ライフサイエンスコーパス: palmitoyltransferase

1 oxidation (acetylCoA carboxylase; carnitine-palmitoyltransferase).

2 f complex sphingolipids downstream of serine palmitoyltransferase.

3 enzyme in sphingolipid biosynthesis, serine palmitoyltransferase.

4 like myriocin FTY720 does not inhibit serine palmitoyltransferase.

5 des a posttranslational modification enzyme, palmitoyltransferase.

6 a functional human ortholog of the yeast Ras palmitoyltransferase.

7 HHC8, which encodes a putative transmembrane palmitoyltransferase.

8 ivities of both ceramide synthase and serine palmitoyltransferase.

9 srupted genes is ZDHHC8, which encodes for a palmitoyltransferase.

10 roteins shown recently in yeast to represent palmitoyltransferases.

11 esidues are replaced by glycine in carnitine palmitoyltransferases.

12 was associated with a decrease in carnitine palmitoyltransferase 1 (cPT1) and cPT2 levels.

13 The enzyme carnitine palmitoyltransferase 1 (CPT1), which is anchored in the

14 centrations are known to derepress carnitine palmitoyltransferase 1 (CPT1).

15 antigen) and the suppression of carnitine O-palmitoyltransferase 1 (Cpt1a) and acyl-CoA synthetase l

16 changes in ACSL1 (R(2) = 0.39) and carnitine palmitoyltransferase 1 (R(2) = 0.30) expressions (P < 0.

17 etyl coenzyme A carboxylase 2, and carnitine palmitoyltransferase 1 alpha) in both WT and ATGL KO mic

18 xidation through the inhibition of carnitine palmitoyltransferase 1 by its product malonyl-CoA.

19 acetyl-coenzyme A carboxylase and carnitine palmitoyltransferase 1 in the liver.

20 pogenic pool but diminution of the carnitine palmitoyltransferase 1 inhibitory pool under cold condit

21 o the PPAR response element on the carnitine palmitoyltransferase 1 promoter.

22 tor alpha and induction of hepatic carnitine palmitoyltransferase 1, suggesting increased energy meta

23 rough its allosteric inhibition of carnitine palmitoyltransferase 1, the enzyme that normally exerts

24 ion by stimulating the activity of carnitine palmitoyltransferase-1 (CPT-1) and inhibiting that of ac

25 In addition, carnitine palmitoyltransferase-1 (CPT-1) inhibitor up-regulated th

26 (LCFAs) into the mitochondria via carnitine palmitoyltransferase-1 (CPT-1) is inhibited by increased

27 Remarkably, 30 does not activate carnitine palmitoyltransferase-1 (CPT-1) nor induces in mice weigh

28 am effects including inhibition of carnitine palmitoyltransferase-1 (CPT-1) with resultant inhibition

29 hibits FAS activity and stimulates carnitine palmitoyltransferase-1 (CPT-1), consistent with its effe

30 Etomoxir, an inhibitor of carnitine O-palmitoyltransferase-1 (CPT-1), reversed the increased e

31 Carnitine palmitoyltransferase-1 (CPT1) is a rate-limiting step of

32 The enzyme carnitine palmitoyltransferase-1 (CPT1) regulates long-chain fatty

33 CoA is an established inhibitor of carnitine palmitoyltransferase-1 (CPT1), an outer mitochondrial me

34 , we targeted the liver isoform of carnitine palmitoyltransferase-1 (encoded by the CPT1A gene) by in

35 is and decrease in the activity of carnitine palmitoyltransferase-1 and total energy expenditure were

36 tment of mice for 4 weeks with the carnitine palmitoyltransferase-1 inhibitor, oxfenicine (150 mg/kg

37 umed diets containing 0.01% of the carnitine palmitoyltransferase-1 inhibitor, R-etomoxir, which prod

