ライフサイエンスコーパス: paraxial mesoderm

1 es derived from neural crest cells (NCC) and paraxial mesoderm.

2 e entire spinal cord and also contributes to paraxial mesoderm.

3 tent inhibitors of myogenesis in the cranial paraxial mesoderm.

4 the primitive streak and a selective loss of paraxial mesoderm.

5 uctive signals from local tissues, including paraxial mesoderm.

6 ll populations, the cranial neural crest and paraxial mesoderm.

7 he lumbosacral (LS) spinal cord and adjacent paraxial mesoderm.

8 d, and after axial displacement of posterior paraxial mesoderm.

9 chondrogenic and myogenic differentiation of paraxial mesoderm.

10 mesenchymal-to-epithelial transition of the paraxial mesoderm.

11 the FGFs, FGF8 is strongly expressed by the paraxial mesoderm.

12 thoracic levels and likely to originate from paraxial mesoderm.

13 d sort symmetrically into the left and right paraxial mesoderm.

14 esoderm mainly at the expense of the somitic paraxial mesoderm.

15 ttern of fak mRNA expression in the anterior paraxial mesoderm.

16 t for retinoic acid signalling from adjacent paraxial mesoderm.

17 g that pMesogenin1 is involved in specifying paraxial mesoderm.

18 o play a significant role in segmentation of paraxial mesoderm.

19 ily devoted to formation and segmentation of paraxial mesoderm.

20 anizing centers, such as the floor plate and paraxial mesoderm.

21 iption factors, Brachyury or Tbx6, also lack paraxial mesoderm.

22 oderm lineages, including chordamesoderm and paraxial mesoderm.

23 ecular and cellular characteristics of early paraxial mesoderm.

24 a5 activation, and FN matrix assembly in the paraxial mesoderm.

25 of EphA4, an anterior segment marker, in the paraxial mesoderm.

26 ated in Wnt3a mutants in cells fated to form paraxial mesoderm.

27 ighly dynamic prepatterned subdomains of the paraxial mesoderm.

28 nd to reduced Notch1 expression in the mouse paraxial mesoderm.

29 , in agreement with its normal expression in paraxial mesoderm.

30 ents required for the formation of axial and paraxial mesoderm.

31 at profoundly affects the differentiation of paraxial mesoderm.

32 initially in Spemann's organizer and then in paraxial mesoderm.

33 n the initiation of patterning of vertebrate paraxial mesoderm.

34 ng notochord and blocking differentiation of paraxial mesoderm.

35 gene may be involved in the specification of paraxial mesoderm.

36 the elongating spinal cord and the adjacent paraxial mesoderm.

37 l requires secondary signals produced in the paraxial mesoderm.

38 to positionally restricted signals from the paraxial mesoderm.

39 a different myogenic potential of the caudal paraxial mesoderm.

40 derived from both cephalic neural crest and paraxial mesoderm.

41 ate, expressing paraxis, a gene expressed in paraxial mesoderm.

42 cells fated to continue ingressing and form paraxial mesoderm.

43 anscription factor in the development of the paraxial mesoderm.

44 lateral plate mesoderm, but is unaffected in paraxial mesoderm.

45 opic induction of PTC in the neural tube and paraxial mesoderm.

46 in the primitive streak and newly recruited paraxial mesoderm.

47 rmation of more posterior derivatives of the paraxial mesoderm.

48 s: neuroectoderm, lateral plate mesoderm and paraxial mesoderm.

49 -expressing embryonic progenitors defined as paraxial mesoderm.

50 r bilaterally symmetric morphogenesis of the paraxial mesoderm.

51 he features of the embryonic spinal cord and paraxial mesoderm.

52 he early E8.5 pioneer neural crest cells and paraxial mesoderm.

53 xpands and generates the spinal cord and the paraxial mesoderm.

54 orm neuroectoderm, lateral plate mesoderm or paraxial mesoderm.

55 the dorsolateral plate rather than from the paraxial mesoderm.

56 rply down-regulated upon segmentation of the paraxial mesoderm.

57 chrony of the differentiation process in the paraxial mesoderm.

58 al and peripheral nervous systems and in the paraxial mesoderm.

59 populations of renal stroma originate in the paraxial mesoderm.

60 tebrates--are rhythmically produced from the paraxial mesoderm.

61 odes are concomitantly at work to set up the paraxial mesoderm.

62 ton of vertebrates derive from the embryonic paraxial mesoderm.

