ライフサイエンスコーパス: oxygenase

1 We categorize the former as "thwarted oxygenases".

2 el the amino acids of a cofactor-independent oxygenase.

3 ite of ribulose-1,5-bisphosphate carboxylase/oxygenase.

4 atophagous) mites, lack a gene encoding haem oxygenase.

5 ysis shows upregulation of ferritin and heme oxygenase.

6 observations on related carotenoid cleavage oxygenases.

7 bsequent induction of CYP1-metabolizing mono-oxygenases.

8 of Fe(II) and 2-oxoglutarate (2OG) dependent oxygenases.

9 tile oxidants formed by nature's most potent oxygenases.

10 common intermediate with the canonical heme oxygenases.

11 iffer from those generated by canonical heme oxygenases.

12 parameters are in the typical ranges for 2OG oxygenases.

13 minals, but resistant to inhibition of cyclo-oxygenases.

14 rt list of structurally characterized Rieske oxygenases.

15 icinal chemistry efforts targeting human 2OG oxygenases.

16 cule inhibitors for AspH and other human 2OG oxygenases.

17 lopment of selective inhibitors of human 2OG oxygenases.

18 e located in this QTL- region: beta-carotene oxygenase 1 (bco1) and beta-carotene oxygenase 1 like (b

19 se 2 (NOV2) and Neurospora crassa carotenoid oxygenase 1 (CAO1), using piceatannol as a substrate.

20 e, glutathione peroxidase 1 (GPX1), and heme oxygenase 1 (Hmox1) and transcription factor nuclear fac

21 KEY POINTS: Haem oxygenase 1 (Hmox1) is a cytoprotective enzyme with anti

22 ulates the expression of genes encoding heme oxygenase 1 (Hmox1), glutamate-cysteine ligase catalytic

23 rf2-regulated genes/proteins, including heme oxygenase 1 (Hmox1).

24 We hypothesized that heme oxygenase 1 (HMOX1; HO-1), an enzyme responsible for deg

25 -regulation of the antioxidant proteins heme oxygenase 1 (HO-1) and sulfiredoxin 1 (SRXN1).

26 Heme oxygenase 1 (HO-1) and the cytochromes P450 (P450s) are

27 erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) gene proteins in retinal tissues (P <

28 tigated whether up-regulation of DAF by heme oxygenase 1 (HO-1) is an underlying mechanism by using H

29 To assess intracellular heme oxygenase 1 (HO-1) isolated PBMCs were used.

30 ignaling response, downstream of which, heme oxygenase 1 (HO-1) was also found to be time-dependently

31 Importantly, mRNA expression of heme oxygenase 1 (HO-1), a potential modulator of immune func

32 10R) by cmvIL-10 led to upregulation of heme oxygenase 1 (HO-1), an enzyme linked with suppression of

33 ase, NF-E2-related factor 2 (Nrf2), and heme oxygenase 1 (HO-1).

34 superoxide dismutase 2 (P <= 0.001) and heme oxygenase 1 (P <= 0.001).

35 (matrix metalloproteinase 1 [MMP-1] and heme oxygenase 1 [HO-1]), and proinflammatory cytokines (inte

36 hypoxia-inducible factor 1alpha-induced heme oxygenase 1 expression resulting in improved survival of

37 sed inducible nitric oxide synthase and heme-oxygenase 1 expression, and increased MDA and plasma cre

38 sed inducible nitric oxide synthase and heme-oxygenase 1 expression, and increased plasma creatinine

39 the latter associated with induction of heme oxygenase 1 expression.

40 tercellular adhesion molecule 1, IL-10, heme oxygenase 1 hypoxia-inducible factor 1 (HIF-1), monocyte

41 of hypoxia-inducible factor 1alpha and heme oxygenase 1 in the hippocampus was increased in the argo

42 Heme oxygenase 1 induction, by counteracting the cytotoxic ef

43 arotene oxygenase 1 (bco1) and beta-carotene oxygenase 1 like (bco1l).

44 egulation of superoxide dismutase 2 and heme oxygenase 1 protein following hypoxia-reoxygenation; fol

45 GP5 (glycoprotein 5), as well as HMOX1 (haem oxygenase 1) and BCL2L1 (BCL2-like 1) which are involved

46 for hypoxia-inducible factor 1alpha and heme oxygenase 1, and 4) immunohistochemistry of hippocampal

47 antioxidant genes, including those for heme oxygenase 1, NAD(P)H quinone oxidoreductase 1, and CD36.