38 Using a skeletal muscle-specific carnitine palmitoyltransferase-1 KO model, we show that prolonged

39 Similarly, carnitine palmitoyltransferase-1 was inhibited after repetitive hy

40 atty acid oxidation such as Cpt-1 (carnitine palmitoyltransferase-1) as well as Pgc-1alpha are induce

41 Activity of carnitine palmitoyltransferase-1, a key enzyme controlling fatty a

42 potent inhibitor of mitochondrial carnitine palmitoyltransferase-1, a key enzyme involved in the mit

43 metabolic bottleneck downstream of carnitine palmitoyltransferase-1, a mitochondrial enzyme that cata

44 uced liver injury due to increased carnitine palmitoyltransferase-1, phosphorylated 5'AMP-activated p

45 of the IMP2 client mRNAs encoding carnitine palmitoyltransferase 1A (CPT1A) and peroxisome prolifera

46 In addition, a missense SNP in the carnitine palmitoyltransferase 1A (CPT1A) gene was associated with

47 98, and cg09737197) in intron 1 of carnitine palmitoyltransferase 1A (CPT1A) were strongly associated

48 itochondrial fatty acid transport, carnitine palmitoyltransferase 1A (CPT1A), as a direct HIF target

49 We found that carnitine palmitoyltransferase 1A (CPT1A), the rate-limiting enzym

50 yl-CoA levels and desinhibition of carnitine palmitoyltransferase 1A (CPT1A), which increases mitocho

51 resulted in reduced expression of carnitine palmitoyltransferase 1A (CPT1A), which is a key mitochon

52 Surprisingly, the inhibition of carnitine palmitoyltransferase 1a (CPT1a), which is elevated in MD

53 ssion of the beta-oxidation enzyme carnitine palmitoyltransferase 1A (CPT1A).

54 down-regulated the mRNA levels of carnitine palmitoyltransferase 1A (in beta-oxidation) and mitochon

55 ransmembrane domain 2 (TM2) of rat carnitine palmitoyltransferase 1A (rCPT1A), to elucidate the role

56 metabolic inputs is underpinned by carnitine palmitoyltransferase 1A and adenosine tri-phosphate citr

57 genes acyl coenzyme A oxidase and carnitine palmitoyltransferase 1A in livers of alcohol-fed MCP-1KO

58 pyruvate carboxykinase and CPT-1a (carnitine palmitoyltransferase 1a) genes.

59 CPT1a (carnitine palmitoyltransferase 1a) in the liver mitochondrial oute

60 ng carnitine O-octaniltransferase, carnitine palmitoyltransferase 1A, hydroxyacyl-CoA-dehydrogenase,

61 lesterol and altered expression of carnitine palmitoyltransferase 1a, sterol regulatory element-bindi

62 of-function experiments identified carnitine palmitoyltransferase -1a (CPT1a), a key regulator of the

63 574958 DNA methylation site at the carnitine palmitoyltransferase-1A (CPT1A) gene to be associated wi

64 ted receptor-gamma (PPARgamma) and carnitine palmitoyltransferase 1alpha (CPT1alpha).

65 1alpha, uncoupling protein 1, and carnitine palmitoyltransferase 1alpha, were increased by EPO but i

66 eletal muscle-specific deletion of carnitine palmitoyltransferase 1b (Cpt1b(M-/-)), which limits mito

67 trix, which requires the action of carnitine palmitoyltransferase 1B (CPT1B) in striated muscle and B

68 oA with simultaneous inhibition of carnitine palmitoyltransferase 1b and 2) catalyze the palmitoyl-Co

69 cids (BCAA) and fatty acids (e.g., carnitine palmitoyltransferase 1B).

