ライフサイエンスコーパス: pain

1 hether calves experience ongoing, non-evoked pain.

2 ) signaling in the PSNL model of neuropathic pain.

3 s against spontaneous and evoked neuropathic pain.

4 onth started complaining of severe abdominal pain.

5 he emergency department with acute abdominal pain.

6 re primary aversive stimuli such as physical pain.

7 l therapeutic target for alleviating chronic pain.

8 e product was computed as an index of facial pain.

9 otential target for the treatment of chronic pain.

10 ntribute to nerve injury-induced neuropathic pain.

11 ureteral stents can cause ureteral colic and pain.

12 cause cranial nerve disorder and unbearable pain.

13 targets for stopping cancer and attenuating pain.

14 ns of viral infection is body-wide aches and pain.

15 viduals' association between temperature and pain.

16 sory and affective manifestations of chronic pain.

17 cal disease to the assessment of acute chest pain.

18 the cause and complicating features of spine pain.

19 , G-carriers were more sensitive to physical pain.

20 development of biomarkers and end points for pain.

21 biased agonist of PAR(2) that evokes cancer pain.

22 rmacotherapeutic target for the treatment of pain.

23 mmon symptom in youth with chronic abdominal pain.

24 or the initiation and maintenance of chronic pain.

25 new behavioral methods to assess mechanical pain.

26 odulation of negative affect associated with pain.

27 s, nausea, vomiting and right upper quadrant pain.

28 mbic dopamine circuitry in acute and chronic pain.

29 on for the treatment of chronic back and leg pain.

30 xcessive tearing, conjunctival injection and pain.

31 developed with generalized, acute abdominal pain.

32 of CCL17 in the control of inflammation and pain.

33 in Schwann cells (SCs) may cause neuropathic pain.

34 ssion result in increased carcinogenesis and pain.

35 heral nerve injury (PNI)-induced neuropathic pain.

36 to the Emergency Room with acute right flank pain.

37 rove functioning among patients with chronic pain.

38 PN) for chronic endometriosis-related pelvic pain.

39 ion (EMT), loss of sensation and neuropathic pain.

40 comes were postoperative opioid consumption, pain (0- 10-point scale; 0: no pain; 10: the most pain i

41 consumption, pain (0- 10-point scale; 0: no pain; 10: the most pain imaginable), nausea and vomiting

42 ent, 1 death, and 5 hospitalizations-1 chest pain, 2 dyspnea, 1 heart failure, and 1 syncope) over 36

43 nce (4.3%; n = 42), and postoperative ocular pain (3.4%; n = 34).

44 (844 former cricketers), 16.9% reported hand pain, 4.3% reported OA.

45 mpared with placebo (abdominal discomfort or pain: 66 [6%] vs 40 [3%], respectively; nausea: 50 [4%]

46 ual acuity (32.1%; n = 317), generalized eye pain (7.4%; n = 73), visual field disturbance (4.3%; n =

47 Judicious, long-term management of pain after diagnosis of MBC will continue to be necessar

48 Consecutive patients admitted for abdominal pain after RYGB and undergoing CT and surgical explorati

49 in developing more effective treatments for pain and addiction.

50 ., endodontic therapy), generally alleviates pain and allows long-lasting dental function.

51 A total of 86 patients with pericarditis pain and an elevated CRP level were enrolled in the run-

52 pendent and unique CCL17-driven inflammatory pain and arthritis models, the latter permitting a radia

53 is needed to alleviate the burden of chronic pain and dependence on opioids.

54 ed with gastrointestinal symptoms (abdominal pain and diarrhea) and musculoskeletal symptoms.

55 ven fMRI studies (N = 165) and five types of pain and discomfort (esophageal, gastric, and rectal dis

56 an differences on the assessment of shoulder pain and function (OSS) at the primary endpoint of 12 mo

57 gnaling responses previously associated with pain and functional recovery after surgery, including ST

58 accharidase may be correlated with abdominal pain and have a unique frequency of GI symptoms due to l

59 zed to underlie phenotypes like phantom limb pain and hinder recovery.

