ライフサイエンスコーパス: paediatric

1 between May 2013 and December 2016 using the Paediatric Active Enhanced Disease Surveillance (PAEDS)

2 Children with varicella or zoster from 5 Paediatric Active Enhanced Disease Surveillance hospital

3 ncluded in this analysis were diagnosed with paediatric acute lymphoblastic leukaemia at St Jude Chil

4 status and quality of life for survivors of paediatric acute lymphoblastic leukaemia requires contin

5 Although changes in paediatric acute lymphoblastic leukaemia treatment proto

6 Paediatric acute myeloid leukaemia (AML) is a heterogene

7 Paediatric acute respiratory distress syndrome (PARDS) i

8 hospitals, at later time periods, and when a Paediatric Admission Record (PAR) was used (OR PAR used

9 Severe anaemia is a leading cause of paediatric admission to hospital in Africa; post-dischar

10 ications for palliative care consultation in paediatric advanced heart disease, and summarise attitud

11 ty of Zika case definitions increased across paediatric age (from 11.3% to 56.1% for the WHO case def

12 nya is still predominantly among the younger paediatric age group and current interventions targeted

13 equently, Zika manifested differently across paediatric age; older Zika cases presented with a dengue

14 a GP with Special Interest (GPwSI) community paediatric allergy clinic, running alongside pre-existin

15 To our knowledge, few paediatric allergy clinics in the UK have funding for de

16 This integrated, multidisciplinary Paediatric Allergy Service could provide a model to impr

17 ave implications for future commissioning of paediatric allergy services in the UK.

18 choice questions describing two hypothetical paediatric allergy specialist clinics described in terms

19 proteins, predominantly affecting infant and paediatric AML and ALL patients.

20 ex screen of 80 apoptotic-inducing agents in paediatric AML pre-clinical models.

21 inant polycystic kidney disease (ADPKD) from paediatric and adult nephrology, human genetics, paediat

22 oup, consisting of an international panel of paediatric and adult neuro-oncologists, clinicians, radi

23 oup, consisting of an international panel of paediatric and adult neuro-oncologists, clinicians, radi

24 Paediatric and adult patients had a similar number of gr

25 TRK inhibitor larotrectinib was approved for paediatric and adult patients with advanced TRK fusion-p

26 fectiveness and safety of oral Triac in male paediatric and adult patients with MCT8 deficiency in ei

27 ageable safety profile in heavily pretreated paediatric and adult patients with relapsed or refractor

28 ological findings of osteoid osteoma in both paediatric and adult patients.

29 een endorsed by the Association for European Paediatric and Congenital Cardiologists Working Groups f

30 extrapolated to predict PK of lamotrigine in paediatric and hepatic impaired populations.

31 The ELIANA trial showed that 61 (81%) of 75 paediatric and young adult patients with relapsed or ref

32 file of tisagenlecleucel in the treatment of paediatric and young adult patients with relapsed or ref

33 in specialties ranging from family medicine, paediatrics and adolescent medicine to endocrinology, gy

34 wellbeing as a blueprint for the practice of paediatrics and child health in the domains of clinical

35 previously undiagnosed diseases in prenatal, paediatric, and adult clinical settings.

36 The burden of cardiorespiratory, paediatric, and maternal diseases associated with househ

37 uated the risk of adverse cardiorespiratory, paediatric, and maternal outcomes from exposure to house

38 tality and clinical practices in 12 general, paediatric, and maternity hospitals in southwest Nigeria

39 ts should focus on developing and evaluating paediatric antibiotic stewardship programmes on the basi

40 The Paediatric Antiretroviral Drug Optimization group review

41 The diagnosis and phenotyping of paediatric asthma are particularly complex due to the la

42 we estimated the annual global number of new paediatric asthma cases attributable to NO(2) exposure a

43 (95% uncertainty interval [UI] 1.8-5.2) new paediatric asthma cases could be attributable to NO(2) p

44 ld help prevent a substantial portion of new paediatric asthma cases in both developed and developing

45 s, and who attended the outpatient clinic of paediatric asthma in Soba or Ahmed Gasim hospitals or th

46 We estimated that about 92% of paediatric asthma incidence attributable to NO(2) exposu

47 Paediatric asthma incidence is associated with exposure

48 We aimed to present data on patterns of paediatric AWaRe antibiotic use that could be used for l

49 oiesis provides a blueprint for the study of paediatric blood and immune disorders, and a reference f

50 may be a determinant in the pathogenesis of paediatric brain cancers.

