ライフサイエンスコーパス: papillary muscle

1 echogenic intracardiac focus (ie, calcified papillary muscle).

2 ng 71 with basal inferolateral wall, 29 with papillary muscle).

3 on and lateral displacement of the posterior papillary muscle.

4 ocardial infarction, including the posterior papillary muscle.

5 t and no-flow ischemia in an isolated rabbit papillary muscle.

6 n of leaflet tissue attached to the anterior papillary muscle.

7 yocardium near the insertion of the anterior papillary muscle.

8 the wall of the left ventricle overlying the papillary muscle.

9 r LV free wall near the root of the anterior papillary muscle.

10 into the myocardium underlying the infarcted papillary muscle.

11 strating enlarged interventricular septa and papillary muscles.

12 bundles isolated from mouse left ventricular papillary muscles.

13 annular dilatation with displacement of the papillary muscles.

14 he ventricle and improved orientation of the papillary muscles.

15 ional changes were also assessed in isolated papillary muscles.

16 fibre bundles prepared from left ventricular papillary muscles.

17 raction is described in 25 reperfused rabbit papillary muscles.

18 ule depolymerization in both control and PAB papillary muscles.

19 ed IGF-1-positive inotropic action in ferret papillary muscles.

20 aequorin-loaded rat whole hearts and ferret papillary muscles.

21 mRNA expression in stretched and unstretched papillary muscles.

22 nulus and its spatial relationship with both papillary muscles.

23 e stretch activation response of the cardiac papillary muscles.

24 ral valve apparatus, leaflet morphology, and papillary muscles.

25 sal-midventricular inferior-lateral wall and papillary muscles.

26 brosis in the infarct border zone and in the papillary muscles.

27 ) because of a different segmentation of the papillary muscles.

28 elevated forces and altered dynamics on the papillary muscles.

29 cle of the left ventricle, especially in the papillary muscles.

30 on (MI), with leaflet tethering by displaced papillary muscles.

31 o displaced the posterior annulus toward the papillary muscles.

32 elaxation in both isolated hearts and intact papillary muscles.

33 tion (61 %) or relaxation (59 %) of isolated papillary muscle, (2) fractional shortening (50 %), ampl

34 nnulus (6) and at the tips and bases of both papillary muscles (4).

35 s (14% decrease in peak developed pressure), papillary muscles (53% decrease in maximum developed for

36 ventricular myocytes (-60%, P<.005) and rat papillary muscles (-55%, P<.05).

37 on (Group II), whereas 26 did (Group III: 12 papillary muscle, 7 subendocardial, 7 transmural).

38 force recovered to 60 +/- 3 % (n = 7) in NTG papillary muscles, 98 +/- 2 % (n = 5) in muscles from TG

39 o by echocardiogram and in vitro by isolated papillary muscle analysis.

40 reimplantation, and early dehiscence of the papillary muscle anastomosis.

41 on the leaflets due to displacement of their papillary muscle and annular attachments, which restrict

42 lar cavity and the direct continuity between papillary muscle and anterior leaflet associated with a

43 lic mitral annulus dimensions, components of papillary muscle and leaflet displacement, were calculat

44 nd quantifying MAD, MVP, and fibrosis in the papillary muscle and myocardium, which may predict and h

45 he tethering line connecting the annulus and papillary muscle and reflects limitation of anterior mot

46 of leaflet tissue attached to the posterior papillary muscle and restriction of leaflet tissue attac

47 ction potentials were recorded from isolated papillary muscle and sinoatrial node by microelectrode t

48 e that increases isometric force in isolated papillary muscle and the extent of shortening in isolate

49 at the free margin of the leaflets tethering papillary muscles and absent/short tendinous cords.

50 ular and electrophysiological changes in the papillary muscles and adjacent myocardium.

51 osin in distinct areas such as at the tip of papillary muscles and at the base close to the valvular

52 Contracting isolated papillary muscles and cardiomyocytes from controls and m

53 s, with a wide array of malformations of the papillary muscles and chordae, that can be detected by t

54 Fiber bundles were dissected from papillary muscles and detergent extracted.

55 Fibrosis of the papillary muscles and inferobasal left ventricular wall,

56 nstability, left ventricular fibrosis in the papillary muscles and inferobasal wall, mitral annulus d

57 aflets and left ventricular (LV) fibrosis of papillary muscles and inferobasal wall.

