ライフサイエンスコーパス: paralog

1 allow for the inclusion of duplicated genes (paralogs).

2 py tends to have more sub-functions than its paralog.

3 onors, a feature only described for the FMO1 paralogs.

4 enes, which may cause them to be mistaken as paralogs.

5 ifferentiate on double knockout of both HNF4 paralogs.

6 vered functional nonequivalence between RUNX paralogs.

7 mber and primary structure of alpha-defensin paralogs.

8 mitochondrial Trap1, the four cellular hsp90 paralogs.

9 which are deficient in two of the four CRWN paralogs.

10 oned cDNA plasmids corresponding to the Defa paralogs.

11 onnected to the core through the Prp42/Prp39 paralogs.

12 riple paralogs, culminating in tens of EXO70 paralogs.

13 res of four functionally distinct plant AAAD paralogs.

14 neofunctionalization of recently duplicated paralogs.

15 ereas active marks are associated with their paralogs.

16 muscle, we searched for additional myospryn paralogs.

17 able and under the modular control of two AR paralogs.

18 ese never-essentials are highly enriched for paralogs.

19 , illustrating the differences between these paralogs.

20 nc fingers that are absent in the other NEIL paralogs.

21 require the system-wide optimization of all paralogs?

22 In Mfn1 and Mfn2 paralogs, a conserved phenylalanine (Phe-202 (Mfn1) and

23 action analysis distinguishes two classes of paralogs: a more functionally divergent subset and anoth

24 We propose that these paralogs act as capstones that prevent stable tetramer f

25 Instead, the DF paralogs act redundantly to mediate mRNA degradation and

26 crop and offer a new approach for assessing paralog activity at the transcript level.

27 ted intestines, while worms lacking its sole paralog (affl-1) appear wild type.

28 ound to miRNAs loaded into two different AGO paralogs, AGO1 and AGO2.

29 (AIF) gene family consists of two identified paralogs - AIF1 and AIF1-like (AIF1L).

30 Selective expression of native paralogs allowed integration of transcription factor act

31 In Arabidopsis, CLV1 paralogs also contribute to homeostasis, by compensating

32 ly identified a nodal role for the caspase-8 paralog and only human pseudo-caspase, FLIP(L), in regul

33 ead, gene duplication with divergence of one paralog and weak positive selection appear to underlie h

34 We discussed the sub-functionization of paralogs and co-evolution of ligand-receptor families.

35 expression of sense-antisense pairs, whereas paralogs and divergent transcripts co-expressed.

36 togenetic mapping of ribosomal genes and Hox paralogs and with microsatellite data, brings a closer l

37 c interactions for a deletion mutant of each paralog, and of trigenic interactions for the double mut

38 nerated data for all gene copies (homeologs, paralogs, and segregating alleles) present in each of th

39 Here, we show that AP2L5 and its related paralog AP2L2 play critical and redundant roles in the s

40 . burtoni possess two androgen receptor (AR) paralogs, ARalpha and ARbeta, providing a unique opportu

41 affl-2 and its paralog are not essential for proper HSF-1 expression an

42 The drl paralogs are co-expressed in lateral floral primordia, b

43 Genome duplication and resulting paralogs are considered to provide the raw genetic mater

44 ation becomes evident only when all three DF paralogs are depleted simultaneously.

45 ount of information that would be ignored if paralogs are discarded, as well as the resulting loss in

46 mortem study confirmed that HDAC1 and HDAC2 paralogs are elevated in white matter tissue from elderl

47 The ATP-binding pockets of the four paralogs are flanked by three side pockets, termed sites

48 MYC paralogs are frequently activated in small cell lung can

49 Thus, HNF4 paralogs are key components of an intestinal transcripti

50 RAD51 mediator proteins (i.e. paralogs) are critical for efficient HR in mammalian cel

51 l binding to just two targets, TXNIP and its paralog ARRDC4.