48 oassociated virus (rAAV)-encoding human heme oxygenase-1 (hHO-1) in attenuating post-ischemic inflamm

49 CX3CR1 receptor induced upregulation of heme-oxygenase-1 (HMOX-1), an antioxidant and anti-inflammato

50 ), cluster of differentiation (CD) 163, heme oxygenase-1 (HMOX1), and biliverdin reductase A (BLVRA)

51 Inactivation of heme oxygenase-1 (Hmox1), one of the most stringently deregul

52 ive response relies on the induction of heme oxygenase-1 (HMOX1; HO-1) and ferritin H chain (FTH) via

53 l downregulation of the redox regulator heme oxygenase-1 (HO-1 or HMOX1).

54 Although heme oxygenase-1 (HO-1) acts downstream of vascular endotheli

55 AD(P)H quinone oxidoreductase 1 (NQO1), heme oxygenase-1 (HO-1) and a high ratio of Bcl-2/Bax.

56 he antioxidant/anti-inflammatory enzyme heme oxygenase-1 (HO-1) and increased neuroinflammation in in

57 L8 secretion and required activation of heme oxygenase-1 (HO-1) and phosphorylated adenosine monophos

58 Despite recent data identifying heme oxygenase-1 (HO-1) as a putative autophagy inducer, its

59 The Nrf2/heme oxygenase-1 (HO-1) axis affords significant protection a

60 Heme oxygenase-1 (HO-1) catalyzes the degradation of heme, wh

61 The enzyme heme oxygenase-1 (HO-1) degrades heme and protects against is

62 ioxidative and anti-inflammatory enzyme heme oxygenase-1 (HO-1) in the brains of individuals with HAN

63 Although Heme Oxygenase-1 (HO-1) induction in various forms of kidney

64 Heme oxygenase-1 (HO-1) is a stress-inducible, anti-inflammat

65 nducing the activity of the host enzyme heme oxygenase-1 (HO-1) on hRSV replication and pathogenesis

66 expression of the cytoprotective enzyme heme oxygenase-1 (HO-1) play a critical role in the growth an

67 Heme oxygenase-1 (HO-1) protein is an antioxidant enzyme usua

68 nly overexpression of the gene encoding heme oxygenase-1 (HO-1) significantly correlated with increas

69 fication with pNaKtide and induction of heme oxygenase-1 (HO-1) with cobalt protoporphyrin (CoPP) mar

70 ntioxidant transcription factor, and of heme oxygenase-1 (HO-1), one of its main target genes, in OA

71 tion as a master protective sentinel is heme oxygenase-1 (HO-1), the rate-limiting step in the catabo

72 We therefore investigated the role of heme oxygenase-1 (HO-1), which catalyzes the degradation of h

73 unctions, preclinical studies encourage heme oxygenase-1 (HO-1)-inducing regimens in clinical orthoto

74 egulation of the heme-degrading enzyme, heme oxygenase-1 (HO-1).

75 ulation of the stress-responsive enzyme heme oxygenase-1 (HO-1).

76 erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1).

77 Heme oxygenase-1 (HO-1, Hmox1) regulates viability, prolifera

78 O-E-CPR, 89 +/- 26 pg/mL; p < 0.05) and heme oxygenase-1 (sham, 1 +/- 0.1; cardiopulmonary resuscitat

79 rses vitamin C-induced up-regulation of heme-oxygenase-1 and ferritin in KRAS-mutant cancer cells, co

80 Nrf2 pathway, enhancing GSH/GSSG ratio, heme oxygenase-1 and glyoxalase 1 in liver tissue.

81 cuss here new insights into the role of heme oxygenase-1 and heme on cardiovascular health, and impor

82 ctility rather than passive stretch via heme oxygenase-1 and histone deacetylase signalling.

83 r DJ-1 attenuated Cu((II))ATSM-mediated heme oxygenase-1 and NADPH quinone oxidoreductase-1 induction

84 le cardioprotective effects ascribed to heme oxygenase-1 are best evidenced by its ability to regulat

85 genicity, whereas markers sensitive to cyclo-oxygenase-1 blockade are increased in the absence of ASA

86 Markers sensitive to cyclo-oxygenase-1 blockade, including platelet reactivity in r

87 ing expression of the IL-10 target gene heme oxygenase-1 by mechanisms dependent on p38 MAPK activity

88 a and FAS concentrations, and increased heme oxygenase-1 concentration.