58 PFA applications to ablate (1) intracavitary papillary muscles and moderator bands, (2) epicardial ta

59 x-ray microanalysis (EPMA) of rapidly frozen papillary muscles and trabeculae incubated with ryanodin

60 For LV parameters counting papillary muscles and trabeculations in the LV mass, poo

61 or 3T was used to trace either counting the papillary muscles and trabeculations in the LV volume or

62 For LV parameters counting papillary muscles and trabeculations in the LV volume, p

63 ot both commonly used tracing techniques for papillary muscles and trabeculations.

64 er in 6 of 6 cardiac arrest patients (4 from papillary muscle) and Purkinje origin of dominant VE was

65 function were assessed by echocardiographic, papillary muscle, and isolated cardiomyocyte studies.

66 quence similar to sinus rhythm or arose near papillary muscles, and (2) stable pattern, in which acti

67 oronary snare and marker placement (annulus, papillary muscles, and anterior and posterior leaflets).

68 impairment of lateral shortening between the papillary muscles, and not passive ventricular size, tha

69 rdium interface in areas of trabeculation or papillary muscles, and of the atrioventricular ring.

70 urements (perfused isolated hearts, isolated papillary muscles, and skinned fiber preparations), bioc

71 ac MRI: LV trabeculations, LV myocardium, LV papillary muscles, and the LV blood cavity.

72 volume, tethering volume, bending angle, and papillary muscle angle were measured.

73 w volume, a more laterally directed anterior papillary muscle angle, and greater annular distance bet

74 greater total billow volume, lower anterior papillary muscle angle, and greater distance between the

75 volume, and more laterally directed anterior papillary muscle angles compared to valves with mild or

76 zing restrictive mitral annuloplasty (RA) or papillary muscle approximation with undersizing restrict

77 K(+)), and lactate (L(-)) in ischemic rabbit papillary muscle are presented for the first time.

78 -dimensional relationship of the annular and papillary muscle attachments of the valve so as to incre

79 the anterior wall, one set at the tip of the papillary muscle (basal) and one at the site of papillar

80 et motion resulting from displacement of the papillary muscle-bearing segments of the left ventricle.

81 , the force-frequency relationships of mouse papillary muscle bundles were measured in the presence o

82 ntegrin, depresses the force production from papillary muscle bundles, partly associated with changes

83 432, reversed the activity of RGD peptide on papillary muscle bundles.

84 ted the hypothesis that repositioning of the papillary muscles can be achieved by injection of polyvi

85 roapical extension can mechanically displace papillary muscles, causing MR despite the absence of bas

86 erences were estimated at a tissue (isolated papillary muscle), cellular (isolated left ventricular c

87 After infarction, the anterior papillary muscle continued to shorten normally, but at E

88 ulted from maintenance of the mitral annular papillary muscle continuity during mitral valve repair.

89 Intact papillary muscle data demonstrated prolonged force trans

90 display a predisposition for trabecular and papillary muscle defects, ventricular septal defects, co

91 valve replacement, the technical problems of papillary muscle dehiscence and mitral regurgitation app

92 -skinned fiber bundles from left ventricular papillary muscle demonstrated a significant inhibition o

93 This papillary muscle discoordination with minimal annular di

94 mmetrical mitral annular (MA) dilatation and papillary muscle dislocation are implicated in the patho

95 e from infarction or cardiomyopathy produces papillary muscle displacement and annular dilatation, ca

96 Apical and posterolateral papillary muscle displacement caused decreased leaflet m

97 over time with mechanical stretch created by papillary muscle displacement through cell activation, n

98 d mitral regurgitation, superior leaflet and papillary muscle displacement with associated exaggerate

99 mitral regurgitation, prolapse, and superior papillary muscle displacement with basal curling and mor

100 ateral annular dilatation, lateral posterior papillary muscle displacement, and apical PL restriction

101 stress, function, and sphericity) and local (papillary muscle displacements and regional wall motion

102 imension, left ventricular volume, and inter-papillary muscle distance were measured.

103 ntly change left ventricular volume or inter-papillary muscle distance.

104 deformation were observed in the area of the papillary muscle during isovolumic contraction.

