ライフサイエンスコーパス: pancreatic fistula

1 pancreas is a risk factor for postoperative pancreatic fistula.

2 validate the ISGPF classification scheme for pancreatic fistula.

3 haematoma, 10 had an abscess, and five had a pancreatic fistula.

4 g factor in the development of postoperative pancreatic fistula.

5 ained group, 11 patients (12.5%) developed a pancreatic fistula.

6 of complications or a decreased incidence of pancreatic fistula.

7 r audits, especially regarding postoperative pancreatic fistula.

8 C patients with a high risk of postoperative pancreatic fistula.

9 morbidity and mortality, including rates of pancreatic fistula.

10 reases the occurrence of clinically relevant pancreatic fistula.

11 dpoint was clinically relevant postoperative pancreatic fistula.

12 ine secretions and may prevent postoperative pancreatic fistula.

13 ding to the International Study Group on the Pancreatic Fistula.

14 cathepsin B, independent of the presence of pancreatic fistulas.

15 morbidity (36% vs 63%) and no postoperative pancreatic fistulas.

16 vated and predictive for clinically relevant pancreatic fistulas.

17 .12-0.76; P = .03) and reduced the number of pancreatic fistulas (10% vs 70%; RD, 0.60; 95% CI, 0.17-

18 being early delayed gastric emptying (19%), pancreatic fistula (14%), and wound infection (10%).

19 7%; P = 0.01), and lower rates of grade >/=3 pancreatic fistula (16% vs 20%; P = 0.05).

20 ference in clinically relevant postoperative pancreatic fistula (18% vs 12%, P = 0.11) or mortality (

21 in part to a significantly increased rate of pancreatic fistulas (18.4% PI versus 8.5% NI, P < 0.001)

22 cations (15 [21%] vs 19 [15%], P = 0.24) and pancreatic fistulas (20 [28%] vs 41 [32%], P = 0.62) wer

23 .01), but worse surgical results with higher pancreatic fistula (21.1% vs 14.6%; P < 0.01) and mortal

24 Furthermore, both postoperative pancreatic fistula (35% vs. 18%; P<0.001) and delayed ga

25 e new-onset insulin-dependent diabetes (8%), pancreatic fistula (5%), intraabdominal abscess (4%), sm

26 3.3% [P < .001], respectively), incidence of pancreatic fistula after 40 cases (27.5% vs 14.4%; P = .

27 er drainage as first intervention for severe pancreatic fistula after pancreatoduodenectomy was assoc

28 d with relaparotomy as primary treatment for pancreatic fistula after pancreatoduodenectomy.

29 tality and reduced the rate of postoperative pancreatic fistula after resection in patients with (bor

30 egarding the relative risks of mortality and pancreatic fistula after these procedures.

31 ations including intra-abdominal abscess and pancreatic fistula (all P < 0.02).

32 Biochemical evidence of pancreatic fistula alone has no clinical consequence and

33 rates of early delayed gastric emptying and pancreatic fistula and a significantly longer mean posto

34 revealed early removal had reduced odds for pancreatic fistula and death or serious morbidity compar

35 Pancreatic fistula and FC are common after DP.

36 ped or worsened a previous diabetes, 24% had pancreatic fistula and one parietal hernia.

37 Postoperative pancreatic fistula and postpancreatectomy hemorrhage had

38 Interventions focusing on postoperative pancreatic fistula and postpancreatectomy hemorrhage may

39 mortality, clinically relevant postoperative pancreatic fistula and wound infection, length of stay,

40 s still occur (eg, delayed gastric emptying, pancreatic fistula, and biliary strictures).

41 argin positivity, incidence of postoperative pancreatic fistula, and mortality.

42 carcinoma (PDAC) when risks of postoperative pancreatic fistula are well identified.

43 Pancreatic fistulas are the most common source of periop

44 Postoperative pancreatic fistula at the early stage can lead to auto-d

45 istics and management approaches for grade B pancreatic fistula (B-POPF) and investigate whether it s

46 GPF has proposed a classification scheme for pancreatic fistula based on clinical parameters; yet it

47 was defined by the absence of postoperative pancreatic fistula, bile leak, postpancreatectomy hemorr

48 erative length of hospital stay and rates of pancreatic fistula, blood transfusion, and readmission w

49 PPFCs associated with pancreatic fistula carry a greater risk for pancreas gra

50 First intervention for pancreatic fistula: catheter drainage or relaparotomy.

51 PF (ISGPF [The International Study Group on Pancreatic Fistula] classification Grade B or C) occurre

52 Pancreatic fistula continues to be a major cause of post

53 ncrease the incidence of clinically relevant pancreatic fistula (CR-POPF) compared with OPD.

