ライフサイエンスコーパス: panic

1 (2), which might be related to CO(2) induced panic.

2 ch, in summary, is with interest and without panic.

3 lization, all of which are key components of panic.

4 yet understudied, conditioning correlate of panic.

5 and societal concern, sometimes bordering on panic.

6 Moral panic about the claim that antidepressant serotonin reup

7 These lessons pertain to handling panic and administrative burdens in the aftermath of clo

8 the same CpG was positively associated with Panic and Agoraphobia scale (PAS) scores (beta=0.005, SE

9 gnoses of anxiety, mixed anxiety/depression, panic and anxiety symptoms.

10 f panic disorder distinguishes between acute panic and anxious apprehension as distinct emotional sta

11 with time after ICU discharge, particularly panic and confusion.

12 Popular media accounts depict panic and cruelty, but in fact individuals often coopera

13 r groups: offspring of referred parents with panic and depression (N=137), offspring of referred pare

14 Parental panic and depression interacted to predict specific phob

15 atients with other anxiety disorders (mainly panic and posttraumatic stress disorders) had decreased

16 if purposefully released, would cause public panic and social disruption.

17 = 0.20-0.21); this association broadened to panic and social phobia symptoms in adolescence (r = 0.1

18 at the amygdala is not required for fear and panic, and make an important distinction between fear tr

19 rks (labeled SEEING, RAGE, FEAR, LUST, CARE, PANIC, and PLAY systems) that evoke distinct emotion act

20 ed positive screens for depression, anxiety, panic, and posttraumatic stress disorder in relation to

21 or depressive, bipolar, generalized anxiety, panic, and posttraumatic stress) and externalizing (atte

22 em may be involved in the pathophysiology of panic anxiety and that ORX antagonists constitute a pote

23 Moreover, we show that human subjects with panic anxiety have elevated levels of ORX in the cerebro

24 that carbon dioxide inhalation could induce panic anxiety in a group of rare lesion patients with fo

25 with focal bilateral amygdala lesions report panic anxiety in response to intravenous infusions of is

26 The induction of panic anxiety provides further evidence that the amygdal

27 not strictly required for the experience of panic anxiety, and suggest that neural systems beyond th

28 a are fundamental to the human experience of panic anxiety, but it remains unclear how the brain dyna

29 brospinal fluid compared to subjects without panic anxiety.

30 s known about the cardiovascular sequelae of panic anxiety.

31 ptive channels would be sufficient to elicit panic anxiety.

32 hological pain that may arise from excessive PANIC arousal, and 3) facilitation of social joy through

33 No subject had a panic attack before hyperventilation.

34 During the panic attack, a strong association with the surrounding

35 icipation of the next uncued (unpredictable) panic attack.

36 f internal and external cues predictive of a panic attack.

37 in both twins, with one twin experiencing a panic attack.

38 tion exists about the epidemiology of DSM-IV panic attacks (PAs) and panic disorder (PD).

39 Recurrent panic attacks (PAs) are a common feature of panic disord

40 any anxiety disorder [OR = 1.3 (1.1, 1.6)], panic attacks [OR = 1.6 (1.1, 2.1)], panic disorder [OR

41 , neutral conditioned stimuli present during panic attacks acquire panicogenic properties.

42 ed anxiety and sympathetic drive seen during panic attacks and in hypercapnic states such as COPD.

43 Panic attacks are a hallmark in panic disorder (PAND).

44 Panic attacks are relatively common among postmenopausal

45 Individuals with panic disorder perceive panic attacks as unpredictable.

46 o Pavlovian conditioning, failure to predict panic attacks could be due to a basic deficit in conditi

47 ion between A2AR polymorphisms and phobia or panic attacks in humans and prompts a therapeutic intere

48 oradrenergic agent yohimbine reliably induce panic attacks in humans with panic disorder but not in h

49 r in panic disorder, evokes intense fear and panic attacks in susceptible individuals.

50 ompleted a questionnaire about occurrence of panic attacks in the previous 6 months.

51 of the respiratory dysfunction manifested in panic attacks occurring in panic disorder.

52 set and was less likely to be complicated by panic attacks or alcoholism.

53 tic anxiety ratings, but not the presence of panic attacks or of any lifetime anxiety disorder, added

54 sorder, with anxiety disorders (particularly panic attacks) being the most common comorbid condition.

