ライフサイエンスコーパス: paradigm shift

1 e common types of epilepsy, and is driving a paradigm shift.

2 estions and opportunities stemming from this paradigm shift.

3 sing and addressing these threats requires a paradigm shift.

4 ll and resources need to be accompanied by a paradigm shift.

5 lators, funders and editors can embrace this paradigm shift.

6 Cerebellar neuroscience has undergone a paradigm shift.

7 global disease outbreaks as well as multiple paradigm shifts.

8 of sepsis, have been accompanied by episodic paradigm shifts.

9 of criticism have changed, reflecting recent paradigm shifts.

10 adulterated beef burgers and could provide a paradigm shift across many authenticity applications.

11 Paradigm-shifting advances have revealed that diverse me

12 n (1962) argued in his seminal discussion of paradigm shifts, an old paradigm cannot be abandoned unt

13 aused by RNA viruses represents an important paradigm shift and a new frontier for future antiviral t

14 pid development of new treatments requests a paradigm shift and a new way of thinking in the mind of

15 The findings are paradigm shifting and may provide a potential liquid-bas

16 Recent paradigm shifts and conflicting reports demonstrate the

17 This work illustrates a paradigm-shifting and biomimetic approach and contribute

18 This resulted in a major paradigm shift, and consequently, the pool of eligible p

19 Cancer epidemiology is at the cusp of a paradigm shift, and the field will need to accelerate th

20 As with most new paradigm-shifting applications, it is not the last word

21 In this work, we propose action decoding, a paradigm-shifting approach for independent, multi-digit

22 As proof of concept, we demonstrate this paradigm-shifting approach for photochemical tissue bond

23 This paradigm-shifting approach has a wide applicability to m

24 e genome sequencing we are in the midst of a paradigm shift as it is now possible to interrogate the

25 when the field of epidemiology again faces a paradigm shift as the tools for research on human health

26 emonstrate comparable performance metrics is paradigm shifting, as these new materials offer the poss

27 Approval of this drug would represent a paradigm shift away from dual antiplatelet therapy towar

28 This work has resulted in a paradigm shift away from dysregulation of single neurotr

29 These results lead to a paradigm shift away from the concept that binding of the

30 A paradigm shift, based on data emerging from the oral mic

31 Electronics is approaching a major paradigm shift because silicon transistor scaling no lon

32 n and growth of particles, the most critical paradigm shift being that the "burst" nucleation assumpt

33 A paradigm shift brought by the recognition that childhood

34 of essential mitotic kinases exemplify this paradigm shift, but intolerable on-target toxicities in

35 ynamics with repair progression and led to a paradigm shift by uncovering the directed movement of re

36 erged from principles of basic immunology to paradigm-shifting clinical immunotherapy.

37 This training represents a paradigm shift compared with more typical module-based o

38 We propose a paradigm-shifting concept in the perception of AD whereb

39 t to independently validate this potentially paradigm-shifting concept.

40 This paradigm shift concerning the cell of origin for the mos

41 We describe a paradigm shift currently under way in computer graphics

42 Paradigm-shifting discoveries about AD have been based o

43 While these new and potentially paradigm-shifting discoveries are intriguing, the field

44 Schizophrenia treatment may see a paradigm shift due to development of new atypical antips

45 atory syndrome in children (MIS-C) has had a paradigm-shifting effect on the perception of severe acu

46 Demonstrating an important paradigm shift, effector Th40 cells from prediabetic mic

47 The new HFPEF paradigm shifts emphasis from LV afterload excess to cor

48 The workshop was motivated by the paradigm-shifting evidence derived from genomic data for

49 s of this new class of albumins that offer a paradigm shift for albumin-based drug delivery.

50 energy storage devices, and could provide a paradigm shift for architecture and design of flexible a

51 thout a clear picture, or truly represents a paradigm shift for cancer research.