105 sually caused by chordae tendinae rupture or papillary muscle dysfunction.

106 chanical stretch of the inferobasal wall and papillary muscles, eventually leading to myocardial hype

107 train relations in resting right ventricular papillary muscles exhibited 60% greater strains (P:<0.01

108 t rate and resonant frequency of the cardiac papillary muscles expressing the mutant essential light

109 The obstacle, together with the papillary muscle, facilitated the transition from VF to

110 uctural heart disease can originate from the papillary muscles, fascicles, and mitral annulus.

111 ead morphology, can help distinguish between papillary muscle, fascicular, and mitral annular VAs.

112 Patients undergoing catheter ablation for papillary muscle, fascicular, or mitral annular VAs were

113 in detergent-treated mouse left ventricular papillary muscle fiber bundles where the endogenous trop

114 illary muscle (basal) and one at the site of papillary muscle fiber insertion (apical).

115 creased approximately 20% in Tg-E22K skinned papillary muscle fibers and intracellular [Ca2+] and for

116 rove the force redevelopment rate (k(tr)) in papillary muscle fibers from cMyBP-C(AAA) (nonphosphoryl

117 f the ATPase and force in transgenic skinned papillary muscle fibers from mutated versus control mice

118 Detergent-skinned papillary muscle fibers from non-TG (NTG) and TG mouse h

119 ients were significantly decreased in intact papillary muscle fibers from Tg-E22K compared to Tg-WT m

120 e were generated, and the skinned and intact papillary muscle fibers from the Tg-D166V mice were exam

121 Skinned papillary muscle fibers from transgenic mice expressing

122 Low-angle X-ray diffraction studies on papillary muscle fibers in rigor revealed a decreased in

123 gle myosins in relaxed permeabilized porcine papillary muscle fibers indicated slightly differently o

124 Both peptides increased the contractility of papillary muscle fibers isolated from a mouse model expr

125 Third, skinned papillary muscle fibers treated with mutant S2 proteins

126 tes (g(app)) was observed in freshly skinned papillary muscle fibers.

127 RLC (RLC-PAGFP) exchanged into permeabilized papillary muscle fibers.

128 (MVP), leaflet degeneration, myocardial and papillary muscle fibrosis, and, potentially, malignant c

129 echanical coupling deficits, we compared the papillary muscle force generated by electrically stimula

130 We developed an ex vivo papillary muscle force transduction and novel neochord l

131 on fraction, systolic blood pressure, and LV papillary muscle force while LV end-diastolic and systol

132 t bileaflet prolapse significantly increases papillary muscle forces by 5% to 15% compared with an op

133 mechanical relationship between prolapse and papillary muscle forces, leveraging advances in ex vivo

134 ic dysfunction leads to significantly higher papillary muscle forces, which could be a possible trigg

135 r dilatation, leaflet tethering by displaced papillary muscles frequently induces mitral regurgitatio

136 In isolated papillary muscle from SERCA2 transgenic mice, the time t

137 arction, total displacement of the posterior papillary muscle from the midseptal annulus ("saddle hor

138 ilarly, the contractile behavior of isolated papillary muscles from diabetic SERCA2a mice was not dif

139 ong the muscle fibers or in fiber tension in papillary muscles from heterozygous global Vcl null mice

140 Skinned papillary muscles from hypertrophic (HCM-D166V) and dila

141 gitation (MR) relates to displacement of the papillary muscles from ischemic ventricular distortion.

142 Papillary muscles from male Sprague-Dawley rats were mou

143 We also isolated papillary muscles from the right ventricle of NTG and TG

144 anical protocol to isometrically contracting papillary muscles from two rabbit heart populations: (1)

145 determine the mechanism by which annular and papillary muscle geometric alterations result in MR, we

146 mitral annulus at end systole; the posterior papillary muscle geometry was unchanged.

147 cadaver, early myocardial infarction of the papillary muscles had been missed.

148 mias (VAs) arising from the left ventricle's papillary muscles has been associated with inconsistent

149 Papillary muscles have been implicated in arrhythmogenes

150 7 patients with non-prolapse of the ruptured papillary muscle head into the left atrium.

151 transients in electrically stimulated intact papillary muscles; however, the R58Q mutation also resul

152 Papillary muscle hypertrophy that produced midcavitary o

153 KI hearts exhibited atrial enlargement, papillary muscle hypertrophy, and fibrosis.

154 free wall near the insertion of the anterior papillary muscle in 6 pigs.