60 nd sheds new light on the pathophysiology of pain and itch as well as the physiology of touch.

61 scovering endogenous mechanisms for reducing pain and itch holds enormous potential for developing ne

62 rons that detect noxious stimuli, leading to pain and itch.

63 cohort 2, we determined clinical features of pain and its impact on daily life.

64 eline characteristics, including severity of pain and level of disability, were similar in the two gr

65 preliminary efficacy for preventing chronic pain and long-term opioid use.

66 closed-loop control system aimed at reducing pain and looked for co-adaptive neural and behavioral ch

67 ve as neuroimaging biomarkers of neuropathic pain and might be used for prediction and monitoring of

68 y of gabapentin in women with chronic pelvic pain and no obvious pelvic pathology.

69 tionship between hand injury and ipsilateral pain and OA in cricketers.

70 marked by debilitating symptoms of abdominal pain and obstruction.

71 ls with cLBP who experienced movement-evoked pain and pain-free controls.

72 d biomechanical footwear therapy may improve pain and physical function in people with symptomatic kn

73 s protected against and reversed spontaneous pain and PNI-mediated cognitive impairment.

74 Secondary outcomes included pain and satisfaction scores over multiple time points a

75 ropathic animals showed signs of spontaneous pain and were significantly impaired in the rule-shiftin

76 nt in the decision-making process, and (iii) pain and/or discomfort.

77 or incidence or number of episodes of dental pain and/or infection experienced by these participants

78 surgery failed to adequately resolve midline pain) and the frequency of operative and postoperative c

79 hetics to realise the sensation of touch and pain, and (iii) assistive technologies to enable disable

80 valued life goals in the face of persistent pain, and further improvements in pain treatment may req

81 mast cells leading to plasma extravasation, pain, and itching.

82 History of knee pain, and socio-demographic, laboratory, and clinical da

83 the EuroQoL-5D-3L, Visual Analogue Score for pain, and the short form 36 health survey) RESULTS:: The

84 wer pain scores in women with chronic pelvic pain, and was associated with higher rates of side-effec

85 r survivors reporting newly-acquired chronic pain; and (3) one-year survivors with pain who lived wit

86 LPB neurons in CCI-Pain animals showed a reduction in inhibitory, GABAergic

87 nsation and homeostasis, where sensation and pain are mediated by spinal afferents and fear and anxie

88 d anxiety (the affective aspects of visceral pain) are the domain of nodose afferents.

89 n, encompassing conditions, such as low back pain, arthritis, persistent post-surgical pain, fibromya

90 econdary outcomes, including changes in knee pain assessed by a visual analog scale (-11.5 in the zol

91 CI, -2.3 to 12.8]; P = .17), changes in knee pain assessed by the Western Ontario and McMaster Univer

92 Of the 179 LKDs who completed the final pain assessment, 74 (41%) met criteria for chronic posts

93 he score on the Owestry Disability Index and pain at 12 months were in the same direction as the prim

94 nguinal hernias a significant higher rate of pain at rest [EHS I vs EHS II: odds ratio, OR = 1.350 (1

95 t work suggests that oxytocin also modulates pain at the cortical insular level by favoring cortical

96 haracterized by short-term, mild-to-moderate pain at the injection site, fatigue, and headache.

97 strategies (safe place), the performance of pain attenuation was explained by diffusion tensor imagi

98 tions, we found that a higher performance of pain attenuation was predominantly associated with highe

99 and diseases, including chronic neuropathic pain, autism, and epilepsy.

100 of nicotinic agents in relieving neuropathic pain best correlated with their activity on alpha6beta4.

101 e have recently been linked to somatosensory pain, but any relationships between gut microbiome and P

102 sally connected with the chronic neuropathic pain, but its mechanisms are poorly understood.

103 (a) to investigate the relationship between pain catastrophizing and the ability to inhibit selectiv

104 Changes in depression, anxiety, and pain catastrophizing were not significantly different be

105 Neuropathic pain caused by peripheral nerve injuries significantly a

106 the weekly average of worst daily abdominal pain compared with baseline in at least 4 weeks.

