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1 erotonin reaches the AL via the diffusion of paracrine 5-HT through the fly hemolymph [8] and by acti
3 Myeloid-derived growth factor (MYDGF) is a paracrine-acting protein that is produced by bone marrow
4 t mesenchymal stem cells (MSCs), since their paracrine action can therapeutically enhance the SC rege
5 nt remodeling in the cornea by promoting the paracrine action of secreted interleukin-1beta (IL-1beta
7 ypeptide factors that exert autocrine and/or paracrine actions, with most cytokines acting in the imm
9 e and stimulate revascularization largely by paracrine activation of angiogenic functions in the peri
10 A) as the causative factor for autocrine and paracrine activation of canonical and noncanonical NF-ka
13 EN-null fibroblasts leading to a loss in the paracrine activation of NOTCH signaling from the surroun
15 As a secreted protein, it is an autocrine/paracrine activator of canonical WNT signaling and, as a
18 hat AMs, but not ECs, constitutively secrete paracrine activity localized to EVs which inhibits influ
20 ior, including migration, proliferation, and paracrine activity, which are essential for angiogenesis
22 of alpha-cells in human islets, suggesting a paracrine alpha to beta-cell signaling through the beta-
24 regulation is mediated by signaling via both paracrine and autocrine diffusible factors that induce d
25 Furthermore, there is growing evidence that paracrine and autocrine factors, especially the endothel
28 e infiltration in the tissue, is mediated by paracrine and autocrine signals mainly regulated by IL13
29 ct as 'synthetic stem cells' which mimic the paracrine and biointerfacing activities of natural stem
30 ew what is known about the interplay between paracrine and circadian control of electrolyte excretion
32 s-organ communication systems-involving both paracrine and circulating regulatory factors-to safeguar
33 h direct contact with adjacent cells and via paracrine and endocrine factors that affect cells in the
34 ystem and other tissues by releasing diverse paracrine and endocrine factors to orchestrate adipose t
36 support direct and rapid actions of Amh as a paracrine and/or autocrine factor in regulating hippocam
37 rtially redundant actions of retina-derived (paracrine) and astrocyte-derived (autocrine) VEGF in con
39 central auditory neurons can be modulated by paracrine ATP signalling, as shown for the cochlear nucl
43 e expression of migration markers, endocrine/paracrine biomolecules, and extracellular matrix compone
44 ons result from primary or secondary loss of paracrine BMP signaling from preosteoblasts and dura, hi
46 -derived complement production and autocrine/paracrine C3ar1/C5ar1 signaling as crucial intermediary
48 entify the distinct secretion of IL-6 as the paracrine cause of PI3Kalpha(H1047R)-associated vascular
49 t studies highlight how redox signalling via paracrine cell-to-cell communication may act as a centra
51 ion response is self-organized by neutrophil paracrine chemoattractant signaling (most notably of the
54 utant mice, thereby demonstrating the robust paracrine control of tumour-initiating stem cells by PGE
55 ricryptal Ptgs2-expressing fibroblasts exert paracrine control over tumour-initiating stem cells via
57 f hematopoietic regeneration and demonstrate paracrine cross-talk between BM osteolineage cells and e
59 a-analytic database analyses, we developed a paracrine cross-talk-based biological mechanism of DCIS
60 een these two tumor populations uncovers the paracrine crosstalk from tumor core that promotes malign
62 ved the same effect, confirming an autocrine-paracrine cytokine loop as a mechanism for BCG-mediated
63 ic target of AML and provides a mechanism of paracrine cytokine/growth factor signaling in this disea
64 r because of the important role of autocrine/paracrine cytokines in modulating PRR-initiated signalin
67 mammary adipose tissue, and establish that a paracrine effect of the tissue adipokine leptin causes l
69 l HIV reservoirs can have both autocrine and paracrine effects contributing to the HIV-associated com
72 ulture experiments were used to evaluate the paracrine effects of EpAT on cardiomyocyte electrophysio
73 in vivo: cell-autonomous effects of protons; paracrine effects of pH mediated by surrounding astrocyt
74 Altogether, these data show autocrine and paracrine effects of Sfrp4 in regulating OCgenesis and d
77 Adipose-derived stem cells (ADSCs) exert paracrine effects protecting chondrocytes from degenerat
78 To dissect the relative contributions of the paracrine effects, we first established a liver organoid
82 eptidergic signaling can involve juxtacrine, paracrine, endocrine, and neuronal signaling, making it
84 t leukaemia inhibitory factor (LIF) is a key paracrine factor from activated PSCs acting on cancer ce
85 impaired ability to upregulate expression of paracrine factor genes and the conditioned media from th
87 thesized that endothelin-1 (ET1), a secreted paracrine factor of ECs, can differentially direct the l
88 in controlling the secretion of IL-1alpha, a paracrine factor that regulates the wound myofibroblast
90 hat resident macrophages and their prorepair paracrine factors are essential for the rescue of irradi
92 skeletal muscle contraction during exercise, paracrine factors coordinate tissue remodeling, which un
93 tudy identifies secreted ASM and ceramide as paracrine factors enhancing intestinal epithelial dysfun
95 nder cortical neurons, suggesting a role for paracrine factors in induction of neuronal apoptosis.
