ライフサイエンスコーパス: paracellular permeability

1 d actin stress fiber formation and prevented paracellular permeability.

2 phorylation of VE-cadherin and p120(ctn) and paracellular permeability.

3 audin isoforms may play a role in regulating paracellular permeability.

4 CFA, resulting in significant changes in BBB paracellular permeability.

5 receptor 2 (PAR2) on colonocytes to increase paracellular permeability.

6 (TJs) regulate epithelial cell polarity and paracellular permeability.

7 pproach, ConA labels only blood vessels with paracellular permeability.

8 histamine results in a transient increase in paracellular permeability.

9 alpha(12) in MDCK cells reversibly increased paracellular permeability.

10 claudin-1, and is associated with increased paracellular permeability.

11 BB tight junctional disruption and increased paracellular permeability.

12 on of intracellular energetics and increased paracellular permeability.

13 1 likely contribute to regulated endothelial paracellular permeability.

14 ite, adenosine, in modulation of endothelial paracellular permeability.

15 may be the unifying mechanism for regulating paracellular permeability.

16 erved a PMN-mediated decrease in endothelial paracellular permeability.

17 resistance is attributable to an increase in paracellular permeability.

18 exhibited TER levels > 150 omega cm2 and low paracellular permeability.

19 d BBB functional properties such as TEER and paracellular permeability.

20 l mucosa, causing inflammation and increased paracellular permeability.

21 d actin stress fiber formation and increased paracellular permeability.

22 audin-1) that critically regulate epithelial paracellular permeability.

23 ns at junctions, wound healing dynamics, and paracellular permeability.

24 ntal or mutant E. faecalis strains indicated paracellular permeability.

25 ansepithelial resistance (TER) and decreased paracellular permeability.

26 nce and reduced the ratio of sodium/chloride paracellular permeability.

27 ght junctions (TJs), structures that control paracellular permeability.

28 s an important role in regulating epithelial paracellular permeability.

29 channel (ENaC) subunits and claudin-8 affect paracellular permeability.

30 human microvascular endothelium and measured paracellular permeability.

31 tion of tight and adherens junctions and BEC paracellular permeability.

32 We studied the role of claudin-1 in hepatic paracellular permeability.

33 ability of junctional proteins and increased paracellular permeability.

34 VE-cadherin pathway responses which increase paracellular permeability.

35 EC adherens junctions, resulting in enhanced paracellular permeability.

36 nction protein internalization and increased paracellular permeability.

37 uption of endothelial cell-cell contacts and paracellular permeability.

38 id not alter the effect of occludin siRNA on paracellular permeability.

39 sed ZO-1 expression and increased epithelial paracellular permeability.

40 wn about the specific molecules that mediate paracellular permeabilities.

41 ng PrP(c) knockdown; the cells had increased paracellular permeability (1.5-fold over 48 hours; P < .

42 methasone significantly reduced [14C]sucrose paracellular permeability (-231% of controls).

43 tent with the autophagy-induced reduction in paracellular permeability, a marked decrease in the leve

44 elationship was developed for enhancement of paracellular permeability across Caco-2 cell monolayers.

45 elial cell determines the characteristics of paracellular permeability across epithelium.

46 n brain endothelial cells leads to increased paracellular permeability, allowing leukocyte entry into

47 ins, ZO-1 and Occludin, and in the increased paracellular permeabilities and the reduced TEER values

48 ions as detected by a 3-fold decrease in the paracellular permeability and a 2-3-fold increase in the

49 l adhesion kinase mediates TGF-beta1-induced paracellular permeability and actin cytoskeleton dynamic

50 TGF-beta1 induces an increase in paracellular permeability and actin stress fiber formati

51 ntially deleterious increases in endothelial paracellular permeability and could serve as a basic mec

52 RalA reduction increased paracellular permeability and decreased incorporation of

53 sms by which they contribute to the enhanced paracellular permeability and disease pathophysiology of

54 s into TJs, whereas RalB reduction decreased paracellular permeability and increased incorporation of

55 d by Claudin-1 absence, leading to increased paracellular permeability and liver injuries secondary t

56 thelial occludin may play a role in enhanced paracellular permeability and PMN transmigration that is