89 -1beta and nitric oxide partially via a heme oxygenase-1 dependent mechanism.

90 ced oxidative stress by down-regulating heme oxygenase-1 expression via nuclear factor (erythroid-der

91 lecular markers (caspase-3 activity and heme oxygenase-1 expression) were analyzed.

92 The Heme Oxygenase-1 in renal Transplantation study was a randomi

93 expression of the Nrf2 target protein, heme oxygenase-1 in the skin and protected against UVB-induce

94 SS), corresponding with elevated plasma heme oxygenase-1 in this group.

95 cruits BAF170 to enhancer region of the Heme oxygenase-1 locus and promotes recruitment of RNA polyme

96 idant systems such as peroxiredoxins-1, heme oxygenase-1, and anti-apoptotic factors, including BCL2,

97 ti-inflammatory factors interleukin-10, heme oxygenase-1, and Hsp70 in macrophages stimulated or not

98 n of the oxidative stress response gene heme oxygenase-1, and we demonstrated that NF-kappaB inhibiti

99 NOS (eNOS), Nrf2, and Phase II enzymes (heme oxygenase-1, catalase, superoxide dismutase-1) in a time

100 of the CBS inhibitor, CO, a product of heme oxygenase-1, flip the operating preference of CSE from c

101 ession of Nrf2-dependent genes, such as heme oxygenase-1, glutamate-cysteine ligase catalytic subunit

102 appaB, hypoxia-inducible factor-1alpha, heme oxygenase-1, inducible nitric oxide synthase, B-cell lym

103 ulation of key Nrf2 target genes (i.e., heme oxygenase-1, NAD(P)H dehydrogenase, quinone 1, glutathio

104 of NF-erythroid 2-related factor 2 and heme oxygenase-1.

105 ulation of the stress-inducible protein heme-oxygenase-1.

106 crophages through coregulation of HO-1 (heme oxygenase-1; HMOX1) and lipid homeostasis genes.

107 i signaling protein (ASIP) and beta-carotene oxygenase 2 (BCO2) are predictably divergent between spe

108 The enzyme beta-carotene oxygenase 2 (BCO2) converts carotenoids into more polar

109 beta-carotene oxygenase 2 (BCO2) is a carotenoid cleavage enzyme locat

110 ed integration site (Wnt), and beta-carotene oxygenase 2 (BCO2).

111 the carotenoid-cleaving enzyme beta-carotene oxygenase 2 (BCO2).

112 ductase (SPR)] and carotenoid [beta-carotene oxygenase 2 (BCO2)] metabolism, demonstrating that a cor

113 eaving CCDs, Novosphingobium aromaticivorans oxygenase 2 (NOV2) and Neurospora crassa carotenoid oxyg

114 Here, we report that mice deficient in heme oxygenase-2 (HO-2), which generates the gaseous molecule

115 Heme oxygenase-2 (HO2) and -1 (HO1) catalyze heme degradation

116 The C-terminal tail region of human heme oxygenase-2 (HO2) contains two HRMs whose cysteine resid

117 itres of lentiviral vectors expressing Cyclo-oxygenase-2 by 600-fold, and adenoviral vectors expressi

118 inding site within the cellular protein heme oxygenase-2 that acts as a trap to inhibit N-myristoylat

119 Cyclo-oxygenase-2(-/-) mice had increased plasma levels of ADM

120 s a putative 2-oxoglutarate Fe(II)-dependent oxygenase (2OGO) and has been identified as a susceptibi

121 bisco (ribulose-1,5-bisphosphate carboxylase/oxygenase), a major component of the liquid-like pyrenoi

122 ytotoxic isoflavone is shown to inhibit heme oxygenase, a desirable yet elusive target that disrupts

123 ng cofactor, several classes of oxidases and oxygenases accelerate direct reactions between substrate

124 e site residues in an apocarotenoid-cleaving oxygenase (ACO) from Synechocystis Most active site subs

125 It possesses unique bi-functional oxygenase activities, acting as both an arginine demethy

126 ings indicate that syNOS has both NOS and NO oxygenase activities, requires H(4)B, and may play a rol

127 t, when normalized to their arachidonic acid oxygenase activities, the lipoxin synthase activities of

128 The counterproductive oxygenase activity of RuBisCO has persisted over billion

129 sphoglycolate, the major side-product of the oxygenase activity of Rubisco that also directly impedes

130 ic photosynthetic organisms triggered by the oxygenase activity of Rubisco.