54 Clinically relevant pancreatic fistula (CR-POPF) following distal pancreatec

55 ed with reduced rates of clinically relevant pancreatic fistula (CR-POPF)-the most common and morbid

56 develop a clinically relevant post-operative pancreatic fistula (CR-POPF).

57 d rates of clinically relevant postoperative pancreatic fistula (CR-POPF).

58 complication after PD - clinically relevant pancreatic fistula (CR-POPF).

59 n expected when International Study Group on Pancreatic Fistula criteria were strictly applied, altho

60 PF according to International Study Group on Pancreatic Fistula criteria.

61 s that RPD is noninferior to OPD in terms of pancreatic fistula development and other major postopera

62 ong all variables, the rate of postoperative pancreatic fistula differed the most: North America 9.8%

63 ancreatic fluid collection (PFC) or external pancreatic fistula (EPF).

64 s, such as clinically relevant postoperative pancreatic fistula, especially when performed near the m

65 The relationship between pancreatic fistula, FC, and surgical drain placement rem

66 From this large analysis of pancreatic fistula following DP, CR-POPF occurrence cann

67 This analysis of pancreatic fistulas following pancreatoduodenectomy demo

68 l injury and increased risk of postoperative pancreatic fistula formation.

69 significant PF (International Study Group on Pancreatic Fistula Grade B or C) and hospital-related in

70 e mortality and International Study Group on Pancreatic Fistula grade B/C postoperative pancreatic fi

71 , conversion to open rate, and postoperative pancreatic fistula grade B/C.

72 The International Study Group on Pancreatic Fistula grade C fistula rate was 4%.

73 Postoperative pancreatic fistulas grade B/C were seen in 39% after MID

74 al site infection 6.3% (n=40), postoperative pancreatic fistula (grade B/C) 26.9% (n=171), and 30-day

75 lications was 44.4% (n = 122), postoperative pancreatic fistula (grade B/C) rate 23.6% (n = 65), 90-d

76 lications was 44.4% (n = 122), postoperative pancreatic fistula (grade B/C) rate 23.6% (n = 65), 90-d

77 Secondary endpoints were clinically relevant pancreatic fistula (grade B/C), mortality, morbidity, an

78 Clinically relevant pancreatic fistula (grade B/C: drain 11.9%, no-drain 5.7

79 ver, its impact on major outcomes, including pancreatic fistula, has yet to be adequately compared wi

80 ata suggest that patients with postoperative pancreatic fistula have (1) increased pancreatic fat and

81 loss, and clinically relevant postoperative pancreatic fistula improved early in the experience and

82 embolisms in 2 patients and hemorrhage after pancreatic fistula in 1 patient).

83 d with early graft pancreatitis in 18 (50%), pancreatic fistula in 20 (56%, 9 with obvious duodenal s

84 than 24%, clinically relevant postoperative pancreatic fistula in 7.8%, 30- and 90-day mortality wer

85 four reported significantly lowered rates of pancreatic fistula in patients receiving prophylactic oc

86 icantly reduces the incidence of significant pancreatic fistula in patients undergoing left pancreate

87 significant lower incidence of postoperative pancreatic fistula in patients who received preoperative

88 Factors associated with postoperative pancreatic fistula include a soft pancreas, a small panc

89 Postoperative pancreatic fistula is a major contributor to complicatio

90 Postoperative pancreatic fistula is a potentially life-threatening com

91 n system of the International Study Group of Pancreatic Fistula (ISGPF) lacks prognostic capacity reg

92 cations (Clavien-Dindo>=3), (3)postoperative pancreatic fistula (ISGPS grade B/C), (4)reoperation, (5

93 The primary end point was the development of pancreatic fistula, leak, or abscess of grade 3 or highe

94 The rate of grade 3 or higher postoperative pancreatic fistula, leak, or abscess was significantly l

95 rate of clinically significant postoperative pancreatic fistula, leak, or abscess.

96 For postoperative pancreatic fistula, no break point could be estimated.

97 my (16%) were the most common procedures and pancreatic fistula occurred in 18% of patients.

98 Grade B/C postoperative pancreatic fistula occurred in 34% of patients, requirin

99 A persistent pancreatic fistula occurred in 66 of the 79 patients (84

100 Pancreatic fistulas occurred more frequently after enucl

101 rval, 1.36-6.79; p < 0.05) and postoperative pancreatic fistula (odds ratio, 2.78; 95% confidence int

102 nfidence interval, 2.31-49.75; p < 0.05) and pancreatic fistula (odds ratio, 6.531; 95% confidence in

103 tive complications (ODP, 50%; MIDP, 39%) and pancreatic fistula (ODP, 29%; MIDP, 21%).

