ライフサイエンスコーパス: overproduction

1 high-affinity sites (thereby mimicking FadR overproduction)?

2 ase (CYP11B2) is associated with aldosterone overproduction.

3 gment Abeta-induced synaptotoxicity by Abeta overproduction.

4 e, retarded swarming motility, and pyocyanin overproduction.

5 s, is associated with intestinal lipoprotein overproduction.

6 , possibly by the infection of pDCs and IL10 overproduction.

7 entioned deleterious effects caused by Hsp90 overproduction.

8 nd to examine underlying mechanisms of PTHrP overproduction.

9 therefore lead to hyperactive B cells and Ig overproduction.

10 ith AERD is associated with prostaglandin D2 overproduction.

11 re neurological manifestations and uric acid overproduction.

12 icroglial neurotoxicity because of glutamate overproduction.

13 stress-related phenotype is not based on IAA overproduction.

14 prion propagation in a manner similar to Ssb overproduction.

15 promote tumour growth through sustained IL-6 overproduction.

16 ctive therapeutic agents that suppress mucus overproduction.

17 istent respiratory tract inflammation and LT overproduction.

18 produces defense compounds, result in auxin overproduction.

19 designing metabolic networks for biochemical overproduction.

20 ved cGAS, MAVS, and IRF3 to prevent cytokine overproduction.

21 COPD progression is characterized by leptin overproduction, a decline in the expression of FoxP3 spl

22 c elimination of staphyloxanthin during AirR overproduction abolished the protective phenotype of inc

23 oped to investigate growth-coupled succinate overproduction, accounting for proteome constraints.

24 hin 4 (NT4) plays an essential role in mucus overproduction after early life allergen exposure by orc

25 RsmS overproduction also resulted in increased PCWDEs and OHH

26 In Pseudomonas aeruginosa, alginate overproduction, also known as mucoidy, is negatively reg

27 e- and dose-dependent increase in superoxide overproduction and accumulation of free ferrous iron in

28 Pathway dysfunction leads to overproduction and accumulation of toxic, prooxidant com

29 and aggressiveness of HCC cells through ROS overproduction and associated activation of TNF- and Fas

30 e were protected from allergen-induced mucus overproduction and changes along the nerve-PNEC axis wit

31 Proinflammatory cytokine overproduction and excessive cell death, coupled with im

32 tes are associated with hepatic triglyceride overproduction and hypertriglyceridemia.

33 synaptogenesis, it is possible to study such overproduction and its role in speeding up development;

34 Alzheimer disease is caused in part by the overproduction and lack of clearance of Abeta protein.

35 tly by ischemia-induced myocardial TNF-alpha overproduction and promotes the development of HF.

36 In this work we report the overproduction and purification of TsrM and the characte

37 can be constructed and tested for metabolite overproduction and secretion.

38 in both polycythemia, which is caused by Epo overproduction, and fatty livers.

39 chanism, the simulations reveal that synapse overproduction appears as an unavoidable concomitant of

40 oblet cell differentiation and related mucus overproduction are critical processes in the development

41 chronic antigenic stimulation, and cytokine overproduction are thought to be the main drivers of HIV

42 m based on early traces of mitochondrial ROS overproduction as lung cells' dysfunctions induced by th

43 rotein (FADD), reactive oxygen species (ROS) overproduction, as well as mitochondrial dysfunction.

44 h in vivo platelet activation and serum TxB2 overproduction; aspirin 100 mg/day seems insufficient to

45 Consistent with sFlt1 overproduction being a significant driver of clinical sy

46 -encoded prg/pcf genes, or constitutive PrgU overproduction, block production of the Prg adhesins and

47 13, which promote airway eosinophilia, mucus overproduction, bronchial hyperresponsiveness (BHR), and

48 ht to establish the molecular basis of IL-13 overproduction by CD8(+) T cells from patients with SSc,

49 This, in turn, induced secondary IFN-gamma overproduction by colonic T cells, leading to prolonged

50 in centriole assembly and promote centriole overproduction, Cetn2 and Cetn3 are not functionally int

51 locytosis, airway hyperresponsiveness, mucus overproduction, collagen deposition, and Th2/Th17 inflam

52 SdhX overproduction confers resistance to hydroxyurea, via re

53 murine inflammation associated with platelet overproduction, contributing to platelet production in v

54 filaments to make new seeds, whereas Hsp104 overproduction curing occurs by a different mechanism.