70 effects, coupled with an increased carnitine palmitoyltransferase 1b, led to increased fatty acid oxi

71 r glucose oxidation and suppresses carnitine palmitoyltransferase-1B (CPT-1B), a key enzyme in fatty

72 Transcriptional regulation of carnitine palmitoyltransferase-1beta (CPT-1beta) is coordinated wi

73 The brain-specific isoform carnitine palmitoyltransferase 1C (CPT1C) has been implicated in t

74 We demonstrate in HeLa cells that carnitine palmitoyltransferase 1C (CPT1C) senses malonyl-CoA and e

75 nstituents of the AMPAR complex is carnitine palmitoyltransferase 1C (CPT1C), a brain-specific isofor

76 2:0, an index for the diagnosis of carnitine palmitoyltransferase 2 (CPT2) deficiency, was independen

77 resistant TNBC cells had increased carnitine palmitoyltransferase 2 (CPT2) protein and CPT1 activity

78 l long-chain fatty acid oxidation, carnitine palmitoyltransferase 2 (CPT2), on muscle and heart struc

79 ncapable of FAO due to the loss of carnitine palmitoyltransferase 2, the product of an obligate gene

80 nockdowns affecting either subunit of serine palmitoyltransferase, a key enzyme in ceramide and sphin

81 Inactivation of serine palmitoyltransferase, a key enzyme in generating endogen

82 ubstrate specificity of virus-encoded serine palmitoyltransferase, a key enzyme of sphingolipid biosy

83 olipids, apparently via modulation of serine palmitoyltransferase, a rate-limiting enzyme in de novo

84 otected from diet-induced increase in serine palmitoyltransferase, acid sphingomyelinase, and neutral

85 -beta-cyclodextrin resulted in inhibition of palmitoyltransferase activity and a redistribution of th

86 at associates with increased monocyte serine palmitoyltransferase activity and chemotaxis toward infl

87 This effect required palmitoyltransferase activity and was abolished if the p

88 e mutations are dominant and decrease serine palmitoyltransferase activity by 50% when the wild-type

89 r ultraviolet B irradiation), whereas serine palmitoyltransferase activity did not change.

90 herefore of interest to determine if protein palmitoyltransferase activity is also present in these d

91 We propose that control of palmitoyltransferase activity levels provides a fundamen

92 delays meiotic entry, while increasing Erf2 palmitoyltransferase activity triggers aberrant meiosis

93 In this study, protein palmitoyltransferase activity, assayed using G-protein a

94 Cycloserine, an inhibitor that blocks serine palmitoyltransferase activity, lowered both sphingosine

95 elin) are reduced secondary to absent serine palmitoyltransferase activity.

96 ne of Saccharomyces cerevisiae reduce serine palmitoyltransferase activity.

97 oxoamine synthase family required for serine palmitoyltransferase activity.

98 c3 mutant cells have severely reduced serine palmitoyltransferase activity.

99 f Tyr(164) to Phe in SPTLC1 increased serine palmitoyltransferase activity.

100 ation, and analyses of the Toxoplasma serine palmitoyltransferase, an enzyme catalyzing the first and

101 ORMDL proteins are key regulators of serine palmitoyltransferase, an enzyme catalyzing the initial s

102 [(3)H]palmitate, a substrate for both serine palmitoyltransferase and ceramide synthase, into C16-cer

103 f [3H]palmitate, a substrate for both serine palmitoyltransferase and ceramide synthase, into C16-cer

104 , specific inhibitors of key enzymes (serine palmitoyltransferase and dihydroceramide synthase, respe

105 ctivity (over 2-fold, p = 0.01); both serine palmitoyltransferase and glucosylceramide synthase activ

106 in obese Zucker rat hearts, muscle carnitine palmitoyltransferase and medium-chain acyl-CoA dehydroge

107 ingosine bypasses the requirement for serine palmitoyltransferase and restores proteolysis.