107 hospital consumption of opioids, and reduced pain, compared to conventional management.

108 ynia are more likely to report other chronic pain conditions, which further alters their quality of l

109 herapeutic target for many neuroinflammatory pain conditions.

110 relation between lead toxicity and abdominal pain consistency and intensity, constipation, and parest

111 e after surgery without negatively impacting pain control.

112 in vitro as a model system for post-surgical pain control.

113 (41%) met criteria for chronic postsurgical pain (CPSP), that is, any donation-related pain on POD56

114 Veterans with GWI related diffuse body pain demonstrated a state of diminished corticomotor exc

115 Opioid reduction of pain depends on coupling of opioid receptors to Galphai/

116 0.99, 1.98]), reporting "severe" on any POD1 pain descriptors (adjusted ratio of means [95% CI]: 1.47

117 oteins during distinct phases of neuropathic pain development produces enhanced antinociception.

118 sensitization of nociceptors by cytokines in pain development.

119 tcomes were similar at 5 years, except chest pain, diarrhea, and bloat symptoms which were more commo

120 Presence of pain did not prompt earlier presentation.

121 Patient-centered outcomes related to pain/discomfort and esthetics were assessed with visual

122 n, history of previous implant failures, and pain/discomfort at the implant site were significantly a

123 ls, and are associated with episodic extreme pain disorders and insensitivity to pain, respectively.

124 Functional abdominal pain disorders are common disorders with a prevalence of

125 surgical pain, fibromyalgia, and neuropathic pain disorders, is highly prevalent but remains poorly t

126 ion, and certain mental health disorders and pain disorders.

127 explore the association between DM and knee pain distribution (unilateral or bilateral versus no pai

128 n severity and unilateral and bilateral knee pain distribution.

129 ity parameters, and GSRS-IBS total score and pain domain (rho = 0.40, p < 0.001, and rho = 0.38, p <

130 Neck pain due to thyroiditis was reported in up to 18% of pat

131 Chronic pain, encompassing conditions, such as low back pain, ar

132 Chronic pain enhances this cortico-cortical connection, as manif

133 in outcome measures were hospital records of pain, fatigue, or circulatory symptoms.

134 Neuropathic pain features were present in 50% (95% CI, 37-68%) of af

135 ligament's matrix and activating innervating pain fibers.

136 ck pain, arthritis, persistent post-surgical pain, fibromyalgia, and neuropathic pain disorders, is h

137 lenges in studying cLBP is that the clinical pain fluctuates over time and often changes during movem

138 entered interventions for managing arthritis pain for older adults.

139 ids first-pass metabolism, but also provides pain-free administration, assists patients with dysphagi

140 LBP who experienced movement-evoked pain and pain-free controls.

141 After 12 months, 56.2% of patients was pain-free in restrictive strategy versus 59.8% after usu

142 er societal willingness to pay for one extra pain-free patient, the lower the probability that the re

143 17.50, p=0.010), while it stayed similar in pain-free patients (Deltamean=2.74, 95% CI -7.36 to 12.8

144 However, identifying the cause of GI pain frequently represents a diagnostic challenge as the

145 ologic and pharmacologic management of acute pain from non-low back, musculoskeletal injuries in adul

146 he initiation of exercise to achieve optimal pain, functional and physiological outcomes and that los

147 ts, downstream of CD44, for the treatment of pain generated by nociceptor sensitization.SIGNIFICANCE

148 ce, for the management of acute and terminal pain has been a major driver of the opioid crisis, toget

149 are widely used for the treatment of severe pain; however, prolonged treatment with these drugs lead

150 nded RNA mimetic poly(I:C) likewise produces pain hypersensitivity that is blunted in mice lacking MN

151 induced spinal cord microglia activation and pain hypersensitivity.

152 output in pathologic conditions, leading to pain hypersensitivity.SIGNIFICANCE STATEMENT Noxious sti

153 Lack of pain identifies patients at low risk of metastasis with

154 (0- 10-point scale; 0: no pain; 10: the most pain imaginable), nausea and vomiting, sedation, minimal

155 culating short-chain fatty acid butyrate and pain improvement following FMT.