131 The enzyme aldehyde-deformylating oxygenase (ADO) catalyzes the conversion of aldehydes an

132 Aldehyde-deformylating oxygenase (ADO) is a ferritin-like nonheme-diiron enzyme

133 P reductase (Aar) and aldehyde deformylating oxygenase (Ado) or olefin synthase (Ols).

134 ) reductase (AAR) and aldehyde-deformylating oxygenase (ADO), which function in a two-step alkane bio

135 2OG oxygenases also catalyze prolyl and asparaginyl hydroxyl

136 duct may support IsdG's dual role as both an oxygenase and a sensor of heme availability in S. aureus

137 aining ribulose-1,5-bisphosphate carboxylase oxygenase and carbonic anhydrase that enhance carbon dio

138 zymes ribulose 1,5-bisphosphate carboxylase/ oxygenase and carbonic anhydrase to facilitate carbon fi

139 nit of ribulose-1,5-bisphosphate carboxylase/oxygenase and its reverse peptide with a series of unrel

140 and rich redox chemistry of Cu to carry out oxygenase and oxidase organic transformations using O(2)

141 ed 2-oxoglutarate oxygenase whose C-terminal oxygenase and tetratricopeptide repeat (TPR) domains pre

142 al substantial conformational changes of the oxygenase and TPR domains during substrate binding.

143 S was found to rebalance homeostasis between oxygenases and anti-oxidative enzymes by decreasing cycl

144 n the catalytic cycle of both enzymes (e.g., oxygenases) and synthetic oxidation catalysts.

145 oding for scavenger receptors, beta-carotene oxygenases, and ketolases.

146 hemical mechanisms of major classes of plant oxygenases are discussed, and their potential utility fo

147 y of nonheme Fe(II)/2-oxoglutarate-dependent oxygenases are essential regulators of RNA epigenetics b

148 Rieske oxygenases are examples of enzymes with the ability to p

149 AO, we considered membrane-bound Rieske-type oxygenases as potential candidates.

150 high frequency of lytic polysaccharide mono-oxygenases, as well as other physiological adaptation su

151 The human 2-oxoglutarate dependent oxygenase aspartate/asparagine-beta-hydroxylase (AspH) c

152 n(II)- and 2-oxoglutarate-dependent (Fe/2OG) oxygenase, AsqJ.

153 In mammalian tissues, beta-carotene 15,15'-oxygenase (BCO1) converts beta-carotene to retinaldehyde

154 r carotenoid oxygenase, beta-carotene 9',10'-oxygenase (BCO2) catalyzes the oxidative cleavage of car

155 can also be cleaved by beta-carotene 9',10'-oxygenase (BCO2) to form beta-apo-10'-carotenal, a precu

156 f mutants of the two Arabidopsis Rieske-type oxygenases (besides PAO) uncovered that phyllobilin hydr

157 Another carotenoid oxygenase, beta-carotene 9',10'-oxygenase (BCO2) catalyz

158 The anti-Markovnikov oxygenase can be combined with other catalysts in synthe

159 By expressing a chlorophyllide a oxygenase (CAO) gene having a 5' mRNA extension encoding

160 2-Oxoglutarate (2OG)-dependent oxygenases catalyze a wide range of chemical transformat

161 Iron(II)- and 2-(oxo)-glutarate-dependent oxygenases catalyze diverse oxidative transformations th

162 describe a new family of carotenoid cleavage oxygenases (CCOs) in metazoans, the BCO2-like (BCOL) cla

163 genes encoding bacteriophytochromes or heme oxygenase clearly show that both bacteriophytochromes ar

164 to an aryl-nitro product catalyzed by the N-oxygenase CmlI in three two-electron steps.

165 ed by the non-heme diiron cluster-containing oxygenase CmlI.

166 report the first structures of the carnitine oxygenase CntA, an enzyme of the Rieske oxygenase family

167 iron containing Acinetobacter baumannii (Ab) oxygenase CntA/reductase CntB is implicated in the onset

168 e Fe(II)- and 2-oxoglutarate (2OG)-dependent oxygenases comprise a large family of enzymes that utili

169 Non-heme iron oxygenases contain either monoiron or diiron active site

170 sign of cross-linked artificial nonheme iron oxygenase crystals, we filled this gap by developing bio

171 tion of the gene encoding cytochrome P450 3A oxygenase (CYP3A) causes a prominent class of dangerous

172 bolic shift to the PPP is controlled by heme oxygenase-dependent generation of carbon monoxide (CO).