108 tion that is installed by the DHHC family of palmitoyltransferases and is reversed by several acyl pr

109 se results suggest a novel mechanism whereby palmitoyltransferases and nuclear import receptors both

110 ion through the de novo pathway (e.g. serine palmitoyltransferase) and via the hydrolysis of sphingom

111 pid biosynthetic pathway (mediated by serine palmitoyltransferase), and at least regulated, de novo s

112 ell cortex, an effect partly mediated by the palmitoyltransferase Approximated under the control of F

113 These results implicate serine palmitoyltransferase as the enzyme controlling de novo c

114 n and highlight individual thioesterases and palmitoyltransferases as potential targets to modulate N

115 identified Approximated (App), a DHHC domain palmitoyltransferase, as a negative regulator of Fat sig

116 yltransferases, DHHC17 is the major ClipR-59 palmitoyltransferase, as evidenced by the fact that DHHC

117 ify Swf1, a member of the DHHC-CDR family of palmitoyltransferases, as the protein responsible for mo

118 ntracellular proteins is mediated by protein palmitoyltransferases belonging to the DHHC family, whic

119 ate sphingolipid synthesis by binding serine palmitoyltransferase, but its role in inflammation is in

120 es express two active but distinct carnitine palmitoyltransferases: carnitine palmitoyltransferase I

121 DHHC palmitoyltransferases catalyze the addition of the fatty

122 nown as the alpha-oxoamine synthases, serine palmitoyltransferase catalyzes the committed step of sph

123 oline octanoyltransferase (ChOT) and choline palmitoyltransferase (ChPT).

124 membrane, and this localization requires the palmitoyltransferase complex Erf2-Erf4.

125 Carnitine palmitoyltransferase (CPT) 1A adopts a polytopic conform

126 Carnitine palmitoyltransferase (CPT) I catalyzes the conversion of

127 Depletion of carnitine palmitoyltransferase (CPT)2 activity through pharmacolog

128 altered lipid metabolism and that carnitine palmitoyltransferases (CPT) have a major role in transpo

129 lic channeling of acyl-CoA through carnitine palmitoyltransferases (CPT-1/2) and attenuated the palmi

130 hibited hypothalamic expression of carnitine palmitoyltransferase (CPT1a and CPT1c) and pyruvate dehy

131 the T(3) induction of the Pdk4 and carnitine palmitoyltransferase (Cpt1a) genes.

132 ported that T(3) induces genes for carnitine palmitoyltransferase (cpt1a), pyruvate dehydrogenase kin

133 Additionally, cancer mutations in palmitoyltransferases decrease MCAM palmitoylation and h

134 rine, and 4-HPR transiently activated serine palmitoyltransferase, demonstrating that 4-HPR induced d

135 We found that, among 23 mammalian DHHC palmitoyltransferases, DHHC17 is the major ClipR-59 palm

136 ic, signal-regulated palmitate turnover; the palmitoyltransferase DHHC2 mediates de novo and turnover

137 ivity was enhanced by co-expression with the palmitoyltransferase DHHC2 that also co-immunoprecipitat

138 palmitoylation, by either knocking down the palmitoyltransferase DHHC20 or expressing a palmitoylati

139 In this study, we show that the protein palmitoyltransferase DHHC3 is upregulated in malignant a

140 we identify a functional network connecting palmitoyltransferases DHHC5/8 with ankyrin-G, ankyrin-G

141 palmitoylating enzyme by screening all known palmitoyltransferases (DHHCs).

142 roduction of the enzymatically active ZDHHC8 palmitoyltransferase encoded by a gene in the 22q11.2 lo

143 d N-Ras are palmitoylated by a human protein palmitoyltransferase encoded by the ZDHHC9 and GCP16 gen

144 s deleted for the PhoPQ-regulated OM lipid A palmitoyltransferase enzyme, PagP.

145 demonstrates that one subunit of the serine palmitoyltransferase enzyme, SPTLC1, but not subunit 2 (

146 Indeed, co-expression of palmitoyltransferase enzymes promoted the aggregation of

147 Although changes in palmitoyltransferase expression are associated with vari

148 ogenic responses in mice with reduced serine palmitoyltransferase expression.