156 an interaction of expectancy and delivery on pain improvement following the intervention.

157 tively treat both oral cancer metastasis and pain in a preclinical model.

158 Abdominal pain in adults represents a wide range of illnesses, oft

159 reported and parent-reported interference of pain in daily functioning (38% and 50%, respectively) an

160 Movement-evoked pain in individuals with chronic low back pain was assoc

161 utative ion channel that mediates mechanical pain in mice.

162 tal carcinoma, causes peripheral neuropathic pain in patients.

163 sis presented with a complaint of increasing pain in the left eye more than the right, along with dec

164 ciations between annular puncture injury and pain in the male network.

165 types of musculoskeletal conditions include pain in the neck and shoulder areas.

166 fects of radioiodine therapy (typically mild pain in the thyroid) can be handled by nonsteroidal anti

167 olecular mechanisms that govern inflammatory pain in the tooth.

168 three loci associated with neck or shoulder pain in the UK Biobank cohort, two of which were weakly

169 i that were associated with neck or shoulder pain in the UK Biobank samples.

170 tribution (unilateral or bilateral versus no pain) in subjects with knee OA.

171 ck score of the 25 patients with neuropathic pain increased from 1 to 12 months (Deltamean=10.08, 95%

172 Pain-induced defensive behaviors affecting fitness have

173 d, patients recorded daily ratings of facial pain intensity and duration; the product was computed as

174 on may improve clinical outcomes by reducing pain intensity and possibly improving the sensory experi

175 At baseline, the mean score for leg-pain intensity was 7.7 in the surgical group and 8.0 in

176 cific mechanism for the promotion of chronic pain involving the neuroendrocrine system and mediated b

177 pared to people with low sensitivity to heat pain (IOR = 3.9; 95% CL, 1.7-8.4).

178 ated in people with high sensitivity to heat pain (IOR = 7.4; 95% CL, 3.1-18.0) compared to people wi

179 Pain is a diagnostic criterion for Gulf War Illness (GWI

180 We measured whether self-reported pain is accompanied by metacognition and variations in c

181 The effective and safe treatment of pain is an unmet health-care need.

182 Cancer pain is attributed to cancer-derived mediators that sens

183 Postsurgical dental pain is mainly driven by inflammation, particularly thro

184 The role of Lgmn in PAR(2)-dependent cancer pain is unknown.

185 battlefield is almost always associated with pain, it is paramount that the administered pain medicat

186 ration of C2I without C2II-CI did not reduce pain-like behavior indicating its intracellular delivery

187 Lgmn evokes pain-like behavior through PAR(2) Exposure of pain-sensi

188 LXR alpha/beta from sensory neurons lead to pain-like behaviors.

189 standing of the mechanisms of virus-mediated pain linked to latency and reactivation.IMPORTANCE The r

190 bowel habit, hoarseness, fatigue, abdominal pain, lower abdominal pain, weight loss, and the "any ot

191 urgeon prescribing and care coordination for pain management after surgery.

192 Pain management after thoracic surgery is not standardiz

193 rescriptions after surgery are effective for pain management but have been a significant contributor

194 ted element throughout this process is acute pain management related to the surgical procedure.

195 There is an unmet need for an effective pain management strategy in this group of patients.

196 tions focused largely on symptom control and pain management, effective targets for small-molecule dr

197 ntial peripheral DRG targets for neuropathic pain management.

198 ioids are needed for effective postoperative pain management.

199 Opioids are critical in pain management; however, the often-forgotten delta opio

200 and adopted new regulations for independent pain-management clinics.

201 (L5) nerve injury in rats causes neuropathic pain manifested with thermal and mechanical hypersensiti

202 Chronic pain may sap the motivation for positive events and stim

203 fter FMT, 0.37; range, 0.00-1.00), abdominal pain (mean reduction, 26%; median score before FMT, 3.88

204 elevant sex differences in acute and chronic pain mechanisms, but we are only beginning to understand

205 pain, it is paramount that the administered pain medication does not disrupt the physiological mecha

206 operative pain medication use, and discharge pain medication prescriptions were analyzed.

