ライフサイエンスコーパス: parent compound

1 roximately 15-40% of the reacted mass of the parent compound.

2 gnitude lower than that of the corresponding parent compound.

3 and not an ideal measure of exposure to the parent compound.

4 of the decrease in the concentration of the parent compound.

5 by ca. 200 nm compared to the unsubstituted parent compound.

6 pite occasionally high concentrations of the parent compound.

7 an and auxin plant hormones; <1% remained as parent compound.

8 bamazepine was significantly higher than the parent compound.

9 products are likely worse than those of the parent compound.

10 tabolite acts with greater efficacy than the parent compound.

11 but it was more readily mineralized than the parent compound.

12 city are not always excreted faster than the parent compound.

13 ride (VC) which are even more toxic than the parent compound.

14 CDK2 liganded with distinct analogues of the parent compound.

15 species), many of which were specific to the parent compound.

16 pealing selectivity profile exhibited by the parent compound.

17 up to 8 h), as compared to the KGOP01 opioid parent compound.

18 acious use of doses 150-fold higher than the parent compound.

19 none had more than twice the potency of the parent compound.

20 bition of enzyme activity as compared to the parent compound.

21 ing 21 chemical structures from the original parent compound.

22 the potentially harmful mitogenicity of the parent compound.

23 essentially no oral bioavailability for the parent compound.

24 h a potency and effectiveness similar to the parent compound.

25 ey can retain part of the bioactivity of the parent compound.

26 8-substitutions provided no benefit over the parent compound.

27 cy, and effectiveness resembling that of the parent compound.

28 s solubility and oral bioavailability of the parent compound.

29 which is responsible for the toxicity of the parent compound.

30 the appearance of the V82A mutation than the parent compound.

31 overy processes to alter the properties of a parent compound.

32 that are more potent and less toxic than the parent compound.

33 he 0.1% level, with no interference from the parent compound.

34 tivity, but are 18-fold less active than the parent compound.

35 a different binding mode as compared to the parent compound.

36 ical and pharmacokinetic properties than the parent compound.

37 perties can differ greatly from those of the parent compound.

38 ic profile very similar to that shown by the parent compound.

39 ning of the group on the biologically active parent compound.

40 case of filamentous fungi than those for the parent compounds.

41 a, they showed to be more effective than the parent compounds.

42 s too were generally lower than those of the parent compounds.

43 ort half-lives and often lack specificity to parent compounds.

44 antimicrobial action than the corresponding parent compounds.

45 that have different toxicity compared to the parent compounds.

46 n with corresponding parameters found in the parent compounds.

47 PCBs may be more toxic and mobile than their parent compounds.

48 eature a similar bacterial toxicity than the parent compounds.

49 ure derivatives comparable in potency to the parent compounds.

50 harges were higher than those calculated for parent compounds.

51 ntly more reactive than their nonhalogenated parent compounds.

52 culture, up to 25-fold lower compared to the parent compounds.

53 that differ in biological activity from the parent compounds.

54 e by a factor of about 2 with respect to the parent compounds.

55 or hole doping of their non-superconducting parent compounds.

56 'holes' are doped into the antiferromagnetic parent compounds.

57 sue is the nature of the ground state of the parent compounds.

58 DNA cleavage activity was compared with the parent compounds.

59 d into the CuO(2) planes of their insulating parent compounds.

60 rrent method are formed from eight different parent compounds.

61 ion of oxidation intermediates back to their parent compounds.

62 e dramatically less potent relative to their parent compounds.

63 the bacterium Aliivibrio fischeri than their parent compounds.

64 r superior in vitro activity relative to the parent compounds.

65 ivity in strains that are insensitive to the parent compounds.

66 rectly rather than daily intake estimates of parent compounds.

67 centrations, but to a lesser extent than the parent compounds.

68 el physical phenomena that are absent in the parent compounds.

69 els accurately predicted the binding for the parent compounds.

70 the stomach and small intestine, containing parent compounds.

71 PDE10A enzyme to alter the planarity of the parent compound 1 and optimize its affinity for PDE10A.

72 The compounds are potential prodrugs for the parent compound 1, a highly potent antitumor agent.

73 The potency of 3 increases, over the parent compound 1, against fIIa (110-fold), much more th

74 7-disubstituted TAPy molecules and the known parent compound 1,3,6,8-tetraazapyrene (II) have been fu

75 ightly against the neuronal isoform over the parent compound (1).

