ライフサイエンスコーパス: oxazolone

1 e exhibited less severe colitis induction by oxazolone.

2 show normal contact sensitivity responses to oxazolone.

3 studying the humoral response to the hapten oxazolone.

4 by topical sensitization and challenge with oxazolone.

5 the time of sensitization or challenge with oxazolone.

6 osinophils developed upon repeat exposure to oxazolone.

7 in the responses to dinitrofluorobenzene and oxazolone.

8 appear to determine the identity of the acyl-oxazolone.

9 , the proposed cycle forms a transient 5(4H)-oxazolone.

10 the CHS response of wild-type recipients to oxazolone.

11 ped significantly worse AD upon induction by oxazolone.

12 ty responses to 2,4-dinitrofluorobenzene and oxazolone.

13 s of contact hypersensitivity in response to oxazolone.

14 ensitivity induced by topical application of oxazolone.

15 acrophages, encodes the biosynthesis of acyl-oxazolones.

16 e same when starting from either (Z)- or (E)-oxazolones.

17 irradiation of (Z)-2-phenyl-4-aryliden-5(4H)-oxazolones 1 in deoxygenated CH(2)Cl(2) at 25 degrees C

18 The 2-oxazolone-4-carboxylates bear functionality that can be

19 New methods for the synthesis of 2-oxazolone-4-carboxylates from 3-nosyloxy- and 3-bromo-2-

20 AgOTf under similar conditions to provide 2-oxazolone-4-carboxylates in comparable yields (30-79%).

21 toluene in the presence of p-TSA provided 2-oxazolone-4-carboxylates in good yields (41-80%).

22 , a model of irritant contact dermatitis and oxazolone, a model of allergic contact dermatitis.

23 MLH1-deficient mice were immunized with oxazolone Ag, and splenic B cells were analyzed for muta

24 hose directed against the haptens 2-phenyl-5-oxazolone and (4-hydroxy-3-nitrophenyl)acetyl.

25 Oxazolone and croton oil were applied in a single sensit

26 e suppression of contact hypersensitivity to oxazolone and delayed-type hypersensitivity to herpes si

27 zolone-type structures, whereas a mixture of oxazolone and macrocycle b fragment structures are forme

28 ated pyrrole-modified chlorins incorporating oxazolone and morpholine moieties.

29 llergic contact hypersensitivity response to oxazolone and oxazolone-induced Langerhans cell migratio

30 ult from the local irritation seen with both oxazolone and phorbol ester.

31 ted an attenuated IgM response to the hapten oxazolone and produced no IgG antioxazolone antibodies.

32 these six cysteine residues are converted to oxazolone and thioamide pairs, similar to those found in

33 ing behavior in mice exposed to the haptens, oxazolone and urushiol, the contact allergen of poison i

34 variety of heteroaryl- and aryl-substituted oxazolones and activated methylene isocyanides, yielding

35 for the synthesis of 1,2,4-triazolines using oxazolones and azodicarboxylates.

36 ermutation, Msh2-/- mice were immunized with oxazolone, and B cells were analyzed for mutation in the

37 ectal instillation of the haptenating agent, oxazolone, and is characterized by a rapidly developing

38 mice did not develop colitis in response to oxazolone, and their levels of IL-4, IL-13, and immunogl

39 organoselenyl)enamides, 4-(organochalcogenyl)oxazolones, and vinyl tosylates.

40 organoselenyl)enamides, 4-(organochalcogenyl)oxazolones, and vinyl tosylates.

41 In delayed pepducin treatment models of oxazolone- and DNFB-induced dermatitis, PZ-235 significa

42 ologic outcomes of treating BALB/c mice with oxazolone- and trinitrobenzene sulfonic acid (TNBS)-indu

43 ity of dinitrobenzene sulfonic acid (DNBS)-, oxazolone-, and dextran-sodium sulfate-induced colitis.

44 8-oxo-dG undergoes facile further oxidation, oxazolone appears to be a stable final product of guanin

45 The hapten oxazolone applied to ear skin in sensitized mice upregul

46 d cyclization has been developed using enone-oxazolones as the precursors.

47 hypersensitivity responses in BALB/c mice to oxazolone, but not irritant contact hypersensitivity res

48 nvolves initial nucleophilic ring opening of oxazolones by cupriomethylene isocyanides followed by se

49 uction of N-acylated tyrazolones, a class of oxazolones, by the tyzACB gene cluster in Mtb.

50 The oxazolones can be converted in a one pot manner to funct

51 thro-pentofuranosyl)amino]-5(2H)-oxazolo ne (oxazolone), can be generated either directly by oxidatio

52 showed exacerbated dermatitis upon repeated oxazolone challenge when compared to their wild-type cou

53 h after inducing contact hypersensitivity by oxazolone challenge, CD103 inhibition increased Treg mig

54 from exacerbated ear swelling after repeated oxazolone challenge.