155 rane potential was recorded in 10 guinea pig papillary muscles in a tissue bath using a double-barrel

156 is was detected at histology at the level of papillary muscles in all patients, and inferobasal wall

157 arction (MI), leaflet tethering by displaced papillary muscles induces mitral regurgitation (MR), whi

158 Background The relationship between papillary muscle infarction (papMI) and the culprit coro

159 The prognostic significance of papillary muscle infarction (PapMI) on hard clinical out

160 MRI, was highly accurate in the detection of papillary muscle infarction (papMI).

161 In HCM, outflow obstruction due to anomalous papillary muscle insertion directly into anterior mitral

162 er in 1997 who demonstrated direct anomalous papillary muscle insertion into the anterior mitral leaf

163 on induces an unloading of myocardium at the papillary muscle insertion site and that the resulting h

164 y to a depression of local function near the papillary muscle insertion site.

165 m(2)), and lack of echocardiographic scar at papillary muscle insertion sites (all P<0.05) and, when

166 eline had a 106 +/- 74 ms time delay between papillary muscle insertion sites (p < 0.001 vs. normal).

167 ordinated timing of mechanical activation of papillary muscle insertion sites appears to be a mechani

168 ults from improved coordinated timing of the papillary muscle insertion sites, using the novel approa

169 argins of the mitral leaflet unencumbered by papillary muscle insertion, and in 1 patient probably re

170 d direct endocardial mapping of the anterior papillary muscle insertion.

171 ssels, ridges of endocardial trabeculae, and papillary muscle insertions.

172 lso determined the kinetics of relaxation of papillary muscles isolated from all four groups of anima

173 to the obstacle and another attaches to the papillary muscle, it may result in stable VT with figure

174 deling (apical and posterior displacement of papillary muscles) leads to excess valvular tenting inde

175 was created within the ventricular septum to papillary muscle level; also, in 1 patient, attachment o

176 ilization by an external patch device of the papillary muscle-LV wall complex that controls mitral va

177 al echocardiographic examination for erratic papillary muscle motion in all patients with suspected r

178 ersus 3.1+/-2.7 (P=0.02), with the posterior papillary muscle moving more laterally (6.8+/-3.4 versus

179 (32 [63%] male; mean age 61+/-15 years) with papillary muscle (n=18), fascicular (n=15), and mitral a

180 n=37; 38.1%), LV trabeculations (n=5; 5.2%), papillary muscle (n=3; 3.1%), and apical-septal bundle (

181 Higher-resolution imaging revealed that papillary muscles (n=10) were most affected.

182 (1) Papillary muscles (n=13) were successfully ablated and t

183 ng from the left ventricular summit (n=4) or papillary muscles (n=2), 6 patients with noninfarct rela

184 in of dominant VE was seen in 5 of 8 (3 from papillary muscle) nonarrest patients.

185 ation normalized myocardial contractility in papillary muscles of PAB cats but did not alter contract

186 ications of catheter ablation of VA from the papillary muscles of the left ventricle with either cryo

187 erolateral papillary muscle or posteromedial papillary muscles of the left ventricle.

188 ctions of the outflow tract alternating with papillary muscle or fascicular origin.

189 from the outflow tract alternating with the papillary muscle or fascicular region (7 of 9 [78%] vs.

190 oci being mapped at either the anterolateral papillary muscle or posteromedial papillary muscles of t

191 herical remodeling distal to the tips of the papillary muscles (P<0.001).

192 aim of this study was to define the role of papillary muscles (PAPs) in post-infarction ventricular

193 we sought to identify mitral valve (MV) and papillary muscle (PM) abnormalities that predisposed to

194 ral regurgitation (MR) was first ascribed to papillary muscle (PM) contractile dysfunction.

195 ) has been attributed to annular dilatation, papillary muscle (PM) displacement ("apical leaflet tent

196 Although papillary muscle (PM) displacement is recognized in func

197 The role of papillary muscle (PM) in the generation and maintenance

198 , involving subendocardial structures as the papillary muscle (PM) or trabeculae.

199 le (LV) may alter tricuspid annulus size and papillary muscle (PM) positions leading to TR.