51 adult low-grade gliomas, and the developing paediatric brain is more susceptible to toxic late effec

52 ulloblastoma (MB), the most common malignant paediatric brain tumour occurs in the cerebellum.

53 blastoma, which is the most common malignant paediatric brain tumour, has a 70% survival rate, but st

54 etabolites were quantified across a range of paediatric brain tumours using (1)H-High-Resolution Magi

55 phi approach to establish principles guiding paediatric cancer NSP data collection.

56 Here, we describe the first paediatric cancer organoid biobank.

57 In 2014, the Toronto Paediatric Cancer Stage Guidelines were developed to sta

58 Neuroblastoma is a paediatric cancer with a poor prognosis.

59 s safety and antitumour activity in advanced paediatric cancer.

60 e-nucleotide variants-which are rare in most paediatric cancers-are confined largely to protein-codin

61 additional research that we identify include paediatric cardiologist education, parental distress, so

62 eater involvement of tertiary specialists in paediatric care is associated with decreased all-cause m

63 ine survey to explore the upper age limit of paediatric care, obtaining responses from 1372 paediatri

64 escription antibiotic dispensing occurred in paediatric cases (from 154 [72.3%] of 213 community phar

65 eoretinal (VR) operating theatres (including paediatric cases managed under anaesthesia) over three y

66 oung people aged 6 to 18 years with CF at 13 paediatric CF treatment centres in the UK.

67 ng the evaluation of assessment measures for paediatric chemotherapy-induced peripheral neurotoxicity

68 Observational data such as these can support paediatric clinical practice.

69 ded when establishing adult, adolescent, and paediatric clinical trials and seeking regulatory approv

70 Contemporary paediatric clinical trials have improved 5-year event-fr

71 ere are no standardised response criteria in paediatric clinical trials, which makes it more difficul

72 ed to all consultant members of the Scottish Paediatric Club and Scottish Glaucoma Club.

73 In the paediatric CMT2A population (autosomal dominant and auto

74 etto-Van Laere (BVVL) syndrome, a hereditary paediatric condition associating motor neuropathy (MN) a

75 intravenous anticonvulsant for treatment of paediatric convulsive status epilepticus in the UK; howe

76 cond-line anticonvulsant in the treatment of paediatric convulsive status epilepticus.

77 levetiracetam for second-line management of paediatric convulsive status epilepticus.

78 However, universally accepted paediatric criteria are needed to ensure prompt diagnosi

79 trial were to study the appropriateness of a paediatric dabigatran dosing algorithm, and the efficacy

80 The existing paediatric data are very limited.

81 ut also include recommendations derived from paediatric data if justified.

82 determine the frequency and distribution of paediatric demyelinating and encephalitic syndromes with

83 icipants were recruited from all 20 regional paediatric departments and four tertiary children's hosp

84 ow Transplantation (EBMT) proposed the first paediatric diagnostic and severity grading guidelines fo

85 We endorse universal adoption of paediatric diagnostic guidelines for sinusoidal obstruct

86 tibiotic dispensing based on scenarios about paediatric diarrhoea and adult acute upper respiratory t

87 Paediatric dolutegravir doses approved by stringent regu

88 e results informed the WHO 2019 dolutegravir paediatric dosing guidelines and have led to US Food and

89 We compared our bedside paediatric early warning (PEW) score and a machine learn

90 that there is no higher likelihood of first paediatric ED attendance in the first 5 years of life fo

91 Main outcomes were likelihood of paediatric ED use (no visits versus at least 1 ED visit

92 udy aimed to examine the association between paediatric ED utilisation in the first 5 years of life a

93 multilayered rosettes (ETMRs) are aggressive paediatric embryonal brain tumours with a universally po

94 Most evidence came from paediatric emergency departments.

95 ith input from an external advisory group of paediatric endocrinologists, paediatric nephrologists an

96 Three of the hallmarks of poor prognosis in paediatric ependymoma are drug resistance, local invasio

97 1 gene expression was observed in 4 out of 5 paediatric ependymoma cell lines and increased in stem c

98 e chemoresistance, migration and invasion in paediatric ependymoma patients at non-toxic concentratio

99 ne fusions have been observed in a subset of paediatric ependymomas.