55 proteins previously implicated in the Hsp104 overproduction curing of [PSI(+)].

56 We show that YvcK T304A overproduction did not rescue the mreB mutant aberrant m

57 zed that dnaE915 cells would respond to DinB overproduction differently from dnaE(+) cells because th

58 olipin deficiency nor conferred by trehalose overproduction during growth at low osmotic pressure, bu

59 In contrast, their overproduction enhanced the resistance to proteotoxic st

60 ith atopy, lymphoproliferation, and cytokine overproduction harboring mutations in NCKAP1L, which enc

61 between conjunctival intraepithelial melanin overproduction ("hyperpigmentation") and intraepithelial

62 eatment with PS (5 to 20 muM) suppressed ROS overproduction in a dose-dependent manner.

63 may be a valid treatment strategy for mucus overproduction in airway diseases, such as childhood ast

64 activity, which we showed to underlie IL-13 overproduction in CD8(+)IL-13(+) cells from patients wit

65 y causing IDO1 overexpression and kynurenine overproduction in cells with T21.

66 A chromosome duplication implicated FtsA overproduction in Deltapbp2b suppression.

67 these no longer effect loss of survival upon overproduction in dnaE(+) strains.

68 In addition, the detection of IL-22 overproduction in HIV(NI) patients suggests that it migh

69 the previously described effects of ethylene overproduction in mature phytochrome-deficient plants.

70 Last, GABA installation restored mucus overproduction in NT4(-/-) mice after early life allerge

71 hese data demonstrate the mechanism for IL-6 overproduction in patients who develop postoperative SIR

72 and dominant-negative when tested following overproduction in recipient cells.

73 Constitutive BH4 overproduction in sensory neurons increases pain sensiti

74 major cause of hepatic apoB100/triglyceride overproduction in type 2 diabetes.

75 oietic progenitors alleviates the neutrophil overproduction in vivo.

76 s for succinate, 2,3-butanediol, and ethanol overproduction in yeast, which predicted high minimum pr

77 zed that the increased oxidative stress (ROS overproduction) in obese condition is a key contributor

78 However, the mechanism of mucin overproduction induced by M. pneumoniae remains unclear.

79 arkably, these cells are insensitive to Plk4 overproduction-induced ectopic centriole formation, yet

80 cell tumors, we present a case of calcitriol overproduction-induced hypercalcemia due to a pancreatic

81 these results give insight into transposase overproduction inhibition by demonstrating that the appe

82 Phytoene overproduction initially interferes with photosynthesis,

83 Its overproduction is a defining characteristic of several B

84 s immune and inflammatory responses, and its overproduction is a hallmark of inflammatory diseases.

85 Mucin overproduction is a hallmark of otitis media (OM).

86 This surfactin overproduction is associated with a strong fitness cost,

87 However, overproduction is associated with autoimmune disorders.

88 When H(2)S overproduction is corrected, the tonic suppression of Co

89 e process most significantly affected by ROS overproduction is glycolysis.

90 the post-transcriptional level and that FtsA overproduction is necessary and sufficient for suppressi

91 ggest that APP overexpression, and not Abeta overproduction, is responsible for EEG abnormalities in

92 the mechanisms underlying the DinB-mediated overproduction loss-of-survival phenotype.

93 genes of unsaturated FA synthesis, but FadR overproduction markedly increases yields of all FA acyl

94 Oxalate overproduction may cause calcium-oxalate crystal formati

95 and suggest that Sac3 protein deficiency or overproduction may facilitate aggregation of aggregation

96 The IFN-beta overproduction observed in the absence of CdnP is due to

97 ry known cellulose synthesis genes, leads to overproduction of a substance that binds the dyes Congo

98 Experimental overproduction of a type 3 secretion system (T3SS1) in t

99 t intercellular cross talk in which neuronal overproduction of Abeta activates astroglial NF-kappaB t

100 etion in the PS2APP mouse AD model, in which overproduction of Abeta peptide leads to amyloid plaque

101 in the inhibition of immune function through overproduction of adenosine.

102 vacuolar protons and (2) elicitor-triggered overproduction of alkaloids.