52 le eIF4E (LeishIF4Es) and eIF4G (LeishIF4Gs) paralogs, as each could be assigned a discrete role duri

53 Here we describe the first set of paralogs, Asn1p and Asn2p, that have differential assemb

54 human p190A, but not its 50% identical p190B paralog, associates with all 13 eIF3 subunits and severa

55 n in the presence of its seemingly identical paralog, AtPAM16.

56 canonical PHD and bromodomain modules of the paralog BAZ1A.

57 better elucidate the role of BB0405 and its paralog BB0406 during infection and in serum resistance,

58 nization of rodents with BBI39, or a diverse paralog, BBI36, or their combination impaired pathogen a

59 ctive inhibitors are not available for Bcl-2 paralog Bfl-1.

60 in vivo, CCCTC-binding factor (CTCF) and its paralog brother of the regulator of imprinted sites (BOR

61 The GSK3alpha paralog, but not GSK3beta, is essential for sperm functi

62 he same fold as angiogenin and other RNase A paralogs, but the toxin does not share sequence similari

63 e predictions, and identifying and excluding paralogs by combining tree- and synteny-based approaches

64 By transcript analysis, we found the paralogs CALHM2, 4, and 6 to be highly expressed in this

65 Mammals express two closely related paralogs called CKS1 and CKS2, but only CKS2 is expresse

66 way, where the lost-of-fitness effect of one paralog can be compensated only in a subset of lines.

67 trA control, and functional citrate synthase paralogs cannot replace CitA in promoting S-phase entry.

68 ere, we demonstrate that MondoA, but not its paralog carbohydrate-responsive element-binding protein,

69 In the absence of caspase-8, another of its paralogs, caspase-10 (also transcriptionally up-regulate

70 ith silencing of both PhGATA19 and its close paralog causing premature plant senescence.

71 Histone acetyltransferase (HAT) p300 and its paralog CBP acetylate histone lysine side chains and pla

72 subunit composed of cyclin C and one each of paralogs Cdk8/Cdk19, Med12/Med12L, and Med13/Med13L.

73 tor of MPF functions in meiosis and that its paralog, CKS1, must be excluded from the germ line for p

74 Dominant mutations in the mitochondrial paralogs coiled-helix-coiled-helix (CHCHD) domain 2 (C2)

75 Such paralogs complicate the interpretation of mitochondrial

76 f-function variants and missense variants at paralog-conserved sites were enriched in voltage-gated s

77 Here, we provide evidence that a Rad51 paralog-containing complex, the budding yeast Shu comple

78 Notch1 and other Notch receptor paralogs cooperate to act as a tumor suppressor in squam

79 ns suggest that multiple interacting RNase J paralogs could provide a strategy for functional improvi

80 , PHR-tail interactions are conserved in the paralog CRY2 and reduced when either CRY is bound to the

81 In contrast, its paralog, CTCFL, is normally only present in the testis.

82 yst subunits are encoded by double or triple paralogs, culminating in tens of EXO70 paralogs.

83 resolving 5'-UTR structures, but whether its paralog, Dbp1, performs similar functions is unknown.

84 ndings expand the concept of SMARCA2/SMARCA4 paralog dependency and suggest that pharmacological inhi

85 missense variants partially or fully rescued paralog dependency, underscoring that careful selection

86 plex genetic interaction analysis with yeast paralogs derived from the whole-genome duplication event

87 ith missense variants in three other DDX/DHX paralogs: DHX16 (four individuals), DDX54 (three individ

88 However, little is known of how RNase J paralogs differ in expression and activity.

89 iology, we observed that activation of these paralogs differs from the voltage- and calcium-gated cha

90 upported by the selective expression of RUNX paralogs during Langerhans cell and inducible regulatory

91 Carboxysome shells contain multiple BMC-H paralogs, each with distinctly conserved residues surrou

92 ity with extrinsic signals, while non-native paralogs enforced differentiation even in the absence of

93 Both ESRP2 and its close paralog ESRP1 are highly expressed in primary prostate c

94 y inference step to account for same-species paralogs evolving at different rates, and (ii) minimizin

95 A pollen-specific depletion of the closest paralog, EXO70C1, using artificial microRNA in the exo70

96 n human term placenta and is the predominant paralog expressed in primary human trophoblast cultures.

