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1  bonds at rates that rival the hydrolysis of paraoxon.
2 laucoma drug echothiophate and the pesticide paraoxon.
3 rocatalytic activity toward the reduction of paraoxon.
4 ter inhibition by the organophosphorus agent paraoxon.
5 ampal kainate and systemic administration of paraoxon.
6 sing platform was developed for detection of paraoxon.
7 osarin, VX, and the OP pesticide metabolite, paraoxon.
8 agnitude lower than with its best substrate, paraoxon.
9  results in 340-fold enhanced reactivity for paraoxon.
10  the kinetic constants for the hydrolysis of paraoxon.
11 nsecticides such as the parathion metabolite paraoxon.
12 osphate pesticides and nerve agents, such as paraoxon.
13 ve to inhibition by organophosphates such as paraoxon.
14 sian blue nanoparticles for the detection of paraoxon.
15 -nitrophenyl acetate, and the organophospate paraoxon.
16 tants such as 1,2-dichloroethane (72 years), paraoxon (13 months), atrazine (5 months), and aziridine
17 ased device was applied for the detection of paraoxon, 2,4-dichlorophenoxyacetic acid, and atrazine a
18  paper-based platform was employed to detect paraoxon, 2,4-dichlorophenoxyacetic acid, and atrazine b
19 ferred phosphotriester (P-O bond) substrate, paraoxon (5-100% kcat).
20 ies, obtaining satisfactory values (e.g. for paraoxon 90 +/- 1% and 88 +/- 2%, for 10 and 20 ppb, res
21  the identical experiment was performed with paraoxon, a "penetrating" AChE inhibitor, high K+ still
22                        Both free ghrelin and paraoxon, a substrate for paraoxonase, can inhibit this
23                         The concentration of paraoxon, an acetylcholine esterase inhibitor, can be qu
24  of achiral, chiral, and racemic mixtures of paraoxon analogues containing various combinations of me
25                    Individual enantiomers of paraoxon analogues were also synthesized and the stereoc
26              The kinetic constants for these paraoxon analogues with the enzyme varied significantly
27  limit was found to be ~0.5 for OP pesticide paraoxon and 1 muM for non-OP pesticide carbaryl, in a w
28 rotect animals from exposure to a pesticide, paraoxon and a warfare agent, VX.
29           Esterase activity was inhibited by paraoxon and dichlorvos.
30 The lower detection limits were 3 microM for paraoxon and parathion and 5 microM for coumaphos.
31 domonas diminuta catalyzes the hydrolysis of paraoxon and related acetylcholinesterase inhibitors wit
32         Two known substrates are considered, paraoxon and sarin, although their turnover rates vary a
33 ates such as the widely utilized insecticide paraoxon and the chemical warfare agent sarin.
34 n explants with the organophosphate compound paraoxon and uncovered a unique mechanism of neurotoxici
35 ydrolyze VR but has improved activity toward paraoxon and VX.
36 d excess of diethyl 4-nitrophenyl phosphate (paraoxon) and subsequent dealkylation, the broad 16.1 pp
37 des like chlorpyrifos, malathion, parathion, paraoxon, and carbaryl which are present in food and env
38 d against methyl-parathion, malathion, ethyl-paraoxon, and methyl-paraoxon, respectively.
39  conjugates formed by sarin, cyclosarin, VX, paraoxon, and tabun are enhanced severalfold in vitro.
40 everal variants to hydrolyze phenyl acetate, paraoxon, and V-type OP nerve agents were examined.
41 terference from lead, cadmium, atrazine, and paraoxon, and without matrix effect in drinking, surface
42                                        Using paraoxon as a model analyte, the ACC-HNFs-based lab-on-p
43 ghly sensitive electrochemical biosensor for paraoxon as a model of organophosphates.
44                 Using spectrofluorimetry and paraoxon as a model organophosphate, paraoxon concentrat
45 ecognition of OP-AChE that was prepared with paraoxon as an OP model agent.
46 araoxonase 1 (PON1) activity determined with paraoxon as substrate has been found to be associated wi
47 ature, and weight of cells immobilized using paraoxon as substrate.