96 support metabolism and express regenerative paracrine factors is a strategy to treat vasculopathies
97 g approach to probe the effect of individual paracrine factors on epicardial progenitors in the adult
100 fter cutaneous injury, keratinocytes secrete paracrine factors that regulate wound cell functions; dy
101 ity of stem cells to secrete a wide range of paracrine factors, a characteristic that could be exploi
102 mother' or 'nurse' cells, provide nutrients, paracrine factors, cytokines, and other biomolecules to
104 doislets depends upon the combined action of paracrine factors, such as insulin and somatostatin, and
108 diovascular effects appear to be mediated by paracrine FGF control of kidney FGFR1 and subsequent reg
113 , our data provide strong evidence against a paracrine ghrelin-GHSR axis mediating insulin secretion
114 facilitate L-cell differentiation through a paracrine GLP-1-dependent and serotonin-mediated mechani
115 endothelial release of NRG (neuregulin)-1-a paracrine growth factor activating ErbB2 (erythroblastic
116 fetus, and adult, intestinal Hh signaling is paracrine: Hh ligands are expressed in the endodermally
117 in CKD stimulates production of intrakidney paracrine hormones including angiotensin II, aldosterone
118 es included negative feedback from autocrine/paracrine IL-10, TGF-beta, IL-4, IL-13, IL-22, and TSLP
119 cularly dependent on PRR-initiated autocrine/paracrine IL-12-induced STAT4 activation to generate IFN
120 y and IL-1 synthesis, resulting in autocrine/paracrine IL-1beta-mediated increases in EC immunogenici
122 res of ZR75-1 and LNCaP with BMSCs exhibited paracrine IL6-induced HT resistance via attenuation of H
128 ed that Hedgehog activation greatly enhances paracrine interactions between salivary gland resident m
129 leted resident macrophages through prorepair paracrine interactions with endothelial cells and epithe
130 ter elongation relies on well-characterized, paracrine interactions with the hosting maternal reprodu
131 o evaluate the tumorigenic effects of CA-MSC paracrine LIF signaling and the redundancy of IL6 and LI
132 Activation of this receptor is dependent on paracrine ligand induction, and its preferred ligand PDG
134 n intra-adipose tissue E2F1-associated TNFSF paracrine loop engaging lymphocytes, macrophages, and ad
135 f TGFbeta ligands that acted in an autocrine/paracrine loop to activate SMAD2 and suppress adipogenes
136 anocyte SASP induces telomere dysfunction in paracrine manner and limits proliferation of surrounding
138 chanistically, NAMPT regulates EOC CSCs in a paracrine manner through the senescence-associated secre
139 by ADAM10, after which it acts largely in a paracrine manner to direct cell motility at the leading
141 rotrophic factors or molecules that act in a paracrine manner, offering a novel therapeutic strategy
154 EGF-C/NRP2/GLI axis is a novel and conserved paracrine means by which EMT cells enhance metastasis, a
156 igrating cells revealed a possible SCF/c-Kit paracrine mechanism contributing to migration via a subp
157 ptor (GHSR), suggesting the possibility of a paracrine mechanism for islet ghrelin to reach high loca
163 Together, these results identify a potential paracrine mechanism that coordinates neuronal homeostasi
165 reendothelialization in a PKCdelta-dependent paracrine mechanism, likely through CXCL7-mediated recru
169 n inhibit glucagon secretion by an indirect (paracrine) mechanism mediated by stimulation of intra-is
170 uggesting this effect is likely mediated via paracrine mechanisms during the initial stages of regene
172 onstrates that proximal tubule YAP-dependent paracrine mechanisms play an important role in diabetic
173 de arterial PCO2 /pH via cell-autonomous and paracrine mechanisms, and via input from other CO2 -resp
177 f neighboring cancer cells via non-canonical paracrine-mediated activation of GLI activity that is de
179 r cells that have undergone an EMT, promotes paracrine-mediated increases in proliferation, migration
182 tive myeloid or lymphoid cells contribute to paracrine miR-210 delivery, we studied miR-210 knockout
186 protein-coupled receptors (GPCRs) respond to paracrine or endocrine peptide hormones involved in cont
188 Silencing of DNMT3A in monocytes induced a paracrine proinflammatory activation and increased adhes
189 the bitter taste cascade leads to immediate paracrine protective responses that can be boosted in an
192 be rupture to release sperm is caused by the paracrine RALF34 peptide from the ovule interfering with
193 PDLSCs in the recognition of P. gingivalis, paracrine recruitment and activation of antimicrobial me
194 In this study, we explored the importance of paracrine regulation by using an optogenetic strategy.
195 e adipocytes suggests evolutionary conserved paracrine regulation of energy dissipation across specie
197 s succinate-SUCNR1 signaling is required for paracrine regulation of muscle innervation, muscle matri
200 reted by neighbouring beta- and delta-cells (paracrine regulation) have been proposed to be important
201 er, our observations show that BMP9 is a key paracrine regulator of liver homeostasis, controlling LS
204 ypical changes depends on enhanced autocrine/paracrine release of the EGFR ligand transforming growth
207 and new data have come forward regarding the paracrine role of the alpha-cell and specifically prepro
208 ocyte proliferation, supporting an autocrine/paracrine role of TNF-alpha on astrocyte proliferation.
