 in mice results in malformed outer segment disks, suppressed expression and function

107 The intensity of inner segment/outer segment (ellipsoid zone line) reflectivity was red

108 at disruption of photoreceptor inner segment-outer segment (ellipsoid) layer on SD-OCT and reduced ER

109 M); external limiting membrane-inner segment outer segment (ELM-ISOS); and inner segment outer segmen

110 of key photoreceptor genes underlies delayed outer segment elongation and possibly mispositioning of

111 the LE pathway of PRPH2 is critical for its outer segment expression.

112 en were deposits juxtaposed to photoreceptor outer segments extending through the outer nuclear layer

113 omes in building the elaborate photoreceptor outer segment filled with hundreds of tightly packed "di

114 vels of all-trans-retinal and retinol in rod outer segments following light exposure.

115 mulates a reduction via translocation to the outer segments for terminating G-protein coupled phototr

116 , a cell layer adjacent to the photoreceptor outer segments, form the well-established "dark" regener

117 ephrocystin-5 is essential for photoreceptor outer segment formation but is dispensable for kidney an

118 Prph2 cannot form the complexes required for outer segment formation, and in cones cannot interact wi

119 protein is required for mouse photoreceptor outer segment formation.

120 diurnal phagocytosis of spent photoreceptor outer segment fragments.

121 ess, presence of the inner nuclear layer and outer segment, gestational age at birth, sex, spherical

122 formed synapses but failed to produce robust outer segments, implying a late defect in photoreceptor

123 information and instead is delivered to the outer segment in the same post-Golgi vesicles as rhodops

124 The lack of outer segments in mutant cones indicates a ciliary dysfu

125 thalmoscope (AOSLO) showed depletion of cone outer segments in the affected retina.

126 tant arrestin-1 is largely excluded from the outer segments in the dark, proving that the normal intr

127 the reason for arrestin-1 exclusion from the outer segments in the dark.

128 d cells to grow and maintain light sensitive outer segments in the host retina, which depends on prop

129 segments and cell bodies in the dark to the outer segments in the light.

130 G protein-coupled receptor found in the rod outer segments in the retina, which triggers a visual re

131 tol-3-phosphate (PI(3)P) levels in rod inner/outer segments increased more than 30-fold after light e

132 an 2 weeks, a time interval during which the outer segment is completely renewed.

133 The outer segment is constantly renewed with new discs added

134 Phagocytosis of daily shed photoreceptor outer segments is an important function of the retinal p

135 ught that the concentration of Ca(2+) in rod outer segments is controlled by a dynamic balance betwee

136 s, the mechanism for its extrusion from cone outer segments is not well understood.

137 d location of cystoid changes, inner segment-outer segment (IS-OS) continuity, quantity and location

138 ivity over lesions with intact inner segment-outer segment (IS-OS) junction was 13.35 +/- 3.75 dB and

139 025), initial BCVA (P = .002), and inner and outer segment (IS/OS) junction disruption on spectral-do

140 d parafoveal loss of the photoreceptor inner/outer segment (IS/OS) junction.

141 ment epithelium (RPE), and inner segment and outer segment (IS/OS) junction.

142 ration of the junction between the inner and outer segments (IS/OS), the retinal pigment epithelium (

143 for the formation of their light sensor, the outer segment, is not well understood.

144 r of detectable cones at height of the inner-outer segment junction (IS/OS) and cone outer segment ti

145 Preoperative features of the inner/outer segment junction correlate well with improvement o

146 in the IPL (P = 0.004), OPL (P < 0.003), and outer segment layer (P </= 0.02), and severe ganglion ce

147 an inflammatory lesion in the photoreceptor outer segment layer displacing ELM.

148 hyper-reflective lesion at the photoreceptor outer segment layer disrupting the ellipsoid zone (EZ) a

149 itant with IMPDH1 aggregate formation at the outer segment layer.

150 ONL thickness as well as photoreceptor outer segment length are relevant functional correlates

151 es with subretinal detachment, photoreceptor outer segment length was significantly correlated with B

152 ickness (i.e., a surrogate for photoreceptor outer segment length) and central RFI were independently

153 ss of foveal specialization features such as outer segment lengthening implies reduced foveal cone de

154 ck of a foveal pit and no cone photoreceptor outer segment lengthening.