63 n; as a result, the embryos have very little paraxial mesoderm.

64 process that results in segmentation of the paraxial mesoderm.

65 the spinal cord originates from the adjacent paraxial mesoderm.

66 ch adjacent to the source of RA synthesis in paraxial mesoderm.

67 issue that transiently stops dividing is the paraxial mesoderm, a dynamically mobile tissue that form

68 We show that RA synthesized in the anterior paraxial mesoderm adjacent to the foregut is necessary f

69 form in a rostrocaudal progression from the paraxial mesoderm adjacent to the neural tube.

70 requires bilateral rhythmic segmentation of paraxial mesoderm along the antero-posterior axis.

71 We show that signals from paraxial mesoderm also control the much finer-grained se

72 Stage 13-14 paraxial mesoderm also exhibited a myogenic response to

73 quent patterning and specification steps for paraxial mesoderm also fail, leading to a complete absen

74 mitotically in concert with the surrounding paraxial mesoderm, although no myogenic potential was ev

75 ed by regulating transcript stability in the paraxial mesoderm and by selective translation and/or de

76 opus, zebrafish chordin is also expressed in paraxial mesoderm and ectoderm and in localized regions

77 potential nature of the progenitor cells for paraxial mesoderm and establish regulatory relationships

78 l to the rostrocaudal axis between the trunk paraxial mesoderm and IM before stage 8 developed a pron

79 /et-1 is expressed in a central core of arch paraxial mesoderm and in arch epithelia, both surface ec

80 Retinoic acid (RA) is produced by the paraxial mesoderm and is an inducer of neural differenti

81 e neural tube to the two flanking columns of paraxial mesoderm and is required for normal vertebrate

82 pically expressing Tbx6 within the segmented paraxial mesoderm and its derivatives using a 3-componen

83 are expressed in overlapping patterns in the paraxial mesoderm and its derivatives.

84 Pax3 gene is an early marker for the entire paraxial mesoderm and its dorsal derivative, the dermomy

85 ene is specifically expressed in unsegmented paraxial mesoderm and its immediate progenitors.

86 se a severe defect in the differentiation of paraxial mesoderm and lead to the formation of additiona

87 uppression of Wnt signals emanating from the paraxial mesoderm and midbrain territory.

88 m myogenic progenitors that originate in the paraxial mesoderm and migrate into the limb-bud mesenchy

89 In both species, expression of Hoxc8 in the paraxial mesoderm and neural tube is associated with mid

90 nous retinoic acid in signalling between the paraxial mesoderm and neural tube.

91 ion in zebrafish resulted in an expansion of paraxial mesoderm and neurectoderm at the expense of mor

92 n progenitor types (neuromesodermal, lateral/paraxial mesoderm and notochord progenitors; NMPs, LPMPs

93 ment of pattern within the neurectoderm, the paraxial mesoderm and other tissues.

94 normal timing of recruitment of prospective paraxial mesoderm and partially rescues the development

95 n is limited to the overlying ectoderm, core paraxial mesoderm and pharyngeal pouch endoderm of the m

96 Outside of the paraxial mesoderm and prior to apparent reduction of the

97 tablishment of a segmental prepattern in the paraxial mesoderm and prior to somite boundary formation

98 ox 1 (Six1), and myogenic factor 5 (Myf5)-in paraxial mesoderm and skeletal myogenesis.

99 unction, we investigated the role of the key paraxial mesoderm and skeletal myogenic commitment facto

100 at Paraxis acts as an important regulator of paraxial mesoderm and somite development and functions i

101 loop-helix transcription factor expressed in paraxial mesoderm and somites.

102 on of three tissue layers, the endoderm, the paraxial mesoderm and the neural crest cells; however, t

103 cells that originate from both the cephalic paraxial mesoderm and the neural crest populate the head

104 n of Wee2 increases the mitotic index of the paraxial mesoderm and this results in the failure of con

105 cription factor expressed in the unsegmented paraxial mesoderm and throughout epithelial somites befo

106 Tbx6 expression is restricted to presomitic, paraxial mesoderm and to the tail bud, which replaces th

107 ing for the PDGF-alpha receptor, a marker of paraxial mesoderm, and for the absence of Flk-1, a marke

108 essential for the specification of posterior paraxial mesoderm, and in its absence cells destined to

109 rimitive streak, make only a small amount of paraxial mesoderm, and the lateral anlage of the heart d

110 xpression was detected in the notochord, the paraxial mesoderm, and the tail bud but was not observed