100 lied in most neurological centres for severe paediatric epilepsies.

101 ist nurse was associated with an increase in paediatric epilepsy admissions.

102 In this longitudinal data linkage study of paediatric epilepsy services in England, we linked unit-

103 ingly recognized as a major cause for severe paediatric epilepsy syndromes such as Lennox-Gastaut syn

104 Paediatric European Network for Treatment of AIDS Founda

105 s and on the relationships between adult and paediatric forms of arthritis.

106 otypic regimens; and accelerated approval of paediatric formulations.

107 Paediatric functional abdominal pain disorders, currentl

108 ulness meditation are being investigated for paediatric functional pain.

109 reference values for interocular symmetry in paediatric GCC parameters.

110 56% response rate, reporting 85 new cases of paediatric glaucoma in Scotland over the preceding 2 yea

111 cts an appetite for a specialist service for paediatric glaucoma in Scotland.

112 and would benefit from a specialist unit for paediatric glaucoma.

113 The decline was greater in the paediatric group, which included the most severe patient

114 ricians reported the mean upper age limit of paediatrics had risen over the past 20 years, the mean p

115 er radius of 8 cm, which could accommodate a paediatric head and neck case, the prompt gamma-ray orig

116 eloped and optimised a protocol for cleaning paediatric height and weight data that incorporates outl

117 Response criteria for paediatric high-grade glioma vary historically and acros

118 to develop response assessment criteria for paediatric high-grade glioma.

119 ajor challenges in assessing the response of paediatric high-grade gliomas to various treatments.

120 teen cohorts from the European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) contributed

121 to a report of an unusually large number of paediatric HIV diagnoses in Larkana, Pakistan.

122 mong children in Pakistan: a 54% increase in paediatric HIV diagnoses over the past 13 years.

123 Despite considerable progress in paediatric HIV treatment and timely revision of global p

124 air pollution, incomplete immunisation, and paediatric HIV), with the exception of low birthweight,

125 search Network, a consortium of 17 adult and paediatric HIV-care providers located in the northeaster

126 asthma are among the most common reasons for paediatric hospital attendance, and the incidence of sev

127 dy, children (aged 0-17 years) attending 107 paediatric hospitals in 28 countries with documented acu

128 valent pneumococcal conjugate vaccine to the paediatric immunisation schedule.

129 ensate volatilome allowed the distinction of paediatric individuals with a medical diagnosis of asthm

130 TCT) has proven an effective strategy to end paediatric infections and ensure HIV-infected mothers ac

131 new and important evidence for maternal and paediatric influenza immunisation, and should inform fut

132 ased on the number of in-hospital deaths, US paediatric influenza-associated death data, and populati

133 4 weeks and 5 years who were admitted to the paediatric intensive care unit (PICU) at Wilhelmina Chil

134 admitted to Cambridge University Hospital's Paediatric Intensive Care Unit between January 2009 and

135 omography is a clinically useful tool on the Paediatric Intensive Care unit.

136 raphy (EIT) as a clinical tool in a tertiary Paediatric Intensive Care unit.

137 e, cross-sectional, observational study, 145 paediatric intensive care units (PICUs) from 27 countrie

138 including physicians with expertise in HSCT, paediatric intensive care, nephrology, hepatology, radio

139 n Wilms tumour(2,3), the most common type of paediatric kidney cancer.

140 Paediatric kidney tumour organoids retain key properties

141 ganoid biobank captures the heterogeneity of paediatric kidney tumours, providing a representative co

142 ny neurofibromatosis type 1 (NF1)-associated paediatric low-grade glioma (WHO grades I and II).

143 nce of recurrent, refractory, or progressive paediatric low-grade glioma after at least one standard

144 selumetinib in patients with newly diagnosed paediatric low-grade glioma both with and without NF1.

145 multicentre, phase 2 study in patients with paediatric low-grade glioma in 11 hospitals in the USA.

146 Paediatric low-grade glioma is the most common CNS tumou

147 g common BRAF aberrations and NF1-associated paediatric low-grade glioma.