149 Thus, palmitoyltransferase facilitates the enrichment of fatty

150 Knowledge about the DHHC palmitoyltransferase family is still limited.

151 ipid modification mediated by members of the palmitoyltransferase family, serves as an important memb

152 are the first genes identified that encode a palmitoyltransferase for a Ras GTPase.

153 L-serine, the mutant HSAN1-associated serine palmitoyltransferase generates deoxysphingolipids, which

154 e the putative homologues of giardial serine palmitoyltransferase (gSPT) subunit genes (gspt-1 and -2

155 oforms of the small subunits of human serine palmitoyltransferase (hssSPTs) that activate the catalyt

156 n unbiased genetic screen, we identified the palmitoyltransferase Huntingtin interacting protein 14 (

157 nsduced with adenoviruses encoding carnitine palmitoyltransferase I (CPT I) isoforms or beta-galactos

158 bitor of the two known isoforms of carnitine palmitoyltransferase I (CPT I), which control mitochondr

159 Carnitine palmitoyltransferase I (CPT-I) catalyzes the rate-contro

160 Carnitine palmitoyltransferase I (CPT-I) catalyzes the transfer of

161 Carnitine palmitoyltransferase I (CPTI) catalyzes the conversion o

162 t carnitine palmitoyltransferases: carnitine palmitoyltransferase I (CPTI), which is malonyl coA-sens

163 deletion mutants of rat liver-type carnitine palmitoyltransferase I (L-CPT I) expressed in Pichia pas

164 ession of the gene encoding muscle carnitine palmitoyltransferase I (M-CPT I), an enzyme involved in

165 cumulation of mRNA encoding muscle carnitine palmitoyltransferase I (M-CPT I), an enzyme that catalyz

166 eart, but the liver isoform (liver carnitine palmitoyltransferase I [L-CPT1]) is elevated in hearts w

167 ithout affecting the activities of carnitine palmitoyltransferase I and II.

168 Muscle carnitine palmitoyltransferase I is predominant in the heart, but

169 ward increased expression of the L-carnitine palmitoyltransferase I isoform.

170 fatty acids into mitochondria via carnitine palmitoyltransferase I relative to overall oxidative rat

171 lic acid cycle rates, flux through carnitine palmitoyltransferase I was 23% lower in hypertrophied (P

172 CPT1 infusion (P<0.05), but muscle carnitine palmitoyltransferase I was unaffected.

173 hout (-) etomoxir (an inhibitor of carnitine palmitoyltransferase I).

174 xidation through the inhibition of carnitine palmitoyltransferase I, a mitochondrial component of the

175 receptor alpha target, muscle-type carnitine palmitoyltransferase I, providing a second mechanism by

176 ty acid oxidation in mitochondria, carnitine palmitoyltransferase I; and by reduction of superoxide l

177 Carnitine palmitoyltransferase-I (CPT-I) catalyzes the rate-contro

178 treatment of fasting rats with the carnitine palmitoyltransferase-I (CPT-I) inhibitor reduced the liv

179 enous, and allosteric inhibitor of carnitine palmitoyltransferase-I (CPT-I), a key enzyme for mitocho

180 coverage for the membrane proteins carnitine palmitoyltransferase-I (CPT-I), long-chain acyl-CoA synt

181 Hepatic carnitine palmitoyltransferase-I (CPT-IL) isolated from mitochondr

182 sponses to fasting are maintained; carnitine palmitoyltransferase-I induction and glucose levels are

183 sion of enzymes of fat catabolism (carnitine palmitoyltransferase-I, acyl-CoA oxidase, and uncoupling

184 Finally, knockdown of carnitine palmitoyltransferase IA in an AML patient-derived xenogr

185 differentiation factor 15), CPT1B (carnitine palmitoyltransferase IB)-protein and oral anticoagulatio