55 used sDC-HIL bound to EC in blood vessels of oxazolone-challenged skin in a scattered and patchy patt

56 T cell mitogen IL-15, which was increased in oxazolone-challenged skin of Sash mice during the accumu

57 le of the pyrrocorphin and the pyrrole-three oxazolone chromophore of the trilactones.

58 Oxazolone colitis (OC) is an experimental colitis that h

59 This feature of oxazolone colitis as well as its cytokine profile have i

60 Although oxazolone colitis has been reported as Th2 mediated, mic

61 The histologic features and distribution of oxazolone colitis have characteristics that resemble ulc

62 Oxazolone colitis is a T helper cell type 2 (Th2)-mediat

63 study, we investigated the role of STAT6 in oxazolone colitis, a murine model of UC, by inducing col

64 In this study we describe oxazolone colitis, a new form of experimental colitis.

65 Nicotine attenuated oxazolone colitis, which was associated with an increase

66 kappaB decoy ODNs also prevented and treated oxazolone-colitis and thus affect a Th2-mediated inflamm

67 utaneous application of the haptens FITC and oxazolone confirmed that topically applied cFLIP antisen

68 n both fluorescein isothiocyanate (FITC) and oxazolone contact hypersensitivity models, WASp-null Lan

69 While the amounts of oxazolone continued to increase with the duration of irr

70 cterized as the mu-isomers and contain two E-oxazolones coupled in an anti-head-to-head form.

71 hydantoin (dSp), 5-guanidinohydantoin (dGh), oxazolone (dZ), 5-carboxamido-5-formamido-2-iminohydanto

72 C-H acidic nucleophiles (beta-ketoesters and oxazolones), electrophilic activation of the alkynoate t

73 ymph nodes draining the skin sensitized with oxazolone, especially activated T cells.

74 to form oxazolone; ii) addition of water to oxazolone forms the dipeptide; and iii) reaction of oxaz

75 s of biologically relevant 3,5-disubstituted oxazolone frameworks.

76 report that mice sensitized with the hapten oxazolone had increased numbers of CCR6+ T cells in the

77 ries of natural products containing the rare oxazolone heterocycle and characterized their biosynthes

78 Ring opening of the oxazolone heterocycle in 2 with a base affords the corre

79 responses (e.g., contact hypersensitivity to oxazolone, IgM response to Pneumovax, IgG response to ke

80 microdroplets undergoes dehydration to form oxazolone; ii) addition of water to oxazolone forms the

81 characteristic of the inflammatory milieu in oxazolone (IL-4) and TNBS (IL-12) colitis, respectively.

82 0 expression, indicating the ability of some oxazolone-immune CD4+ T cells to mediate IP-10 expressio

83 e quantitative analysis of both 8-oxo-dG and oxazolone in DNA from biological sources.

84 itive and specific detection of 8-oxo-dG and oxazolone in enzymatic DNA hydrolysates was achieved by

85 d that contact hypersensitivity reactions to oxazolone in mice were associated with significant incre

86 ing PCR to analyze the Ab response to phenyl-oxazolone in the mouse, we show that the Ab repertoire o

87 a delayed-type hypersensitivity response to oxazolone in vivo.

88 We studied induction of colitis with oxazolone in wild-type mice and those with CD4(+) T cell

89 s pathway in Mtb highlights the diversity of oxazolones in mycolic acid-producing bacteria, broadens

90 Rab25 knockout mice to AD, we established an oxazolone-induced AD model.

91 ht increased (approximately 1.5-fold) in the oxazolone-induced allergic dermatitis model, and 22ROH a

92 challenge phase inhibited the development of oxazolone-induced atopic dermatitis (AD).

93 ng allergic contact dermatitis, we evaluated oxazolone-induced changes in cell populations and cytoki

94 his study, we report that the development of oxazolone-induced chronic allergic dermatitis, in a mous

95 ression reduced production of TGF-beta(1) in oxazolone-induced colitis and that prevention of IL-13Ra

96 cell numbers and confers protection against oxazolone-induced colitis in adulthood.

97 cells to produce IgE, which together mediate oxazolone-induced colitis in mice.

98 induction of immunopathology associated with oxazolone-induced colitis, a colitis model mediated prim

99 deletion reduced dextran sodium sulfate- and oxazolone-induced colitis.

100 9-expressing mucosal T cells in experimental oxazolone-induced colitis.

101 ted against experimental iNKT cell-mediated, oxazolone-induced colitis.

