ライフサイエンスコーパス: pair rule gene

1 Oncopeltus, even-skipped is not acting as a pair-rule gene.

2 twork of regulatory interactions between the pair-rule genes.

3 ression plus extensive pre-patterning of the pair-rule genes.

4 athway are expressed at the same time as the pair-rule genes.

5 a reclassification of ftz and odd as primary pair-rule genes.

6 he complex transcriptional regulation of the pair-rule genes.

7 efly resembles a sequence that is typical of pair-rule genes.

8 nd wingless (wg) via regulation of secondary pair-rule genes.

9 rule genes in the absence of the other known pair-rule genes.

10 egulatory interactions between the different pair-rule genes.

11 he anteriormost stripes of several different pair-rule genes.

12 ators that shape the patterned expression of pair-rule genes.

13 l decisions, in particular the regulation of pair-rule genes and fly hematopoiesis.

14 in a dynamic pattern reminiscent of gap and pair-rule genes and is required for the appropriate expr

15 f 27 genes; these include several gap genes, pair-rule genes, and anterior, posterior, trunk, and ter

16 olarity genes are initially activated by the pair-rule genes, and later maintain each other's express

17 iped expression of the even-skipped and runt pair-rule genes are both necessary and sufficient to ori

18 of almost all the eight canonical Drosophila pair-rule genes are expressed in pair-rule domains, but

19 Although orthologs of some Drosophila pair-rule genes are not required for proper segmentation

20 The pair-rule genes are pivotal in this process as they are

21 l and gap gene patterns, whereas 'secondary' pair-rule genes are thought to rely on 7-stripe elements

22 ges of segment patterning, regulated by the "pair-rule" genes, are still not well understood at the s

23 he observed spatiotemporal expression of the pair-rule genes, but only when the system is provided wi

24 y that specifies regions in the embryo where pair-rule genes can be activated or repressed.

25 This pair-rule gene circuit provides insight into short-germ

26 lated by the nuclear proteins of the gap and pair-rule gene classes but, after gastrulation, wg trans

27 al code of Toll-like receptors downstream of pair-rule genes contributes to Myosin II polarization vi

28 ndependent of Wingless signaling, suggesting pair-rule gene control.

29 ating that maternal/gap-mediated control and pair-rule gene cross-regulation are closely integrated.

30 ing both early stripe elements recapitulates pair-rule gene-dependent regulation in a manner beyond w

31 nctional division into primary and secondary pair rule genes described in insects.

32 Since secondary pair-rule genes directly regulate segment polarity genes

33 odicity, defined by the expression of seven 'pair-rule' genes, each in a pattern of seven stripes.

34 Drosophila hairy is a primary pair-rule gene encoding a basic helix-loop-helix class t

35 In Drosophila, primary pair-rule genes establish the parasegmental boundaries a

36 FF state of expression of the earlier acting pair-rule genes eve and ftz.

37 pe, and exhibited aberrant expression of the pair rule gene even skipped (eve) at the cellular blasto

38 te transcription of target genes such as the pair rule gene even-skipped.

39 The striped expression pattern of the pair-rule gene even skipped (eve) is established by five

40 The Drosophila pair-rule gene even skipped (eve) is required for embryo

41 The product of the pair-rule gene even skipped has previously been shown to

42 ap genes Kruppel (Kr) and giant (gt) and the pair-rule gene even-skipped (eve) during cellularization

43 netic activity, the stripe 2 enhancer of the pair-rule gene even-skipped (eve) was used to express kn

44 nes Kruppel (Kr) and hunchback (hb), and the pair-rule gene even-skipped (eve).

45 ad gap gene buttonhead (btd) and the primary pair-rule gene even-skipped (eve).

46 gulation of the seven-striped pattern of the pair-rule gene even-skipped (eve).

47 (Kr) affects transcriptional dynamics of the pair-rule gene even-skipped (eve).

48 stinct regulatory regions (enhancers) of the pair-rule gene even-skipped (eve).

49 tion of insect segmentation, homologs of the pair-rule gene even-skipped have been studied in several

50 e have identified homologs of the Drosophila pair-rule gene even-skipped in the glossiphoniid leeches

51 The pair-rule gene even-skipped is required for the initiati

52 similar to those caused by mutations in the pair-rule gene even-skipped.

53 or the appropriate expression of the primary pair-rule genes even skipped, hairy and runt.

54 gand Delta, and homologues of the Drosophila pair-rule genes even-skipped and hairy, show periodic ex

55 -type, but striped patterning of the primary pair-rule genes even-skipped and runt is disrupted.

56 However, the Nasonia pair-rule genes even-skipped, odd-skipped, runt and hair

57 We propose that pair-rule genes, exemplified by Ftz/Ftz-F1, promote segm

58 aneously regulate all stripes, responding to pair-rule genes expressed in stripes.

59 We found pair rule gene expression continuously deformed, flowing

60 precise scaling in the placement of gap and pair-rule gene expression along the anterior-posterior a

61 s might suggest that the factors upstream of pair-rule gene expression are not conserved across insec

62 n the dipterans and that similar patterns of pair-rule gene expression can be obtained with different

63 factor "runt," a known repressor of gap and pair-rule gene expression in Drosophila.

64 domains is critical for striped patterns of pair-rule gene expression in the Drosophila embryo.

65 Detailed analysis of engrailed and pair-rule gene expression in various mutant combinations

66 These results, interpreted within the pair-rule gene expression patterns, suggest separate mod

67 he segmentation phenotype and the effects on pair-rule gene expression suggests that this role is to

68 vity lack segments and show abnormal gap and pair-rule gene expression, although no LIM domain protei

69 tion clock generates a repeating sequence of pair-rule gene expression, and how this is converted int

70 lly analysing the spatiotemporal dynamics of pair-rule gene expression, we demonstrate that frequency

71 tead plays a limited role as an activator of pair-rule gene expression.