173 In addition, nitric oxide and cyclo-oxygenase-derived byproducts are required for full expre

174 ske-type, [2Fe-2S](2+) cluster in the AbCntA oxygenase domain with and without the substrate, carniti

175 me which is a key component of the P450 mono-oxygenase drug-metabolizing system.

176 evelopment of safer inhibitors for other 2OG oxygenases, e.g. screens of the hypoxia-inducible factor

177 PvfB is a member of the non-heme diiron N-oxygenase enzyme family that commonly convert anilines t

178 ween ammonium and CH(4) for the methane mono-oxygenase enzyme.

179 ydroxylation reaction taking place at Rieske oxygenase enzymes and is regarded as a difficult problem

180 Predictions indicated hydrolase or oxygenase enzymes catalyzed the initial reactions.

181 remarkable chemistry of the family of Rieske oxygenase enzymes, nonheme iron complexes of tetradentat

182 ratures through the evolution of oxidase and oxygenase enzymes.

183 hanges are observed in another 2OG dependent oxygenase, ethylene-forming enzyme, indicating that dyna

184 in the ribulose-1,5-bisphosphate carboxylase/oxygenase family of enzymes.

185 tine oxygenase CntA, an enzyme of the Rieske oxygenase family.

186 trapped in ferritin-like diiron oxidases and oxygenases (FDOs) and, more recently, the HO-like fatty

187 non-heme iron, alpha-ketoglutarate-dependent oxygenase for hydroxylation of the C3 of the glutamine,

188 roducts have raised interest in oxidases and oxygenases for biotechnological applications.

189 c model of ribulose bisphosphate carboxylase/oxygenase function.

190 Here we show that the Aedes aegypti heme oxygenase gene (AeHO - AAEL008136) is expressed in diffe

191 we showed that heterologous expression of an oxygenase gene (oxyBAC) present in this gene array in E.

192 on and ribulose 1,5-bisphosphate carboxylase/oxygenase gene clusters, underscoring its ability to den

193 n(II)- and 2-oxoglutarate-dependent (Fe/2OG) oxygenases generate iron(IV)-oxo (ferryl) intermediates

194 allows us to delineate a subgroup of Rieske oxygenases (group V) from the prototype ring-hydroxylati

195 g superfamily of HO-like diiron oxidases and oxygenases (HDOs).

196 eviously shown the catalytic actions of heme oxygenase (HemO) along with the cytoplasmic heme transpo

197 infections, such as the iron-regulated heme oxygenase (HemO) of Pseudomonas aeruginosa, due to links

198 for interaction with the iron-regulated heme oxygenase (HemO).

199 l round, we discovered that deletion of heme oxygenase (HMX1) increases total heme concentration and

200 We hypothesize that in beta-thalassemia heme oxygenase (HO) 1 could play a pathogenic role in the dev

201 Heme oxygenase (HO) catalyzes heme degradation, a process cru

202 o biliverdin (BV) through the action of haem oxygenase (HO) is a critical step in haem metabolism.

203 Heme oxygenase (HO) is a ubiquitous enzyme responsible for he

204 Free heme is metabolized by heme oxygenase (HO), resulting in the generation of carbon mo

205 Carbon monoxide (CO), an end-product of heme oxygenase (HO)-1 activity, can confer anti-inflammatory

206 Heme oxygenase (HO)-1 overexpression or induction has been sh

207 xpression of antioxidant genes, such as heme oxygenase (HO)-1, that protect parasites from oxidative

208 ne potential and increases in cytosolic heme oxygenase (HO-1) expression and mitochondrial colocaliza

209 t interact with HIV-1 MA, we found that heme oxygenase (HO-2) specifically binds the myristate moiety

210 s expression of the CO-producing enzyme heme oxygenase (HO1) and that CO is sensed by M. tuberculosis

211 nated the critical features common to Rieske oxygenases, however, structural information for enzymes

212 They typically act as mono-oxygenases; however, the recently discovered P450 subfam

213 recently discovered mononuclear nonheme iron oxygenases: hydroxyethylphosphonate dioxygenase (HEPD) a

214 r paralogous 2-oxoglutarate/Fe(II)-dependent oxygenases in Arabidopsis thaliana as JA hydroxylases an

215 Recent work has identified roles for 2OG oxygenases in the modification of translation-associated

216 KDM4A-C with selectivity over other KDMs/2OG oxygenases, including closely related KDM4D/E isoforms.

217 trificans, a beta-proteobacterium, adopts an oxygenase-independent pathway to degrade cholesterol.