207 Demographics, operative data, perioperative pain medication use, and discharge pain medication presc

208 systems, thus impacting emotion, cognition, pain, metabolic function, and aging, and in so doing pot

209 activity in the formalin inflammatory mouse pain model.

210 icant effects on the CCI-induced neuropathic pain model.

211 accompanied by activation of the endogenous pain modulation system, manifested by the attentional mo

212 bility, suggesting a maladaptive supraspinal pain modulatory state.

213 astatic cancers from patients reporting high pain (n = 5) compared to N0 cancers (n = 10) and normal

214 only to combat cancer but also to alleviate pain, nausea, and anxiety, many of which target GPCRs.

215 e 5 years' trajectories in functionality and pain of patients with hip or knee osteoarthritis and art

216 rotal: OR = 1.363 (1.125-1.650), P = 0.002], pain on exertion [EHS I vs EHS II: OR = 1.342 (1.223-1.4

217 (OR = 9.35; P = 0.009) and to not experience pain on palpation (OR = 6.278; P = 0.007).

218 l pain (CPSP), that is, any donation-related pain on POD56.

219 or the treatment of drug addiction, anxiety, pain or obesity.

220 ealthcare utilization, with no difference in pain or patient satisfaction.

221 2 were found to be associated with abdominal pain (OR = 2.25; 95% CI = 1.25-4.04; p < 0.05), Subjects

222 on, and may cause bowel obstruction, chronic pain, or infertility.

223 nt diseases, such as osteoarthritis (OA), is pain, originating from both inflammatory and neuropathic

224 ght be used for prediction and monitoring of pain outcomes and stratification of patients in interven

225 In our experiment, chronic back pain patients and healthy controls completed an appetiti

226 s and accurately classified chronic low-back pain patients in two additional independent datasets.

227 cible across two cohorts of chronic low-back pain patients obtained from different sites and accurate

228 We compared pain perception (100 mm visual analogue scale), muscle s

229 eatures, we developed a system for detecting pain perception and reaction in the brain, which success

230 Neural correlates of altered pain perception in C9orf72 expansion carriers were the b

231 ntify neuroanatomical correlates of abnormal pain perception.

232 nsitivity that characterizes the neuropathic pain phenotype.

233 rmediate duration, often in narrowly defined pain populations of patients who could tolerate the drug

234 matic cholecystolithiasis reports persisting pain post-cholecystectomy.

235 e of oxytocinergic mechanisms modulating the pain process at the RAIC level.SIGNIFICANCE STATEMENT Ox

236 surgical procedures were asked to complete a pain questionnaire at four time points: 1) before surger

237 manifested by the attentional modulation of pain ratings and enhanced pain responses in pregenual an

238 However, retrospective pain ratings show an effect of expectancy but not of del

239 ive to older adults' experience of arthritis pain, realize the importance of providers' support on pa

240 he ability to inhibit selective attention to pain-related faces (attentional bias); and (b) to determ

241 sure was also associated with higher risk of pain-related readmissions [low: aOR=1.27, 95% CI=1.23-1.

242 emogenetics in the skin evokes itch- but not pain-related scratching or wiping behaviors.

243 provide a clinically meaningful reduction in pain relative to a control group.

244 We aimed to examine pain relief and the extent of spinal cord activation wit

245 ure) to establish and validate generalizable pain representations.

246 : OR = 1.492 (1.296; 1.717), P < 0.001], and pain requiring treatment [EHS I vs EHS II: OR = 1.594 (1

247 extreme pain disorders and insensitivity to pain, respectively.

248 The primary endpoint was abdominal pain response, as defined by the US Food and Drug Admini

249 onal modulation of pain ratings and enhanced pain responses in pregenual anterior cingulate cortex an

250 61 [1.03, 6.62]) were associated with higher pain scores across time.

251 rst and average numerical rating scale (NRS) pain scores at 13-16 weeks after randomisation.