111 nts are regarded as exclusively derived from paraxial mesoderm, any transition presumes both co-optio

112 signals from a localized region of the trunk paraxial mesoderm are both required and sufficient for t

113 pieces of dorsal neural tube and unsegmented paraxial mesoderm are combined in tissue culture, myocyt

114 ndaries of expression in the neural tube and paraxial mesoderm are located between 11 and 19 kb downs

115 for a paraxis null mutation, cells from the paraxial mesoderm are unable to form epithelia and so so

116 mining Ca(2+) dynamics in the intact Xenopus paraxial mesoderm as it differentiates into the mature m

117 eriments do not, however, implicate adjacent paraxial mesoderm as the only source of graded signals.

118 head structures, neural tube, notochord, and paraxial mesoderm as well as NCAM and XMyoD expression.

119 e proper positioning and segmentation of the paraxial mesoderm as well as the complete elongation of

120 d derriere, are coexpressed in the posterior paraxial mesoderm at neurula stage.

121 s in the anterior tailbud only gives rise to paraxial mesoderm, at the exclusion of axial mesoderm.

122 During vertebrate embryogenesis, the paraxial mesoderm becomes segmented into somites, which

123 During embryonic development, the paraxial mesoderm becomes segmented into somites, within

124 In contrast, transplanted cells in paraxial mesoderm behave according to the host genotype;

125 onsiveness with the caudal (more 'immature') paraxial mesoderm being more myogenically responsive to

126 idney, originate from the somites- blocks of paraxial mesoderm best known for their contribution to m

127 nscription factor, Tbx6, is expressed in the paraxial mesoderm but is downregulated as somites develo

128 in vitro led to induction of IM genes in the paraxial mesoderm but not in the lateral plate mesoderm.

129 photon images of zebrafish neuroectoderm and paraxial mesoderm by comparing its results with those de

130 evelopment begins with the patterning of the paraxial mesoderm by inductive signals from midline tiss

131 To determine whether the trunk paraxial mesoderm caudal to the fifth somite maintains i

132 ssed in developmentally immature unsegmented paraxial mesoderm, causes complete failure of somite for

133 their initial rostrocaudal position, cranial paraxial mesoderm cells migrate to fill the core of spec

134 rulation, but the recruitment of prospective paraxial mesoderm cells to the primitive streak is delay

135 senchyme, composed of mixed neural crest and paraxial mesoderm cells, as well as cells from adjacent

136 ling centers, and not directly in the NC and paraxial mesoderm cells.

137 s a more proximal distribution of cells with paraxial mesoderm character within the primitive streak,

138 -dependent ectopic expression of Bmp4 in the paraxial mesoderm consistent with Noggin antagonizing an

139 anging signalling properties of the adjacent paraxial mesoderm control the progression of neurogenesi

140 We also show that RA produced by the paraxial mesoderm controls branchiomotor differentiation

141 We show that this restriction to the somitic paraxial mesoderm correlates well with the ability of Sc

142 , leading to a complete absence of all trunk paraxial mesoderm derivatives, which include skeletal mu

143 tissue completely devoid of neural crest and paraxial mesoderm derivatives.

144 t palate, and a striking loss of many NC and paraxial mesoderm derived cranial bones.

145 ligand mRNA is expressed by arch epithelium, paraxial mesoderm-derived arch core and the arch vessel

146 In all vertebrates examined so far, paraxial mesoderm-derived signals specify distinct moton

147 e role that Pax3 plays during development of paraxial mesoderm-derived structures, we followed the de

148 al for the maintenance of segment borders in paraxial mesoderm-derived structures.

149 ved signals can induce motoneuron formation, paraxial-mesoderm-derived signals can pattern motoneuron

150 is an essential upstream regulator of trunk paraxial mesoderm development and segmentation.

151 dorsomedial quadrant grafts of all stages of paraxial mesoderm development tested, indicating that pe

152 rafish mutants that have distinct effects on paraxial mesoderm development.

153 astrulating mouse embryo and is required for paraxial mesoderm development.

154 , which has been suggested to play a role in paraxial mesoderm development.

155 F signaling function antagonistically during paraxial mesoderm development.

156 In embryos expressing these antimorphs, the paraxial mesoderm differentiated normally into somitic t

157 We propose that Delta signaling from paraxial mesoderm diversifies midline cell fate by induc

158 ements is crucial for the maintenance of the paraxial mesoderm domain of Hoxb4 expression.