200 cle, 8 on the mitral annulus (MA), 1 on each papillary muscle (PM) tip, and 1 on the anterior and pos

201 around the mitral annulus (MA) and 1 on each papillary muscle (PM) tip.

202 The mid-systolic 3D relations of the papillary muscle (PM) tips and mitral valve were reconst

203 try and dynamics of the mitral annulus (MA), papillary muscle (PM), and the chordae tendineac, chorda

204 odeling increases tethering to the infarcted papillary muscle (PM).

205 d that this focal source is located near the papillary muscle (PM).

206 Papillary muscles (PM) ventricular arrhythmias (VAs) exh

207 trophic cardiomyopathy phenotype observed in papillary muscles (PMs) of R58Q mice is also manifested

208 The papillary muscles (PMs) play an important role in normal

209 me was increased tethering distance from the papillary muscles (PMs) to the anterior annulus, especia

210 et tethering by displaced attachments to the papillary muscles (PMs), it is incompletely treated by a

211 tricular remodeling with displacement of the papillary muscles (PMs).

212 implanted to silhouette the LV, annulus, and papillary muscles (PMs); 3 transmural bead columns were

213 r placement (left ventricle, mitral annulus, papillary muscles [PMs], and leaflets).

214 veloped that allows independent variation of papillary muscle position, annular size, and transmitral

215 r dilatation increased regurgitation for any papillary muscle position, creating clinically important

216 lvular repair technique addressing posterior papillary muscle (PPM) displacement.

217 igated in an isolated, blood-perfused rabbit papillary muscle preparation with a confined extracellul

218 Papillary muscle relocation restores the physiologic con

219 fraction or less frequently due to ischemic papillary muscle remodeling.

220 is study is to ascertain whether subvalvular papillary muscle repair in conjunction with restrictive

221 Subvalvular papillary muscle repair plus restrictive mitral annulopl

222 Subvalvular papillary muscle repair plus restrictive mitral annulopl

223 he hospital for heart failure is subvalvular papillary muscle repair plus restrictive mitral annulopl

224 This was followed by subvalvular papillary muscle repair plus restrictive mitral annulopl

225 ute reverse remodeling of the ventricle with papillary muscle repositioning to decrease MR.

226 Papillary muscle retraction was combined with apical MI

227 ocardiograms of 21 consecutive patients with papillary muscle rupture (20 involved the left ventricle

228 Papillary muscle rupture (PMR) is an infrequent but cata

229 ial infarction includes partial and complete papillary muscle rupture or functional mitral regurgitat

230 The single patient with right ventricular papillary muscle rupture showed erratic motion as well a

231 ses include right ventricular infarction and papillary muscle rupture with acute severe mitral regurg

232 left ventricle is useful in the diagnosis of papillary muscle rupture, especially in those patients i

233 ee-wall rupture, ventricular septal rupture, papillary muscle rupture, pseudoaneurysm, and true aneur

234 In some patients with papillary muscle rupture, the ruptured head may not prol

235 7 (35%) of 20 patients with left ventricular papillary muscle rupture, the ruptured head was not seen

236 are acute mitral regurgitation secondary to papillary muscle rupture, ventricular septal defect, pse

237 d but was less sensitive in the diagnosis of papillary muscle rupture.

238 Papillary muscle scarring (papSCAR) can occur without ep

239 e as the left ventricle (LV) dilated and the papillary muscles shifted posteriorly and mediolaterally

240 s force and [Ca(2+)]i measurements on intact papillary muscles show that enhancement of relaxation in

241 orce and [Ca(2+)]in measurements in isolated papillary muscles showed that the increased force and tw

242 s prominent erratic motion or flutter of the papillary muscle still attached to the left ventricular

243 Mechanical performance of skinned papillary muscle strips derived from mutant and wild-typ

244 nical properties of skinned left ventricular papillary muscle strips from mouse hearts bearing the R4

245 Herein, we used skinned, ventricular papillary muscle strips from rats to investigate the eff

246 Papillary muscle studies revealed isoproterenol hyporesp

247 s study sought to investigate the benefit of papillary muscle surgery on long-term clinical outcomes

248 tility at 16 hrs as assessed by the isolated papillary muscle technique.