48  irreversibly inhibited by echothiophate and paraoxon, but G117H regained 100% activity within 2-3 mi
49  substitution enhances ySFGH reactivity with paraoxon by >1000-fold ( k i (W197I) = 16 +/- 2 mM (-1)
50 c activity of Dr-OPH toward ethyl and methyl paraoxon by 126- and 322-fold and raised the specificity
51  the reaction mechanism of the hydrolysis of paraoxon by phosphotriesterase (PTE).
52 000-fold for hydrolysis of echothiophate and paraoxon by the G117H mutant compared to the nonenzymati
53                                              Paraoxon, chosen as nerve agent simulant, is linearly de
54                The reduction peak current vs paraoxon concentration was linear over the range 50nM to
55 try and paraoxon as a model organophosphate, paraoxon concentrations as low as 8 x 10(-7) M could be
56 inear relationship with the logarithm of the paraoxon concentrations in the range of 0.05-50mugL(-1)
57  organophosphate (sarin, cyclosarin, VX, and paraoxon) conjugates of human acetylcholinesterase (hACh
58 ic/fluorescence approach was established for paraoxon detection with no interference from redox subst
59 d onto a quartz substrate for utilization in paraoxon detection.
60 d for all of the mutants with the substrates paraoxon, diethylphenylphosphate, acephate, and diisopro
61 exposure to lethal doses of soman, sarin, or paraoxon effectively and safely counteracted their toxic
62 Ps used were chlorpyriphos-oxon (CPO), ethyl paraoxon (EPOx) and malaoxon (MOx).
63 s employed for the amperometric detection of paraoxon-ethyl, fenitrothion and chlorpyrifos ranging fr
64                                              Paraoxon-exposed hippocampal slice cultures exhibited pr
65 ere were significant increases in the Km for paraoxon for all mutants except F132H.
66 hos>methylparathion>parathion>methylparaoxon>paraoxon>fench lorphos>profenofos>malathion.
67  and a decrease in the kinetic constants for paraoxon (I).
68 anato-4-methylcoumarin) for the detection of paraoxon in aqueous solution, ranging from 10(-9) to 10(
69 easuring the hydrolysis of phenylacetate and paraoxon in serum samples of 87 patients with type 2 DM
70 roduction from hydrolysis of an insecticide, paraoxon, in a coupled assay involving phosphotriesteras
71 properties of the developed electrode toward paraoxon indicated that the nanocomposite possesses a pr
72                                          The paraoxon-induced beta1 integrin response was targeted to
73 drolysis and oxidation of acetylcholine, and paraoxon-induced inhibition of acetylcholinesterase acti
74 ther administered during (kainate) or after (paraoxon) induction of SE.
75 m oximes to reactivate VX-, tabun- and ethyl paraoxon-inhibited human AChE.
76                         The structure of the paraoxon-inhibited W197I variant was determined by molec
77               In comparison, the insecticide paraoxon irreversibly inhibited mosquito and human AChEs
78                The P=O bond of the substrate paraoxon is activated by adopting a tight coordination t
79               Low serum PON1 activity toward paraoxon is an independent risk factor for coronary even
80  VR inhibits H115W HuPON1 competitively when paraoxon is the substrate and noncompetitively when VX i
81 ncement of the rates of phosphorylation with paraoxon ( k i = 42 or 80 mM (-1) h (-1), respectively)
82 Km of (2.0 +/- 1.3) x 10(-1) M(-1)s(-1)) and paraoxon (kcat/Km of (4.6 +/- 0.8) x 10(3) M(-1)s(-1)),
83 or was used to measure as low as 2 microM of paraoxon, methyl parathion, and diazinon.
84  2000 V, baseline resolution is observed for paraoxon, methyl parathion, fenitrothion, and ethyl para
85 osure but does not protect against parathion/paraoxon or nerve agents.