57 To test for paracellular permeability and size exclusion, FITC-label

58 rectly responsible for increasing epithelial paracellular permeability and that mice deficient in a m

59 ency of alkylphosphocholines as enhancers of paracellular permeability and the inhibitors of phosphol

60 Both paracellular permeability and the localization of TJ pro

61 TJ proteins, and TJ damage that may increase paracellular permeability and thereby contribute to the

62 mutation within ECs prevented VEGF-initiated paracellular permeability and tumor cell transmigration

63 oxin induces actin reorganization, increased paracellular permeability, and endothelial cell detachme

64 l cells in junction formation, regulation of paracellular permeability, and epithelial morphogenesis.

65 , and resulted in cell retraction, increased paracellular permeability, and facilitated eosinophil tr

66 VE-cadherin and beta-catenin, increased BMEC paracellular permeability, and facilitated the ability o

67 ion of claudins, the primary determinants of paracellular permeability, and measured transepithelial

68 , alters intestinal ion transport, increases paracellular permeability, and stimulates inflammation.

69 Our findings indicate that transcytosis and paracellular permeability are co-regulated through a sig

70 Claudins regulate cell adhesion and paracellular permeability as fundamental components of n

71 ation, immunoblotting, immunohistochemistry, paracellular permeability assay, FACS, cytokine assay, a

72 determined by reduced electrical resistance, paracellular permeability assays, and cell surface E-cad

73 eir basolateral side significantly decreased paracellular permeability; astrocyte-conditioned media d

74 Tight junctions (TJs) create ion-selective paracellular permeability barriers between extracellular

75 on of apical F-actin structures and enhanced paracellular permeability but did not alter the distribu

76 prototypic barrier-forming claudin, reduces paracellular permeability by a previously unrecognized m

77 n proteins that regulate tissue cohesion and paracellular permeability by assembling dense adhesion p

78 fore, phosphocholines are likely to increase paracellular permeability by modulating the signal trans

79 s, occludin S408 dephosphorylation regulates paracellular permeability by remodeling tight junction p

80 etworks that increase inflammation, regulate paracellular permeability, cause epithelial damage, up-r

81 nslocation appears to be due to increases in paracellular permeability caused by migrating PMNs.

82 hat PKC signaling regulates toxin A-mediated paracellular permeability changes and ZO-1 translocation

83 SU6656 reduced TNF-alpha-mediated paracellular permeability changes, restored occludin, p1

84 The PAMPA data were modified to include the paracellular permeability component found in cellular mo

85 Paracellular permeabilities conferred by claudin-2 are c

86 thereby providing a mechanism for increased paracellular permeability during helminth infection.

87 Paracellular permeability enhancers have been used to im

88 disruption of tight junctions and increases paracellular permeability, facilitating HIV-1 paracellul

89 olines as inhibitors of PLC and enhancers of paracellular permeability fit well into this correlation

90 sendothelial electrical resistance), reduced paracellular permeability (fluorescein isothiocyanate-de

91 With the use of cultured podocytes, a paracellular permeability flux assay was established to

92 We observed significant increase in paracellular permeability following siRNA-mediated suppr

93 nge as in controls, along with the unaltered paracellular permeabilities for fluorescein and FITC-dex

94 ithelial electrical resistance by decreasing paracellular permeability for cations.

95 resistance (TEER), indicating an increase of paracellular permeability for ions.

96 ovide the molecular basis for regulating the paracellular permeability for water, solutes, and immune

97 Cl(-) and HCO(3) (-) had similar paracellular permeabilities in human airway epithelia.

98 In conclusion, VEGF induces a sustained paracellular permeability in capillary endothelial cells

99 Clostridium difficile toxin A increases paracellular permeability in colonic epithelial T84 cell

100 n-regulation of Sgpp2 attenuated LPS-induced paracellular permeability in cultured cells and enhanced

101 ion protein 1 (TJP1) gene, is a regulator of paracellular permeability in epithelia and endothelia.

102 blishment of cell polarity and regulation of paracellular permeability in epithelia.

103 , knockdown of JAM1 was observed to increase paracellular permeability in epithelial monolayers.