103 In contrast, we discovered that overproduction of an artificial MinCc-MinD fusion protei

104 The condition of enzymatic overproduction of Ang II relative to Ang (1-7) is termed

105 alifornica react to a fungal elicitor by the overproduction of antimicrobial benzophenanthridine alka

106 used by single-gene mutations that result in overproduction of beta-amyloid 42.

107 sugars, glycerol and galactose, and chemical overproduction of betaxanthins, leading to the identific

108 mmaturity of UGT1A1, in combination with the overproduction of bilirubin during the developmental sta

109 iciency of C1 inhibitor (C1-INH), leading to overproduction of bradykinin.

110 Overproduction of Btn2p, involved in late endosome to Go

111 uation of S Typhimurium virulence was due to overproduction of c-di-GMP-regulated cellulose, as delet

112 liver metastases, suggesting that excessive overproduction of calcitriol by this neuroendocrine tumo

113 of hypervirulence are not fully defined, but overproduction of capsular polysaccharide significantly

114 hese mutants collectively exhibited a strong overproduction of capsular polysaccharides, including al

115 Overproduction of catecholamines is the biochemical hall

116 Overproduction of CelC2 also increased root hair tip red

117 The overproduction of centrosomes (known as centrosome ampli

118 A well-established mechanism of CIN is the overproduction of centrosomes, which promotes tumorigene

119 esponse to defects in LPS core biosynthesis, overproduction of certain lipoproteins, and the global r

120 Heterologous overproduction of Chlorobaculum tepidum BchF revealed an

121 anobacterium Synechocystis PCC 6803 leads to overproduction of chlorophyll molecules that accumulate

122 ers, which was accompanied by a compensatory overproduction of cholesteryl esters.

123 e N4, and more generic defenses, such as the overproduction of colanic acid capsular polysaccharide t

124 This transition coincides with the overproduction of collagen type I (COL1) and other extra

125 Collagen remodeling can lead to either an overproduction of collagen which can cause excessive col

126 g, we found that SigX is the missing link in overproduction of ComR.

127 The overproduction of connective tissue shares features with

128 Reduced expression of DUSP2 led to overproduction of COX-2-derived prostaglandin E2, which

129 ctions to aspirin, each involving the marked overproduction of cysLTs.

130 flammatory disorder of the airways, involves overproduction of cysteinyl leukotrienes (cysLTs), activ

131 e idea that DapE strengthens the Ter signal, overproduction of DapE supports cell division with reduc

132 onsistent with this hypothesis, we find that overproduction of DDK leads to premature Eco1 degradatio

133 pACC is characterized by the usual overproduction of dehydroepiandrosterone sulfate (DHEAS)

134 e PgaA-dependent pathway was stimulated upon overproduction of DsrA, via negative regulation of H-NS,

135 Overproduction of E2 increased apoptosis-independent ext

136 crease in arachidonic acid and a concomitant overproduction of eicosanoids, acting to promote cell pr

137 Overproduction of endogenous PI(3,5)P(2) by the fab1(T22

138 helial dysregulation in patients with CRS is overproduction of eosinophil-promoting C-C chemokines by

139 ng EPS, while the Cheng report suggests that overproduction of EPS is a responsive mechanism for the

140 Deletion of exon 5 of Grin1 leads to an overproduction of excitatory synapses in layer 5 pyramid

141 n by a misdirected cell response causing the overproduction of extracellular matrix and tissue dysfun

142 nalyses, such as in strain selection for the overproduction of fuels, chemicals and pharmaceuticals.

143 d features of normal development, an initial overproduction of functionally immature connections bein

144 In vivo, overproduction of FzlC causes cytokinesis defects wherea

145 Overproduction of GABA, an oncometabolite, can directly

146 anoids exhibit an accelerated cell cycle and overproduction of GABAergic inhibitory neurons.

147 cription factor FOXG1 is responsible for the overproduction of GABAergic neurons.

148 Overproduction of gain-of-function MtrAY102C advanced th

149 nal lamination, which is partially caused by overproduction of glia and subsequent disruption of the

150 excitatory neurotransmission associated with overproduction of glutamate has been implicated in the d

151 roduction (an energy-wasting state); and (4) overproduction of glutamate that caused NMDA receptor-de

152 Extreme overproduction of gratuitous proteins can overload cellu

153 with the accumulation of oleic acid and the overproduction of growth hormone.