76 ized as an extension of our discovery of the parent compound (+/-)-1.HCl as an anti-microtubule agent

77 ns and was up to 7-fold more potent than the parent compound (+/-)-1.HCl.

78 ikely due to biochemical transformation from parent compounds (17beta-estradiol, 4-nonylphenolpolyeth

79 tolerated, and tumour growth delays for the parent compound (2.6 d) were improved to 4.3 d; performa

80 increased the plasma exposure of the active parent compound 20-fold compared to when 1 was dosed ora

81 owed higher uptake (2.6- to 9-fold) than the parent compound 3-HPG.

82 g and 4g, respectively) as compared to their parent compounds (3a and 4a) in all cell lines.

83 ced pharmacological profiles compared to the parent compound 4, and the N-methylpyrrolidine analogue

84 compared to the different affinities of the parent compound (4).

85 intermediates using the same non-chlorinated parent compound, 4-ethylphenol (4EP).

86 ved metabolic stability in comparison to the parent compound 5 while retaining favorable pharmacologi

87 Unlike the parent compound, 7b is toxic to both p53 positive and ne

88 rameters with a four-pool model containing a parent compound, a metabolite, a volatile, and a NER poo

89 mass balances ranged from 49 to 130% of the parent compound added to the microsomal incubations.

90 1.1% of SMX in plant tissues present as the parent compound after 10 days of exposure.

91 Similar to its parent compound AG490, WP1066 inhibited the phosphorylat

92 2 were similar to those of the indomethacin parent compound against WT COX-2, and the R120A substitu

93 nding is the dominant bonding feature in its parent compound ammonia borane.

94 mechanisms distinct from those of either its parent compound, amonafide, or sorafenib.

95 The persistence of the parent compound and formation of incomplete intermediate

96 Accurate mass determination of the unknown parent compound and its fragments obtained in MS/MS prov

97 ite levels in TMF values calculated for both parent compound and its metabolite(s) is weak compared t

98 her into site 3 of Grp94 compared with their parent compound and that selectivity is due to paralog-s

99 P102A1 is capable of inactivating the active parent compound and the products of both known pathways

100 evated rates of [3 + 2] cycloaddition as the parent compound and were used for imaging glycans on liv

101 More than 100 parent compounds and 40 transformation products were det

102 minated heparin had higher activity than the parent compounds and authentic heparin, indicative of su

103 g differences of functional activity between parent compounds and expected metabolites.

104 29)Si HSQC, were assigned by comparison with parent compounds and GIAO-DFT calculations.

105 Bioaccumulation factors were calculated for parent compounds and metabolite enrichment factors for m

106 scribed the measured fetal concentrations of parent compounds and metabolites quite accurately (withi

107 ptake, biotransformation, and elimination of parent compounds and metabolites were modeled with a fir

108 strongly affected internal concentrations of parent compounds and metabolites.

109 d after UV irradiation were analyzed for the parent compounds and products using a high performance l

110 y concentration trends of the metabolite and parent compounds and the complementary use of HILIC.

111 t upon the structural characteristics of the parent compounds and the specific position of the modifi

112 eference for cis-amides as compared to their parent compounds and thus provide novel strategies for a

113 mation reactions were used to link potential parent compounds and TPs, while the structural similarit

114 ations of sum of parabens (Sigmaparabens = 6 parent compounds) and paraben-metabolites (Sigmametaboli

115 HDP-P-5-F-2dUrd) were synthesized from their parent compounds arabinofuranosylguanine (AraG) and 5-fl

116 The rotational constants for the parent compound are A = 5657.335(1), B = 5349.2807(5), a

117 Although dissipation half-lives of the parent compound are directly extractable from OECD 308 d

118 e in unhatched eggs, it can be inferred that parent compounds are absorbed into the bird through the

119 he predicted concentration profiles for both parent compounds are consistent with experimental data.

120 We show that its parent compound, argued to exist only as a weakly correl

121 te the reduction of DMABN(*+) to re-form its parent compound as the basic reaction governing the inhi

122 e 14 (IC50=7.7 microM) were more potent than parent compounds as antiproliferation agents.