218 from the prototype ring-hydroxylating Rieske oxygenases involved in bioremediation of aromatic pollut

219 lectively referred to as carotenoid cleavage oxygenases is responsible for oxidative conversion of ca

220 sco (d-ribulose 1,5-bisphosphate carboxylase/oxygenase) is responsible for the vast majority of globa

221 f 2OG to ethylene, atypical among Fe(II)/2OG oxygenases, is facilitated by the binding of l-Arg which

222 ry, and antioxidant (enzymes, including heme oxygenase isoforms [HO-1, HO-2]) markers.

223 Our data support roles for heme oxygenase isoforms in modulating recovery from synaptic

224 nduced by JA we named them JASMONATE-INDUCED OXYGENASES (JOXs).

225 n the mouse identified the kynurenine 3-mono-oxygenase (KMO) gene (Kmo) as a candidate gene associate

226 se, or ribulose 1,5-bisphosphate carboxylase/oxygenase, large subunit (RuBisCO) superfamily.

227 The enzyme's central heme-oxygenase-like (HO-like) domain sequentially hydroxylate

228 ive carbocyclization catalyzed by the Rieske oxygenase-like enzyme RedG.

229 rystal structure showed that UndA has a heme-oxygenase-like fold, thus associating it with a structur

230 nonheme iron, alpha-ketoglutarate-dependent oxygenases likely responsible for this chemistry.

231 (JMJD6) is a 2-oxoglutarate (2OG)-dependent oxygenase linked to various cellular processes, includin

232 ydrate polymers by lytic polysaccharide mono-oxygenases (LPMOs).

233 ied lipid A dependent on the PhoPQ-regulated oxygenase LpxO.

234 varying flux ratio of RubisCO carboxylase to oxygenase may contribute to the adaptive stress response

235 which H2 S, reactive oxygen species and haem oxygenase may integrate to provide a rapid oxygen sensin

236 nced flux between haem biosynthesis and haem oxygenase-mediated degradation.

237 of the proximal tubular enzyme myo-inositol oxygenase (MIOX) induces oxidant stress in vitro However

238 Conceivably, upregulation of myo-inositol oxygenase (MIOX) is associated with altered cellular red

239 The catabolic enzyme myo-inositol oxygenase (MIOX) is expressed in proximal tubules and up

240 -dependent cytochrome P450, and four nonheme oxygenases, namely, tetrahydrobiopterin-dependent aromat

241 syNOS retains the oxygenase (NOS(ox)) and reductase (NOS(red)) domains pre

242 ed mutants affecting either chlorophyllide a oxygenase or the chloroplastic lipocalin, now renamed pl

243 ase (OsGGP) by 80%, while KO of myo-inositol oxygenase (OsMIOX) did not affect foliar AsA levels.

244 y revealing Tet2 as an iterative, de novo mC oxygenase, our study provides insight into how features

245 d when ribulose-1,5-bisphosphate carboxylase-oxygenase oxygenates rather than carboxylates ribulose-1

246 is catalyzed by two enzymes: pheophorbide a oxygenase (PaO) and red chl catabolite reductase (RCCR).

247 by the Rieske-type oxygenase PHEOPHORBIDE a OXYGENASE (PAO), are the end products of chlorophyll deg

248 is degraded in the multistep pheophorbide a oxygenase (PAO)/phyllobilin pathway.