154 relationship between zinc deficiency and the overproduction of Hh ligand.

155 Deficiency or overproduction of Hsp104 cures the [PSI(+)] prion.

156 Overproduction of hydrogen peroxide (H2O2) causes oxidat

157 nction in limiting T cell overactivation and overproduction of IFN-gamma, a key lupus cytokine.

158 se include an elevated type I IFN signature, overproduction of IFNs, and an absence of Langerhans cel

159 ort that loss of DBC1 results in spontaneous overproduction of Ig in mice after 10 mo of age.

160 0 promoters, causing a decrease in IL-10 and overproduction of IL-12 in Sb(R)LD-Mvarphis.

161 idered in pathologic states characterized by overproduction of IL-18 and/or IL-22.

162 patients with Schnitzler syndrome, systemic overproduction of IL-1beta translates into a profound lo

163 17 differentiation secondary to the aberrant overproduction of IL-2 with T cell receptor (TCR) stimul

164 egulated and hyperactive Th17 phenotype with overproduction of IL-22 and IL-17.

165 d4-family interacting protein 1 to show that overproduction of IL-4 in the periphery leads to an expa

166 preventing inflammatory response because of overproduction of IL-6.

167 ess cytokine production and can abrogate the overproduction of IL-8 in ROS-deficient cells.

168 owed higher MsgA and NanA activity, although overproduction of ILY in FBS was undetectable in mutants

169 Overproduction of immunoglobulin light chains leads to s

170 tion of inflammatory signalling pathways and overproduction of inflammatory cytokines and chemokines

171 observation that ASD-derived organoids show overproduction of inhibitory neurons.

172 feration of RGPs, together with a subsequent overproduction of intermediate progenitor cells, which l

173 Furthermore, overproduction of Jac1 protected Isu from degradation in

174 sis that in this diabetic model, there is an overproduction of ketone-bodies within the vessels using

175 icular hydrocarbon profile, resulting in the overproduction of known queen pheromones as well as some

176 on caused, in part, by lytic replication and overproduction of KSHV vIL-6 in XBP-1s-expressing lymph

177 Application of k-OptForce to the overproduction of L-serine in E. coli and triacetic acid

178 Overproduction of LapG inhibited biofilm formation and,

179 Overproduction of large, flexible or rod-like biopolymer

180 n direct neurogenesis and subsequently to an overproduction of layer V neurons in newborn mice.

181 oid lineage of blood cells, characterized by overproduction of leukemic blasts.

182 A hallmark of AMD is the overproduction of lipid- and protein-rich extracellular

183 broth, and growth inhibition was relieved by overproduction of LppA or by metal ion titration.

184 at high efficiency, accompanied by a massive overproduction of LRV1-specific siRNAs, representing as

185 cIAPs and XIAP in the myeloid lineage caused overproduction of many proinflammatory cytokines, result

186 Hepatic fibrosis is associated with an overproduction of matrix proteins and a pathological inc

187 loss of lymphatic vessels while endothelial overproduction of miR-204 accelerates lymphatic vessel f

188 ith the help of chaperones, meaning that the overproduction of mitochondrial proteins or the limited

189 hildhood that is clinically characterized by overproduction of monocytic cells that can infiltrate or

190 neoplasm but its driver mutations result in overproduction of morphologically and functionally norma

191 Co-overproduction of MraW suppressed MraZ toxicity, and los

192 Furthermore, overproduction of Mre11 causes DNA damage sensitivity on

193 otic SPBs lost cohesion prematurely, whereas overproduction of Ndj1 delayed SPB separation.

194 ural circuit assembly is achieved by initial overproduction of neurons and synapses, followed by refi

195 s a plausible therapeutic strategy to combat overproduction of neurotoxic Abeta.

196 finding that inhibition of STING blocks the overproduction of neurotoxic cytokines.