104 octreotide does not reduce the incidence of pancreatic fistula or total complications after pancreat

105 Older age (OR-1.07), grade B/C pancreatic fistula (OR-3.84), and epidural use (OR-3.12)

106 ominal bleeding, enterocutaneous fistula, or pancreatic fistula) or death.

107 d by the ISGPF (International Study Group on Pancreatic Fistula) pancreatic leak grading system.

108 This was associated with a 56% reduction in pancreatic fistula/pancreatic leak/abscess (PF/PL/A) (21

109 The pancreatic fistula patients were less likely (P < 0.05)

110 ministration of pasireotide for reduction of pancreatic fistula (PF).

111 Grade-B/C postoperative pancreatic fistula (POPF) (23% vs 13%, P < 0.001) occurr

112 iated with higher frequency of postoperative pancreatic fistula (POPF) (48.1% vs 27.7%, P = 0.012) an

113 clinical models for predicting postoperative pancreatic fistula (POPF) after pancreatoduodenectomy (P

114 fistula risk score (a-FRS) for postoperative pancreatic fistula (POPF) after pancreatoduodenectomy, w

115 osts of clinically significant postoperative pancreatic fistula (POPF) and to evaluate the cost-effec

116 ectomy hemorrhage (PPH) due to postoperative pancreatic fistula (POPF) is a life-threatening complica

117 Postoperative Pancreatic Fistula (POPF) is the most consequential comp

118 Postoperative pancreatic fistula (POPF) represents the most significan

119 Secondary outcomes were postoperative pancreatic fistula (POPF), delayed gastric emptying (DGE

120 k, and 162 (13.4%) developed a postoperative pancreatic fistula (POPF).

121 -term complications, including postoperative pancreatic fistula (POPF).

122 ated with an increased risk of postoperative pancreatic fistula (POPF).

123 denectomy (PD) at high risk of postoperative pancreatic fistula (POPF).

124 n Pancreatic Fistula grade B/C postoperative pancreatic fistula (POPF).

125 , 276 patients (14%) developed postoperative pancreatic fistula (POPF).

126 Post-operative pancreatic fistulas (POPF) are a major complication caus

127 Postoperative pancreatic fistulas (POPFs), postpancreatectomy hemorrha

128 ients with clinically relevant postoperative pancreatic fistulas (POPFs).

129 tion of each complication (ie, postoperative pancreatic fistula, postpancreatectomy hemorrhage, bile

130 de A vs grade B vs grade C) of postoperative pancreatic fistula, postpancreatoduodenectomy hemorrhage

131 Postoperative complications including pancreatic fistula predicted higher rates of readmission

132 and lower clinically relevant postoperative pancreatic fistula rate (43.5% vs 61.1%, P =0.040).

133 yze the impact of teres ligament covering on pancreatic fistula rate after distal pancreatectomy (DP)

134 and superior in terms of clinically relevant pancreatic fistula rate and fistula-associated complicat

135 f 3.3%, a clinically significant (grade B/C) pancreatic fistula rate of 6.9%, and a median length of

136 The postoperative pancreatic fistula rate remained stable along the learni

137 The pancreatic fistula rate was significantly lower in the P

138 uated were other postoperative outcomes (eg, pancreatic fistula rate, length of stay), antibiotic use

139 duodenal resections, and all trials had high pancreatic fistula rates (>19%) in the placebo group.

140 Pancreatic fistula rates are similar for OLP and LLP.

141 The pancreatic fistula rates were 9% in the control group an

142 red in 15%of patients and were due mainly to pancreatic fistula, requiring 10 radiologic drainage pro

143 ctrum of individual patient presentations of pancreatic fistula risk, and to define the utility of mi

144 een markedly reduced, whereas others such as pancreatic fistula still remain a problem.

145 lows infected collections to be resolved and pancreatic fistulas to be avoided, with few complication

146 The primary postoperative endpoints were pancreatic fistula, total complications, death, and leng

147 ncreatitis, indications for IAT were grade C pancreatic fistula (treated with completion or left panc

148 Definitions of postoperative pancreatic fistula vary widely, precluding accurate comp

149 The presence of postoperative pancreatic fistula was a significant risk factor for bot

150 Pancreatic fistula was defined by ISGPF criteria.

151 urviving grafts showed that the incidence of pancreatic fistula was greater in the former (90% pancre

152 Forty patients with and without a pancreatic fistula were identified from an Indiana Unive

153 creatoduodenectomy, 309 patients with severe pancreatic fistula were included.

154 previously validated Fistula Risk Score, and pancreatic fistulas were stratified by International Stu

155 s a result of the late diagnosis of a native pancreatic fistula with cholestatic damage to the reduce

156 Any efforts to reduce postoperative pancreatic fistula would decrease the incidence of incis

157 imilar rates of other complications, such as pancreatic fistula, wound infection, intraabdominal absc