52 o the primary therapy, suggesting a possible paradigm shift for clinical treatment of dormant disease

53 A paradigm shift for implantable medical devices lies at t

54 n EZH2, EED, and SUZ12 supports the emerging paradigm shift for implementation of DNAm signatures int

55 Processing in dry conditions represents a paradigm shift for incorporating high active-material ma

56 or self-powered sensor, but also presents a paradigm shift for large-scale energy harvesting by TENG

57 A paradigm shift for models of MT assembly is suggested by

58 erature tunability demonstrated represents a paradigm shift for nanoscale metamaterial and metasurfac

59 ed within a single nanorod and may provide a paradigm shift for one-dimensional tunnelled materials,

60 The method presents a paradigm shift for the addressing of plasmonic nanostruc

61 Our technique constitutes a paradigm shift for the analysis of complex molecular mix

62 -based MFC technology, which could provide a paradigm shift for the architecture and design of paper-

63 h GLP-1 and glucagon and presents a critical paradigm shift for the field.

64 ic-level structural observations represent a paradigm shift for the mechanism of base selection in th

65 In turn, this development has created a paradigm shift for the synthesis of stereodefined acycli

66 fficile infection, and possibly represents a paradigm shift for the treatment of diseases linked to i

67 The promise of a major paradigm shift for the treatment of respiratory and card

68 Over the past few decades, this paradigm shifted for the chromosphere and corona that co

69 vaccine approaches have the potential to be paradigm shifting for the influenza vaccine field, with

70 The results strongly support three paradigm shifts for nucleation and growth of particles,

71 e genotype-phenotype relationship requires a paradigm shift from a focus on single SNPs to pathway as

72 management of breast cancer are undergoing a paradigm shift from a one-size-fits-all approach to an e

73 imate, which in recent years has undergone a paradigm shift from a text-book example of an extended g

74 We unveil a paradigm shift from an allergen-centered view to a more

75 ibrillation by inflammation and represents a paradigm shift from conventional antiarrhythmic drugs, w

76 ws promising results that signal a potential paradigm shift from conventional NMR data interpretation

77 ies, thereby presenting an opportunity for a paradigm shift from conventional restorative/prosthetic

78 Mastering the nonlinear channels requires paradigm shift from current modulation, coding and trans

79 s determine cell physiology and represents a paradigm shift from descriptive to predictive biology.

80 George Oster stood out as a pioneer of this paradigm shift from descriptive to quantitative biology

81 cess provides strong support to the on-going paradigm shift from energy-negative to energy-neutral in

82 This brings a paradigm shift from expensive surgical treatment of cata

83 This has resulted in a paradigm shift from focusing on the carriage of antibiot

84 A paradigm shift from hard to flexible, organic-based opto

85 Reducing the burden of stunting requires a paradigm shift from interventions focusing solely on chi

86 , maximizing conservation success requires a paradigm shift from maintaining ecosystems in idealized

87 ding of the pathophysiology of depression, a paradigm shift from monoamine to glutamatergic neurotran

88 a number of emerging applications require a paradigm shift from passivation to functionalization, wh

89 A paradigm shift from preventive therapy to aggressive pla

90 SOM dynamics require inclusion of the recent paradigm shift from SOM recalcitrance as an 'intrinsic p

91 Psychiatry is undergoing a paradigm shift from the acceptance of distinct diagnoses

92 This is a paradigm shift from the current model of enamel developm

93 We propose a paradigm shift from the current postoperative risk adjus

94 data from the last 2 years have suggested a paradigm shift from the notion that DES are less safe th

95 This represents a paradigm shift from traditional, enthalpy-based mechanis

96 The need for a paradigm shift from type-specific immunity against S. py

97 It also requires a second paradigm shift, from the classic infection control hiera

98 Paradigm-shifting gains in scientific knowledge are occu

99 A paradigm shift has occurred in the management of advance

100 s within distinct healthy tissues provides a paradigm shift in adaptive immunity.

101 onential growth as these systems represent a paradigm shift in alloy development, in some cases exhib

102 Together, these results represent a paradigm shift in anisotropic gold NP synthesis.

103 ently or soon to be available, that offers a paradigm shift in CAD management.