159 In spt embryos, which lack normal paraxial mesoderm due to incorrect cell migration, early

160 d signals originating from Hensen's node and paraxial mesoderm establish and refine the Hox-c positio

161 Embryo surgery and paraxial mesoderm explant experiments show that each of

162 Addition of BMP2 or BMP4 to paraxial mesoderm explants blocks Shh-mediated induction

163 raxis failed to be expressed, cells from the paraxial mesoderm failed to epithelialize and somites we

164 e an abnormally thick mesoderm layer; later, paraxial mesoderm fails to organize into somites.

165 derm and by controlling specification of the paraxial mesoderm fate in the tail bud.

166 c expression of msgn1, a master regulator of paraxial mesoderm fate, or if transplanted into the bipo

167 factors: retinoic acid (RA) signals from the paraxial mesoderm; fibroblast growth factor (Fgf) signal

168 embryoid body differentiation enhances both paraxial mesoderm formation and the myogenic potential o

169 suggest that the mechanisms responsible for paraxial mesoderm formation are largely conserved across

170 This is due to the paucity of paraxial mesoderm formation during embryoid body (EB) in

171 Here, we reinvestigate paraxial mesoderm formation in the chicken embryo and de

172 een in embryonic stem cells, is required for paraxial mesoderm formation in the mouse.

173 sgn1 and Tbx6, each of which is critical for paraxial mesoderm formation, since absence of any one of

174 ryos cut between the notochord and the trunk paraxial mesoderm formed pronephric structures on both s

175 s Pax-1, MyoD, and Pax-3 after separation of paraxial mesoderm from axial structures.

176 k inhibitory kinase that is expressed in the paraxial mesoderm from mid-gastrula stages onwards.

177 ecessary for otic placode induction and that paraxial mesoderm from other locations cannot induce the

178 rfaces between the zebrafish neural tube and paraxial mesoderm function as optimally engineered adhes

179 ssic studies in the chick embryo showed that paraxial mesoderm generates a subset of somite-derived e

180 on of KDR(-)PDGFRalpha(+) progeny expressing paraxial mesoderm genes and the mesendoderm reporter MIX

181 Cells of the cranial paraxial mesoderm give rise to parts of the skull and mu

182 During vertebrate embryogenesis, paraxial mesoderm gives rise to somites, which subsequen

183 pothesis that determinative aspects of early paraxial mesoderm growth and morphogenesis occur in earl

184 explants from neurulae in which movement of paraxial mesoderm had not yet begun also developed taste

185 latory network operating in the formation of paraxial mesoderm has been described.

186 om the neural plate, non-neural ectoderm and paraxial mesoderm have all been suggested to play a role

187 The hindbrain and cranial paraxial mesoderm have been implicated in the induction

188 BAT derives from the multipotent paraxial mesoderm; however, the identity of embryonic br

189 Here we show that in the paraxial mesoderm, Hoxb genes are first activated in a t

190 s that contribute to the spinal cord and the paraxial mesoderm in concert with the body axis elongati

191 nopus, mouse and zebrafish implicate lateral/paraxial mesoderm in supplying the transforming influenc

192 ptional WNT targets and specification of the paraxial mesoderm in tail bud precursors.

193 Paraxial mesoderm in vertebrates gives rise to all trunk

194 ancers, and the subdivision of the axial and paraxial mesoderm in vertebrates.

195 Brachyury and differentiate into neural and paraxial mesoderm in vitro and in vivo.

196 function of PAPC during segmentation of the paraxial mesoderm in Xenopus embryos.

197 r, they show a complete absence of segmented paraxial mesoderm, including anterior somites.

198 ecombination assay, we show that prospective paraxial mesoderm induces a panel of neural crest marker

199 dels to the lateral edges of the neural tube-paraxial mesoderm interfaces where shear stress is highe

200 metamerism can be traced to the division of paraxial mesoderm into individual units, termed somites,

201 ing pathway are required for subdividing the paraxial mesoderm into repeating segmental structures, c

202 vertebrate embryos is the subdivision of the paraxial mesoderm into repeating, metameric structures c

203 mitogenesis involves the segmentation of the paraxial mesoderm into units along the anteroposterior a

204 Finally, the paraxial mesoderm intrinsically controls its competence

205 tion of somites, and Nrarp expression in the paraxial mesoderm is altered in several Notch pathway mu

206 As a result, chicken Hoxc8 expression in the paraxial mesoderm is at a posterior axial level, extendi

207 sion of Wnt3a, Msgn1 and Tbx6 at a time when paraxial mesoderm is being formed.

