ライフサイエンスコーパス: pancreatic polypeptide

1 ocytochemistry (e.g., insulin, glucagon, and pancreatic polypeptide).

2 n, peptide YY, cholecystokinin, insulin, and pancreatic polypeptide.

3 secretion by the gut hormones peptide YY and pancreatic polypeptide.

4 ls also produced glucagon, somatostatin, and pancreatic polypeptide.

5 a levels of epinephrine, norepinephrine, and pancreatic polypeptide.

6 rmones: insulin, glucagon, somatostatin, and pancreatic polypeptide.

7 +/- 424 pmol/l, respectively; P < 0.05) and pancreatic polypeptide (97 +/- 32 and 98 +/- 8 vs. 223 +

8 Administration of either pancreatic polypeptide (a strong agonist of the receptor

9 proach, the small, well-folded protein avian pancreatic polypeptide acts as a scaffold to present and

10 re, the interaction of receptor mutants with pancreatic polypeptide analogs was studied through doubl

11 the model PEGylated peptides, 20K PEGylated-Pancreatic Polypeptide analogue (PPA) and 20K PEGylated-

12 ic hormones insulin, glucagon, somatostatin, pancreatic polypeptide and ghrelin.

13 2 responses of epinephrine, norepinephrine, pancreatic polypeptide and MSNA compared to day 1 cortis

14 detected the presence of insulin, glucagon, pancreatic polypeptide and somatostatin-producing cells

15 ities blunted key autonomic (epinephrine and pancreatic polypeptide) and metabolic (endogenous glucos

16 in, glucagon, vasoactive intestinal peptide, pancreatic polypeptide, and 24-hour urinary 5-hydroxyind

17 and high-density lipoprotein (HDL), leptin, pancreatic polypeptide, and amylin.

18 e, norepinephrine, glucagon, growth hormone, pancreatic polypeptide, and cortisol levels, was signifi

19 e AR42J cells to differentiate into insulin, pancreatic polypeptide, and glucagon-positive cells.

20 ents in subsequent glucagon, growth hormone, pancreatic polypeptide, and muscle sympathetic nerve act

21 leptin, monocyte chemoattractant protein-1, pancreatic polypeptide, and peptide YY.

22 de YY (PYY), oxyntomodulin (enteroglucagon), pancreatic polypeptide, and somatostatin.

23 cluding insulin, glucagon, somatostatin, and pancreatic polypeptide; and B cell transcription factors

24 l face of the small yet stable protein avian pancreatic polypeptide (aPP).

25 es encoding receptors with high affinity for pancreatic polypeptide are not clustered with the genes

26 5%), beta-cells (92%), delta-cells (1%), and pancreatic polypeptide cells (2%).

27 conversion of beta-cells lacking Abcc8 into pancreatic polypeptide cells but not to alpha- or delta-

28 subunits were expressed in alpha, beta, and pancreatic polypeptide cells, whereas kainate receptors

29 -c-peptide, fibrinogen, alpha-1-antitrypsin, pancreatic polypeptide, complement C3, vitronectin, cort

30 and percentage body fat) and fasting plasma pancreatic polypeptide concentrations (both before and a

31 dies resulted in significantly higher plasma pancreatic polypeptide concentrations compared with the

32 Plasma insulin and pancreatic polypeptide concentrations peaked at 250% and

33 Adjustment for fasting plasma pancreatic polypeptide concentrations, a marker of paras

34 hologic dedifferentiation of beta-cells to a pancreatic polypeptide-fold hormone-positive state.

35 ease in gastric acid output, a rise in serum pancreatic polypeptide following sham feeding, and prese

36 2 did not alter epinephrine, norepinephrine, pancreatic polypeptide, free fatty acid, or endogenous g

37 pha-helix onto a small stable protein, avian pancreatic polypeptide, generated a helical 30-amino-aci

38 s, steady state epinephrine, norepinephrine, pancreatic polypeptide, glucagon, ACTH and muscle sympat

39 2 steady state epinephrine, norepinephrine, pancreatic polypeptide, glucagon, growth hormone, and mu

40 and fasting plasma concentrations of GLP-1, pancreatic polypeptide, glucose, and insulin.

41 an Y4 receptor (hY4R) interaction with human pancreatic polypeptide (hPP) is crucial, not only for un

42 also higher Y(4)R affinity compared to human pancreatic polypeptide (hPP).

43 y [Leu(31),Pro(34)]NPY, NPY(13-36) and human pancreatic polypeptide (hPP).

44 the binding pocket of the endogenous ligand pancreatic polypeptide in the core of the Y(4)R transmem

45 This compound attenuated bovine pancreatic polypeptide induced food intake in rats but f

46 and masking any binding to Y4 using 1 nM rat pancreatic polypeptide left a small amount of binding re

47 YY, glucagon-like peptide 1, oxyntomodulin, pancreatic polypeptide, leptin, and adiponectin concentr

48 ect group of patients identified an elevated pancreatic polypeptide level and pancreatic tail mass le

49 ypoglycemia-induced increase in the arterial pancreatic polypeptide level.

50 Pancreatic polypeptide levels tended to increase in CON

51 ine, glucagon, growth hormone, cortisol, and pancreatic polypeptide levels were similarly significant

52 rine, muscle sympathetic nerve activity, and pancreatic polypeptide), neuroendocrine (glucagon and gr

53 dditional significant blunting (P < 0.01) of pancreatic polypeptide, norepinephrine, growth hormone,

54 ed derivatives of the endogenous YR agonists pancreatic polypeptide or peptide YY.

55 (4) receptor (Y(4)R) is unique as it prefers pancreatic polypeptide over NPY and peptide YY.