252 utcomes included total inpatient opioid use, pain scores determined using a 100 mm visual analog scal

253 pentin did not result in significantly lower pain scores in women with chronic pelvic pain, and was a

254 n endoscopy-first approach resulted in lower pain scores when integrated over 18 months.

255 When employed, the validated pain screen had a sensitivity of 100% (95% CI 72%-100%)

256 rrent study aimed to pilot the Perioperative Pain Self-management (PePS) intervention, based on princ

257 propagates toward the CNS, thus shaping the pain sensation.

258 ain-like behavior through PAR(2) Exposure of pain-sensing neurons to Lgmn decreased the current requi

259 upled receptor (Gq-GPCR) signaling modulates pain sensitivity in vivo using Gfap-hM3Dq mice.

260 contributions of jaw injury and experimental pain sensitivity to risk of developing painful temporoma

261 ave been linked to individual differences in pain sensitivity, depressive symptoms, and reward proces

262 el of PTSD, as well as associated changes in pain sensitivity.

263 pain threshold, memory of prior injury, and pain sensitization/desensitization.

264 udy found that DM was associated with higher pain severity and unilateral and bilateral knee pain dis

265 xamining the association between DM and knee pain severity, and to explore the association between DM

266 health care providers treating patients with pain should monitor such patients for signs and symptoms

267 In addition, she reported progressive back pain since she was 5 years old.

268 abinoids provide long-term relief of chronic pain states.

269 vals (CIs) as the measure of effect for each pain stimuli.

270 ead to inaccurate sensory impressions of the pain stimulus.

271 trally to pathways associated with affective pain, such as parabrachial nucleus and medial thalamic n

272 c nucleus, as well as sensory-discriminative pain, such as ventral posteromedial thalamic nuclei.

273 dichotomous roles in oral carcinogenesis and pain, such that ET(A)R activation and silenced ET(B)R ex

274 es revealed asymmetric effects of effort and pain, suggesting that cognitive effort may not share the

275 comes (Child Health-Related Quality of Life, Pain, Survival, and Communication).

276 been increasing rates of complex hematologic pain syndromes, present in up to 60% of patients with ma

277 H) is used to treat osteoarthritis and other pain syndromes.

278 r, in America today, the elderly report less pain than those in midlife.

279 nths before she had had right upper quadrant pain that was interpreted as biliary colic.

280 s, such as inflammation, fever, allergy, and pain, their roles in COVID-19 are poorly characterized.

281 ate important characteristics of PPN such as pain threshold, memory of prior injury, and pain sensiti

282 oth sleep conditions, we tested cold pressor pain tolerance before and 40-min after double-blind inje

283 thway are attractive therapeutic targets for pain treatment because nociceptive signals emanating fro

284 persistent pain, and further improvements in pain treatment may require a paradigm shift toward more

285 may prevent patients from receiving adequate pain treatment, adding to the initial cost and disabilit

286 Different pain types may be encoded in different brain circuits.

287 t relationships between IVD degeneration and pain using an in vivo rat model.

288 or cold and heat detection and cold and heat pain via a thermode placed on the right hand.

289 Pain was assessed by von Frey assay and dorsal root gang

290 ed pain in individuals with chronic low back pain was associated with longer reaction times, delayed

291 Pain was reported more often in hemiplegic than non-hemi

292 ss, fatigue, abdominal pain, lower abdominal pain, weight loss, and the "any other symptom" category)

293 ses to all three question sets except ocular pain were consistent with significant improvement (p < 0

294 dyspigmentation, scar appearance, edema, and pain were detected at low rates, and cosmetic outcome an

295 At 2 years, increases in pain were similarly reduced in the HMIE compared with th

296 hronic pain; and (3) one-year survivors with pain who lived within 50 km from the study hospital.

297 ction has gained importance in assessment of pain with total hip arthroplasty (THA).

298 Episodes of acute myocardial injury (chest pain with troponin elevation and normal coronary angiogr

299 gs for treating inflammatory and neuropathic pain without the psychoactivity of CB1.

300 rs to Develop Non-Addictive Therapeutics for Pain workshop convened scientific leaders from academia,