123 ons of up to 0.1 mug g(-1) were detected for parent compounds as well as terbutryn degradation produc

124 ofunctional-intercalative DNA adducts as the parent compounds, as demonstrated in a plasmid unwinding

125 ism was rapid, with approximately 50% of the parent compound at 5 min and 17% at 60 min after injecti

126 Furthermore, the parent compounds at a high concentration, as opposed to

127 he proportion of alkyl PACs was greater than parent compounds at all sites.

128 uction between the active metabolite and its parent compound (B[a]PDE versus B[a]P) or between active

129 The undoped parent compound, BaTi(2)Sb(2)O [P4/mmm; a = 4.1196(1) A;

130 discovered BaTi2Sb2O superconductor and its parent compound BaTi2As2O form a symmetry-breaking nemat

131 We find that, unlike its parent compound BeH2, lithium-beryllium hydride LiBeH3 e

132 des, which are structurally related to their parent compound, BeH2, offer the highest hydrogen storag

133 omprising the EFGH- and BCDEFGH-rings of the parent compound, both of which surprisingly showed simil

134 altered membrane capacitance similar to the parent compound but produced no voltage-dependent fluore

135 and carbamazepine treatments was due to the parent compounds but that diclofenac was degraded in the

136 ly weak inhibitors of gyrase relative to the parent compound, but their combination generates a more

137 logs retained the activator character of the parent compound, but, more interestingly, other derivati

138 c response are shifted with respect to their parent compounds, but the aromatic/nonaromatic character

139 phy-mass spectrometry and by detecting their parent compounds by liquid chromatography-high resolutio

140 In complex with A/N8 sialidase, the parent compound (C3 OH) inverts its solution conformatio

141 ay were mineralized, while 21 and 35% of the parent compound carbon was incorporated into the biomass

142 a striking resemblance to those found in the parent compound, challenging the perception that spin ex

143 t is 2-3 orders of magnitude higher than the parent compound cocaine.

144 The remedial injection successfully reduced parent compound concentrations on site.

145 All five parent compounds contributed to the observed inhibition

146 ing only a total of 52 Da to the mass of the parent compound, creating an efficient ligand as an exce

147 o 10) exhibited a similar rate and extent of parent compound decay and defluorination, the reactions

148 The amphetamine parent compound decreased in the artificial streams from

149 microscopic analysis showed that, unlike the parent compounds, derivative 2b did not show any signifi

150 for the three CECs, a majority (>75%) of the parent compounds disappeared at the 15 min reaction time

151 are likely to have a higher NDMA FP than the parent compound due to a reduced steric hindrance and/or

152 nd subsequent NDMA formation compared to the parent compound during chloramination.

153 Parent compounds (e.g., buproprion, carbamazepine, lamot

154 strate improved properties compared to their parent compounds (e.g., circumventing multidrug resistan

155 e diagrams of Eu(Fe0.925Co0.075)2As2 and the parent compound EuFe2As2 were also made.

156 to understand how the magnetic phase of the parent compounds evolves.

157 six (epoxiconazole) BTPs were identified per parent compound except for prochloraz, which showed exte

158 rugs that are efficiently metabolized to the parent compound for improved solubility and ocular perme

159 logical superconductors), making it a unique parent compound for the study of these states and the ph

160 Moreover, the structures of parent compound GLB and its two major metabolites M1 and

161 ies indicate that apogossypol is superior to parent compound gossypol with respect to toxicology and

162 or binds in the active site similarly to its parent compound GSK180736A.

163 As for the parent compound, half-lives of the metabolites varied co

164 g data, we suggest the time until 50% of the parent compound has been transformed in the entire syste

165 erved for SPMs expressed as a ratio of their parent compound, higher cortical 18R/S-hydroxy-5Z,8Z,11Z

166 be affected by the influent concentration of parent compounds, hydraulic retention times, and chlorin

167 Treatment with the parent compound (I3C) or DIM (1 micromol/L) protected ag

168 al features and the protonation state of the parent Compound II when studied by EPR and 1H and 14N EN

169 brozil enhanced the antiandrogenicity of the parent compound in a model fish species, demonstrating t

170 provided zones of inhibition larger than the parent compound in agar diffusion assays against the ind

171 city of DCF-M310.03 was also higher than the parent compound in both species, which correlated well w

172 %, and 30% of the antibiotic activity of the parent compound in chlorinated samples at 2.0, 3.0, and

173 age of the administered NMP recovered as the parent compound in larvae compared to adults.