97 The two paralogs expressed in mammals, Cks1 and Cks2, share an o

98 ane-bound compartments is encoded by several paralog families, including small GTPases, coiled-bundle

99 A male-specific AGAMOUS paralog, FhAG2, was identified as a candidate gene for s

100 ed by ELAV, the transcript encoding the ELAV paralog FNE acquires a mini-exon, generating a new prote

101 Phylogenetic analyses revealed that paralogs found in mammals, sauropsids, amphibians, and c

102 iphon and the presumably more primitive OCP2 paralog from the same organism, we show that an NTD-CTD

103 e show that genetic redundancy of Gata3 with paralog Gata2 in trophoblast progenitors ensures the suc

104 n though silk-specific genes belong to multi-paralog gene families.

105 tion of CHyMErA to the ablation of mammalian paralog gene pairs reveals extensive GIs and uncovers ph

106 ing mouse embryogenesis, the Arpp19 and Ensa paralog genes display specific functions by differential

107 We use synthetic lethality between paralog genes to show that genetic interactions can intr

108 eral recent structures of MraY and its human paralog, GlcNAc-1-P-transferase, have provided insights

109 ppressor candidate region 1 (GLTSCR1) or its paralog GLTSCR1-like (GLTSCR1L).

110 eticulum (ER)-resident heat shock protein 90 paralog, glucose regulated protein 94 (Grp94), but their

111 and two other Tetrahymena RPA large subunit paralogs had higher DNA binding affinity than their larg

112 In addition to KWL1, 19 additional KWL paralogs have been identified in maize.

113 indicate that at least some archaeal histone paralogs have evolved to play distinct and conserved fun

114 it has been generally assumed that all Hsp70 paralogs have similar activities and are largely functio

115 ervations indicated that the CELA1 and CELA3 paralogs have some different but also overlapping specif

116 Genetic inactivation of Hnf4a and its paralog Hnf4g revealed that HNF4 factors are redundantly

117 edundantly with an intestine-restricted HNF4 paralog, HNF4G, to activate enhancer chromatin and upreg

118 We found that both paralogs HoxA alpha and beta were distinguishable withou

119 or SHF of embryos lacking both Hoxb1 and its paralog Hoxa1 results in atrioventricular septal defects

120 HISTONE MONOUBIQUITINATION1 (HUB1) and its paralog HUB2 act in a conserved heterotetrameric complex

121 escent protein-labeled forms of EGFR and its paralog, human epidermal growth factor receptor 2 (HER2/

122 iochemical properties of the products of two paralogs, identified in Salmo salar.

123 in new functions, it is less clear how other paralogs impact or constrain gene duplication.

124 irst evidence that LIN28B is the predominant paralog in human placenta and that decreased LIN28B may

125 Rdh54 (a.k.a. Tid1), a Rad54 paralog in Saccharomyces cerevisiae, is well-known for i

126 Functional divergence of tshbeta paralogs in Atlantic salmon supports a specific role of

127 ore ATG genes, such as highly divergent ATG8 paralogs in dermatophytes and multiple ATG15 duplication

128 ics simulations, we go on to identify unique paralogs in M. stadtmanae and Methanobrevibacter smithii

129 Germline knockout of both paralogs in mice results in early embryonic lethality.

130 rovement strategies is assigning function to paralogs in polyploid crops.

131 cture that these capstones, as well as other paralogs in the Methanobacteriales, have been maintained

132 Expression profiles of both paralogs in the pituitary were measured by qPCR througho

133 characterize the functions of two Argonaute paralogs in the sea anemone Nematostella vectensis of th

134 epetitive elements and unique sequences with paralogs in the somatic genome.

135 sites 1, 2, and 3, which differ between the paralogs in their accessibility to inhibitors.