72 pe-specific versus 7-stripe elements for the pair-rule gene ftz.

73 We present a new model of pair-rule gene function that explains the response of th

74 How pair-rule genes function during the progressive mode of

75 that hedgehog (hh) and wingless (wg) mediate pair-rule gene functions in the mesoderm, probably partl

76 The Drosophila pair-rule gene fushi tarazu (ftz) is a derived Hox gene

77 The pair-rule gene fushi tarazu (ftz) of Drosophila is expre

78 e binary cell fate dynamics of the fruit fly pair-rule gene fushi tarazu (ftz), which is regulated by

79 The 'primary' pair-rule genes generate their 7-stripe expression throu

80 omic resources we identify a complete set of pair rule gene homologues from the centipede Strigamia m

81 we find that the expression of the Strigamia pair rule genes in periodic patterns is restricted to th

82 JAK signaling to stimulate transcription of pair-rule genes in a segmentally restricted manner in th

83 The striped expression of pair-rule genes in Drosophila embryos is a paradigm for

84 enesis shares many properties with canonical pair-rule genes in other insects.

85 xamined the results of expressing one or two pair-rule genes in the absence of the other known pair-r

86 at refines the expression pattern of gap and pair-rule genes in the Drosophila blastoderm embryo.

87 The complement of primary pair-rule genes in Tribolium differs from Drosophila in

88 be below eve in the regulatory hierarchy of pair-rule genes, in fact plays a critical role in the re

89 egmentation of the embryo via the control of pair rule genes including even skipped and the establish

90 nt, the 'late element', under the control of pair-rule genes including eve itself.

91 The periodicity of the Tribolium pair-rule gene interactions reveals components of the ge

92 lative expression of a number of the primary pair rule genes is divergent between myriapods and insec

93 The fushi tarazu pair-rule gene is required for the formation of alternat

94 also support the idea that prepatterning by pair-rule genes is conserved between these two insects.

95 At gastrulation, interactions between the pair-rule genes lead to frequency doubling and the patte

96 mRNA transcripts of pair-rule genes localise to the apical cytoplasm of the

97 onstrated stage-specific architecture of the pair-rule gene network.

98 the vertebrate homologues of the Drosophila pair rule gene odd-paired.

99 A mouse homolog of the Drosophila pair-rule gene Odd Oz (Odz4) maps to the critical region

100 of the vertebrate homologs of the Drosophila pair-rule gene odd-paired (opa).

101 d-paired-like) that resembles the Drosophila pair-rule gene odd-paired and encodes a zinc finger prot

102 m 1), one of five homologs of the Drosophila pair-rule gene odd-paired, encodes a transcription facto

103 The Drosophila pair-rule gene paired is required for the correct expres

104 ia uses a mixed mode of segmentation wherein pair-rule genes pattern the embryo in a manner resemblin

105 The even-skipped (eve) pair-rule gene plays a key role in the establishment of

106 rther indicates that mutual repression among pair-rule genes plays an important role in establishing

107 tinuously knock down the function of primary pair-rule genes (pPRGs), caudal or Wnt pathway component

108 The discovery of pair-rule genes (PRGs) in Drosophila revealed the existe

109 development of body segments, including the "pair-rule" genes (PRGs), which subdivide embryos into do

110 gamma-heregulin, a Drosophila receptor-type pair-rule gene product, Odd Oz (Odz) / Ten(m), and Ten(a

111 arity genes is initiated by a pre-pattern of pair-rule gene products and maintained by a network of r

112 Pair-rule gene products subsequently 'imprint' segment p

113 Our findings indicate that the pair-rule gene regulatory network has a temporally modul

114 The protein encoded by the pair-rule gene runt functions as a transcriptional regul

115 o these genes, a subdivision that depends on pair-rule genes such as even-skipped (eve).

116 na (grasshopper), the expression patterns of pair-rule genes such as even-skipped are not conserved b

117 Recently, the cyclic nature of the pair-rule gene Tc-odd-skipped was demonstrated in the gr

118 ifically, we show that the Tribolium primary pair-rule gene, Tc-even-skipped (Tc-eve), is expressed i

119 ctivated Tc-wg in the absence of the primary pair-rule genes, Tc-even-skipped (Tc-eve), Tc-runt (Tc-r

120 Expression of one or both of the secondary pair-rule genes, Tc-sloppy-paired (Tc-slp) and Tc-paired

121 ch were initially described as ten-a and the pair-rule gene ten-m/odz in Drosophila, are a family of

122 sults indicate that lilli represents a novel pair-rule gene that acts in cytoskeleton regulation, seg

123 embryogenesis, paired acts as one of several pair-rule genes that define the boundaries of future par

124 ream target genes regulated by Ftz and other pair-rule genes to direct segment formation are not know

125 emporally modulated topology, permitting the pair-rule genes to play stage-specific patterning roles.

126 Within this hierarchy, the pair-rule genes translate gradients of information into

127 gmentation hierarchy, periodic expression of pair-rule genes translates gradients of regional informa

128 Pair-rule genes were identified and named for their role

129 We report here that paired (prd), a pair-rule gene which had been considered to be below eve

130 alyzed the Tribolium orthologs of Drosophila pair-rule genes, which display pair-rule expression patt

131 skipped, runt and odd-skipped act as primary pair-rule genes, while the functions of paired (prd) and

132 a conserved hierarchical organisation of the pair rule genes, with a division into early- and late-ac