104 This paradigm shift in cancer cell biology and mitochondrial

105 latform, which has great potential to make a paradigm shift in cancer chemotherapy.

106 therapy for B cell malignancies represents a paradigm shift in cancer immunotherapy.

107 therapy over the past few years represents a paradigm shift in cancer therapy.

108 Cancer immunotherapy, as a paradigm shift in cancer treatment, has recently receive

109 te antitumor T-cell immunity have heralded a paradigm shift in cancer treatment.

110 bcutaneous pulse generator could represent a paradigm shift in cardiac pacing.

111 This study provides proof of concept for a paradigm shift in cardiovascular intervention, suggestin

112 us disease represents an illness ready for a paradigm shift in care delivery and outcomes, and the pr

113 r kinase inhibitor (KI) therapy represents a paradigm shift in chronic lymphocytic leukemia (CLL) man

114 te the affective sphere of pain represents a paradigm shift in chronic pain management.

115 aluation of exosomal markers could lead to a paradigm shift in clinical analysis and associated care.

116 an pathophysiology in many ways represents a paradigm shift in clinical-psychological and psychiatric

117 We advocate that it is time for a paradigm shift in comparative phylogeography, especially

118 f intrinsic microporosity (PIMs) represent a paradigm shift in conceptualizing molecular sieves from

119 serving many of these species necessitates a paradigm shift in conservation toward a holistic approac

120 ements of wearable electronics have caused a paradigm shift in consumer electronics, and the emerging

121 cent decades, with the potential to create a paradigm shift in decision theories.

122 n, the therapeutic landscape has undergone a paradigm shift in determining safety, stability and effi

123 This may constitute a paradigm shift in developing efficient protocols for hig

124 r into a drug uptake pump would constitute a paradigm shift in efforts to overcome cancer drug resist

125 of a causative link with malaria would be a paradigm shift in efforts to prevent and control hyperte

126 g, and redirect our approaches likely with a paradigm shift in how the disease is viewed.

127 tates of the respiratory virome, and drive a paradigm shift in how the practicing pulmonologist views

128 in western and southern India, we show that paradigm shift in Indian groundwater withdrawal and mana

129 ive approach to open surgery, resulting in a paradigm shift in liver surgery.

130 umorigenic phenotype (M1) have facilitated a paradigm shift in macrophage immunotherapy.

131 vements in the field have already produced a paradigm shift in melanoma treatment: Metastatic melanom

132 the United States, suggesting the need for a paradigm shift in methods for mitigating emissions.

133 :target interaction networks and advocates a paradigm shift in miRNA studies.

134 thin materials has the potential to enable a paradigm shift in modern technologies by introducing mul

135 Discoveries over the past decade portend a paradigm shift in molecular biology.

136 The past few years have witnessed a paradigm shift in molecular systematics from phylogeneti

137 w generation of nanovesicles can represent a paradigm shift in nanomedicine: they may complement lipo

138 inal uptake and transport will bring forth a paradigm shift in nanoparticle engineering for oral deli

139 rt X-ray pulse durations and is leading to a paradigm shift in our ability to explore nonlinear X-ray

140 The results from these studies created a paradigm shift in our collective thinking as to why reco

141 These findings represent a paradigm shift in our concepts of mt-nuclear interaction

142 pressant effects of ketamine has 1) led to a paradigm shift in our perception of what is possible in

143 process termed gliotransmission has caused a paradigm shift in our thinking about brain function.

144 This has led to a paradigm shift in our treatment methodology.

145 New findings necessitate a paradigm shift in our understanding of acute pancreatiti

146 This work provides a paradigm shift in our understanding of HCV-specific immu

147 chytridiomycosis in amphibians represented a paradigm shift in our understanding of how emerging infe

148 dentify and destroy tumor cells has driven a paradigm shift in our understanding of human cancer.