136 Thus, both IL-4/13 and IL-10 paralogs in zebrafish exhibit aspects of conserved funct

137 agellins, five structural and one regulatory paralog, in Caulobacter crescentus, a monopolarly flagel

138 diversified into cognate and heat-inducible paralogs independently from other crustaceans.

139 that compensation among ligand and receptor paralogs is critical for stem cell homeostasis, but that

140 ut the role of the additional helices in the paralogs is not understood.

141 importance, misregulation of RAD51, and its paralogs, is associated with diseases such as cancer and

142 rdless of whether it comes from orthologs or paralogs, is most likely to lead to higher prediction ac

143 Here, we demonstrate that the KCTD15 paralogs kctd15a and kctd15b function in concert to rest

144 7 histone demethylase KDM6A/UTX, but not its paralog KDM6B, is oxygen sensitive.

145 -incompatibility locus (S locus) consists of paralogs (Lal2, SCRL) of the canonical Brassicaceae S lo

146 e differences between the two mammalian SAR1 paralogs lead to pronounced biochemical differences that

147 s of independently arising mutations in AAAD paralogs leading to the convergent evolution of the deri

148 ymus, T cell-specific ablation of the Roquin paralogs leads to a dramatic expansion of NKT17 cells, w

149 e found that Lin28b (and its closely related paralog, Lin28a) directly interacted with Igf2bp3, anoth

150 Lin28 is an RNA-binding protein with two paralogs, Lin28a and Lin28b, in mammals.

151 opposite effects, and manipulating Lin28a's paralog, LIN28B caused similar yet distinct phenotypes.

152 ential subunit that combines with any of its paralogs, LRRC8B-E, to form hexameric VRAC complexes.

153 germ cell-expressed (Gce) and its duplicate paralog, methoprene-tolerant (Met).

154 MISTR1(NDUFA4) followed by replacement with paralogs MItochondrial STress Response AntiViral (MISTRA

155 ast cancer, elevated levels of the mammalian paralogs MMP2, MMP9, and MMP13 are associated with a 4-

156 Platelets express all Munc18 paralogs (Munc18-1, -2, and -3), but their roles in plat

157 re different, independent functions, the two paralogs must acquire mutations that effectively insulat

158 Their less responsive sister paralogs-myosin IIB (MYH10), alpha-actinin 1, and filami

159 Mammals express three Hook paralogs, namely Hook1, Hook2, and Hook3, that have dist

160 tandemly duplicated, coexpressed with their paralogs, narrowly expressed at lower levels, less conse

161 heterochromatin-localizing protein like its paralog Oddjob, also an evolutionarily dynamic yet essen

162 as largely sustained by 4CL5, a low-affinity paralog of 4CL1 typically with only minor xylem expressi

163 rferes with the interaction between ARC3 and PARALOG OF ARC6 (PARC6), another key regulator of chloro

164 astid by the inner envelope membrane protein PARALOG OF ARC6 (PARC6).

165 ility of choline kinase alpha (Chka), a gene paralog of Chkb, to improve dystrophic phenotypes when u

166 The physiological role of LepA, a paralog of EF-G found in all bacteria, has been a myster

167 or the gene activation function of EZH1, the paralog of EZH2.

168 ily members in Arabidopsis, FtsZ2-1, a close paralog of FtsZ2-2, and the functionally distinct FtsZ1-

169 that TgSPY, an ortholog of plant SPINDLY and paralog of host OGT, is required for nuclear O-fucosylat

170 systems are orthologous and originated as a paralog of NPY/NPF-type signalling in Urbilateria.