197 Overproduction of NO by nNOS is implicated in the pathog

198 However, overproduction of NO by the neuronal isoform of nitric o

199 and consequent inducible NOS (iNOS)-mediated overproduction of NO, which in combination with excess s

200 Overproduction of non-ecotropic ERV (NEERV) envelope gly

201 f the virus to escape neutralization through overproduction of non-infectious subviral particles, whi

202 In addition, overproduction of OspC in spirochetes also decreased the

203 The overproduction of polysaccharide alginate is responsible

204 manifest in attacks and are characterized by overproduction of porphyrin precursors, producing often

205 Overproduction of PPM1A suppressed apoptosis of Mtb-infe

206 s that act to mitigate toxicity accompanying overproduction of PrgB-like adhesins in E. faecalis and

207 However, tumor overproduction of pro-angiogenic ligands can overcome th

208 ranscriptional program and are biased toward overproduction of pro-B cells at the expense of T cell p

209 f the senescent phenotype, which involves an overproduction of pro-inflammatory and pro-oxidant signa

210 naling but rather is likely an effect of the overproduction of pro-inflammatory cytokines generated i

211 onse in obesity is unclear, it is known that overproduction of proinflammatory cytokines by innate im

212 ophages causes intensified NLRP3 activation, overproduction of proinflammatory cytokines IL-1beta and

213 adopt an active phenotype that includes the overproduction of proinflammatory cytokines that are tox

214 or lethality in F. novicida infection due to overproduction of proinflammatory effectors including pr

215 irectly invokes the activation and secondary overproduction of proinflammatory IL-6 from naive macrop

216 These studies suggest that the overproduction of proteases is one factor contributing t

217 kinase, IKKgamma (or NEMO), resulting in the overproduction of proteins that promote cellular surviva

218 low production, intermediate production, and overproduction of pyocyanin) in the presence or absence

219 associated with the primary injury, such as overproduction of reactive oxygen species (ROS) and infl

220 hanochemical disruption caused a significant overproduction of reactive oxygen species (ROS) in multi

221 Previously, we showed that overproduction of reactive oxygen species (ROS), arising

222 atrial fibrillation, which is accompanied by overproduction of reactive oxygen species (ROS).

223 Finally, Rab7 inhibition reduced overproduction of reactive oxygen species and increased

224 Oxidative stress (an overproduction of reactive oxygen species in relation to

225 gh glucose concentrations and the associated overproduction of reactive oxygen species.

226 T2440 is characterized by a slight catabolic overproduction of reducing power.

227 tion of FA-CS-UA-NPs in mitochondria induced overproduction of ROS and destruction of mitochondrial m

228 t left shift, thereby normalizing persistent overproduction of ROS and its pathophysiologic consequen

229 photodriven NR system reduces the degrees of overproduction of ROS and pro-inflammatory cytokines bot

230 gulators of numerous cellular functions, and overproduction of ROS is a hallmark of various pathologi

231 portion of this defect could be bypassed by overproduction of RpoS.

232 and Vps33 function are required to withstand overproduction of Sec17.

233 The VdDfs modulate the synthesis and overproduction of secondary metabolites, such as NAE 12:

234 amage-response protein, caused age-dependent overproduction of secreted IgD resulting from increased

235 combinatorial metabolic engineering for the overproduction of secreted metabolites.

236 okines, particularly interleukin 6, leads to overproduction of serum amyloid A (SAA) by the liver.

237 rglycemia features increased bacterial load, overproduction of several cytokines, and increased immun

238 Specifically, the heterologous overproduction of six Apd6 enzymes demonstrated that Apd

239 Overproduction of SosA inhibits cell division, while sos

240 The overproduction of specialized metabolites requires plant

241 our data suggest a strain-specific effect of overproduction of Sse1 - a nucleotide exchange factor of

242 Overproduction of superoxide anion (O(2) (.-) ), the pri

243 o reduce cellular oxidative stress caused by overproduction of superoxide, we developed a compound th

244 I(+) ] or [PIN(+) ] (prion form of Rnq1), or overproduction of Swi1 prion-domain (PrD) can considerab

245 evelopment of proper connections is an early overproduction of synapses.