104 tein degradation and translocation to reduce paracellular permeability in human brain microvascular e

105 ve previously shown that IFN-gamma increases paracellular permeability in model T84 epithelial cells

106 Similarly, we observed an increase of paracellular permeability in NRC cells silenced for clau

107 altering junctional complexes and increasing paracellular permeability in polarized ARPE-19 cells cul

108 alizes to tight junctions and contributes to paracellular permeability in polarized epithelia.

109 Defect in claudin-1 expression increases paracellular permeability in polarized hepatic cell line

110 ertain the mechanism by which VEGF regulates paracellular permeability in rats.

111 d to study cerebrovascular transcellular and paracellular permeability in vivo.

112 artially able to prevent the increase in BEC paracellular permeability induced by cytokines.

113 lts show that HMTBA prevents the increase in paracellular permeability induced by H2O2 or tumour necr

114 K8 silencing abolished the decrease in paracellular permeability induced by IL-6.

115 The increase in paracellular permeability induced by TcdA and TcdB was a

116 Epithelial paracellular permeability is conferred by tight-junction

117 As a morphological marker of increased paracellular permeability, its presence in patients with

118 tercellular junctional distance, and induced paracellular permeability, loss of apico-basal polarity

119 We show that murine paracellular permeability markedly decreases during post

120 ma-induced increase in intestinal epithelial paracellular permeability may be an important mechanism

121 We speculate that paracellular permeability may have evolved as a general

122 etween transcellular sodium reabsorption and paracellular permeability may prevent the backflow of re

123 Using an in vitro endothelial paracellular permeability model, cell-free supernatants

124 Using an in vitro endothelial paracellular permeability model, we observed a PMN-media

125 luten-sensitized mice, P(HEMA-co-SS) reduced paracellular permeability, normalized anti-gliadin immun

126 Decreased endothelial paracellular permeability occurred through adenosine A2B

127 cells, while the endocochlear potential and paracellular permeability of a biotin-based tracer in th

128 miRNA functions contributes to the enhanced paracellular permeability of ANDV-infected ECs and that

129 Consistent with this finding, paracellular permeability of AQP1(s) AV-infected TM mono

130 rm that psychological stress compromises the paracellular permeability of bladder mucosa and its non-

131 The paracellular permeability of bovine retinal endothelial

132 Paracellular permeability of cell monolayers to fluoresc

133 PAR(2) agonists increased paracellular permeability of colonic epithelial cells, i

134 lonocytes, mast cell degranulation increased paracellular permeability of colonocytes.

135 The paracellular permeability of endothelial cells is unique

136 esistance was associated with an increase in paracellular permeability of glucose.

137 cofilin-1 by RNA interference increased the paracellular permeability of human colonic epithelial ce

138 ot stimulate Cl- secretion but increases the paracellular permeability of intestinal epithelia.

139 tructural changes may selectively affect the paracellular permeability of ions or small molecules, re

140 e gate functions to transiently regulate the paracellular permeability of large solutes and ions coul

141 eins and results in a 2-fold increase in the paracellular permeability of MDCK cell monolayers.

142 of apically applied occludin peptide on the paracellular permeability of molecular tracers and viral

143 ght junction membrane proteins that regulate paracellular permeability of renal epithelia to small io

144 SP27)/EV and EV/HSP27 mixtures decreased the paracellular permeability of small and large molecular m

145 akdown of TJs but in a selective increase in paracellular permeability of small molecules.

146 Nutrient starvation reduced the paracellular permeability of small-sized urea but not la

147 ed TAL tubules of claudin-10-deficient mice, paracellular permeability of sodium is decreased, and th

148 This coincided with an increase of paracellular permeability of the BBB to the small tracer

149 d decreases the effect of swainsonine on the paracellular permeability of the cell monolayer and also

150 promoting contraction of BBEC and increasing paracellular permeability of the CNS vasculature.

151 cytes also induced a twofold increase in the paracellular permeability of the endothelial monolayer.