171 Siglec-9, the functionally equivalent human paralog of Siglec-E, occurs as a monomer.

172 One example is the Bmp16 gene, a paralog of the developmental key genes Bmp2 and -4.

173 r signalling molecule and a well-established paralog of the insect peptide prothoracicotropic hormone

174 Here, we detail the contribution of MCUB, a paralog of the pore-forming subunit MCU, in mtCU regulat

175 to the gene ALBINO4 (ALB4), which encodes a paralog of the well-known thylakoid protein targeting fa

176 n (TNNI1 R37C(+/-)) is in the fetal/neonatal paralog of TnI, a gene thought to be expressed in the he

177 We show that a paralog of Toc75, outer envelope protein 80 kD (OEP80),

178 ng XRCC4-like factor (XLF)/Cernunnos and the paralog of XRCC4 and XLF, PAXX nonhomologous end joining

179 IgSF) domains discovered a network formed by paralogs of Beaten Path (Beat) and Sidestep (Side), a li

180 s single-copy CYCLOIDEA-like genes and three paralogs of CINCINNATA (CIN) in early diverging angiospe

181 Expression analyses of all paralogs of class II TCP genes in Aristolochia fimbriata

182 tiana benthamiana incorporates two different paralogs of each catalytic subunit into active proteasom

183 eins 1 and 2 (FXR1P and FXR2P) are autosomal paralogs of FMRP that are involved in promoting muscle d

184 Further we tested, whether paralogs of Hox gene clusters originated from this paddl

185 s japonicus mutants defective in AM-specific paralogs of lipid biosynthesis genes (KASI and GPAT6).

186 europeptide-F (sNPF) have been identified as paralogs of NPY/NPF in vertebrates and protostomes, resp

187 athways and for individual PR genes, such as paralogs of PR1 and PR5, and other factors of the salicy

188 ow that Arabidopsis BSK1 and BSK2, two close paralogs of SSP that are conserved in flowering plants,

189 oteins (Helical Carotenoid Proteins [HCPs]), paralogs of the N-terminal domain of OCP, were described

190 at Nedd4-2 exhibits broad specificity for E2 paralogs of the Ubc4/5 clade to assemble Lys(63)-linked

191 ly by a complex containing ULK1 or ULK2 (two paralogs of the yeast Atg1 protein).

192 es present in the four genomes were syntenic paralogs (ohnologs) generated by the pre-gamma, gamma an

193 enitor Aegilops tauschii contains W2 and Iw2 paralogs on chromosome 2D.

194 rom the negative modulation exerted by Hox13 paralogs on Gli3 regulatory sequences.

195 Of the four human Argonaute (AGO) paralogs, only AGO2 has been shown to have slicer activi

196 Transcriptional compensation between ligand paralogs operates in tomato, facilitated by an ancient g

197 n compared to the disruption of BRCA1, RAD51 paralogs, or RAD54.

198 subunit 1 (eIF2alpha), the SG assembly G3BP paralogs, or release of mRNAs from ribosomes via transla

199 as patient-derived data showed that the two paralogs orchestrated nonoverlapping transcriptional pro

200 anemone phylogeny, we conclude that the two paralogs originated due to a Nematostella-specific dupli

201 Most paralogs originating from the Salicaceae whole-genome du

202 nsferases CREB-binding protein (CBP) and its paralog p300 play a critical role in numerous cellular p

203 Genome duplication in eukaryotes created paralog pairs of ribosomal proteins (RPs) that show high

204 We observe 24 synthetic lethal paralog pairs that have escaped detection by monogenic k

205 buffering among approximately 400 candidate paralog pairs using CRISPR/enCas12a dual-gene knockout s

206 that genes encoding human PDIA1 and its two paralogs PDIA8 and PDIA2 are each flanked by genes encod

207 stitutions per synonymous site (K(s) ) among paralogs, phylogenomic (gene tree) reconciliation, and a

208 Avr2 also targets Rcr3 paralog Pip1, which is not required for Avr2 recognition

209 PR isoforms of PRDM3 and its closely related paralog, PRDM16.

210 stribution of observed relationships between paralogs produced across hundreds of models inferred fro

211 n is partly interchangeable with that of the paralog protein tumor-suppressor candidate 3 (TUSC3) but

212 ng the unique and diverse functions of these paralog proteins in neurodevelopment, excitatory synapti

213 osol, whereas organelle-specific Hsp70/Hsp90 paralogs provide similar protection for mitochondria and

214 Plasmodium vivax merozoite surface protein 1 paralog (PvMSP1P), which has epidermal growth factor (EG

215 Using the paralog ratio test, AMY1 CNs were accurately measured in

216 NCP and its paralog RCB are non-catalytic thioredoxin-like proteins

217 cant overlap and are delineated by the Rad54 paralog Rdh54 in an ATPase-independent fashion.