55 ionnaire-2 [PHQ-2], GAD-2, and an item about panic attacks), and a diagnostic evaluation using PHQ-9

56 two were characterized by past or concurrent panic attacks, a rate that was not significantly differe

57 A 6-month history of full-blown panic attacks, endorsed by 10% of postmenopausal women i

58 laxis, undifferentiated somatoform disorder, panic attacks, globus hystericus, vocal cord dysfunction

59 of 35% CO(2) evoked not only fear, but also panic attacks, in three rare patients with bilateral amy

60 common in women and are not associated with panic attacks, suggesting a late-life subtype.

61 the pattern observed during the 34 reported panic attacks.

62 AS predicts panic attacks.

63 nxiety disorder with recurrent, debilitating panic attacks.

64 condition caused by the experience of uncued panic attacks.

65 ically to suppress excessive arousal such as panic attacks.

66 n implicated in the pathophysiology of acute panic attacks.

67 Ebola outbreak because it shows how fear and panic can endanger the individual, our society, and our

68 y responses to acute exposure to a threshold panic challenge (ie, 20% CO(2)/normoxic gas).

69 ith panic, resulting in the proliferation of panic cues.

70 that give rise to adaptive anger/fight, fear/panic, depression/shutdown, pain, and predatory behavior

71 r (27%), generalized anxiety disorder (10%), panic disorder (10%), or complicated grief disorder (5%)

72 MDD (47%), specific phobia (24%), panic disorder (16%), obsessive-compulsive disorder (9%)

73 lized anxiety disorder (31%), agoraphobia or panic disorder (22%), social phobia (17%), and specific

74 anxiety disorder (21 versus 2%, P < 0.005), panic disorder (36 versus 13%, P < 0.001) and somatizati

75 nctional MRI scanning with 118 patients with panic disorder (compared with 150 healthy control subjec

76 recurrent major depressive disorder (N=224), panic disorder (N=75), bipolar II disorder (N=62), or bi

77 .9), anxiety (OR 3.2, 95% CI 2.8 to 3.6) and panic disorder (OR 3.4, 95% CI 2.9 to 4.0).

78 pts in multivariate analysis: pre-enlistment panic disorder (OR = 0.1 [95% CI, 0.0-0.8]), pre-enlistm

79 xiety disorder (OR, 1.3; 95% CI, 1.06-1.49), panic disorder (OR, 1.3; 95% CI, 1.06-1.59), and social

80 ssion (OR, 4.8 [95% CI, 1.2-19.4]; P < .05), panic disorder (OR, 14.5 [95% CI, 5.7-36.6]; P < .001),

81 y (OR, 2.7 [95% CI, 1.1-6.3]; P < .001), and panic disorder (OR, 3.1 [95% CI, 1.5-6.5]; P < .01) and

82 0.46, P<0.001), and the panic item predicted panic disorder (OR=49.61, P<0.001).

83 Panic attacks are a hallmark in panic disorder (PAND).

84 panic attacks (PAs) are a common feature of panic disorder (PD) and post-traumatic stress disorder (

85 Individuals with panic disorder (PD) exhibit a hypersensitivity to inhale

86 Panic disorder (PD) has a lifetime prevalence of 2-4% an

87 ecular genetics approaches in examination of panic disorder (PD) has implicated several variants as p

88 Panic disorder (PD) is a debilitating anxiety disorder c

89 Prior evidence suggests panic disorder (PD) is characterized by neurometabolic a

90 rasting the SAD group to a separate group of panic disorder (PD) subjects.

91 with generalized anxiety disorder (GAD) and panic disorder (PD) to generate individual subject treat

92 The molecular genetics of panic disorder (PD) with and without agoraphobia (AG) ar

93 (PTSD), generalized anxiety disorder (GAD), panic disorder (PD), and phobias (agoraphobia, social ph

94 (MD), generalized anxiety disorder (GAD) and panic disorder (PD), as well as depressed affect and anx

95 idemiology of DSM-IV panic attacks (PAs) and panic disorder (PD).

96 aimed to evaluate CRHR1 as a risk factor for panic disorder (PD).

97 hether these features discriminated SAD from panic disorder (PD, N=16), and SAD from controls in an i

98 umber at risk: 4200), PTSD 31.9% (4342), and panic disorder 21.2% (4953).