155 particularly from removal of Na(+) entering outer segment light-dependent channels and inner segment

156 ure retina, including exuberant outgrowth of outer segment-like structures and synaptic ribbons, phot

157 t this interaction enhances the formation of outer segment-like structures and the establishment of i

158 The advanced outer segment-like structures reported here support the

159 In all patients, a disrupted inner segment/outer segment line and the external limiting membrane we

160 midperipheral retina, the rod inner segment/outer segment line was disrupted and blurry, and the rod

161 subretinal drusenoid deposits, photoreceptor outer segment loss, RPE drusen complex volume, and RPE d

162 autonomous role of the glycolytic pathway in outer segment maintenance and provide evidence that aero

163 ne proteins that differ between rod and cone outer segments, making it likely that they contribute to

164 responsible for normal phagocytosis of shed outer segment material, lacks the capacity to clear the

165 d the unglycosylated RDS binding partner rod outer segment membrane protein 1 (ROM-1) were found in N

166 uch as PRPH2, the PRPH2 binding partner, rod outer segment membrane protein 1 (ROM1), and rhodopsin w

167 ein lost the ability to oligomerize with rod outer segment membrane protein 1 (Rom1), but retained th

168 cannot interact with its binding partner rod outer segment membrane protein 1.

169 icalis, these processes are connected to the outer-segment membrane by links composed of protocadheri

170 RGS9Gbeta5 is tethered to the outer segment membranes by its membrane anchor, R9AP.

171 ipidome analyses of Mfsd2a (-/-) retinas and outer segment membranes corroborated the previously repo

172 1gamma1 The complex was formed on native rod outer segment membranes upon light activation, solubiliz

173 of Ca(2+) regulate phototransduction in the outer segment, metabolism in the cell body, and neurotra

174 Rbpr2 loss resulted in shorter photoreceptor outer segments, mislocalization and decrease in visual p

175 r-specific exons in transcripts critical for outer segment morphogenesis, ciliogenesis, and synaptic

176 d displayed severely disrupted photoreceptor outer segment morphology and ciliary defects.

177 We also observed disorganized photoreceptor outer-segment morphology and defective trafficking of op

178 as used to image the photoreceptor inner and outer segment mosaics.

179 ls in the outer retina (ONL to photoreceptor outer segments). OCT-based retinal sublayer thickness me

180 ein Numb localizes to the inner, but not the outer segment of mouse photoreceptor cilia.

181 ion by impairing the proper formation of the outer segment of photoreceptors, a modified cilium.

182 f this cluster causes the destruction of the outer segment of the photoreceptors, which subsequently

183 The light-sensitive outer segment of the vertebrate photoreceptor is a highl

184 hich seem to be rods and cones; however, the outer segments of both have an identical cone-like morph

185 found that PTPRG and CNTN3 associate in the outer segments of mouse rod photoreceptor cells.

186 Electron microscopy revealed differentiating outer segments of photoreceptor cells.

187 These structures interdigitate with the outer segments of rod and cone photoreceptor cells.

188 Rhodopsin, the light-sensing molecule in the outer segments of rod photoreceptors, is responsible for

189 The bipolar synapse and the inner and outer segments of the photoreceptor may serve as critica

190 present in the cavefish inner segments, the outer segments of the photoreceptors in cavefish are mis

191 We observed similar vacuolization in outer segments of transgenic mice expressing human rhodo

192 The outer segments of vertebrate rod photoreceptors are rene

193 ated in the light-sensing cilium (called the outer segment) of the vertebrate photoreceptor.

194 y expressed in the light-sensing cilium, the outer segment, of the vertebrate photoreceptor.

195 The light-sensitive outer segment organelle of the vertebrate photoreceptor

196 ating complex located in the light-sensitive outer segment organelle.

197 d for biogenesis of vertebrate photoreceptor outer segment organelles.

198 Rod photoreceptors consist of an outer segment (OS) and an inner segment.

199 ve a modified ciliary compartment called the outer segment (OS) as well as non-OS compartments.

200 s a small protein localized to photoreceptor outer segment (OS) disc membranes.

201 -cone degeneration (PRCD) is a photoreceptor outer segment (OS) disc-specific protein with unknown fu

202 0-fold intensity range caused correlated rod outer segment (OS) elongation and increased light scatte

203 The photoreceptor outer segment (OS) is a sensory compartment specialized

204 The photoreceptor outer segment (OS) is a unique modification of the prima

205 f synthesis in the inner segment (IS) to the outer segment (OS) is critical for photoreceptor functio

206 layer (INL), outer plexiform layer (OPL), or outer segment (OS) layer.

