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1 ] and neurofibrillary tangles (consisting of paired helical and straight filaments containing tau pro
2                                              Paired helical and straight filaments differ in their in
3 esolution and corresponding atomic models of paired helical and straight filaments from the brain of
4 ates and becomes hyperphosphorylated forming paired helical and straight filaments, which can further
5 osits, where it takes the form of aggregated paired helical and straight filaments.
6 crotubule-binding protein tau assembled into paired helical and straight filaments.
7             Neurofibrillary lesions comprise paired helical and straight tau filaments, whereas tau f
8            We show that 4E tau adopts the AD paired helical filament (PHF) fold in the presence of th
9 n and intermolecular interactions leading to paired helical filament (PHF) formation.
10 isease (AD), immunohistochemistry of WT1 and paired helical filament (PHF) in serial sections was car
11                                          The paired helical filament (PHF) is the major component of
12  formation of amyloid fibrils displaying the paired helical filament (PHF) morphology characteristic
13     Ser 262 is phosphorylated extensively in paired helical filament (PHF) tau from Alzheimer's disea
14 elated positively with binding levels of the paired helical filament (PHF) tracer [(18)F]Flortaucipir
15 m the progressive pattern of neuropathology [paired helical filament (PHF)-tau and amyloid-beta] in A
16 r AV-1451 exhibits high binding affinity for paired helical filament (PHF)-tau pathology in Alzheimer
17                                              Paired helical filament (PHF)-tau, alpha-synuclein, and
18                                              Paired helical filament (PHF)/tau immunoreactive dystrop
19 a fragment of tau containing the aggregating paired helical filament (PHF6*).
20 idue amino-acid sequence, referred to as the paired helical filament 6 (PHF6), which may play an impo
21 te-specific PTMs located within the PHF6(*) (paired helical filament [PHF] residues 275-280) and PHF6
22 ide (Abeta) concentration, Abeta deposition, paired helical filament formation, cerebrovascular amylo
23 sociated protein, has not been implicated in paired helical filament formation.
24  nucleation and lead to filaments displaying paired helical filament morphology.
25 a tangle-like appearance that coevolves with paired helical filament pathology within neurons.
26 ur phosphospecific probes also revealed that paired helical filament preparations exhibited phospho-t
27 ognizing independent phospho-epitopes in the paired helical filament proteins (PHF) found in AD brain
28 portant roles in tau aggregation kinetics or paired helical filament structure.
29    Neuropathologic measures of amyloid-beta, paired helical filament tangles, neocortical Lewy bodies
30  with or without LOC was not associated with paired helical filament tangles, transactive response DN
31 ylated at the same amino acid residues as AD paired helical filament tau (PHFtau), but they exhibited
32 vasive analyses in cortical regions in which paired helical filament tau accumulation is expected in
33 vasive analyses in cortical regions in which paired helical filament tau accumulation is expected in
34 d in clinical studies) provides estimates of paired helical filament tau burden in good correlation w
35 d in clinical studies) provides estimates of paired helical filament tau burden in good correlation w
36 t analysis, Tau-nY29 detects soluble tau and paired helical filament tau from severely affected Alzhe
37 rol of the microRNA miR-128a, which can tune paired helical filament Tau levels in neurons.
38            The development of tau-PET allows paired helical filament tau pathology to be visualized i
39 a did not alter endogenous tau production or paired helical filament tau phosphorylation.
40 ripts of SORL1 and ABCA7 was associated with paired helical filament tau tangle density, and the expr
41 ific hallmarks of AD, namely, Abeta load and paired helical filament tau tangle density.
42              Amyloid load and the density of paired helical filament tau tangles were also quantified
43 inding to primary tauopathy in cases without paired helical filament tau was found to be within the r
44 e phosphorylation site consistently found in paired helical filament tau, serine 413, is modified by
45 global pathology score, and as amyloid load, paired helical filament tau-positive (PHFtau) tangle den
46 tic subtypes, as well as amyloid beta 42 and paired helical filament tau.
47 n have the deposition of Alzheimer's disease paired helical filament type hyperphosphorylated tau.
48 tau hyperphosphorylation further extended to paired helical filament-1 and TG3 epitopes.