186 of the 5'-flanking sequence of the carnitine palmitoyltransferase Ibeta (CPT-Ibeta) gene defines regu

187 utionarily related to the prokaryotic serine palmitoyltransferase, identified in the Sphingomonadacea

188 ensitive and detergent-labile; and carnitine palmitoyltransferase II (CPTII), which is malonyl coA-in

189 Biallelic mutations in CPT2 cause carnitine palmitoyltransferase II deficiency, sometimes associated

190 lated RAW264.7 cells (and mutation of serine palmitoyltransferase in CHO-LYB cells); furthermore, an

191 e novo sphingoid base biosynthesis by serine palmitoyltransferase in the transient G0/G1 arrest media

192 Recent reports of protein palmitoyltransferases in Saccharomyces cerevisiae and Dr

193 ase renders mutant cells sensitive to serine palmitoyltransferase inhibition due to impaired sphingoi

194 armacologically through exposure to a serine palmitoyltransferase inhibitor (myriocin) show strongly

195 The serine palmitoyltransferase inhibitor myriocin reversed these d

196 kdown, ORMDL3 overexpression, and the serine palmitoyltransferase inhibitor myriocin.

197 In all eukaryotes analyzed to date, serine palmitoyltransferase is a highly conserved heterodimeric

198 synthases are soluble homodimers, but serine palmitoyltransferase is a membrane-associated enzyme com

199 We also show that serine palmitoyltransferase is an Lcb1p small middle dotLcb2p h

200 Ser palmitoyltransferase is essential for plant viability.

201 Modeling studies suggest that serine palmitoyltransferase is likely to have a single active s

202 e that the gene encoding a subunit of serine palmitoyltransferase is located within the HSN1 locus, e

203 itoylation of a cysteine residue by the Akr1 palmitoyltransferase is required both for the switch of

204 esult suggests that the activation of serine palmitoyltransferase is the event responsible for increa

205 which harbors a temperature-sensitive serine palmitoyltransferase, lacked increased de novo generated

206 logue to be a functional, homodimeric serine palmitoyltransferase localized to the endoplasmic reticu

207 ow Swf1p, a member of the DHHC-CRD family of palmitoyltransferases, localizes to actin cables and cor

208 ide, through the rate-limiting enzyme serine palmitoyltransferase long chain (Sptlc)-2, is required f

209 ed that the ER-resident human protein serine palmitoyltransferase long chain-1 (SPTLC1), which is the

210 enzyme of de novo ceramide synthesis, serine palmitoyltransferase long-chain base subunit 1 (SPTLC1)/

211 europathies are dominant mutations in serine palmitoyltransferase, long chain base subunit 1 (SPTLC1)

212 ne was identified as SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1.

213 crease in the message and activity of serine palmitoyltransferase (P < 0.05).

214 a lipid A 3-O-deacylase, PagL, and a lipid A palmitoyltransferase, PagP.

215 Palmitoyltransferase (PAT) catalyses protein S-palmitoyl

216 Protein palmitoyltransferases (PATs) represent an exciting new t

217 Protein S-acyltransferases, also known as palmitoyltransferases (PATs), are characterized by the p

218 Overexpression of the palmitoyltransferase Pfa4 DHHA or DHHR mutants also resu

219 re we show that the Saccharomyces cerevisiae palmitoyltransferase Pfa4 enhanced heterochromatin forma

220 the FWC signature, which is palmitoylated by palmitoyltransferase Pfa4.