102 rmines their effector functions and mediates oxazolone-induced colitis.

103 not produce IgE, were also protected against oxazolone-induced colitis.

104 l cell apoptosis and chronic inflammation in oxazolone-induced colitis.

105 In this issue, Lehtimaki et al. use an oxazolone-induced contact hypersensitivity (CHS) model t

106 se activation in the epidermis of mice in an oxazolone-induced contact hypersensitivity model.

107 S FC mice showed more severe inflammation in oxazolone-induced contact hypersensitivity, a model of a

108 resting and inflamed skin of mice undergoing oxazolone-induced contact hypersensitivity.

109 macodynamic effects on ITK, which reduces an oxazolone-induced delayed type hypersensitivity reaction

110 hibit thioglycollate-induced peritonitis and oxazolone-induced delayed-type hypersensitivity.

111 Our findings show that oxazolone-induced dermatitis caused a marked increase in

112 Oxazolone-induced increases in ear thickness and ear wei

113 mpair sensitization, but potently suppressed oxazolone-induced inflammation by inhibiting the infiltr

114 t hypersensitivity response to oxazolone and oxazolone-induced Langerhans cell migration from epiderm

115 In an oxazolone-induced mouse model of AD, localized inhibitio

116 he microdroplet reaction, both involving the oxazolone intermediate.

117 e-specific mutagenesis studies indicate that oxazolone is a strongly mispairing lesion, inducing appr

118 tion of colitis in mice by administration of oxazolone is mediated by T-helper (Th) 2 cells and has f

119 At the end of 4 wk of chronic exposure to oxazolone, it was found that serum IgE levels had signif

120 Continued exposure to oxazolone led to a downregulation of interferon-gamma an

121 The formation of oxazolone lesions in rat liver DNA, their relative stabi

122 tent mispairing characteristics suggest that oxazolone may play a role in oxidative stress-mediated m

123 Moreover, oral tolerance to oxazolone, mediated by Tregs, was impaired in Dock8(-/-)

124 tion in the trinitrobenzenesulfonic acid and oxazolone models by reducing the trafficking of Ly6C(+)

125 olactone N-oxide carrying the N-oxide on the oxazolone moiety is reported.

126 ived from the degradation of a porpholactone oxazolone moiety.

127 p replacement of a pyrrole moiety in 1 by an oxazolone moiety.

128 droxy-functionalized pyrroline group into an oxazolone or (substituted) oxazole.

129 Colitis was induced by administration of oxazolone or 2,4,6-trinitrobenzenesulfonic acid to contr

130 not develop colitis after administration of oxazolone or 2,4,6-trinitrobenzenesulfonic acid; lamina

131 type mice, with or without sensitization to oxazolone or croton oil, we observed mixed Th1/Th2 cytok

132 ery mild dermatitis when treated with either oxazolone or croton oil.

133 Peptide fragmentation can lead to an oxazolone or diketopiperazine b(2)(+) ion structure.

134 rrent with HEV reversion, at day 4 following oxazolone or OVA immunization, reduced accumulation of E

135 ically stable, fused isoxazolone, isoxazole, oxazolone, or cyano substituents on the aromatic rings.

136 mice with 2,4-dinitrofluorobenzene (DNFB) or oxazolone (Ox) resulted in increased and prolonged CHS r

137 Here, 9-10 challenges with oxazolone (Ox) to hairless mice also produced a chronic

138 tact sensitizer 2-phenyl-4-ethoxymethylene-5-oxazolone (oxazolone) to stimulate the skin and draining

139 ced by fluorescein isothiocyanate (FITC), or oxazolone (OXZ).

140 igh in animal fat contained 2-6 molecules of oxazolone per 10(7) guanines, while 8-oxo-dG amounts in

141 the isotype in a splenic response to phenyl-oxazolone (phOx) on a chicken serum albumin carrier.

142 the formal replacement of a pyrrole with an oxazolone (porphyrin-like chromophore) or (substituted)

143 Oxazolones possessing benzylic-type substituents were fo

144 methylthio)hetero(aryl)methylene]-2-phenyl-5-oxazolone precursors by alkoxides, amines, amino acid es

145 g indane/indene derivatives from the ene-yne-oxazolone precursors was reported.

146 the reacting amino acids is preserved in the oxazolone product, and strong chiral selectivity is obse

147 T cells from E-/P-deficient mice transferred oxazolone reactivity into naive wild-type mice.

148 of interferon-gamma and interleukin-4 in the oxazolone response may be the infiltrating lymphocytes;

149 previously shown to predominate in the anti-oxazolone response).

150 oiminodihydantoin, 5-guanidinohydantoin, and oxazolone resulting from H2O as the nucleophile.