211 PCa bone and visceral metastases, activating paracrine Shh signaling in tumor-stromal interactions.
212 eted trypanosome oligopeptidases generates a paracrine signal that accelerates stumpy formation in vi
213 ytes in substantial quantities and acts as a paracrine signal that affects neighbouring collagen-prod
214 n receptor signalling nexus may operate as a paracrine signal that sustains tumour cell expansion and
215 produced by neutrophils acts as an autocrine/paracrine signal to direct the vascular recruitment, arr
219 Increased lymphangiogenic signaling suggests paracrine signaling between LECs and breast cancer cells
221 more slowly developing mechanisms involving paracrine signaling by extracellular peptides (C-type na
223 le DE patterning is fairly well studied, the paracrine signaling controlling SM regionalization and h
224 hypothesize here that alpha3beta1-dependent paracrine signaling from keratinocytes regulates the dif
225 hout heart development, we hypothesized that paracrine signaling from the endocardium to the myocardi
226 ular vesicles (EVs) are important vectors of paracrine signaling implicated in a range of (patho)phys
227 eviously unknown role for PDGFB-to-PDGFRbeta paracrine signaling in the promotion of breast cancer br
230 d that arachidonic acid (AA), a precursor of paracrine signaling molecules for regulation of inflamma
232 ncovers an intricate IBC-initiated autocrine-paracrine signaling network between IBC cells and monocy
234 sicle release blocks LTB4-mediated autocrine/paracrine signaling required for neutrophil arrest and e
235 t aminoglycoside-induced hair cell death via paracrine signaling that requires extracellular heat sho
237 ricate balancing act involving autocrine and paracrine signaling to maintain pollen tube growth and i
238 hat ILC2(10)s can utilize both autocrine and paracrine signaling to suppress proinflammatory ILC2 eff
240 factor-2 (CSF-2) in decidual cells triggers paracrine signaling via its receptor (CSF2R) in trophobl
241 ions in initiating and maintaining autocrine/paracrine signaling with relevance to wound healing and
243 n-specific hydrogels regulate hMSC adhesion, paracrine signaling, and osteoblastic differentiation in
260 se effects, Wnts act as autocrine as well as paracrine signalling molecules between Wnt-producing and
262 daptive mechanism that harnesses synergistic paracrine signalling via IL-6/8, which is amplified by c
264 types, enabling the modelling of sequential paracrine-signalling events, such as tumour-cell-mediate
265 fine-tuning the endosomal pH in response to paracrine signals and is therefore an important regulato
269 the importance of the dynamic multifactorial paracrine signals in mediating remedial effects of strom
270 ng specification of the stroma, dysregulates paracrine signals necessary for uterine development, eve
274 hat mural cells can control tumor growth via paracrine signals regulated by beta3-integrin, providing
275 analysis predicts transcription factors and paracrine signals that affect fates and experiments vali
276 These reciprocal actions involve exchange of paracrine signals that govern implantation and placentat
277 of FAK in a subpopulation of CAFs regulates paracrine signals that increase malignant cell glycolysi
278 ts as an internal modulator of autocrine and paracrine signals that maintain immune suppression in ag
279 found that rotavirus-infected cells produce paracrine signals that manifested as intercellular calci
281 enal (local) production allows GCs to act as paracrine signals, specifically targeting activated T ce
284 tivates latent TGFbeta1 in Mphis, leading to paracrine SMAD2-mediated signaling in endothelial cells
286 t to induce hyperplasia through Wnt-mediated paracrine stimulation, and suggest that this tumor suppr
289 nsing of cytokine production was mediated by paracrine TNF-alpha-TNFR1 signaling rather than direct l
292 mination during cell isolation, in vivo mRNA paracrine transfer from parenchymal cells to ECs, or cel
293 Moreover, AGR2 expression was inducible by paracrine transfer of ER stress and pro-inflammation bet
294 imply a result of technical contamination or paracrine transfers of mRNAs, and indicate that local cu
295 ponding FcepsilonRIalpha(+) macrophages send paracrine transforming growth factor beta (TGF-beta) sig
296 er damage, reactive oxygen species (ROS) and paracrine tumor necrosis factor (Tnf) from Kupffer cells
297 which renders them dependent for survival on paracrine Wnt provided by low-Myc-expressing clones.
298 g activation by autocrine Wnt ligands and/or paracrine Wnts emanating from the bone marrow (BM) niche