208 orsal neural tube, myogenesis in the cranial paraxial mesoderm is blocked by these same signals.

209 In contrast, in lower vertebrates, paraxial mesoderm is formed as a result of the continuat

210 In amniotes, paraxial mesoderm is formed bilaterally to the nerve cor

211 e show that although myogenesis in the trunk paraxial mesoderm is induced by Wnt signals from the dor

212 In vertebrates, paraxial mesoderm is partitioned into repeating units ca

213 At the same time, the paraxial mesoderm is patterned along the anterior-poster

214 est that the FN matrix on the surface of the paraxial mesoderm is required for body elongation via it

215 se genetics to show that RA derived from the paraxial mesoderm is required for lateral LMC induction

216 Retinoic acid (RA) generated by Raldh2 in paraxial mesoderm is required for specification of the p

217 ons, demonstrating that Tbx6 activity in the paraxial mesoderm is required not simply for somite spec

218 nclude that neither cranial neural crest nor paraxial mesoderm is responsible for the induction of em

219 The development of axial and paraxial mesoderm is severely abnormal in lin28 knockdow

220 During vertebrate embryonic development, the paraxial mesoderm is subdivided into metameric subunits

221 ion of the vertebrate embryo begins when the paraxial mesoderm is subdivided into somites, through a

222 To determine whether paraxial mesoderm is sufficient for pronephros induction

223 Paraxial mesoderm is the tissue which gives rise to the

224 fish mutant fused somites (fss), because its paraxial mesoderm lacks segment polarity.

225 nd later in the node, midbrain, spinal cord, paraxial mesoderm, lateral plate mesoderm, and limb bud.

226 sterior tissues (e.g. neural tube, axial and paraxial mesoderm, lateral plate, ectoderm, endoderm) to

227 Furthermore, tail paraxial mesoderm length is not reduced upon direct remo

228 Thus, hPS cell-derived KDR(-)PDGFRalpha(+ )paraxial mesoderm-like cells have potential in engineere

229 embryonic stem cells (ESCs) generate rostral paraxial mesoderm-like progeny in 5-6 days of differenti

230 ak, Ch-Tbx6L becomes restricted to the early paraxial mesoderm lineage and could play a role in regul

231 otential is lost in some of the cells of the paraxial mesoderm lineage in no tail and spadetail embry

232 e chondrogenic in vitro, and expressed trunk paraxial mesoderm markers such as Tcf15 and Meox1, and s

233 originate from hedgehog-responsive cephalic paraxial mesoderm (Mes) cells, which migrate rapidly to

234 orrelation spectroscopy within the zebrafish paraxial mesoderm mesenchyme reveals a physical associat

235 f axial mesoderm and failed specification of paraxial mesoderm, mimicking phenotypes in embryos with

236 oducing mesodermal boundaries, generating in paraxial mesoderm morphological boundaries between somit

237 hinge (CNH), contributes descendants to the paraxial mesoderm, notochord and neural tube, and is ser

238 is the sequential production from posterior paraxial mesoderm of blocks of cells termed somites.

239 lunatic fringe expression in the unsegmented paraxial mesoderm of chick embryos.

240 ch signaling system, is not expressed in the paraxial mesoderm of early segmentation stage fss embryo

241 t restoration of Eph/Ephrin signaling in the paraxial mesoderm of fss mutants rescues most aspects of

242 locks cardiogenesis in the adjacent anterior paraxial mesoderm of stage 8-9 chick embryos can be mimi

243 atically down-regulated, suggesting that the paraxial mesoderm of the fss mutant embryo is profoundly

244 demonstrate that expression of Hoxb4 in the paraxial mesoderm of the mouse embryo is transcriptional

245 ion is first seen distinctly in the emerging paraxial mesoderm of the primitive streak stage chick em

246 The paraxial mesoderm of the somites of the vertebrate embry

247 In addition, we demonstrate that the entire paraxial mesoderm of wild-type embryos has the potential

248 rder cells, delaminate and migrate along the paraxial mesoderm on either side of the neural tube, eve

249 Ventral somite fragments (sclerotome), head paraxial mesoderm or non-paraxial (lateral plate) mesode

250 efore migration or by grafting quail cranial paraxial mesoderm orthotopically.

251 gh the process of somitogenesis in which the paraxial mesoderm periodically segments into bilateral t

252 Thus, the low mitotic index of the paraxial mesoderm plays an essential function in the int

253 , indicating that the signal arises from the paraxial mesoderm (PM) and not from axial mesoderm.

