ライフサイエンスコーパス: parathyroid gland

1 rogenital tract, pancreas, liver, brain, and parathyroid gland.

2 thymus hypoplasia and mislocalization of the parathyroid gland.

3 requiring surgical removal of the offending parathyroid glands.

4 ur parathyroid glands and resecting enlarged parathyroid glands.

5 best tool available for imaging of abnormal parathyroid glands.

6 ion of calcium homeostasis in the absence of parathyroid glands.

7 factor whose expression is restricted to the parathyroid glands.

8 cule exists in zebrafish, species which lack parathyroid glands.

9 ction that is expressed in the pituitary and parathyroid glands.

10 thyroid glands in one patient, and 51 normal parathyroid glands.

11 aging device was used to image a total of 37 parathyroid glands.

12 order caused by one or more hyperfunctioning parathyroid glands.

13 cell microenvironment in both human and NHP parathyroid glands.

14 detect similar differences in blood flow to parathyroid glands.

15 d hypercalcemia and caused by hypersecreting parathyroid glands.

16 he likelihood of additional hyperfunctioning parathyroid glands.

17 ized by precise preoperative localization of parathyroid glands.

18 , the coreceptor for FGF23 in the kidney and parathyroid glands.

19 retion of parathyroid hormone (PTH) from the parathyroid glands.

20 continue to guide surgical resection of the parathyroid glands.

21 ng endodermal progenitors of both thymus and parathyroid glands.

22 CD44/CD24 population was 10.93% for enlarged parathyroid glands.

23 by varying defects of the heart, thymus, and parathyroid glands.

24 rathyroid imaging except in locating ectopic parathyroid glands.

25 ied 89% of the surgically confirmed diseased parathyroid glands.

26 metabolism and a potent hormone made by the parathyroid glands.

27 ide counts > background to localize abnormal parathyroid glands.

28 Nineteen parathyroid glands (9 adenomas, 1 atypical adenoma, and

29 c-sestamibi scan demonstrated a hyperplastic parathyroid gland, a large anterior mediastinal mass and

30 The parathyroid glands acting through PTH play a critical ro

31 o vitamin D2-treated animals with suppressed parathyroid gland activity produced marked elevation in

32 regulate overactivity and hyperplasia of the parathyroid gland after the onset of renal insufficiency

33 Obtaining a parathyroid gland and a kidney from the same donor reduc

34 uorescence intensity was calculated for each parathyroid gland and compared with speckle contrast in

35 receptor proteins (CaRs) enable cells in the parathyroid gland and kidney thick ascending limb of Hen

36 about E11, each of which separates into one parathyroid gland and one thymus lobe by E13.5.

37 ardiac outflow defects and hypoplasia of the parathyroid gland and thymus due to haploinsufficiency o

38 g CD44 antibody was performed on 27 abnormal parathyroid glands and 7 normal parathyroid gland biopsi

39 ent mice in association with ablation of the parathyroid glands and correction of the severe hyperpar

40 rch arteries, cardiac outflow tract, thymus, parathyroid glands and craniofacial structures.

41 Here we show that Gcm2-deficient mice lack parathyroid glands and exhibit a biological hypoparathyr

42 the white matter of uremic dogs with intact parathyroid glands and in normal dogs and TPTX uremic do

43 binding protein-beta, in human hyperplastic parathyroid glands and in the human epidermoid carcinoma

44 roidism is due to enlargement of one or more parathyroid glands and is most often treated by surgical

45 he likelihood of additional hyperfunctioning parathyroid glands and let the surgeon determine whether

46 1(-/-) double knockout mice preserved intact parathyroid glands and reinstated CKD-induced secondary

47 eleton, we used a genetic approach to ablate parathyroid glands and remove the confounding effects of

48 the neck with the intent of visualizing four parathyroid glands and resecting enlarged parathyroid gl

49 ptin is a functionally active product of the parathyroid glands and stimulates PTH release.

50 t EGFR signaling is elevated in Sema3d (-/-) parathyroid glands and that pharmacological inhibition o

51 ry conservation of abundant miRNAs in normal parathyroid glands and the regulation of these miRNAs in

52 n aging-related protein found in the kidney, parathyroid gland, and choroid plexus, acts as an essent

53 CaR is highly expressed in the parathyroid gland, and is activated by extracellular cal

54 n protein predominantly expressed in kidney, parathyroid glands, and choroids plexus of the brain.