86 optimized conditions, the biosensor measured paraoxon, parathion, and coumaphos pesticides with high
87 his set included analogues of the pesticides paraoxon, parathion, and dimefox, and the nerve agents D
88 ble microplate format with three substrates: paraoxon, phenyl acetate and the lactone dihydrocoumarin
89 ociation between PON1 substrate specificity (paraoxon/phenylacetate substrate activity ratios) and -9
90                                     However, paraoxon prevented the K(+)-induced loss of [14C]ACh fro
91 d pesticide diethyl-4-nitrophenyl phosphate (Paraoxon) promoted by 1,2,4-triazole (TAZ) was investiga
92    The Arg192 (R192) PON1 isoform hydrolyses paraoxon rapidly, while the Gln192 (Q191) isoform hydrol
93 thion, malathion, ethyl-paraoxon, and methyl-paraoxon, respectively.
94 e of hydrolyzing beta-lactam antibiotics and paraoxon, respectively.
95             Phosphorylation of the enzyme by paraoxon results in covalent modification of the active
96 d for analyzing the purity of the commercial paraoxon sample.
97          The cholinesterase inhibitor methyl paraoxon significantly decreased AChE staining intensity
98 with IC50 = 10(-7) M for the organophosphate paraoxon, similar to mammalian cell culture-derived AChE
99 , while the Gln192 (Q191) isoform hydrolyses paraoxon slowly.
100 ity in addition to the ability to react with paraoxon solutions.
101             Here we report the structures of paraoxon, soman, and sarin complexes of group-VIII phosp
102 icate that low PON1 activity determined with paraoxon substrate is independently associated with SLE
103 ith findings in controls, PON1 activity with paraoxon substrate was reduced both in white lupus patie
104 ose proximity to the pro-S-ethoxy arm of the paraoxon substrate, was mutated to arginine, alanine, hi
105 , 10 ppb lead, 10 ppb bisphenol A, and 1 ppb paraoxon, tested as safety limits.
106 ys catalytic constants for the hydrolysis of paraoxon that are essentially the same as those of the w
107  of the nerve agents soman and sarin, and of paraoxon, the active metabolite of the insecticide parat
108 he substrate and can range from 6000 s-1 for paraoxon to 0.03 s-1 for the slower substrates such as d
109  AChE (mAChE) were fractionally inhibited by paraoxon to form diethyl phosphoryl enzyme.
110 could efficiently catalyze the hydrolysis of paraoxon to yellow p-nitrophenol, which further reduced
111 d inhibitor 4-nitrophenyl diethyl phosphate (paraoxon) to the free enzyme at pH 7.5, and subsequent d
112 ly hydrolyse 4-methylumbelliferyl acetate in paraoxon-treated cells, while the native enzyme was foun
113 ilar antiepileptogenic effect was found when paraoxon-treated rats were exposed to isoflurane after S
114                                          The paraoxon undergoes electro-reduction at -550 mV on the m
115 cally toward the pesticides ethyl and methyl paraoxon, using structure-based and random approaches.
116 es for the mutant enzymes with the substrate paraoxon varied from near wild type values to a 4-order
117 H on the cell surface degraded parathion and paraoxon very effectively without any diffusional limita
118 se reacted with the organophosphate compound paraoxon via its active site Ser273.
119                      The detection limit for paraoxon was found to be 1.1 ppb and that for carbofuran
120                   Serum PON1 activity toward paraoxon was measured in 1353 participants.
121 plete protection against the lethal doses of paraoxon was observed with nano-OPH administered iv and
122                                              Paraoxon was studied as an example of OPs.
123                            Echothiophate and paraoxon were hydrolyzed with the same kcat of 0.75 min-
124 relation to neutral hydrolysis of DEDNPP and Paraoxon were observed, respectively, consistent with al
125 N1s are better able to promote hydrolysis of paraoxon, whereas HuPON1 is considerably better at catal
126 drolase (OPH), and to detect the presence of paraoxon, which is an organophosphorus compound, using t
127 osensor was used to measure as low as 0.4 pM paraoxon with a 6-min inhibition time.
128 F26G/C72I mutant catalyzed the hydrolysis of paraoxon with a kcat of 1.14 min-1, an increase of 16-fo
129 ound to catalyze the very slow hydrolysis of paraoxon with values of kcat and kcat/Km of 0.07 min-1 a
130 N male mice challenged with a lethal dose of paraoxon, with complete elimination of short-term clinic

 
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