152 The CaSR specifically regulated the paracellular permeability of the TAL, especially for cal

153 uences resting intracellular volume and thus paracellular permeability of TM cell monolayers in vitro

154 tinal epithelium to dynamically regulate its paracellular permeability properties and better define t

155 s for the molecular components that regulate paracellular permeability properties in epithelial tissu

156 as been demonstrated to transiently increase paracellular permeability properties to provide an addit

157 opose these patterns underlie differences in paracellular permeability properties, such as electrical

158 Epithelial tight junctions regulate paracellular permeability, restrict apical/basolateral i

159 cture and function, although the increase of paracellular permeability returned to baseline after 24

160 ed alterations of the epithelial barrier and paracellular permeability suggest that common mechanisms

161 tine tissues from PrP(c-/-) mice had greater paracellular permeability than from wild-type mice (105.

162 ng the "loosening" of TJs and an increase in paracellular permeability, the BBB is able to "bend with

163 Despite the increased paracellular permeability, there were no changes in gros

164 s cell polarity, cytoskeleton integrity, and paracellular permeability through inhibition of the smal

165 Occludin depletion increased diffusive paracellular permeability to 467 Da TAMRA by 15%, and pe

166 ell death and resulted in an increase in the paracellular permeability to [(3)H]inulin as a function

167 cing of Claudin-1 in Can 10 clones increased paracellular permeability to a level similar to that of

168 ased TEER (1.28- to 1.31-fold) and decreased paracellular permeability to FITC-Dextran, and this effe

169 sepithelial resistance, a marked decrease in paracellular permeability to fluorescence isothiocyanate

170 l TER, these monolayers do exhibit increased paracellular permeability to fluorescent dextrans.

171 rties, including transepithelial resistance, paracellular permeability to hydrophilic solutes, and th

172 ltured epithelial cells demonstrate enhanced paracellular permeability to large molecules, revealing

173 rier-forming Caco-2 monolayers and increases paracellular permeability to macromolecular FITC-dextran

174 es, claudin-8 expression was found to reduce paracellular permeability to monovalent inorganic and or

175 This indicates decreased paracellular permeability to NaCl but increased permeabi

176 rrent, and pH stat measurements, to estimate paracellular permeability to protons, ammonium and bicar

177 84 monolayers and demonstrated that enhanced paracellular permeability to small solutes occurred in t

178 aired the development of TEER, and increased paracellular permeability to sodium fluorescein in airwa

179 abundance was associated with a reduction in paracellular permeability to sodium, whereas decreased c

180 t junction (TJ) has a key role in regulating paracellular permeability to water and solutes in the ki

181 port controls tight-junction composition and paracellular permeability via modulating expression of t

182 Paracellular permeability was assessed by apical-to-basa

183 Paracellular permeability was assessed by fluorescein is

184 ion and hyperalgesia were confirmed, and BBB paracellular permeability was assessed by in situ brain

185 The role of autophagy in the modulation of paracellular permeability was confirmed by pharmacologic

186 lones, Claudin-1 was localized at the TJ and paracellular permeability was decreased, compared to par

187 Paracellular permeability was determined by quantifying

188 Paracellular permeability was measured by using fluoresc

189 -alkoxypropylphosphocholines as enhancers of paracellular permeability was not dependent on their exi

190 ays a role in mediating the shear effects on paracellular permeability, we overexpressed hAQP5 in 16H

191 fects on ER stress activation and epithelial paracellular permeability were examined in vitro as well

192 Changes in barrier function and abnormal paracellular permeability were found in both interfollic

193 In this study, highly potent enhancers of paracellular permeability were identified in the 3-alkyl

194 Zonulin production and changes in paracellular permeability were monitored in Ussing chamb

195 ell cultures from a VEGF-induced increase in paracellular permeability, whereas recombinant OCLN expr

196 nsil epithelial tight junctions and increase paracellular permeability, which facilitates HCMV spread

197 role in regulating the maintenance of TJ and paracellular permeability, which may explain how various

198 and interferon-gamma significantly increased paracellular permeability, which was blocked by cotreatm

199 vated in the cecum of WD-fed mice, increased paracellular permeability, while the BA-binding resin se

200 l barrier integrity and decreased intestinal paracellular permeability with a lower level of serum en

201 ronic IP, we demonstrated alterations in BBB paracellular permeability with correlating changes in ti

202 DRA-KO mice exhibited an increased colonic paracellular permeability with significantly decreased l