99 number at risk: 3648), PTSD 9.3% (3761), and panic disorder 8.4% (3780).

100 1.6)], panic attacks [OR = 1.6 (1.1, 2.1)], panic disorder [OR = 1.6 (1.01, 2.3)], GAD [OR = 1.8 (1.

101 eteen patients with a DSM-IV-TR diagnosis of panic disorder and 19 healthy comparison subjects were r

102 n 19 individuals meeting DSM-IV criteria for panic disorder and 19 sex- and age-matched healthy compa

103 reactivity in a large group of patients with panic disorder and agoraphobia (PD/AG).

104 Panic disorder and agoraphobia patients differed substan

105 disorder significantly increases the risk of panic disorder and any anxiety disorder.

106 Panic disorder and avoidant personality disorder were as

107 Individuals with panic disorder and comorbid depression, indicative of a

108 Panic disorder and GAD do not contribute to adverse preg

109 cence in offspring of parents with confirmed panic disorder and major depressive disorder.

110 ed study tested the hypothesis that parental panic disorder and offspring response to CO(2) are assoc

111 anxiety disorder in childhood leads to adult panic disorder and other anxiety disorders.

112 Post-traumatic stress disorder, panic disorder and phobia manifest in ways that are cons

113 iety disorders (ADs), namely generalized AD, panic disorder and phobias, are common, etiologically co

114 proclivity toward fear overgeneralization in panic disorder and provide a methodology for laboratory-

115 (n = 51), comorbid MDD and anxiety (n = 59), panic disorder and/or social anxiety disorder without co

116 ings, generalized anxiety disorder (GAD) and panic disorder are common but underrecognized illnesses.

117 to test the hypothesis that individuals with panic disorder are impaired in associative learning task

118 Patients with panic disorder are overly sensitive to unpredictable ave

119 reliably induce panic attacks in humans with panic disorder but not in healthy controls.

120 ictability could be etiologically related to panic disorder by sensitizing an individual to danger, u

121 ed assessment of this potential correlate of panic disorder by testing the degree to which panic pati

122 For example, adults with panic disorder did not have histories of juvenile disord

123 o healthy comparison subjects, patients with panic disorder displayed equivalent levels of fear-poten

124 The learning perspective of panic disorder distinguishes between acute panic and anx

125 ndard CBT and pharmacotherapy treatments for panic disorder do not need to be "tailored" to be effect

126 l from 4.0 to 2.2/1000PYAR, and incidence of panic disorder fell from 0.9/1000PYAR in 1998 to 0.5/100

127 e this different respiratory response in the panic disorder group, brain pH increases were not signif

128 f healthy subjects showed pH blunting in the panic disorder group.

129 Although subjects with panic disorder had greater hypocapnea during hyperventil

130 d feasible screening instruments for GAD and panic disorder has the potential to improve detection an

131 has been implicated in an increased risk of panic disorder in humans.

132 unique studies for the detection of GAD and panic disorder in primary care patients Across all studi

133 predicted new onset of depression, parental panic disorder independently predicted new onset of soci

134 Panic disorder is a severe anxiety disorder with recurre

135 anxiety disorder were more likely to develop panic disorder later on (odds ratio=3.45; 95% CI=2.37-5.

136 In adjusted models, neither panic disorder nor GAD was associated with maternal or n

137 To determine whether panic disorder or generalized anxiety disorder (GAD) in

138 spring of adults presenting for treatment of panic disorder or major depressive disorder.

139 Thirteen panic disorder participants and 13 matched control subje

140 tly greater increase in the visual cortex of panic disorder participants.

141 sual cortex and anterior cingulate cortex of panic disorder participants.

142 Individuals with panic disorder perceive panic attacks as unpredictable.

143 drugs that are clinically effective against panic disorder preferentially alter rodent flight behavi

144 The Panic Disorder Severity Scale, rated by blinded independ

145 Generalized Anxiety Disorder Severity Scale, Panic Disorder Severity-Self-report Scale, Social Phobia

146 tion (73% versus 39%), using the Multicenter Panic Disorder Study response criteria.