151 Once the oxazolone ring forms, it facilitates racemization at the

152 in linear fragment ions with a five-membered oxazolone ring on their C-terminal side.

153 ransfer kinetics from the b ion's C-terminal oxazolone ring to the N-terminus.

154 ynaphthalenamides 2 by a C-C bond formation, oxazolone ring-opening, and aromatization in good yields

155 a free alpha-carboxyl group and can form an oxazolone ring.

156 Our data also indicate that oxazolone rings instead of hydroxyimidazolate rings form

157 For example, the oxazolone rings make methanobactin structurally more sim

158 stereoselective formation of cyclobutane-bis(oxazolone)s 2 as single stereoisomers.

159 ytokine profile and inflammatory response in oxazolone sensitized mouse skin.

160 ing Langerhans cells from the lymph nodes of oxazolone-sensitized mice and transfer to naive mice res

161 Transfer of Tregs from oxazolone-sensitized wild-type mice, but not Dock8(-/-)

162 ve COX-2 inhibitor within the thiazolone and oxazolone series of di-tert-butylphenols.

163 In addition, this work showed that pyrido-oxazolones serve as effective nitrene precursors under p

164 cate a second population corresponding to an oxazolone species.

165 ion has been obtained and, for this ion, the oxazolone structure proposed based on prior calculations

166 ches best to the theoretical spectrum for an oxazolone structure protonated on the ring nitrogen.

167 n for b(6)-b(7), while the "fast"-exchanging oxazolone structure represents the remainder (70%).

168 e-Gly-Leu-Met), is confirmed not to adopt an oxazolone structure, even upon collisional activation.

169 oscopy confirms that smaller fragments adopt oxazolone structures.

170 mixture of b(2)(+) ion diketopiperazine and oxazolone structures.

171 ly, we identified the di-domain enzyme as an oxazolone synthetase, validating CO-ED-guided genome min

172 Treatment of the oxazolone template with a range of aromatic nucleophiles

173 s/Robinson-Gabriel synthesis using a general oxazolone template.

174 developed more severe colitis in response to oxazolone than control mice.

175 those seen in the class-switched response to oxazolone that we have also analyzed.

176 Following exposure to oxazolone, the intralesional production of inflammatory

177 In the contact hypersensitivity induced by oxazolone, the OGG-1(-/-) mice showed reduced neutrophil

178 alpha-substituted 2-oxindoles, cyanoesters, oxazolones, thiazolones, and azlactones) to alpha'-oxy e

179 at one MNIO, homologous to MbnB, installs an oxazolone-thioamide at a Thr-Cys dyad in the precursor.

180 The paired oxazolone-thioamide bidentate ligands of methanobactins

181 phores was reduced with increasing number of oxazolone to pyrroline replacements, showing the importa

182 selectivity is observed when converting the oxazolone to tripeptide.

183 izer 2-phenyl-4-ethoxymethylene-5-oxazolone (oxazolone) to stimulate the skin and draining prescapula

184 s with activated amino acids, such as 5(4 H)-oxazolones, to form aminoacyl-RNA.

185 e oxysterol-treated sites from both TPA- and oxazolone-treated animals.

186 r Diels-Alder cycloaddition of N-substituted oxazolone triene I allows direct entry to the functional

187 b(n) fragments (n = 2, 3) exclusively adopt oxazolone-type structures, whereas a mixture of oxazolon

188 parison to the known lesions imidazolone and oxazolone using primer extension and pyrosequencing expe

189 generating the reactive excited state of the oxazolone via an energy-transfer process.

190 N-(Boc)-Ynamides are converted to oxazolones via a cyclization reaction.

191 sticity of PLN HEVs during immunization with oxazolone was apparent as a reversion to an immature phe

192 as injected intravenously, and within 30 min oxazolone was painted on injected skin sites.

193 sensitivity reaction of mAb-treated mice to oxazolone was the same as that of normal rat IgG-treated

194 (-/-) ) mice, sensitized and challenged with oxazolone, was used as a criterion to assess the relevan

195 y fragment recognising the hapten 2-phenyl-5-oxazolone were grown in a mutator strain of bacteria (Es

196 The 4-(organochalcogenyl)oxazolones were selectively obtained with ynamides havin

197 topical application of a contact sensitizer, oxazolone, which also induced markedly elevated IL-1beta

198 d contact hypersensitivity (CHS) response to oxazolone with increased ear swelling, T-cell infiltrati

199 ne forms the dipeptide; and iii) reaction of oxazolone with other amino acids forms tripeptides.

200 (2-thienyl)-4-[(aryl/heteroaryl)methylene]-5-oxazolones with activated methylene isocyanides has been