55 receptor were present in normal and diseased parathyroid glands, and if so, whether they had any func

56 erations for bleeding, inadvertently removed parathyroid glands, and recurrent hyperthyroidism after

57 rior lobes of the pituitary, the thyroid and parathyroid glands, and the adrenal medulla within the f

58 congenital disorder that affects the heart, parathyroid glands, and thymus.

59 al pharyngeal pouch derivatives (the thymus, parathyroid glands, and thyroid gland), heart, and gut.

60 In all terrestrial vertebrates, the parathyroid glands are critical regulators of calcium ho

61 The thymus and parathyroid glands are derived from the third pharyngeal

62 hyroidism post-thyroidectomy arises when all parathyroid glands are devascularized or injured.

63 The parathyroid glands are the only known source of circulat

64 The thymus and parathyroid glands arise from a shared endodermal primor

65 ccompanied by an increase in the size of the parathyroid gland as well as an increase in PTH mRNA lev

66 the effects of extracellular calcium in the parathyroid gland as well as other tissues has been iden

67 a 9% chance for additional hyperfunctioning parathyroid glands based on the WIN nomogram.

68 n vertebrate-specific tissues, placenta, and parathyroid glands, begging questions on the evolutionar

69 27 abnormal parathyroid glands and 7 normal parathyroid gland biopsies from the same patients.

70 tivating the calcium-sensing receptor in the parathyroid glands, but clinical experience with them is

71 The same effect is seen in wild-type murine parathyroid glands, but not in CaSR knockout glands.

72 by dividing the mean pixel intensity of the parathyroid gland by the background tissue.

73 The sensitivity for abnormal parathyroid glands by visual comparison of early images

74 imaging modality in localizing pathological parathyroid glands, calculated on a per-quadrant and a p

75 elated to the accuracy of localizing ectopic parathyroid glands, calls for a refinement of interpreta

76 ures, including hypoplasia of the thymus and parathyroid glands, cardiac outflow tract abnormalities,

77 Altered CaSR expression in the kidney or the parathyroid glands could not account for the observed ph

78 m (PHPT), discovering a minimally "enlarged" parathyroid gland creates a dilemma for the surgeon rega

79 nd laser confocal microscopy of normal human parathyroid gland demonstrated expression of parafibromi

80 tions of the aortic arch, heart, thymus, and parathyroid glands described as DiGeorge syndrome (DGS).

81 showed that this technique is able to detect parathyroid gland devascularization before it is visuall

82 The parathyroid glands develop with the thymus from bilatera

83 not reverse the arrest in tooth, thymus, and parathyroid gland development, suggesting that the relat

84 ntifying Gcm2 as a master regulatory gene of parathyroid gland development.

85 Parathyroid glands diagnosed as nodular hyperplasia were

86 was very low (3 mg/dl) due to damage to the parathyroid gland during total thyroidectomy for toxic g

87 he likelihood of additional hyperfunctioning parathyroid glands during parathyroidectomy.

88 ed should be kept in mind when assessing the parathyroid glands during surgical exploration.

89 scularized (n = 32) and compromised (n = 27) parathyroid glands during thyroid surgery with an accura

90 yroidism is due to increased activity of the parathyroid glands, either from an intrinsic abnormal ch

91 of function of the GCMB gene impairs normal parathyroid gland embryology and is responsible for isol

92 cterized primarily by multiple tumors in the parathyroid glands, endocrine pancreas, and anterior pit

93 Manifestations include neoplasms of the parathyroid glands, enteropancreatic neuroendocrine cell

94 Chief cells within bovine parathyroid glands exhibit a similar pattern of staining

95 he CaSR represents a phosphate sensor in the parathyroid gland, explaining the stimulatory effect of

96 PT may result from reduced expression of the parathyroid gland extracellular Ca(2+)-sensing receptor

97 ne-associated antigen of 120-140 kD in human parathyroid gland extracts using immunoblot analysis.

98 We sought to examine abnormal parathyroid glands for the presence of stem cells.

99 is required for the initiation of thymus and parathyroid gland formation.

100 obtained for FACS analysis from 25 enlarged parathyroid glands from 20 patients, 17 with primary HPT

101 We profiled microRNA (miRNA) in parathyroid glands from experimental hyperparathyroidism

102 lation that expresses SC markers in abnormal parathyroid glands from patients with HPT.

103 ivation analyses have demonstrated that most parathyroid glands from patients with uremic refractory

104 Little is known about parathyroid gland function in patients receiving total p

105 Parathyroid gland function is abnormal in long-term TPN

106 Our objective was to determine whether parathyroid gland function is abnormal in TPN recipients

107 n bone mineralization, vitamin D metabolism, parathyroid gland function, and renal phosphate handling

108 ance the understanding of PTH metabolism and parathyroid gland function.