249 Mechanical stresses imposed by papillary muscle tethering increase MV leaflet area and

250 chordae can improve annuloplasty by reducing papillary muscle tethering.

251 extending to the inferior apex displaces the papillary muscles, tethering the mitral leaflets to caus

252 ium while at the same time repositioning the papillary muscles that become apically tethered in MR.

253 Papillary muscles that lie within an infarct zone might

254 ithin the body and to study the integrity of papillary muscles, the fibrous tissue of cardiac valve a

255 R attributable to unequal contraction of the papillary muscles, the magnitude of regurgitation is gre

256 R by correcting the position of the affected papillary muscle, thus relieving apical tethering.

257 ps: 1) markedly increased r of the posterior papillary muscle tip (10.3 versus 6.4 mm, MR versus no-M

258 its attachments to the anterior annulus and papillary muscle tip (angular difference = 3 +/- 7 degre

259 the intercommissural dimension with anterior papillary muscle tip displacement toward the annulus is

260 a (MAA), anterior (APM), and posterior (PPM) papillary muscle tip distances to midseptal MA ("saddle

261 The anterior papillary muscle tip in EXP was displaced from CTL by 2.

262 end-systole) and increased r of the anterior papillary muscle tip; 2) dilation (in the septal-lateral

263 anterior and posterior mitral leaflets, and papillary muscle tips and bases in 2 groups of sheep.

264 Both papillary muscle tips avulsed in the first animal, leavi

265 ETHODS AND Under cardiopulmonary bypass, the papillary muscle tips in 6 adult sheep were retracted ap

266 Under cardiopulmonary bypass, the papillary muscle tips in 6 sheep were retracted apically

267 creasing the leaflet tethering distance from papillary muscle tips to the anterior mitral annulus (P<

268 markers were sutured to the mitral annulus, papillary muscle tips, and leaflet edges in 13 sheep.

269 ords at anterior mitral leaflet (S1 and S2), papillary muscle tips, fibrous trigones, mitral annulus,

270 illow height (P<0.0001), longer lengths from papillary muscles to coaptation (P<0.0001), and more fre

271 a from electrically paced rat trabeculae and papillary muscles to provide a molecular explanation of

272 cTnC for the thin filament in reconstituted papillary muscles to provide evidence of an allosteric m

273 e with MR (>/= moderate) had higher systolic papillary muscle-to-annulus tethering length (P < 0.01).

274 was associated with a decrease in infarcted papillary muscle-to-mitral annulus tethering distance (2

275 ry mechanistic theory is rooted in increased papillary muscle traction and forces due to prolapse, ye

276 Papillary muscle VAs were distinguished electrocardiogra

277 Patients with papillary muscle VAs were older and had higher prevalenc

278 thm, the accuracy rates for the diagnosis of papillary muscle VAs, fascicular VAs, and mitral annular

279 syndrome is characterized by fascicular and papillary muscle VE that triggers ventricular fibrillati

280 tion, the normal shortening of the posterior papillary muscle was obliterated to allow its tip to mov

281 n of isolated rat left ventricular posterior papillary muscle was virtually eliminated at the end of

282 The contractility of cardiac papillary muscles was also restored in CRISPR-edited car

283 and cryostat sections of rat left ventricle papillary muscles, we localized AKAP100 to the nucleus,

284 oporation and conduction block thresholds in papillary muscles were 281+/-64 V and 380+/-79 V, respec

285 RV trabeculations and papillary muscles were considered cavity volume.

286 Left ventricular papillary muscles were excised from aortic-banded or sha

287 Accordingly, RV papillary muscles were isolated from 25 cats with RV pre

288 transients in electrically stimulated intact papillary muscles were observed in Tg-R145G compared wit

289 Papillary muscles were stretched from 88 to 98% of the l

290 e into a cylindrical construct, resembling a papillary muscle, which we have termed a cardioid.

291 o, in 1 patient, attachment of anterolateral papillary muscle with the lateral free wall was partiall

292 staining of transverse cross-sections of the papillary muscles with AKAP100 plus alpha-actinin-specif

293 0.75) and posterior (r=0.70) displacement of papillary muscle, with confirmation in multivariate anal

294 rated anterior displacement of hypertrophied papillary muscles within the left ventricular cavity and

295 or motion relative to the posteriorly placed papillary muscles without a decrease in total orifice ar