207 quantitative analysis: photoreceptor length, outer segment (OS) length, and foveal developmental inde

208 (CMZ) cell death and decreased photoreceptor outer segment (OS) length, as well as gross morphologica

209 ion of biosynthetic intermediates, improving outer segment (OS) length, enhancing photoreceptor survi

210 protein and the key RDS-binding partner, rod outer segment (OS) membrane protein 1 (ROM-1), were prop

211 PRPH2 oligomerizes with its homologue rod outer segment (OS) membrane protein 1 (ROM1), and non-pa

212 of ARL13B, photoreceptors failed to develop outer segment (OS) membranous discs and axonemes, result

213 The outer segment (OS) of rod photoreceptors consist of a hi

214 The outer segment (OS) of the rod photoreceptor is a light-s

215 Rod and cone photoreceptor outer segment (OS) structural integrity is essential for

216 linked complexes which were localized to the outer segment (OS) where they impaired the formation of

217 ing compartment of photoreceptors called the outer segment (OS).

218 (IS) of photoreceptor cells, as well as the outer segments (OS) of cone cells.

219 The outer segments (OS) of rod and cone photoreceptor cells

220 L13b is located exclusively in photoreceptor outer segments (OS) presumably anchored to discs by palm

221 ne for ABCA4, a transporter in photoreceptor outer segments (OS) that clears retinaldehyde and preven

222 rated by and accumulate in the photoreceptor outer segments (OS), which is the retinal layer with the

223 in in the form of phagocytized photoreceptor outer segments (OS).

224 the formation of rod and cone photoreceptor outer segments (OS).

225 ed progressive degeneration of photoreceptor outer segments (OSs) and increased apoptosis of retinal

226 The degeneration of rods' outer segments (OSs) is predominant, followed by the deg

227 ion of the disc/lamella rim in photoreceptor outer segments (OSs), but plays a different role in rods

228 essential for the formation of photoreceptor outer segments (OSs), where it functions in oligomers wi

229 ptors did exhibit long-term defects in their outer segments (OSs), which were less severe when more p

230 tion, also causes shortening and loss of rod outer segments (OSs); the symptoms frequently observed i

231 in vivo-like physiological processes such as outer segment phagocytosis and calcium dynamics.

232 tachment, and interactions needed for normal outer segment phagocytosis.

233 ltage was considerably less than that of the outer segment photocurrent following equivalent pigment

234 Measurements of the rod outer segment photocurrent in transgenic mice, which hav

235 of the rod photovoltage with respect to the outer segment photocurrent, which is eliminated upon int

236 ubstantial as the desensitization of the rod outer segment photocurrent.

237 s difference in desensitization with the rod outer segment photocurrent.

238 hotovoltages and with suction electrodes the outer segment photocurrents of Lampetra fluviatilis reti

239 a change in current at the rod photoreceptor outer segment plasma membrane.

240 e features, such as a delay in photoreceptor outer segment (POS) clearance and accumulation of lipofu

241 derived from the ingestion of photoreceptor outer segment (POS) disk membranes, is a major role of t

242 ntal extent of the ONL and the photoreceptor outer segment (POS) interdigitation zone (IZ).

243 cells by macrophages and spent photoreceptor outer segments (POS) by retinal pigment epithelial (RPE)

244 hagocytosis and degradation of photoreceptor outer segments (POS) necessary for photoreceptor surviva

245 e daily phagocytic turnover of photoreceptor outer segments (POS) required for maintenance of vision.

246 (RPE) is the clearance of shed photoreceptor outer segments (POS) through a multistep process resembl

247 s and lysosomal degradation of photoreceptor outer segments (POS) within the retinal pigment epitheli

248 promotes its targeting to the photoreceptor outer segments (POS).

249 cipated in the phagocytosis of photoreceptor outer segments (POSs) and contributed to a persistent bu

250 Phagocytosis of shed photoreceptor outer segments (POSs) by retinal pigment epithelial (RPE

251 ndicated that axonemes gradually shorten and outer segments progressively degenerate.