109 , intravenous calcitriol appears to decrease parathyroid gland functional mass, as reflected by decre

110 Despite their lack of parathyroid glands, Gcm2-deficient mice have PTH serum l

111 Radioguided resection of hyperfunctioning parathyroid glands has been shown to be technically feas

112 , its potential utility in the assessment of parathyroid glands has yet to be established.

113 l phenotype, which were manifested by larger parathyroid glands, higher serum parathyroid hormone lev

114 djunctive intraoperative tool for localizing parathyroid glands; however, its potential utility in th

115 of hypoPT has involved visual inspection of parathyroid glands; however, near-infrared autofluoresce

116 Fifty-eight percent of patients had 4 parathyroid glands identified.

117 maps of the chromatin landscape of the human parathyroid glands, identifying active regulatory elemen

118 lume group were more likely to have a missed parathyroid gland in a normal anatomic location (89% vs.

119 glycoprotein, is expressed in the developing parathyroid gland in mice.

120 se, Met-PET/CT identified 2 hyperfunctioning parathyroid glands in 1 patient, 1 gland in 3 individual

121 adenomas in 6 patients, and 10 hyperplastic parathyroid glands in 3 patients).

122 en early and late images of hyperfunctioning parathyroid glands in 44 patients (69%); in 13 patients

123 reoperative localization of hyperfunctioning parathyroid glands in a larger series of PHPT patients.

124 cular imaging for localizing visually occult parathyroid glands in both anatomic and ectopic location

125 PET/CT for localization of hyperfunctioning parathyroid glands in comparison with other imaging test

126 in SHP, increased PTH expression ex vivo in parathyroid glands in culture and in transfected cells t

127 ative failure can be due to hyperfunctioning parathyroid glands in ectopic locations, less experience

128 The thymus and parathyroid glands in mice develop from a thymus/parathy

129 cells and is critical for development of the parathyroid glands in mice.

130 adenomas in one patient; and 3 hyperplastic parathyroid glands in one patient, and 51 normal parathy

131 rathyroidism rats and in vitro in uremic rat parathyroid glands in organ culture.

132 ferred method for detecting hyperfunctioning parathyroid glands in patients with clinical hyperparath

133 th SPECT/CT for the localization of abnormal parathyroid glands in patients with primary hyperparathy

134 identifying and localizing hyperfunctioning parathyroid glands in preoperative settings.

135 or the preoperative localization of enlarged parathyroid glands in primary hyperparathyroidism.

136 These findings suggest that parathyroid glands in single- vs multigland disease may

137 nt this complication include preservation of parathyroid glands in situ and autotransplantation of pa

138 Although preservation of parathyroid glands in situ is desirable, routine parathy

139 e thyroidectomies attempting to preserve the parathyroid glands in situ with an intact vascular pedic

140 Ectopic parathyroid glands in the aortopulmonary window are usua

141 ion computed tomography to localize enlarged parathyroid glands in three dimensions, limited explorat

142 individual microdissected regions from seven parathyroid glands in three female patients.

143 athyroid hormone (PTH) release from isolated parathyroid glands in vitro.

144 Maintaining parathyroid gland integrity is a dynamic process regulat

145 d and is essential for maintaining postnatal parathyroid gland integrity throughout life and for the

146 t the secretion of PTH by chief cells in the parathyroid gland is regulated by extracellular ionized

147 Surgical removal of hyperfunctional parathyroid gland is the definitive treatment for primar

148 ing receptor (CaSR), first identified in the parathyroid gland, is expressed in several tissues and c

149 autonomous growth in two, three, or all four parathyroid glands, is a distinct molecular entity and d

150 In the parathyroid gland, it mediates the inhibitory effects of

151 wed specific immunoreactivity in adrenal and parathyroid glands, kidney, heart, and skeletal muscle.

152 emic level causes promiscuous effects in the parathyroid glands, kidneys, and other tissues, and the

153 rain regions, coronary arteries, thyroid and parathyroid glands, large intestine, colon, bladder, tes

154 n the general population, blacks have higher parathyroid gland mass and circulating parathyroid hormo

155 s known to be required for normal thymus and parathyroid gland morphogenesis, whereas Pax1, Hoxa3, Ey

156 ostic study analyzed in vivo NIRAF images of parathyroid glands obtained during parathyroidectomies b

157 show that loss of Men1 gene function in the parathyroid glands of mice results in histological chang

158 on, with rates >fourfold higher than that in parathyroid glands of wild-type littermates (P<0.0001).