148 Paediatric low-grade gliomas (also known as pLGG) are th

149 In general, paediatric low-grade gliomas show clinical and biologica

150 s recommendations for response assessment in paediatric low-grade gliomas.

151 s study investigates clinical the profile of paediatric malaria admissions ahead of the introduction

152 ssment of health outcomes among survivors of paediatric malignancies.

153 e of the scarcity of data to inform specific paediatric management practices and policy.

154 Analogous to normative growth charts used in paediatric medicine for plotting child development in te

155 gnancies, including basal cell carcinoma and paediatric medulloblastoma(2).

156 es identified two families with a history of paediatric medulloblastoma.

157 Paediatric melanoma is rare and challenging to diagnose.

158 r assays, and summarise the genetic basis of paediatric melanoma.

159 The spectrum of paediatric MOG antibody-associated syndromes is wider th

160 disease remains one of the leading causes of paediatric mortality.

161 Fingolimod in paediatric MS was associated with consistent control of

162 ic patients (n = 132) from the US Network of Paediatric Multiple Sclerosis Centers (NPMSC) registry.

163 Evaluate risk factors for paediatric myopia in a contemporary French cohort taking

164 visory group of paediatric endocrinologists, paediatric nephrologists and patient representatives.

165 Here, members of the European Society for Paediatric Nephrology (ESPN) CKD-Mineral and Bone Disord

166 sociation (IPNA) and the European Society of Paediatric Nephrology (ESPN).

167 ren using data from the European Society for Paediatric Nephrology/European Renal Association and Eur

168 ectively represent the most common inherited paediatric neurodegenerative disorders worldwide.

169 pertise, an epilepsy specialist nurse, and a paediatric neurologist (where appropriate) in round 1 an

170 A paediatric neurologist and neonatologist categorised par

171 s where all eligible patients were seen by a paediatric neurologist were estimated to have absolute r

172 no or some eligible patients were seen by a paediatric neurologist.

173 l versus no eligible patients were seen by a paediatric neurologist.

174 units with data for the analyses relating to paediatric neurologists, 79 (7%) of 1164 patients died,

175 A paediatric neuroradiologist, masked to the iuMRI results

176 irrespective of age at 21 regional adult and paediatric neurosurgery centres in the UK and Ireland.

177 ial, and extent of disease affect outcome in paediatric non-rhabdomyosarcoma soft-tissue sarcoma (NRS

178 Wide adoption of the resultant Paediatric NSP Guidelines and updated Toronto Stage Guid

179 delivering specialty oncology services (eg, paediatric oncology and palliative care), improving acce

180 ogical Oncology and the European Society for Paediatric Oncology jointly developed clinically relevan

181 isting of experts from relevant disciplines (paediatric oncology, paediatric surgery, medical oncolog

182 testing has been widely adopted for severe, paediatric-onset epilepsies.

183 d versus interferon beta-1a (IFN beta-1a) in paediatric-onset multiple sclerosis (PoMS).

184 .2+ MAIT T cells and CD4+CCR2+CCR5+ Teffs in paediatric-onset multiple sclerosis, compared to both co

185 Paediatric-onset multiple sclerosis, though rare, offers

186 We enrolled paediatric or adult patients in two ongoing, multicentre

187 e hypothalamic-pituitary-gonadal axis during paediatric or pubertal life may result in delayed pubert

188 and treated in a phase 1 adult, a phase 1/2 paediatric, or a phase 2 adolescent and adult trial.

189 gonists or fondaparinux) was compared with a paediatric oral dabigatran dosing regimen (an age-adjust

190 ed in the adult patient's muscle, whilst the paediatric patient displayed a combined mitochondrial re

191 n relation to a proprioceptive stimulus in a paediatric patient population.