147 These results suggest that individuals with panic disorder suffer from a deficit in declarative asso

148 The false-suffocation hypothesis of panic disorder suggested delta-opioid receptors as a pos

149 ntribute to the maintenance and worsening of panic disorder symptoms by increasing anticipatory anxie

150 T1rho imaging may provide information about panic disorder that is distinct from conventional BOLD i

151 In individuals with panic disorder there is evidence of decreased central ga

152 -2 was an effective screening tool; however, panic disorder was rare.

153 The best-performing test for panic disorder was the Patient Health Questionnaire, wit

154 Nine subjects with panic disorder were compared to 11 healthy subjects at b

155 viduals with DSM-IV-defined anxiety syndrome panic disorder were compared with 21 unaffected healthy

156 Twenty-eight untreated patients with panic disorder were randomized to a single session of ex

157 ts (n = 42), treatment-seeking patients with panic disorder with agoraphobia (n = 25), and 17 healthy

158 al factor in the etiology and maintenance of panic disorder with agoraphobia (PD/A).

159 ontrol participants as well as patients with panic disorder with agoraphobia and generalized social a

160 Evidence suggests that panic disorder with agoraphobia is characterized by dysf

161 y (CBT) is an effective treatment option for panic disorder with agoraphobia, the neural substrates o

162 ated with treatment outcome in patients with panic disorder with agoraphobia.

163 on-free patients with a primary diagnosis of panic disorder with agoraphobia.

164 ted with treatment response in patients with panic disorder with agoraphobia.

165 eatment center with a principal diagnosis of panic disorder with or without agoraphobia, generalized

166 ng specific phobia, social anxiety disorder, panic disorder with or without agoraphobia, obsessive-co

167 , post-traumatic stress disorder [PTSD], and panic disorder), and spirometric abnormalities.

168 of parents with depression (with or without panic disorder), with the highest rates in the offspring

169 ved a diagnosis (143 depression, 129 GAD, 30 panic disorder).

170 ychiatric diagnoses (depression, anxiety and panic disorder).

171 rientation, 5.14 (95% CI=4.54-5.82); and for panic disorder, 1.45 (95% CI=1.15-1.85).

172 ssive-compulsive disorder, 2.5% vs. 6.7% for panic disorder, 12.6% vs. 25.3% for social phobia, 9.1%

173 re non-Hispanic white (1957 [73.7%]), 98 had panic disorder, 252 had GAD, 67 were treated with a benz

174 , specific phobias, social anxiety disorder, panic disorder, agoraphobia, and generalised anxiety dis

175 in offspring of multiple anxiety disorders, panic disorder, agoraphobia, social phobia, and obsessiv

176 hymia, bipolar disorder), anxiety disorders (panic disorder, agoraphobia, specific phobia, social pho

177 iety disorder, 6.8% (CI, 5.3% to 8.6%) had a panic disorder, and 6.2% (CI, 4.7% to 7.9%) had a social

178 icide attempt, psychosis, mania, depression, panic disorder, and delirium, confusion, or disorientati

179 generalized anxiety disorder, social phobia, panic disorder, and posttraumatic stress disorder) among

180 he life course for major depressive episode, panic disorder, and posttraumatic stress disorder.

181 Major depressive disorder (MDD), panic disorder, and social anxiety disorder are among th

182 iety disorder, generalized anxiety disorder, panic disorder, and specific phobia.

183 et was lower and rates of attempted suicide, panic disorder, and substance abuse were higher than amo

184 idence rates of depression, mania, delirium, panic disorder, and suicidal behaviors in patients treat

185 cifically post-traumatic stress disorder and panic disorder, and therefore represents an endophenotyp

186 In a rat model of panic disorder, chronic inhibition of GABA synthesis in

187 iological challenge and pathologic marker in panic disorder, evokes intense fear and panic attacks in

188 Panic disorder, GAD, or use of benzodiazepines or seroto

189 GAD and the Patient Health Questionnaire for panic disorder, have good performance characteristics an

190 c priming paradigm specifically tailored for panic disorder, in which panic symptoms (e.g., "dizzines

191 Parental panic disorder, independently of parental depression, pr

192 ation anxiety disorder with regard to future panic disorder, major depressive disorder, any anxiety d

193 Registry data show that maternal panic disorder, or anxiety disorders in general, increas

194 In panic disorder, persistent symptoms of anxiety are cause

195 months, including major depressive disorder, panic disorder, posttraumatic stress disorder (PTSD), op

196 and adolescents with confirmed diagnoses of panic disorder, social anxiety disorder, specific phobia

197 Associations between AUD and panic disorder, specific phobia, and generalized anxiety

198 indings support a biased semantic network in panic disorder, which is normalized after CBT.