49 was a significant decrease in the density of paired helical filament-1-positive neurons in the immuni
50 vidence for hyperphosphorylated tau protein (paired helical filament-I tau), which has been associate
51 aneously in physiological conditions to form paired helical filament-like fibres in vitro in the abse
52                    Full-length MAP-2c formed paired helical filament-like polymers.
53              We now describe the assembly of paired helical filament-like structures from MAP-2 polyp
54                                    Abeta and paired helical filament-tau were reduced (61.0% and 44.1
55 h wt mice, prominent inner retinal Abeta and paired helical filament-tau, and decreased retinal gangl
56 ain tau pathology in the form of tangles and paired helical filament-tau-containing neurites in Alzhe
57 adopt the same molecular structure as the AD paired-helical filament (PHF) tau but are unable to temp
58 pal (hilar subregion) amyloid plaque and tau paired-helical filament load, and microgliosis compared
59 nstrate that all Tau isoform fibrils exhibit paired-helical-filament-like structures consisting of tw
60 t et al reports that antibodies generated to paired helical filaments (AMY antibodies) unexpectedly l
61 bodies which recognize phosphorylated tau in paired helical filaments (AT8 and PHF-1) show positive i
62                                              Paired helical filaments (PHF) are abnormal, approximate
63                                              Paired helical filaments (PHF) composed of hyperphosphor
64                                          The paired helical filaments (PHF) formed by the intrinsical
65 gical aggregation and deposition of tau into paired helical filaments (PHF) in neurofibrillary tangle
66 hosphorylated and accumulates in the form of paired helical filaments (PHF) in the brains of patients
67                                              Paired helical filaments (PHF) occur in Alzheimer's dise
68  of several solvents to solubilize insoluble paired helical filaments (PHF) of Alzheimer disease.
69 orylation is implicated in the biogenesis of paired helical filaments (PHF) seen in Alzheimer's disea
70             The main type of aggregates, the paired helical filaments (PHF), incorporate about 20% of
71                             The formation of paired helical filaments (PHF), which are composed of hy
72                                              Paired helical filaments (PHFs) accumulate in the brains
73 drated tau 2-19 and collagen I and insoluble paired helical filaments (PHFs) and collagen I of weak h
74 an important contributor to the formation of paired helical filaments (PHFs) and neurofibrillary tang
75 ng of tau protein leads to the generation of paired helical filaments (PHFs) and neurofibrillary tang
76 generation of muscle fibers characterized by paired helical filaments (PHFs) composed of phosphorylat
77 s the neurofibrillary tangle, which contains paired helical filaments (PHFs) composed of the microtub
78         The use of these NPs to label native paired helical filaments (PHFs) from the postmortem brai
79 o determine if the high phosphate content of paired helical filaments (PHFs) in Alzheimer's disease (
80 llular inclusions that consist of aggregated paired helical filaments (PHFs) in neurons.
81 ion of human Alzheimer high-molecular-weight paired helical filaments (PHFs) in the dentate gyrus of
82                                              Paired helical filaments (PHFs) in the neurofibrillary t
83 rils are structurally closely related to the paired helical filaments (PHFs) isolated from Alzheimer'
84 lzheimer disease (AD) is the accumulation of paired helical filaments (PHFs) of hyperphosphorylated m
85                         The tight bundles of paired helical filaments (PHFs) of tau protein found in
86                   Tau protein assembles into paired helical filaments (PHFs) that constitute the neur
87 table aggregates leading to the formation of paired helical filaments (PHFs) which deposit into neuro
88  specific serine/threonine residues found in paired helical filaments (PHFs), and its expression is u
89                     Alzheimer's disease (AD) paired helical filaments (PHFs), building blocks of neur
90  that phosphorylated tau, like that found in paired helical filaments (PHFs), does not promote microt
91 rous neurons with neurofibrillary tangles of paired helical filaments (PHFs).
92 ough the repeat domain to form intraneuronal paired helical filaments (PHFs).
93 ontain aberrantly hyperphosphorylated Tau as paired helical filaments (PHFs).
94 y pathway and also enhance fibrillation into paired helical filaments (PHFs).
95 two distinct aggregates, amyloid fibrils and paired helical filaments (PHFs).
96 ents (SFs) in vitro, only the Tau MTBR forms paired helical filaments (PHFs).
97 cal tau conformation detectable in authentic paired helical filaments (PHFtau).
98 tion and vacuolated muscle fibers containing paired helical filaments and 6- to 10-nm fibrils, both r
99 mmunoelectron microscopy localized mainly to paired helical filaments and 6- to 10-nm filaments.