192 Here, we present a rare paediatric patient with no significant past medical hist

193 All paediatric patients (<18 years of age) with inflammatory

194 interictal spikes over time in 20 adult and paediatric patients (12 females, mean age = 34.5 years,

195 a phase 3, multicentre, randomised trial in paediatric patients (aged 1 month to 18 years) with tran

196 centre, retrospective, cohort study included paediatric patients (aged 1-18 years) with newly diagnos

197 iple Sclerosis at Brigham study (CLIMB), and paediatric patients (n = 132) from the US Network of Pae

198 RK-NG (NCT02650401; treating young adult and paediatric patients [aged <=21 years]), who received at

199 In this inception cohort study, we recruited paediatric patients aged 4-17 years with newly diagnosed

200 However, data on this topic for paediatric patients are scarce and inconclusive.

201 00,000 patient records collected from 60,000 paediatric patients attending a regional teaching hospit

202 G gene sequences from samples collected from paediatric patients in Kilifi, Kenya, between 2003 and 2

203 However, whether an association exists among paediatric patients is not known.

204 stly at a dose of 100 mg twice daily, and to paediatric patients mostly at a dose of 100 mg/m(2) (max

205 at reported data on the outcomes of adult or paediatric patients that were treated with anti-CD19 CAR

206 fficient as a biomarker for the selection of paediatric patients who are likely to respond to PD-1 ch

207 ore, we identified three additional sporadic paediatric patients with a remarkably similar phenotype,

208 the baseline characteristics and outcomes of paediatric patients with ABL-class fusion B-cell acute l

209 ls to provide accurate clinical guidance for paediatric patients with cancer.

210 From 2012-15, otherwise healthy paediatric patients with culture-confirmed, community-on

211 activity of venetoclax plus chemotherapy in paediatric patients with heavily relapsed and refractory

212 bination should be tested in newly diagnosed paediatric patients with high-risk acute myeloid leukaem

213 Among 2817 paediatric patients with IBD, we identified 618 episodes

214 lence of genetic predisposition to 40% among paediatric patients with MB(SHH).

215 DIGMS, a double-blind phase III trial in 215 paediatric patients with multiple sclerosis (MS) (10 to

216 We identified 122 paediatric patients with newly diagnosed ABL-class fusio

217 re validated in an independent cohort of 274 paediatric patients with newly diagnosed ulcerative coli

218 with standard and high-dose chemotherapy in paediatric patients with relapsed or refractory acute my

219 nd showed encouraging antitumour activity in paediatric patients with relapsed or refractory Hodgkin

220 sed, open-label, phase 1/2 clinical study in paediatric patients with severe Wiskott-Aldrich syndrome

221 s-of-function variants across ELP1 in 14% of paediatric patients with the medulloblastoma subgroup So

222 In paediatric patients with transfusion-dependent haemoglob

223 he patients, 56% had extra-articular (65% in paediatric patients) and 44% had intraarticular (69% in

224 patients) and 44% had intraarticular (69% in paediatric patients) osteoid-osteoma.

225 Among 1213 deferasirox-treated paediatric patients, 162 cases of AKI and 621 matched co

226 ing of haploidentical transplantation and in paediatric patients, but no formal recommendations on th

227 quality of life is particularly important in paediatric patients, who may live for many years with th

228 ation is available on safety and efficacy in paediatric patients.

229 expensive iron chelator, with deferasirox in paediatric patients.

230 x-induced kidney injury has been reported in paediatric patients.

231 ications for under-resourced settings and in paediatric patients.

232 rive a diverse range of cancers in adult and paediatric patients.

233 ighting the need for tailored treatments for paediatric patients.

234 colony variants, was common in a multicentre paediatric population with cystic fibrosis and associate

235 nt increase in prevalence in both adults and paediatric population with new drugs included as culprit

236 nolone resistance has been documented in the paediatric population, although their use is limited in

237 ed as biomarkers for asthma diagnosis in the paediatric population.

238 nt neurological condition, especially in the paediatric population.

239 l epidemiology of anaphylaxis in the general paediatric population.

240 lts, together with more efficacy data in the paediatric population.

241 reas will help define calcium utilization in paediatric populations and provide information that may

242 availability of more chelation treatments in paediatric populations, deferiprone offers a valuable tr

243 nagement of hyperammonaemia requiring KRT in paediatric populations.

244 s, would be to extend the upper age limit of paediatric practice to embrace adolescent health.

245 ate how this new knowledge can be applied in paediatric practice.

246 nnovative Therapies for Children with Cancer-Paediatric Preclinical Proof-of-Concept Platform and the

247 ergy, followed by a discussion of the use of paediatric psychological services for long-term conditio

248 ents and vardenafil, currently used to treat paediatric pulmonary hypertension in children, could be

249 In this report, paediatric radiation oncologists from leading centres in

250 iatric and adult nephrology, human genetics, paediatric radiology and ethics specialties together wit

251 s and nivolumab 3 mg/kg was confirmed as the paediatric recommended phase 2.