249 of the chlorin macrocycle by the Rieske-type oxygenase PHEOPHORBIDE a OXYGENASE (PAO), are the end pr

250 branch, an apparently typical 2-oxoglutarate oxygenase reaction to give succinate, carbon dioxide, an

251 from Acidianus ambivalens, including sulphur oxygenase reductase (SOR) that disproportionates S degre

252 erstanding the structural features of Rieske oxygenases responsible for control over selectivity is e

253 phylogenetically classified as a Rieske-type oxygenase (RO) and belongs to a group which catalyzes th

254 Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) activase (Rca) is a AAA(+) enzyme th

255 zymes, ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) and carbonic anhydrase (CA), in an e

256 enzyme ribulose 1,5-bisphosphate carboxylase/oxygenase (Rubisco) forms dead-end inhibited complexes w

257 enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) in a paracrystalline lattice, making

258 Ribulose 1,5-bisphosphate carboxylase/oxygenase (RubisCO) is a critical yet severely inefficie

259 enzyme ribulose 1,5-bisphosphate carboxylase/oxygenase (rubisco) is inhibited by nonproductive bindin

260 Ribulose 1,5-bisphosphate carboxylase/oxygenase (Rubisco) is the cornerstone of atmospheric CO

261 Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) is the key enzyme involved in photos

262 Ribulose-1,5-biphosphate carboxylase/oxygenase (Rubisco) is the most abundant enzyme in plant

263 Ribulose 1,5-bisphosphate carboxylase/oxygenase (RuBisCO) is the most abundant enzyme on Earth

264 enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) often limit plant productivity.

265 nzymes ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) to enhance carbon assimilation.

266 ion of ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) to show that the sterile spikelet as

267 enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) with carbonic anhydrase.

268 PPDK), ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO), and phosphoenolpyruvate carboxylase

269 CBB cycle, ribulose-bisphosphate carboxylase/oxygenase (RubisCO), is a main determinant of de novo or

270 ite of ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco), simultaneously enhancing carbon fix

271 enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco).

272 ing enzyme ribulose bisphosphate carboxylase/oxygenase (RuBisCO).

273 ite of ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco).

274 ion of ribulose 1,5-bisphosphate carboxylase/oxygenase (Rubisco).

275 ration for Ribulose bisphosphate carboxylase/oxygenase (Rubisco).

276 Stilbene cleavage oxygenases (SCOs) cleave the central double bond of stil

277 lancelet, nematode, and molluscan carotenoid oxygenase sequences.

278 re Fe(II) and 2-oxoglutarate (2OG)-dependent oxygenases, some of which are associated with cancer.

279 coding ribulose-1,5 bisphosphate carboxylase-oxygenase subunit proteins of the Calvin cycle and AMP s

280 celet) suggests that the carotenoid cleavage oxygenase superfamily has evolved in the "extremely high

281 e Fe(II)- and 2-oxoglutarate (2OG)-dependent oxygenase superfamily.

282 retinal-forming Synechocystis apocarotenoid oxygenase (SynACO) but similar to the vertebrate retinoi

283 The cytochrome P450-dependent mono-oxygenase system is responsible for the metabolism and d

284 ide hydrolases and lytic polysaccharide mono-oxygenases targeting cellulose, xylan, and chitin, were

285 ochemical investigation of the 2OG-dependent oxygenase, taurine hydroxylase (TauD), revealed a strong

286 monas paucimobilis TMY1009 is a nonheme iron oxygenase that catalyzes the cleavage of lignostilbene,

287 e (AspH) is a 2-oxoglutarate (2OG)-dependent oxygenase that catalyzes the post-translational hydroxyl

288 Here we delete in a moss the P450 oxygenase that defines the entry point in angiosperm lig

289 gal iron(II)- and 2-(oxo)glutarate-dependent oxygenase that installs the endoperoxide of verruculogen

290 Ds) are Fe(II)- and 2-oxoglutarate-dependent oxygenases that act as hypoxia-sensing components of the

291 ygenases make up a rapidly growing family of oxygenases that are rarely identified in secondary metab

292 phosphonate synthase (MPnS) are nonheme iron oxygenases that both catalyze the carbon-carbon bond cle

293 Nonheme iron oxygenases that carry out four-electron oxidations of su

294 l as a model system, we use nature's favored oxygenase, the cytochrome P450, to perform high-level ox

295 Unlike heme oxygenases, this intermediate does not form with added H

296 bisco (ribulose 1,5-bisphosphate carboxylase/oxygenase) to release tightly bound sugar phosphates.

297 catalyzed by 2-oxoglutarate (2OG)-dependent oxygenases, was first identified in collagen biosynthesi

298 kidneys, whereas high levels of C3 and heme oxygenase were identified in pancreas biopsies.

299 iculum (ER) membrane-anchored 2-oxoglutarate oxygenase whose C-terminal oxygenase and tetratricopepti

300 ET1 (mTET1) and Naegleria gruberi TET (nTET) oxygenases with DNA substrates containing extended deriv