56 her reduced the epinephrine (P = 0.0001) and pancreatic polypeptide (P = 0.0030) responses, tended to

57 e (P = 0.0027), norepinephrine (P = 0.0007), pancreatic polypeptide (P = 0.0030), and neurogenic symp

58 0), perhaps norepinephrine (P = 0.0838), and pancreatic polypeptide (P = 0.0034) responses to hypogly

59 (P = 0.0094), epinephrine (P = 0.0063), and pancreatic polypeptide (P = 0.0046) responses to stepped

60 = 0.6270), neurogenic symptom (P = 0.6470), pancreatic polypeptide (P = 0.0629), or glucagon (P = 0.

61 a-cell-associated genes (IAPP [islet amyloid pancreatic polypeptide], PDX-1 [pancreatic and duodenal

62 rogenitor stage, but favor somatostatin- and pancreatic polypeptide-positive cells at the expense of

63 , 12.1%+/-0.7% somatostatin, and 1.5%+/-0.2% pancreatic polypeptide-positive cells.

64 hobiology and shows differential dynamics of pancreatic polypeptide (PP) cell abundance and CD8(+) T

65 absence of peptide YY with the exception of pancreatic polypeptide (PP) cells, indicating that pepti

66 rticularly the less abundant delta and gamma/pancreatic polypeptide (PP) cells.

67 Neuropeptide Y (NPY) and pancreatic polypeptide (PP) control central and peripher

68 ural ligands of Y(5) R, peptide YY (PYY) and pancreatic polypeptide (PP) dock to the receptor in a si

69 ects of peptides of the neuropeptide Y (NPY)/pancreatic polypeptide (PP) family on synaptic transmiss

70 (PYY), glucagon-like-peptide-1 (GLP-1), and pancreatic polypeptide (PP) in humans and rodents follow

71 Pancreatic polypeptide (PP) increased by 62%, 5 min afte

72 Pancreatic polypeptide (PP) is a regulatory peptide that

73 Pancreatic polypeptide (PP) is released from the pancrea

74 the pancreas as assessed by increased plasma pancreatic polypeptide (PP) levels (delta = 135.0 +/- 36

75 Pancreatic polypeptide (PP) microinjected into the dorsa

76 malian neuropeptide Y (NPY)/peptide YY (PYY)/pancreatic polypeptide (PP) receptors comprises several

77 To determine if pancreatic polypeptide (PP) secretion is likewise involv

78 example, in the neuropeptide Y (NPY) family, pancreatic polypeptide (PP) shows significant structural

79 perinsulinemia and elevated plasma levels of pancreatic polypeptide (PP), an islet hormone considered

80 1 (GLP-1), peptide tyrosine tyrosine (PYY), pancreatic polypeptide (PP), and leptin.

81 neuropeptide Y (NPY), peptide YY (PYY), and pancreatic polypeptide (PP), are found in the central an

82 an Y4 receptor (Y4R) and its cognate ligand, pancreatic polypeptide (PP), are involved in the regulat

83 he related peptide YY(3-36) (PYY(3-36)), and pancreatic polypeptide (PP), important modulators of ARC

84 -receptor (Y(4)R) and its endogenous ligand, pancreatic polypeptide (PP), suppress appetite in respon

85 ogenous peptides, i.e., NPY, peptide YY, and pancreatic polypeptide (PP), the latter showing a prefer

86 eptide 1 analogue, cholecystokinin (CCK) and pancreatic polypeptide (PP).

87 on preferences for NPY, peptide YY (PYY), or pancreatic polypeptide (PP).

88 he endocrine peptides, peptide YY (PYY), and pancreatic polypeptide (PP).

89 ffinity (Kd = 2.8 nM) for 125I-labeled human pancreatic polypeptide (PP).

90 31, Pro34]NPY (Y1/Y5), NPY (Y3/Y1/Y5/Y2) and pancreatic polypeptide (PP, Y4) injected i.c. at 500 ng

91 ribed Y1, Y2 and Y3 NPY receptors and the Y4 pancreatic polypeptide- (PP-) preferring receptor.

92 Pancreatic polypeptides (PPs) such as neuropeptide Y (NP

93 Peptide YY (PYY) and pancreatic polypeptide (PPY) are members of the neuropep

94 The cellular identity of pancreatic polypeptide (Ppy)-expressing y-cells, one of

95 islet non-beta-cells, namely alpha-cells and pancreatic polypeptide (PPY)-producing gamma-cells, obta

96 ells, somatostatin-producing delta cells and pancreatic polypeptide-producing PP cells.

97 ny of the normal islet cell types except for pancreatic-polypeptide-producing cells.

98 as assessed by 70% reductions of the plasma pancreatic polypeptide response and epinephrine response

99 tion was measured by gastric acid output and pancreatic polypeptide response to sham feeding.

100 th hormone, epinephrine, norepinephrine, and pancreatic polypeptide responses during day 2 exercise w

101 lucose-dependent insulinotropic peptide, and pancreatic polypeptide responses were reduced in gastric

102 r of the transplanted groups (IH and IP) had pancreatic polypeptide responses.

103 ephrine), and parasympathetic neural (plasma pancreatic polypeptide)-responses to hypoglycemia were n

104 exin neurons, we examined the effects of rat pancreatic polypeptide (rPP), a Y4-selective ligand, or

105 However, pancreatic polypeptide, somatostatin, and ghrelin cells

106 5% of NETs demonstrated focal positivity for pancreatic polypeptide, somatostatin, insulin, and/or gl

107 Pancreatic polypeptide was significantly lower (P < 0.05

108 Modeling based on the avian pancreatic polypeptide X-ray structure suggested that an

109 Guinea-pig neuropeptide Y1 and rat pancreatic polypeptide Y4 receptors expressed in Chinese