218 ion or by gene conversion, in which the babB paralog recombines into the babA locus.

219 Altogether, we show that Roquin paralogs regulate the development and function of NKT ce

220 e functions for these evolutionary conserved paralogs remain elusive, and their role in clathrin-medi

221 strongly suggest that functionally redundant paralogs represent a targetable set of genetic dependenc

222 nd predicted structural analyses of the nine paralogs revealed that PpFAAH1 to PpFAAH4 were closely r

223 molecular mechanism of the antagonistic gene paralogs RH1 and RH2 in determining anthocyanin leaf mar

224 es of two Staphylococcus epidermidis RNase J paralogs, RNase J1 and RNase J2.

225 uring the mitotic cell cycle, instead of its paralog, Scc1.

226 We demonstrated that the paralog selective-GSK3beta inhibitor, but not GSK3alpha

227 ites 1 and 2 have resulted in development of paralog-selective inhibitors targeting these sites, but

228 We found that neither paralog-selective nor simultaneous knockdown of HSPA1 an

229 s required for the H3K4me2/3 activity of the paralog SET1ACoreC.

230 The NAHR site was localized to a 160-kb paralog shared between the LCR22A and -D in seven 22q11D

231 Its paralog, ShK-like2, is a neuropeptide localized to neuro

232 with F-actin and is, along with its putative paralog SINE2, expressed in guard cells.

233 Cells exhibiting loss of SMARCA4 rely on its paralog, SMARCA2, making SMARCA2 an attractive therapeut

234 rent compound and that selectivity is due to paralog-specific differences in ligand pose and ligand-i

235 The USP11 peptide ligands and the paralog-specific functional site in USP11 identified her

236 Paralog-specific inhibitors may lead to drugs with fewer

237 These analyses uncover MYC-paralog-specific regulation of the apoptotic machinery w

238 e redundant activity of the HX motif and two paralog-specific residues of the HOXA9 HD.

239 amino acid clusters that have conserved SAR1 paralog-specific sequences.

240 Thus, a detailed mapping of MYC-paralog-specific vulnerabilities may help to develop eff

241 omplexes originate from gene duplication and paralog specification.

242 r whether specialized ribosomes exist and if paralog specificity controls translation.

243 ion may confer specialized functions, and RP paralog specificity defines a novel means of translation

244 A led to the emergence of two human-specific paralogs: SRGAP2B and SRGAP2C.

245 also appear to be robust to the inclusion of paralogs, suggesting a promising way to take full advant

246 we use the two Schizosaccharomyces pombe HP1 paralogs, Swi6 and Chp2, as model systems to compare and

247 interacted with CLF, its partially redundant paralog SWINGER (SWN), and LHP1.

248 expression is meiocyte enriched, whereas its paralog TAF4 is broadly expressed.

249 Paralogs (tandem duplication and disperse duplicated) we

250 The wheat genome contains two VIT paralogs, TaVIT1 and TaVIT2, which have different expres

251 nstrate that genetic deletion of YAP and its paralog TAZ promotes the growth of these tumors.

252 hich are rescued by deletion of YAP1 and its paralog TAZ.

253 The inactive PRMT paralog, TbPRMT1(PRO), is essential for catalytic activi

254 The P. furiosus genome encodes an NfnI paralog termed NfnII, and the two are differentially exp

255 antation stage of the mouse embryo, when its paralogs Tet2 and Tet3 are not detectably expressed.

256 of ABHD5 and ABHD4, a functionally distinct paralog that diverged from ABHD5 500 million years ago,

257 sequence corresponds to copy-number-variable paralogs that are absent from the human reference genome

258 Mammals have two SAR1 paralogs that genetic data suggest may have distinct phy

259 s a mutual antagonism between Gli3 and Hox13 paralogs that has important implications for Hox and Gli

260 YnaI is the only one of the six paralogs that has this GGxGG motif allowing the sensor p

261 well conserved for the few metabolic enzyme paralogs that have been studied in yeast.