199 as been suggested to play a critical role in panic disorder.

200 ns are consistent with a pH dysregulation in panic disorder.

201 ese data support the learning perspective of panic disorder.

202 zodiazepines, which are widely used to treat panic disorder.

203 ication treatment was observed in visits for panic disorder.

204 ion manifested in panic attacks occurring in panic disorder.

205 nxiety-related associations of patients with panic disorder.

206 itute a potential new treatment strategy for panic disorder.

207 prominently in many etiological accounts of panic disorder.

208 tions for novel treatments and prevention in panic disorder.

209 vents, is a psychophysiological correlate of panic disorder.

210 hysical symptoms prominently associated with panic disorder.

211 tical psychotherapy for patients with DSM-IV panic disorder.

212 anic-focused psychodynamic psychotherapy for panic disorder.

213 ere 49 adults ages 18-55 with primary DSM-IV panic disorder.

214 inical trial of subjects with primary DSM-IV panic disorder.

215 sions, a phenomenon similar to patients with panic disorder.

216 epression, generalized anxiety disorder, and panic disorder.

217 ic-related semantic network in patients with panic disorder.

218 ocial anxiety disorder, specific phobia, and panic disorder.

219 relevance to psychiatric conditions such as panic disorder.

220 of 2637 patients assessed had a diagnosis of panic disorder.

221 sion were commonest aged 45-64 years, whilst panic disorder/attacks were more common in those 16-44 y

222 sion, generalized anxiety disorder (GAD), or panic disorder; understand the predictive value of indiv

223 tion for dissecting the bases of anxiety and panic disorders.

224 potential therapeutic target in anxiety and panic disorders.

225 ing instinctive fear and human emotional and panic disorders.

226 The twin who did not panic displayed signs of impaired cardiorespiratory inte

227 sions revealed that CO2 can trigger fear and panic even in the absence of amygdalae, suggesting the i

228 it has demonstrated preliminary efficacy of panic-focused psychodynamic psychotherapy for panic diso

229 Subjects in panic-focused psychodynamic psychotherapy had significan

230 All subjects received assigned treatment, panic-focused psychodynamic psychotherapy or applied rel

231 this study was to determine the efficacy of panic-focused psychodynamic psychotherapy relative to ap

232 Furthermore, those receiving panic-focused psychodynamic psychotherapy were significa

233 cacy randomized controlled clinical trial of panic-focused psychodynamic psychotherapy, a manualized

234 errors correlated with subjective reports of panic for the high compared with low probability of capt

235 rder (ie, major depressive episode, phobias, panic, generalized anxiety disorder, and obsessive-compu

236 on between a fungal endophyte and a tropical panic grass allows both organisms to grow at high soil t

237 t also varied by diagnosis (bipolar I > or = panic > bipolar II > or = major depressive disorder) but

238 ced anxiety in both patients, and full-blown panic in one (patient B.G.).

239 en off the mark by social media, rumors, and panic in the early phase of the COVID-19 pandemic." In t

240 ministered during two separate conditions: a panic induction and an assessment of cardiorespiratory i

241 at has relevance today-namely, that fear and panic intensified the disruption of society and damage t

242 Although the major societal burden of panic is caused by PD and PA-AG, isolated PAs also have

243 ontrol worrying: OR=10.46, P<0.001), and the panic item predicted panic disorder (OR=49.61, P<0.001).

244 -or-flight response, as well as anxiety- and panic-like behaviors in rodents.

245 of saralasin into the DMH did not block the panic-like responses elicited by intravenous infusions o

246 ry only those rats with L-AG pumps exhibited panic-like responses to lactate infusions.

247 n the dorsomedial hypothalamus (DMH) develop panic-like responses, defined as tachycardia, tachypnea,

248 physiological components of lactate-induced panic-like responses.