246 olecular and biochemical events that lead to overproduction of TGF-beta, oxidative stress, and limite

247 Further analysis revealed that depletion or overproduction of the AirR response regulator resulted i

248 zation toward the Th1 and Th1/17 states, and overproduction of the autoimmunity-related cytokines IL-

249 Overproduction of the exopolysaccharide succinoglycan is

250 athionine-beta-synthase (CBS) and subsequent overproduction of the gaseous transmitter hydrogen sulfi

251 Overproduction of the mucin MUC5AC is an additional dise

252 Mutant IDH1 drives overproduction of the oncometabolite d-2-hydroxyglutarat

253 Overproduction of the STING agonist c-di-AMP significant

254 pressions impart flux changes that favor the overproduction of the target product thereby requiring f

255 Overproduction of the type I IFN family of cytokines is

256 Overproduction of the UA alarmin in the local microenvir

257 We show that overproduction of the zorO gene is toxic to E. coli; co-

258 r the target genes regulated by the TFs, for overproduction of these desired compounds by in vivo exp

259 Depending on the cell type, overproduction of those mutant forms of Lyn could even u

260 alkaloid scaffolds and enables the targeted overproduction of thousands of THIQ products, including

261 IKKalpha(DeltaIEC) mice were associated with overproduction of thymic stromal lymphopoietin (TSLP) by

262 cy of activated B cells (CD19(hi)HLADR(hi)), overproduction of TNFalpha and increased frequency of pe

263 Both absence and overproduction of Toddler reduce the movement of mesendo

264 -dependent cleavage of APP, resulting in the overproduction of toxic Abeta isoforms.

265 nd NAP1 share some properties, including the overproduction of toxins, the binary toxin, and mutation

266 rogen-limited cells results in the transient overproduction of transcripts required for protein trans

267 erting to normal diet, and is accompanied by overproduction of transient amplifying cells, their acce

268 he functional activity of TSLP in humans and overproduction of TSLP may be a key trigger for the ampl

269 e models were employed: (1) triggered by the overproduction of TSLP through topical application of MC

270 us is an autoimmune disease characterized by overproduction of type 1 IFN that causes multiple organ

271 elian disorders associated with constitutive overproduction of type I IFN has provided unique insight

272 d production of the antibiotic actinorhodin, overproduction of undecylprodigiosin, and diminished pro

273 Excessive alcohol consumption leads to overproduction of urates and renal function plays a crit

274 o identify genes potentially involved in the overproduction of vascular tissues in central pedicels.

275 Overproduction of wild-type (MtrA+) or phosphorylation-d

276 Overproduction of wild-type or constitutively active Lyn

277 analyzed rescue of the mreB mutant strain by overproduction of YvcK in which the phosphorylation site

278 s have focused on effects of Myc mutation or overproduction on the circadian clock in comparison to t

279 Overproduction or deficiency of many chaperones and othe

280 Interleukin-10 (IL10) overproduction (P = .0003) was found in patients develop

281 The platelet overproduction phenotype was reversed by treatment with

282 ocalizations are rarely seen during Swi1-PrD overproduction-promoted Swi1 prionogenesis.

283 ways produces the greatest amount of synapse overproduction, reduce adult performance by three measur

284 igated the association among systemic leptin overproduction, reduced engagement of glycolysis in T ce

285 Early life allergen-induced mucus overproduction requires augmented neural stimulation of

286 Amazingly, its overproduction rescues growth and morphology defects of

287 Sclerostin overproduction results in the opposite metabolic phenoty

288 trast, variables that denote nocturnal urine overproduction sharply discriminate the risk of nocturia

289 Furthermore, IL-10 overproduction substantially reduced the immunopathology

290 etric localization of FtsZ during MinCc-MinD overproduction, suggesting that a downstream activity of

291 ds on ZapB to localize to the Z ring and its overproduction suppresses the division defect caused by

292 possible to study other outcomes of synapse overproduction that are seemingly new to the literature.

293 f SNERV underlies the lupus autoantigen gp70 overproduction that promotes nephritis in susceptible mi

294 an propagate [PSI(+)], but cannot cure it by overproduction, thus separating filament cleavage from c

295 In contrast, ectopic Cyclin E overproduction uncouples short G1 from fast MCM loading.

296 We aimed to determine whether OmpA overproduction was a risk factor associated with pneumon

297 IgD overproduction was dependent on activation-induced cytid

298 Cutaneous IL-19 overproduction was reflected by elevated IL-19 blood lev

299 iprion systems curing [PSI+] without protein overproduction, we detected Siw14p as an antiprion eleme

300 ifferentiation with a 75% reduction in mucus overproduction while improving airway responsiveness to