221 Study describes how a palmitoyltransferase regulates the Hippo pathway in flie

222 istidine-cysteine 5/8 (DHHC5/8) as ankyrin-G palmitoyltransferases required for ankyrin-G lateral mem

223 interaction between Orm1 and Orm2 and serine palmitoyltransferase, responsible for the first committe

224 n ZDHHC8 knockout mice deficient in a PSD-95 palmitoyltransferase, results in increased PSD-95 nitros

225 , and ISP-1, myriocin an inhibitor of serine palmitoyltransferase, significantly attenuated the ultra

226 nd and activated the gene promoter of serine palmitoyltransferase small subunit A (SPTSSA), which enc

227 The relationship between serine palmitoyltransferase (SPT) activity and ORMDL regulation

228 sors and intermediates, and increased serine palmitoyltransferase (SPT) and fatty acid (FA) elongase

229 Serine palmitoyltransferase (SPT) catalyses the de novo biosynt

230 Serine palmitoyltransferase (SPT) catalyzes the first committed

231 Serine palmitoyltransferase (SPT) catalyzes the first step in s

232 Serine palmitoyltransferase (SPT) catalyzes the first step in s

233 Serine palmitoyltransferase (SPT) catalyzes the first step of s

234 The enzyme serine palmitoyltransferase (SPT) catalyzes the formation of th

235 Mutations in the SPTLC1 subunit of serine palmitoyltransferase (SPT) cause an adult-onset, heredit

236 ry neuropathy due to mutations in the serine palmitoyltransferase (SPT) enzyme.

237 Serine palmitoyltransferase (SPT) is a key enzyme in the first

238 Serine palmitoyltransferase (SPT) is the first and rate-limitin

239 Serine palmitoyltransferase (SPT) is the first rate-limiting en

240 Serine palmitoyltransferase (SPT) is the key enzyme in SM biosy

241 The LCB chain length is determined by serine palmitoyltransferase (SPT) isoenzymes, which are trimeri

242 we utilized two models: heterozygous serine palmitoyltransferase (SPT) subunit 2 (Sptlc2) gene knock

243 id-like proteins (ORMs) interact with serine palmitoyltransferase (SPT) to negatively regulate sphing

244 l-5'-phosphate (PLP)-dependent enzyme serine palmitoyltransferase (SPT) which is a promising therapeu

245 ion of alanine with palmitoyl-CoA via serine palmitoyltransferase (SPT), as indicated by incorporatio

246 1 gene, encoding the Lcb1p subunit of serine palmitoyltransferase (SPT), cause hereditary sensory neu

247 Serine palmitoyltransferase (SPT), composed of LCB1 and LCB2 su

248 either L-cycloserine, an inhibitor of serine palmitoyltransferase (SPT), or fumonisin B(1), an inhibi

249 eled with [14C]serine, a substrate of serine palmitoyltransferase (SPT), the enzyme catalyzing the in

250 base 1 (LCB1), one of two subunits of serine palmitoyltransferase (SPT), the enzyme catalyzing the in

251 rectly alter the in vitro activity of serine palmitoyltransferase (SPT), the enzyme responsible for i

252 the ehv050 gene predicted to encode a serine palmitoyltransferase (SPT), the first and rate-limiting

253 crease in LCB levels, indicating that serine palmitoyltransferase (SPT), the first and rate-limiting

254 ciated with changes in mRNA levels of serine palmitoyltransferase (SPT), the rate-limiting enzyme in

255 SPTLC1 encodes one subunit of serine palmitoyltransferase (SPT), the rate-limiting enzyme in

256 sis in Leishmania, we have focused on serine palmitoyltransferase (SPT), which catalyses the first, r

257 osynthesis is initiated by the enzyme serine palmitoyltransferase (SPT), which resides in the endopla

258 phingolipid synthesis is catalyzed by serine palmitoyltransferase (SPT).

259 ing 2 of the 3 subunits of the enzyme serine palmitoyltransferase (SPT).

260 from mutations in the LCB1 subunit of serine palmitoyltransferase (SPT).

261 catalyzed by the PLP-dependent enzyme serine palmitoyltransferase (SPT).

262 nthesis of sphingolipids catalyzed by serine palmitoyltransferase (SPT).

263 uced by the activity of virus-encoded serine palmitoyltransferase (SPT).