149 nd how this fast-evolving field is driving a paradigm shift in our understanding of immunoregulation

150 al approaches has the potential to produce a paradigm shift in our understanding of infectious diseas

151 e outline recent developments that support a paradigm shift in our understanding of lesion progressio

152 ascular changes caused by DM and represent a paradigm shift in our understanding of ocular diabetic c

153 This model represents a paradigm shift in our understanding of SERCA regulation

154 These data represent a paradigm shift in our understanding of the function of C

155 n the solvent-filled interface and lead to a paradigm shift in our understanding of the mononuclear d

156 These data represent a paradigm shift in our understanding of the role of andro

157 This paradigm shift in our understanding of vascular-resident

158 These observations prompt a paradigm shift in P. vivax biology and open avenues to i

159 d with clinical protection, thus prompting a paradigm shift in P. vivax biology toward deeper studies

160 A paradigm shift in pacemaker technology has been the deve

161 to the pain expression pathway have led to a paradigm shift in pain management, allowing clinicians t

162 Enhanced Recovery After Surgery (ERAS) is a paradigm shift in perioperative care, resulting in subst

163 eart failure following infarction requires a paradigm shift in pharmacotherapy.

164 idics and mechanical engineering, creating a paradigm shift in physiologically relevant environments

165 though operative modalities have undergone a paradigm shift in recent years.

166 Given the recent paradigm shift in regard to how oncoproteins promote tra

167 ng and transplantation experiments support a paradigm shift in reproductive biology involving active

168 t article, Kalisch and colleagues advocate a paradigm shift in research on stress-related mental diso

169 s by 2030, but achieving this will require a paradigm shift in river restoration that recognizes the

170 r-thin solution processable MXene proposes a paradigm shift in shielding of lightweight, portable, an

171 iplexed "QCR-on-chip" technology, bringing a paradigm shift in speed, accessibility and affordability

172 This new guideline endorses a paradigm shift in strategies for reducing atheroscleroti

173 This represents a paradigm shift in structure determination methods, which

174 onal imaging and outline the potential for a paradigm shift in surgical and endoscopic visualization.

175 asure of risk), these elements have led to a paradigm shift in the ability to diagnose osteoporosis a

176 led "immunoparalysis" is currently causing a paradigm shift in the adjunctive treatment of sepsis fro

177 A paradigm shift in the approach to management of the olde

178 A sustained paradigm shift in the approach to treating sepsis has ye

179 We believe this work represents a paradigm shift in the assessment of the human face, hold

180 the experimental data sets will enhance the paradigm shift in the community towards a much more dyna

181 From the 1860-1880s, they articulated a paradigm shift in the conceptualization of psychiatric d

182 -enhanced experimental approach represents a paradigm shift in the design of electrified chemical tra

183 (MOFs) in the form of colloids has brought a paradigm shift in the design of new functional porous ma

184 g in comparison with Pt, and may represent a paradigm shift in the design of self-supported catalysts

185 However, a major paradigm shift in the epidemiology and bacteriology of i

186 ion of DES being safer than BMS represents a paradigm shift in the evolution of percutaneous coronary

187 sm repair using stent grafts causing a major paradigm shift in the field of aortic aneurysm surgery.

188 o methodological advances, enabling a needed paradigm shift in the field of bacterial transcription t

189 on of unactivated C-H bonds is ushering in a paradigm shift in the field of retrosynthetic analysis.

190 This represents a paradigm shift in the field, showing that GR uses multip

191 methods can potentially lead to a desirable paradigm shift in the handling of drug evidence.

192 ted tomography angiography (CCTA) has seen a paradigm shift in the last decade.

193 ases of pituitary diseases, there has been a paradigm shift in the management by conservative measure

194 iving donor-RAPID" procedure may represent a paradigm shift in the management of i-CRLM.

195 development of psoriasis has led to a major paradigm shift in the pathogenic model for this conditio

196 stead of the functional groups, represents a paradigm shift in the standard logic of organic synthesi

197 in the brain." This prize recognizes both a paradigm shift in the study of cognitive neuroscience, a

198 artilage, or stromal cells could represent a paradigm shift in the therapeutic regeneration of skelet

199 dominantly drive absorption, resulting in a paradigm shift in the traditional concepts of ultrafast

200 apies over the past decade has resulted in a paradigm shift in the treatment of cancer.