249 or developing a panic-prone state in the rat panic model, and either silencing of the hypothalamic ge

250 In 'sudden onset' cases, panic (n=29, 59%), dissociative symptoms (n=19, 39%) and

251 of referred parents with depression without panic (N=48), and offspring of nonreferred parents with

252 ors including: cold, heat, hypoxia, pain and panic on the contributions of fR and VT to VE to see if

253 t generalized anxiety, obsessive-compulsive, panic, or posttraumatic stress disorders; social phobia;

254 anic disorder by testing the degree to which panic patients and healthy subjects manifest generalizat

255 Panic patients displayed stronger conditioned generaliza

256 Conditioned fear in panic patients generalized to rings with up to three uni

257 rms included depression, dysthymia, anxiety, panic, phobia, obsession, compulsion, posttraumatic, car

258 This panic-priming effect in patients (compared with control

259 Similar to optogenetic activation of PeF, panic-prone rats also exhibited delayed extinction.

260 Next, we demonstrate that panic-prone rats had altered inhibitory and enhanced exc

261 Treating panic-prone rats with mGluR2 PAM blocked sodium lactate

262 ate neurotransmission in the BLA slices from panic-prone rats.

263 sizing neurons is necessary for developing a panic-prone state in the rat panic model, and either sil

264 These data demonstrate that a panic-prone state leads to specific reduction in mGluR2

265 ceptor antagonist saralasin into the DMH of "panic-prone" rats blocked the anxiety-like and physiolog

266 a sporadic cluster of mental comorbidities (panic, PTSD, conduct disorder and substance use disorder

267 ingulate cortex activation for processing of panic-related associations provides a potential mechanis

268 re during the circa-strike threat, and these panic-related locomotor errors were correlated with midb

269 the behavioral and neural correlates of the panic-related semantic network in patients with panic di

270 cardiac sensation, patient A.M., who did not panic, reported a complete lack of awareness for dyspnea

271 2 PAM blocked sodium lactate (NaLac)-induced panic responses and normalized fear extinction deficits.

272 wers brain pH and induces anxiety, fear, and panic responses in humans.

273 in regions are involved in the regulation of panic responses, such as perifornical hypothalamus (PeF)

274 stemic ORX-1 receptor antagonists blocks the panic responses.

275 o stimuli resembling those co-occurring with panic, resulting in the proliferation of panic cues.

276 loneliness, depression, generalized anxiety, panic, social phobia) have remained the strongest predic

277 baseline or T1, patients rated panic-trigger/panic-symptom word pairs with higher relatedness and hig

278 ulate cortex for processing of panic-trigger/panic-symptom word pairs.

279 atients made faster lexical decisions to the panic-symptom words when they were preceded by panic-tri

280 ically tailored for panic disorder, in which panic symptoms (e.g., "dizziness") were primed by panic

281 The correspondence between panic symptoms and functional T1rho response identified

282 No relationships were found between panic symptoms and the BOLD signal.

283 Conditioned stimuli triggering panic symptoms are not limited to the original condition

284 shing checkerboard and their relationship to panic symptoms assessed using the Beck Anxiety Inventory

285 GluR2 PAMs could be a targeted treatment for panic symptoms in PD and PTSD patients.

286 Panic symptoms were elicited by a bolus injection of the

287 escape behavior, self-reports of anxiety and panic symptoms, autonomic arousal (heart rate and skin c

288 gnificantly greater reduction in severity of panic symptoms.

289 mGluR2 PAM resulted in complete remission of panic symptoms.

290 center implicated in attention, arousal, and panic that projects throughout the brain.

291 nic-symptom words when they were preceded by panic-trigger words.

292 At baseline or T1, patients rated panic-trigger/panic-symptom word pairs with higher relat

293 anterior cingulate cortex for processing of panic-trigger/panic-symptom word pairs.

294 symptoms (e.g., "dizziness") were primed by panic triggers (e.g., "elevator") compared with neutral

295 bition of GABA synthesis in the PeF produces panic-vulnerable rats.

296 re, we investigate the mechanisms by which a panic-vulnerable state could lead to persistent fear.

297 The recurrence risk for depression or panic was much shorter after rapid than after gradual di

298 light, freezing, sympathetic activation, and panic, while inhibition reduces defensive responses to p

299 ganized ranging from anxious apprehension to panic with increasing proximity of interoceptive threat.

300 (N=137), offspring of referred parents with panic without depression (N=26), offspring of referred p