262 However, there are known and unknown nuclear paralogs that have fundamentally different genetic prope

263 veal evidence for divergence between B. rapa paralogs that may be driven in part by variation in cons

264 cies that have HP1 proteins possess multiple paralogs that perform non-overlapping roles in vivo.

265 rent Hox TFs, even among the posterior group paralogs that share similar DNA-binding domains.

266 f 72 of 79 core RPs, RACK1 and 2 of the 8 RP paralogs, the stoichiometry of which remained constant a

267 In contrast to its paralogs, the TMEM16A/B calcium-activated chloride chann

268 c analysis to shed light on archaeal histone paralogs, their evolutionary history, and capacity to ge

269 mics screen, we identified the TNRC6 protein paralogs, TNRC6B and TNRC6C, as functionally important b

270 domains play unique roles in targeting each paralog to distinct binding sites to regulate transcript

271 ion, however, and the capacity of individual paralogs to assemble into histone-DNA complexes with dis

272 re-based mutational analysis of numerous Epa paralogs to generally determine the role of diverse stru

273 Prior work demonstrates that torsinA and its paralog torsinB have conserved functions at the nuclear

274 al divergence of duplicated TSH beta-subunit paralogs (tshbetaa and tshbetab) in Atlantic salmon.

275 appear to act in opposition to their closest paralog, TSO1, revealing complexity in the gene family t

276 e of the redundant functions of OCRL and its paralog type 2 inositol polyphosphate-5-phosphatase (INP

277 erved in muscles with deficiency of the ULK2 paralog, ULK1.

278 have been reported for these domains in the paralog USP11, a key regulator of DNA double-strand brea

279 that can be assembled from its seven histone paralogs vary substantially in DNA binding affinity and

280 Rab5 GEFs (Muk1 and Vps9) or its three Rab5 paralogs (Vps21/Ypt51, Ypt52, and Ypt53) or overexpressi

281 drug development.IMPORTANCE The Vpr and its paralog Vpx are accessory proteins encoded by different

282 rom resolution crystal structure of the ArnB paralog vWA2, disclosing a complex topology comprising t

283 Lower expression of the SMARCA2 paralog was associated with cellular sensitivity to EZH2

284 ariable loops often differ amongst KH domain paralogs, we hypothesize that this is a general mechanis

285 specificity is achieved between the numerous paralogs, we used a combination of structural and comput

286 Its paralogs, which arose from ancient gene duplications of

287 low-level sequencing noise and mitochondrial paralogs while not impacting variant calling, while comp

288 nome duplication, teleost fish have two ridA paralogs, while other extant vertebrates contain a singl

289 -redundant subcomplex of NuRD protein family paralogs, whose composition we corroborated by affinity

290 ers and different organisms have evolved TBP paralogs with additional protein regions.

291 ated expression of RUNX transcription factor paralogs with apparent functional redundancy.

292 Escherichia coli has six osmoprotective paralogs with different numbers of transmembrane helices

293 other splicing regulators within families of paralogs with indistinguishable RNA binding sites.

294 ility, we targeted the N. benthamiana NbAGO1 paralogs with one sgRNA and also multiplexed two sgRNAs

295 ic and biochemical interactions between ATP7 paralogs with the conserved oligomeric Golgi (COG) compl

296 (a Hox2 ortholog) and zen2 (a divergent Hox3 paralog), with disparate spatial and temporal expression

297 Biochemical and genetic analyses of the paralogs within Sulfolobus islandicus supported the hypo

298 Thease findings show that oncogenic paralogs YAP and TAZ have distinct roles in NSCLC and ar

299 ctor of TORC2 is protein kinase Ypk1 and its paralog Ypk2.

300 the loss of SFK activity, whereas its T cell paralog ZAP-70 is not capable of this compensation.