201 ion of atrophic non-union and could enable a paradigm shift in the treatment of fractures at high ris

202 These recent discoveries may enable a paradigm shift in the treatment of this complex disease,

203 tance led to significant advancements and to paradigm shift in the treatment.

204 rematurity, and are poised to benefit from a paradigm shift in the treatment.

205 the genesis, development, and future of this paradigm shift in the understanding of osteogenesis impe

206 This paper presents a paradigm shift in the understanding of the role of S in

207 These findings suggested consideration of a paradigm shift in the understanding of the therapeutic r

208 ing tumour DNA (ctDNA) analysis, represent a paradigm shift in the use of genomic biomarkers with con

209 Our methodology represents a paradigm shift in the use of NMR active tags in structur

210 Remote patient monitoring represents a paradigm shift in the way physicians care for patients.

211 predict neurologic outcome would represent a paradigm shift in the way spinal cord injury clinical tr

212 indings are directly relevant to the ongoing paradigm shift in the WM field.

213 his provides molecular genetic support for a paradigm shift in theories of lycophyte leaf evolution.

214 oss a broad spectrum of cancers has led to a paradigm shift in therapy for patients with advanced can

215 in chronic lymphocytic leukemia has led to a paradigm shift in therapy, and relapse has been uncommon

216 esonances or interference effects, marking a paradigm shift in thermal engineering approaches.

217 This work represents a paradigm shift in thermal-based modulation-demodulation

218 Epidemics require a paradigm shift in thinking about all possible solutions.

219 whether the use of ocriplasmin will bring a paradigm shift in treating MHs or will be just an additi

220 dvances in medical treatments have enabled a paradigm shift in treatment goals from symptomatic relie

221 This study demonstrates a paradigm shift in treatment of MAAA in Sweden, with EVAR

222 in the African Meningitis Belt represents a paradigm shift in vaccines against poverty: the developm

223 In recent years, there has been a paradigm shift in virology with the realization that ext

224 This approach suggests a paradigm shift in which targeting late necrotic-secreted

225 ge-scale analysis of proteins and facilitate paradigm shifts in biological concepts that address impo

226 One of the most significant paradigm shifts in membrane remodeling is the emerging v

227 This study points to the need for paradigm shifts in neuroscience modeling: greater emphas

228 inal imaging have proven fundamental to many paradigm shifts in our understanding and treatment of oc

229 ophosphatemic rickets, has also driven major paradigm shifts in our understanding of the pathophysiol

230 Here we review two major recent paradigm shifts in our understanding of tissue macrophag

231 t several years have brought revelations and paradigm shifts in research on the cerebellum.

232 eractions in neuropsychiatric disorders, how paradigm shifts in the phenotypic classification of pati

233 Our results prompt a paradigm-shift in our mechanistic understanding of PTCy.

234 pendently predictive of outcome, demanding a paradigm-shift in patient-stratification strategy for pr

235 A similar major paradigm shift is emerging due to the rapidly expanding

236 ; however, recent literature suggests that a paradigm shift is in order.

237 A paradigm shift is made by a new study that monitors simu

238 so to gain additional biological insights, a paradigm shift is needed.

239 This discovery indicates a paradigm shift is needed.

240 Perhaps this paradigm shift is no more apparent than in the study of

241 A paradigm shift is required if surgery is to be considere

242 A paradigm shift is underway in the field of quantitative

243 But a paradigm shift is underway.

244 Prions are a paradigm-shifting mechanism of inheritance in which phen

245 of infected human populations, but a recent paradigm shift now entails moving from control to elimin

246 cilitators of nutrient absorption but recent paradigm shifts now recognize BAs as signaling molecules

247 A paradigm shift occurred at the turn of the 21st century.

248 The trend denotes a professional paradigm shift of major importance.

249 This collective knowledge compels a paradigm shift-one in which maternal transmission of mic

250 d study before mainstream acceptance of this paradigm-shifting phenomenon.