159 secondary outcome was the visibility of each parathyroid gland on NIRAF imaging before it became appa

160 tigraphy separately showed a hyperfunctional parathyroid gland on the same side or in the same ectopi

161 UC) for localization of the hyperfunctioning parathyroid gland or glands at sestamibi SPECT/CT and 4D

162 arathyroidism can be cured by removal of the parathyroid gland or glands but identification of patien

163 The parathyroid glands originate from the endoderm of the ca

164 e brain, musculoskeletal system, thyroid and parathyroid glands, pancreas, kidney, lung, and breast;

165 Despite the sustained stimulation to the parathyroid gland, parathyroid cells did not undergo hyp

166 -/-) mice displayed apoptotic loss of intact parathyroid glands postnatally and reduced mechanistic t

167 cts of dietary P on serum PTH, PTH mRNA, and parathyroid gland (PTG) hyperplasia in uremic rats.

168 Accurate identification and preservation of parathyroid glands (PTG) during thyroidectomy are crucia

169 urce for unraveling the mechanisms governing parathyroid gland regulation in health and disease.

170 tream mechanisms by which CKD stimulates the parathyroid glands remain elusive.

171 iple Endocrine Neoplasia type 2A should have parathyroid glands resected at the time of thyroidectomy

172 Normal parathyroid glands resected or devascularized during thy

173 id glands in situ and autotransplantation of parathyroid glands resected or devascularized during thy

174 d by hypoplasia or atresia of the thymus and parathyroid glands resulting in T cell-mediated deficien

175 racellular calcium ions (Ca2+o), cloned from parathyroid gland, serves a critical function in Ca2+o h

176 tiating single and multiple hyperfunctioning parathyroid glands, showed PET/CT to be most valuable in

177 In man, GCMB encodes a 506 amino acid parathyroid gland-specific protein, mutations of which h

178 hyroidism and enlargement of only one or two parathyroid glands that the resection be limited to thes

179 This axis is essential for preserving intact parathyroid glands throughout life, with relevance to CK

180 , but does not affect the sensitivity of the parathyroid gland to changes in iCa, as set point and no

181 ]o) in the physiological range, allowing the parathyroid gland to regulate serum [Ca2+]o; however, th

182 within the physiological range, allowing the parathyroid gland to regulate serum Ca(o); however, the

183 The accuracy for localizing a pathologic parathyroid gland to the correct side of the neck was 59

184 Renal and parathyroid gland VDR content is an important factor in

185 -98%, while the sensitivity for hyperplastic parathyroid glands was only 47%-58%.

186 0.07) and the rate of inadvertently removed parathyroid glands was significantly higher after NTT (1

187 upled receptor for external Ca2+ cloned from parathyroid gland, was shown to be expressed in PF cells

188 cytometric analysis of resected adenomatous parathyroid glands, we have isolated and characterized c

189 am, consisting of the combination of WIN and parathyroid gland weight, accurately predicted the likel

190 xcision, radionuclide counts of each ex vivo parathyroid gland were determined and expressed as a per

191 on: In most patients (89%), hyperfunctioning parathyroid glands were adequately visualized on early i

192 In 143 patients, 148 abnormal parathyroid glands were found at surgery; 137 (93%) of t

193 All resected parathyroid glands were hypercellular (mean weight = 895

194 In these patients, 130 abnormal parathyroid glands were identified at surgery.

195 A mean (SD) of 3.4 (1.1) parathyroid glands were identified in the procedures.

196 More parathyroid glands were identified with autofluorescence

197 s 61% [95% CI, 56%-66%]) (P < .001) and less parathyroid glands were inadvertently excised (4% [95% C

198 PET/CT for localization of hyperfunctioning parathyroid glands were retrospectively analyzed.

199 n), and had histologically proven pathologic parathyroid glands were retrospectively included in the

200 ur patients were included, and a total of 71 parathyroid glands were surgically removed.

201 dental disruption of blood supply to healthy parathyroid glands, which are responsible for regulating

202 mic progression of cell states within normal parathyroid glands, which can be used to better understa

203 ts from the calcium-sensing receptors on the parathyroid glands, which detect changes in calcium conc

204 arathyroid adenomas are benign tumors in the parathyroid glands, whose pathogenesis is largely unknow

205 PT-mTOR(-/-) mice lacked intact parathyroid glands yet maintained normal serum PTH level