252 Rhodopsin is the most abundant outer segment protein and its proper transport is essent

253 afish also showed mislocalisation of certain outer segment proteins (rhodopsin, opn1lw, opn1sw1, GNB3

254 rmation and does not affect the abundance of outer segment proteins and the photoreceptor's ability t

255 re absent, thereby preventing trafficking of outer segment proteins to their destination.

256 nt dimensions without any mislocalization of outer segment proteins, whereas photoreceptors of F45L m

257 n implicated in trafficking of photoreceptor outer segment proteins.

258 opment, most likely by trafficking cilia and outer-segment proteins.

259 The R838S RetGC1 expression in rod outer segments reduced inhibition of cGMP production in

260 Daily renewal of 10% of photoreceptor outer segments requires stringent control of gene expres

261 Trafficking and confinement of most outer segment-resident proteins appeared to be unaffecte

262 although it is associated with photoreceptor outer segments, retbindin's expression is not dependent

263 urosensory retina, photoreceptor layer (PRL) outer segments, retinal pigment epithelium plus drusen (

264 outer segment (ELM-ISOS); and inner segment outer segment-retinal pigment epithelium (ISOS-RPE).

265 with TM1, TM2, TM4, and TM5 peptides in rod outer segment (ROS) membranes shifted the resulting dete

266 accumulation of all-trans-retinal in the rod outer segments (ROS).

267 hic analyses of the basal-most region of the outer segment show changes in shape of the ciliary plasm

268 Our findings explain how the outer segment structure evolved from the primary cilium

269 r-specific knock-out mice, the photoreceptor outer segment structure was severely impaired at 4 weeks

270 improvements in Prph2 protein levels and rod outer segment structure, but not functional rescue in ro

271 ice trafficked normally to the photoreceptor outer segment, suggesting that the failure to remove the

272 idden by association with R9AP, which allows outer segment targeting of the entire complex.

273 s of formerly missing outer segments and new outer segments that had appeared over the course of the

274 ther, it localizes to a small region of cone outer segments: the cell membranes surrounding the axone

275 al visit (P < 0.001) and correlated with PRL outer segment thickness (r = 0.33; P =0.02).

276 The rate of PRL outer segment thinning was higher in eyes with SDDs than

277 ss, the continuous current entering the cone outer segment through cGMP-gated (CNG) channels is carri

278 cilium, regulates rhodopsin transport to the outer segment through its effect on the turnover of acti

279 rom milliseconds to seconds) inside the cone outer segment, thus exposing the phototransduction casca

280 external limiting membrane disruption, cone outer segment tip (COST) visibility, cysts, subretinal a

281 t line was disrupted and blurry, and the rod outer segment tip line was absent.

282 urry line at the central fovea, and the cone outer segment tip line was absent.

283 xternal limiting membrane (ELM) and the cone outer segment tips (COST) line were least frequently ide

284 nner-outer segment junction (IS/OS) and cone outer segment tips (COST) was counted manually in AO-OCT

285 Outer segment transmembrane protein accumulation in Nphp

286 odopsin is transported from the inner to the outer segment via the ciliary plasma membrane, subsequen

287 We showed that, in addition to outer-segment volume, the most important differences bet

288 ng and internalization of shed photoreceptor outer segments was subjected to changes in localization.

289 al retina at postnatal day 6 (P6) and older, outer segments were absent, thereby preventing trafficki

290 isks displayed excessive outgrowth, and cone outer segments were curved, with lamellae of heterogeneo

291 inal parts, photoreceptors (particularly the outer segments) were noticeably tilted with respect to t

292 However, RD3GFP became distributed to the outer segments when bred into a GCAPs (-/-) genetic back

293 d (iii) localizing phase changes to the cone outer segment, where photoactivation occurs.

294 f a specialized membrane-rich organelle, the outer segment, which is the primary site of phototransdu

295 ls phagocytize and digest shed photoreceptor outer segment, which provides a rich source of fatty aci

296 epends upon the formation and maintenance of outer segments, which are lost in degenerative diseases.

297 en agnatha and gnathostomata, and a rod-like outer segment with cytosolic disks surrounded by a plasm

298 Vision begins in photoreceptor outer segments with light captured by opsins in continua

299 is essential to create functional, organized outer segments with stacked membrane discs that house th

300 he identification of small fragments of cone outer segments within the RPE led us to characterize the