251 thereafter the Verstraetearchaeota, led to a paradigm shift, pushing back the evolutionary origin of

252 Our results offer a paradigm shift regarding the role of TIDC and a framewor

253 This has led to a paradigm shift, rejecting cosmopolitism of marine meiofa

254 ional enzyme models but might benefit from a paradigm shift related to recent findings in biological

255 er freedom of player experience) calls for a paradigm shift relative to the approach taken in the fie

256 The paradigm shift resulting from radiosurgery continues to

257 These paradigm-shifting studies have reframed our understandin

258 A paradigm shifting study demonstrated that induction of M

259 This paradigm-shifting study provides a mechanism for distal

260 pproach closely aligns with Kuhn's notion of paradigm shift, suggesting that this is a particularly g

261 oreover, with the premise of Fyn kinase as a paradigm-shifting target in Alzheimer's drug discovery,

262 l conditions, iOCT has the potential to be a paradigm-shifting technology in the operating room.

263 in ASD as a monolithic deficit and suggest a paradigm shift that deconstructs BM into distinct levels

264 rs are poised to play an important role in a paradigm shift that fundamentally challenges the current

265 ratory movement and blood flow are part of a paradigm shift that is on the horizon.

266 The recent paradigm shift that microglia are yolk sac-derived, not

267 l sustainability of the healthcare system, a paradigm shift that places more emphasis on cardiovascul

268 Together, these data support the emerging paradigm shift that pore-forming toxins, including CDCs,

269 It was Ginj et al. who proposed in 2006 the paradigm shift that radiolabeled sstr antagonists may pe

270 Our work suggests a paradigm shift that the interactions between the RNA gen

271 This system proposed a paradigm shift that unites molecular and pathologic imag

272 In this focused review, I examine recent paradigm shifts that have transformed our understanding

273 hrough the common hub of RL, has facilitated paradigm shifts that relate multiple levels of analysis

274 oxidative stress and will discuss the major paradigm shifts that the field has undergone and continu

275 A paradigm shift to piezoelectric antennas utilizing strai

276 Paradigm shifts to MR imaging owing to concerns over rad

277 A paradigm shift toward biology occurred in the 1990s and

278 A paradigm shift toward deploying integrated, smart, and e

279 deconstruction are identified, portending a paradigm shift toward first-principles design and evalua

280 The recent literature signals a growing paradigm shift toward integrating therapeutics and diagn

281 improvements in pain treatment may require a paradigm shift toward more personalized approaches.

282 nctional materials and devices may lead to a paradigm shift toward new, intelligent, and efficient co

283 The paradigm shift toward organ preservation in highly selec

284 er geneticists will be required to drive the paradigm shift toward personalized or precision medicine

285 A paradigm shift toward the development of nonantibiotic a

286 d a sleep-promoting role, but eventually the paradigm shifted toward a wake-promoting function for th

287 This is a conceptual and paradigm shift towards a focus on the abnormal prenatal

288 r markers in the circulation, resulting in a paradigm shift towards data science-driven liquid biopsi

289 rial and self-assembling peptides provides a paradigm shift towards development of antibacterial agen

290 mizing this uncertainty therefore requires a paradigm shift towards engineering at the genomic level.

291 To this end, we emphasize the need for a paradigm shift towards integrative disease modeling and

292 and programmed-death 1 (PD-1), has become a paradigm-shifting treatment in solid tumor oncology.

293 ynamic calcium signaling, establishes a new, paradigm-shifting understanding of the spatial and tempo

294 This creates a new paradigm-shifting vaccine approach to prevent toxoplasmo

295 inical and experimental findings bring about paradigm-shifting views of our understanding of absence

296 nnate immune system is programmed has led to paradigm-shifting views on immunomodulation.

297 future epidemiologic efforts that reflects a paradigm shift whereby studies are now being conducted w

298 Our study demonstrates that the ongoing paradigm shift, which recognizes that both biotic and ab

299 sed efficiency, it is not clear whether this paradigm shift will change how we decide when our self-i

300 Nowadays, recent advances lead to a paradigm shift, with only 12% ES rate in low rectal canc