254 etail (spt) mutant embryos, which lack trunk paraxial mesoderm (PM) due to a cell-autonomous defect i

255 rafish that FGF is continuously required for paraxial mesoderm (PM) induction in post-gastrula NMPs.

256 southpaw is expressed bilaterally in paraxial mesoderm precursors and then within the left la

257 suggest that in the absence of signals from paraxial mesoderm, primary motoneurons have a hybrid ide

258 al of most of the neural plate and axial and paraxial mesoderm prior to neural tube closure does not

259 -specific antisense oligonucleotide into the paraxial mesoderm produced discrete segmentation anomali

260 nomous function of T as a gatekeeper between paraxial mesoderm production and the building of the NMP

261 ng posterior trunk truncations, and inhibits paraxial mesoderm production in culture.

262 ubject to directed differentiation through a paraxial mesoderm progenitor state that generates BAs at

263 on and prospective isolation of chondrogenic paraxial mesoderm progeny from human pluripotent stem (P

264 or a broader source of origin, including the paraxial mesoderm (PXM).

265 result from a failure to produce sufficient paraxial mesoderm, rather than a failure of mesoderm pre

266 rafted quail trunk mesoderm into the cranial paraxial mesoderm region.

267 ts in which posterior neural segments and/or paraxial mesoderm segments were placed at different axia

268 an integration of Hensen's node-derived and paraxial mesoderm signaling.

269 show that although FGF alone does not mimic paraxial mesoderm signals, it is directly required in ep

270 ment of the correct anterior boundary in the paraxial mesoderm (somite 6/7).

271 or limits of expression in the hindbrain and paraxial mesoderm (somites), respectively.

272 erous tissues of the mouse embryo, including paraxial mesoderm, somites, branchial arches, vibrissae,

273 mouse that we call pMesogenin1 (referring to paraxial mesoderm-specific expression and regulatory cap

274 ertebrates first arises when the unsegmented paraxial mesoderm subdivides to form paired epithelial s

275 aining excluded from head, heart and somitic paraxial mesoderm territories.

276 Our fate mapping further shows that the paraxial mesoderm territory in the epiblast is regionali

277 e derives from the adaxial cells, a layer of paraxial mesoderm that differentiates medially within th

278 3 is expressed in the neural tube and in the paraxial mesoderm that gives rise to skeletal muscles.

279 of paraxis expression, an early phase in the paraxial mesoderm that is dependent on signals from the

280 iferation, and differentiation of the NC and paraxial mesoderm that make the face.

281 primitive streak at the level of prospective paraxial mesoderm, the primitive streak at the level of

282 , that contribute to the spinal cord and the paraxial mesoderm throughout axial elongation.

283 Little is known about how this paraxial mesoderm tissue is specified.

284 Sall4 is involved in the development of the paraxial mesoderm tissue.

285 e embryos arises through segmentation of the paraxial mesoderm to form somites.

286 that an RA signal initially travels from the paraxial mesoderm to r3, forming a boundary next to the

287 itx2 homeobox gene functions in both cranial paraxial mesoderm, to regulate eye muscle, and in splanc

288 rived from epithelium (oral sulcus), cranial paraxial mesoderm (tongue) and cranial neural crest (Mec

289 in which caudal is the default identity for paraxial mesoderm, upon which is patterned rostral ident

290 ) to promote myogenesis in stage 10-14 chick paraxial mesoderm utilizing 72 hour explant cultures.

291 Disruption of somite formation from the paraxial mesoderm was observed in 67% of the surviving t

292 In chick and mouse embryos, paraxial mesoderm was proposed to derive from a populati

293 None of the allantoic regions contributed to paraxial mesoderm when placed into the fetus, but all th

294 edian fins arise predominantly from somitic (paraxial) mesoderm, whereas paired appendages develop fr

295 tablished through interactions with adjacent paraxial mesoderm which develops as sclerotome in some v

296 in chick embryos, we also show that cranial paraxial mesoderm which normally lies beneath the presum

297 th no tail-expressing midline precursors and paraxial mesoderm, which expresses deltaC and deltaD.

298 mplished by Polycomb and Hox proteins in the paraxial mesoderm, while their subsequent morphogenesis

299 somitogenesis, RALDH-2-IR is present in the paraxial mesoderm with a rostral boundary at the level o

300 on can be induced by signals from underlying paraxial mesoderm without concomitant induction of an am