100 at in Alzheimer's disease, the copresence of paired helical filaments and Abeta-amyloidosis indicates
101 he formation and/or stabilization of NFT and paired helical filaments and provide a model system to i
102 ation of isolated tau filaments demonstrated paired helical filaments and ribbon-like structures.
103                 Assembly of tau protein into paired helical filaments and straight filaments is a key
104 ylated tau (P-tau) in the form of tangles of paired helical filaments and/or straight filaments is on
105 nd beta-amyloid precursor protein, and their paired helical filaments are composed of phosphorylated
106 idely regarded as the principal component of paired helical filaments comprising Alzheimer neurofibri
107 ly hyperphosphorylated tau polymers known as paired helical filaments constitute one of the major cha
108 angles in neuronal somata or axons, nor were paired helical filaments evident ultrastructurally.
109  recognition of the role of proteoglycans in paired helical filaments formation makes proteoglycans o
110 ments by a method used for the extraction of paired helical filaments from Alzheimer's disease brain.
111                                           No paired helical filaments have yet been observed in the h
112 hreonine(214), a tau epitope associated with paired helical filaments in AD patients.
113 ongly binds to tau lesions primarily made of paired helical filaments in Alzheimer brains (eg, intran
114 mentia through its deposition in the form of paired helical filaments in Alzheimer's disease neurofib
115 We document the first case of tauopathy with paired helical filaments in an aged chimpanzee (Pan trog
116 phosphorylated tau is the major component of paired helical filaments in neurofibrillary lesions asso
117  tau (microtubule-binding protein that forms paired helical filaments in neurons of the Alzheimer's d
118 s disease (AD) and accumulates as tangles of paired helical filaments in neurons undergoing degenerat
119                                     Although paired helical filaments in the form of neurofibrillary
120 eadily bound thioflavin-S, a dye that stains paired helical filaments in the histochemical diagnosis
121 ociated protein tau is found aggregated into paired helical filaments in the intraneuronal neurofibri
122 cytochemistry, including colocalization with paired helical filaments in the neuropil and perikarya.
123 ubule-associated protein tau aggregates into paired helical filaments in which each protofilament has
124 s dysfunction and aggregation into insoluble paired helical filaments is involved in the pathogenesis
125                  The aggregation of Tau into paired helical filaments is involved in the pathogenesis
126 lated tau adopt a fold comparable to that of paired helical filaments isolated from the brains of AD
127 otein tau that is the major component of the paired helical filaments observed in Alzheimer's disease
128     Tau PET has enabled the visualization of paired helical filaments of 3 or 4 C-terminal repeat tau
129 s of Alzheimer disease (AD), are composed of paired helical filaments of abnormally hyperphosphorylat
130                           We also found that paired helical filaments of aggregated and hyperphosphor
131  differ in diameter and periodicity from the paired helical filaments of Alzheimer disease.
132 cated tau (amino acid residues 297-391) into paired helical filaments of Alzheimer's disease or into
133 tern blots, similar to cross-linked tau from paired helical filaments of Alzheimer's disease.
134 ed, ribbon-like morphology distinct from the paired helical filaments of Alzheimer's disease.
135 of neuritic plaques (NPs) and from the 24 nm paired helical filaments of neurofibrillary tangles (NFT
136 tau is the major structural component of the paired helical filaments present in the brains of Alzhei
137 The introduction of PET ligands that bind to paired helical filaments provides the ability to measure
138 mbling straight filaments or Pronase-treated paired helical filaments raises fundamental questions co
139 nds pathological hyperphosphorylated tau and paired helical filaments tau directly but not non-phosph
140 were highly correlated with neuritic plaque, paired helical filaments tau neurofibrillary tangle and
141 SP), tau proteins assemble into straight and paired helical filaments that form intraneuronal deposit
142 nds microtubules, and self-assembles to form paired helical filaments that likely contribute to neuro
143 ormation of either sarkosyl-insoluble tau or paired helical filaments was not induced by Abeta42.
144 ed on both human AD brain homogenate and Tau-paired helical filaments were employed.
145 lary tangles consisted of tau-immunoreactive paired helical filaments with a diameter and helical per
146 otracers depicted tau inclusions composed of paired helical filaments with high specificity, both in
147 rmation and filament polarity orientation of paired helical filaments within tissue.
148 e-associated protein tau into fibers termed "paired helical filaments" (PHFs).
149 ulofilaments (previously shown, by us, to be paired helical filaments).