252 could result in inappropriate management of paediatric respiratory illness and misdirection of poten

253 ational cohort study, we asked international paediatric rheumatologists from specialised centres to e

254 We aimed to develop paediatric rivaroxaban regimens for the treatment of ven

255 esin subunits are common in bladder cancers, paediatric sarcomas, leukaemias, brain tumours and other

256 Paediatric seizures have been linked to psychiatric diso

257 apeutic promise and are being studied in the paediatric setting, with a focus on target relevance, av

258 Paediatric skull lesions are commonly identified on imag

259 The European paediatric Soft tissue sarcoma Study Group (EpSSG) aimed

260 e-art overview of the molecular landscape of paediatric solid tumours, including their underlying gen

261 nificant single-agent activity in the common paediatric solid tumours.

262 mortality in children, but until recently no paediatric-specific diagnostic criteria existed.

263 [72.9-87.2, I(2)=54.45%]) of 346 patients in paediatric studies achieved complete remission, p=0.24.

264 ICP have not been specifically validated in paediatric studies.

265 m relevant disciplines (paediatric oncology, paediatric surgery, medical oncology, pathology, psycho-

266 2014, to April 30, 2015, through the British Paediatric Surveillance Unit, microbiology reference lab

267 pproach yielded a diagnostic performance for paediatric TB comparable to that of Xpert MTB/RIF and in

268 e management of adult high-grade glioma, for paediatrics there is inclusion of diffusion-weighted ima

269 ths before and 24 months after transfer from paediatric to adult health care.

270 with sickle cell disease transitioning from paediatric to adult health care: skills transfer, increa

271 ardised solution for patient transition from paediatric to adult sickle cell disease health care is u

272 ocus on adolescent health is required within paediatrics to ensure that the future paediatric workfor

273 adolescent health education within national paediatric training suggest that this education is large

274 In the past 10-15 years, paediatric transgender care has emerged at the forefront

275 portantly, the historical paradigm that most paediatric transmission occurs in households should be r

276 re no tested in-hospital care programmes for paediatric traumatic brain injury.

277 tes of HBV replication; and establishment of paediatric treatment registries and international consor

278 er disease in children; and establishment of paediatric treatment registries and international consor

279 ug optimisation for neonatal prophylaxis and paediatric treatment, and those relating to the investig

280 atic review identified 27 eligible adult and paediatric trials that evaluated amifostine, sodium diet

281 dentify host biomarkers in serum to diagnose paediatric tuberculosis (TB) disease.

282 ng is predicated on the assumption that most paediatric tuberculosis infections are acquired within t

283 e at birth would substantially reduce global paediatric tuberculosis mortality.

284 Retrospective multi-centre study within the Paediatric Tuberculosis Network European Trials Group, c

285 Retrospective multicenter study within the Paediatric Tuberculosis Network European Trials Group, c

286 some of the challenges and controversies in paediatric tuberculosis, including the epidemiology and

287 d low antitumour activity in the majority of paediatric tumour types, and responses were observed in

288 recapitulate the extensive heterogeneity of paediatric tumours and thereby, hopefully, improve the a

289 tures such as the immune microenvironment of paediatric tumours in comparison with adult cancers - cu

290 We validate our key findings in adult and paediatric UC cohorts of 408 participants.

291 A total of 155 children from the Paediatric University Hospital of Nice were screened (bo

292 Paediatric vaccination against influenza can result in i

293 Kawasaki Disease (KD) is the most common paediatric vasculitis affecting small to medium arteries

294 ed, controlled trial was done in the general paediatric ward of Salima District Hospital, Malawi.

295 bCPAP treatment in a paediatric ward without daily physician supervision did

296 within paediatrics to ensure that the future paediatric workforce is appropriately equipped to respon

297 human monoclonal antibody against FGF23, in paediatric X-linked hypophosphataemia.

298 Most paediatric Zika cases go undetected under the WHO and PA

299 d PAHO case definitions in a large cohort of paediatric Zika cases.

300 We provide the most thorough description of paediatric Zika to date.