264 riant in SPTLC1 encoding a subunit of serine palmitoyltransferase (SPT).

265 s are claimed to be inhibitors of the serine palmitoyltransferase (SPT).

266 lipids are 2-amino, 1,3-diols made by serine palmitoyltransferase (SPT).

267 sphingolipids that are formed by the serine-palmitoyltransferase (SPT).

268 nt reaction is mediated by the enzyme serine-palmitoyltransferase (SPT).

269 catalysed by the PLP-dependent enzyme serine palmitoyltransferase (SPT; EC 2.3.1.50), which is a memb

270 Lcb1p subunit of yeast and mammalian serine palmitoyltransferases (SPT) were investigated.

271 osomatid protozoan Leishmania lacking serine palmitoyltransferase (spt2-) and SLs grow well, although

272 f the key de novo biosynthetic enzyme serine palmitoyltransferase subunit 2 (SPT2).

273 t that HSAN-I-associated mutations in serine palmitoyltransferase subunit SPTLC2 dampened human T cel

274 To determine which palmitoyltransferases (termed DHHCs) regulate the channe

275 s recently been shown to be an ER-associated palmitoyltransferase that can palmitoylate Cys-318 of Ra

276 TSSA), which encodes a subunit of the serine palmitoyltransferase that catalyzes the first and rate-l

277 ZDHHC9 is a palmitoyltransferase that catalyzes the posttranslationa

278 Furthermore, now that the first palmitoyltransferase that causes mental retardation has

279 We suggest that DHHC17 is a ClipR-59 palmitoyltransferase that modulates ClipR-59 plasma memb

280 Furthermore, we identify several zDHHC palmitoyltransferases that influence NMNAT2 palmitoylati

281 ocin (50 nm), a specific inhibitor of serine palmitoyltransferase (the first step in de novo synthesi

282 tlc1 Sptlc1 is an obligate subunit of serine palmitoyltransferase, the enzyme responsible for the fir

283 is that form a conserved complex with serine palmitoyltransferase, the first and rate-limiting enzyme

284 reduced by myriocin, an inhibitor of serine palmitoyltransferase, the first committed step in de nov

285 We therefore inactivated serine palmitoyltransferase, the first enzyme in the sphingolip

286 with myriocin, a potent inhibitor of serine palmitoyltransferase, the rate-limiting enzyme in SM bio

287 igation using a labeled substrate for serine palmitoyltransferase, the rate-limiting enzyme in the pa

288 Nogo-B inhibits serine palmitoyltransferase, the rate-limiting enzyme of the de

289 se, but not by ISP-1, an inhibitor of serine palmitoyltransferase, the rate-limiting step in the de n

290 golipids are produced when the enzyme serine palmitoyltransferase uses l-alanine instead of l-serine

291 multiple cognate substrates of a single Erf2 palmitoyltransferase, we demonstrate that control of Erf

292 deletion mutant of BF2461, a putative serine palmitoyltransferase whose yeast homolog catalyzes the c

293 Nogo-B, pharmacological inhibition of serine palmitoyltransferase with myriocin reinstates endothelia

294 n, we have examined all known mammalian DHHC palmitoyltransferases with respect to their ability to p

295 S. pombe erf2 (sp-erf2), encoding sp-Erf2, a palmitoyltransferase, with various activities.

296 d by a subset of Golgi zinc finger DHHC-type palmitoyltransferase (zDHHC) enzymes, particularly zDHHC

297 smic reticulum, is controlled by an upstream palmitoyltransferase, ZDHHC16, revealing the first palmi

298 We identified palmitoyltransferase ZDHHC3 (DHHC3) as the main acetyltr

299 rsion of this Article originally published, 'palmitoyltransferase ZDHHC3 (DHHC3)' was incorrectly ref

300 diated by zinc finger DHHC domain-containing palmitoyltransferases (ZDHHCs), but which members of thi