150 phorylated tau is the principal component of paired helical filaments, a pathological hallmark of Alz
151 , amyloid-beta immunoreactive filaments, and paired helical filaments, all of which are pathological
152 f AD include neurofibrillary tangles (NFTs), paired helical filaments, and amyloid plaques.
153                         They are composed of paired helical filaments, are labeled with antibodies th
154 curred on material in close proximity to the paired helical filaments, but never was on the paired he
155 ed to, but distinct from, the PTMs of mature paired helical filaments, consistent with the idea that
156 endent epitope of tau in Alzheimer's disease paired helical filaments, demonstrates positivity in the
157 n IBM muscle and AD brain phenotypes include paired helical filaments, hyperphosphorylated tau protei
158 rus neurons showed cytoplasmic inclusions of paired helical filaments, P-tau aggregates characteristi
159  specific Serine/Threonine residues found in paired helical filaments, suggesting its role in tauopat
160 onoclonal antibody Alz50 much like authentic paired helical filaments, suggesting that the conformati
161                   Tau proteins isolated from paired helical filaments, the major building blocks of A
162 demonstrates two novel components of the IBM paired helical filaments, which may lead to better under
163 ngle-associated epitopes and accumulation of paired helical filaments-(PHF-) like fibrils.
164  are major components of Alzheimer's disease paired helical filaments.
165  believed to play a role in the formation of paired helical filaments.
166 sitive inclusions, and structures resembling paired helical filaments.
167 cally by vacuolated muscle fibres containing paired helical filaments.
168  the dentate gyrus and midbrain demonstrated paired helical filaments.
169 poradic myositis was localized mainly to the paired helical filaments.
170 cally by vacuolated muscle fibers containing paired helical filaments.
171 l repeat region formed structures resembling paired helical filaments.
172 ired helical filaments, but never was on the paired helical filaments.
173 but may also play a role in the formation of paired helical filaments.
174 -sheet secondary folding of tau protein into paired helical filaments.
175 e-associated protein Tau forms intracellular paired helical filaments.
176 antibodies, and electron microscopy revealed paired helical filaments.
177 cytochemistry using antibodies against human paired helical filaments.
178  immuno-electron microscopy were confined to paired helical filaments.
179 main component of "plaques") and tau protein paired helical filaments/fibrils (the main component of
180                                              Paired-helical filaments (PHFs) are an important diagnos
181 osphorylated form, aggregates into insoluble paired-helical filaments (PHFs) in Alzheimer's disease (
182 angstrom structure of AD patient-derived tau paired-helical filaments bound to the PET ligand GTP-1.
183 , including hippocampal amyloid plaques, tau paired-helical filaments, neuronal loss and microgliosis
184 amorphous tufts adjacent to the muscle fiber paired-helical filaments.
185 rm a right-handed, double-stranded, and base-paired helical form.
186  with three microtubule-binding repeats form paired helical-like filaments under physiological condit
187 ons, where oxidation may contribute to final paired helical morphology, but is not a necessary prereq
188 synthetic straight filaments gradually adopt paired helical morphology.
189 onal cryo-EM density for flortaucipir for AD paired helical or straight filaments (PHFs or SFs), but
190  molecules stack in polar clefts between the paired helical protofilaments that pathologically define
191 n of pRNA for gp16 interaction was the 5'/3' paired helical region.
192 es, reflecting the presence of the same base paired helical regions and GNRA tetraloop in each.
193 and C634 to C651 and is composed of two base paired helical regions that flank a phylogenetically con
194 rils (21 supplements tested) and tau protein paired helical/straight filaments (13 supplements tested
195  of memory loss i.e. AB 1-42 fibrils and tau paired helical/straight filaments (major constituents of
196 pt AB 1-42 fibrils (range of 25-89%) and tau paired helical/straight filaments (range of 26-86%) at a
197 y support supplement effects on reducing tau paired helical/straight filaments (tau:memory supplement
198 egate/reduce AB 1-42 fibrils and tau protein paired helical/straight filaments as demonstrated by a v
199 to inhibit/reduce AB 1-42 fibrils and/or tau paired helical/straight filaments based on recent findin
200 d inhibiting AB 1-42 fibrils and tau protein paired helical/straight filaments in comparison to 17 ot
201 egate/reduce both AB 1-42 fibrils and/or tau paired helical/straight filaments.
202 use they form potentially informational base paired helical structures.
203 euron loss, intracytoplasmic tau aggregates, paired helical tau filaments, increased 4R tau messenger

 
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