174 OA exposure resulted in detectable levels of parent compound in larval tissue but yielded negative to

175 tain the low micromolar IC(50) values of the parent compound in Plasmodium falciparum (clone 3D7) inf

176 hate was metabolized more efficiently to the parent compound in vivo than 2-methoxyestradiol 17-phosp

177 LOBSTAHS putatively identified 1969 unique parent compounds in 21869 features that survived the mul

178 ed since it is based only on the analysis of parent compounds in biological matrices.

179 ts were detected in total, between 30 and 50 parent compounds in each two-week composite sample in co

180 erference from the many tens of thousands of parent compounds in the oil.

181 and quantitative analyses of metabolites and parent compounds in worm tissue, water, and sediment wer

182 cosidic bond of glucuronides to generate the parent compound, in human breast cancer.

183 ng that reversed the selectivity seen in the parent compound, in human hD2(L)R- or hD3R-transfected H

184 4 h at pH 4.7 was different from that of the parent compound indicating a different type of interacti

185 than a factor of 20 longer than that of the parent compound, indicating that the structural modifica

186 The parent compound inhibits influenza virus sialidase at a

187 oninvasive character and the presence of the parent compound instead of its metabolites.

188 from multiple sources and transformation of parent compounds into degradates having estrogenic activ

189 Further, we show that only the intact parent compound is found in the region of interest.

190 LTC(4), the parent compound, is secreted from mast cells following C

191 to design an improved analog of the pyrrole parent compound, JG-03-14.

192 a superfused rat pituitary system than their parent compound JV-1-36 and had increased binding affini

193 JWH-210, JWH-250, RCS-4, and AM2201 and the parent compounds JWH-018, JWH-073, JWH-081, JWH-122, JWH

194 talline phase between the nonsuperconducting parent compound K(2)Fe(4)Se(5) and the superconducting K

195 is derived from the Ruddlesden-Popper (R-P) parent compound La4Ni3O10-x by removing two oxygen atoms

196 rs were significantly more potent than their parent compounds lacking the amino acid group.

197 sed systemic dissemination relative to their parent compounds, leading to 30-fold increases in T-cell

198 Glutaric acid, the parent compound linked with human neurological manifesta

199 e compound, 7I, that is more active than the parent compound, LQZ-7, and when given orally effectivel

200 The parent compounds (Me(2)NH(2))(2)[M(2)L(3)] (M = Zn, Mn;

201 OPD, or neither condition, and metabolite-to-parent compound molar ratios were compared between group

202 ivably be as dangerous and persistent as the parent compounds; most prominently, OH-PCBs are endocrin

203 The material is synthesized from the parent compound Na2IrO3 by a topotactic reaction where s

204 The parent compound Na2IrO3 is proposed to be relevant to th

205 creased magnetic frustration compared to the parent compound NaCrS(2).

206 ilized poly(dA).2poly(dT) much more than its parent compound, neomycin.

207 ed by modifying positions 5, 7, and 8 of the parent compound nitroxoline.

208 roducts-does not account for the loss of the parent compound observed during the initial phase of the

209 Significant reductions in extractable parent compound occurred under light conditions for prom

210 on its properties and is expected to be the parent compound of a new family of superconductors.

211 zatricyclo[3.3.1.1(3,7)]decan-2-one (3), the parent compound of a rare class of 90 degrees -twisted a

212 For Fe1+yTe, the parent compound of Fe1+ySe1-xTex superconductors, bulk-s

213 The parent compound of high-[Formula: see text] superconduct

214 with the tripeptide GSH to produce LTC4, the parent compound of the cysteinyl leukotrienes, important

215 llurium (Fe(1+ y)Te), the nonsuperconducting parent compound of the iron chalcogenides, by using a ST

216 The layered telluride, Fe(1+x)Te, is a parent compound of the isostructural and superconducting

217 The parent compounds of ammonium borohydride, ammonia borane

218 of long-range antiferromagnetic order in the parent compounds of high-transition-temperature (high-T(

219 The parent compounds of iron pnictide superconductors are ba

220 The parent compounds of the 1,5-benzodiazepine CCK receptor

221 The parent compounds of the cuprate and iron-pnictide superc

222 This analogy is quite surprising as the parent compounds of the two families have rather differe

223 between ubiquitous antiferromagnetism in the parent compounds of unconventional superconductors and t

224 ite(s) is weak compared to TMF values of the parent compound only in a riverine food web.

225 f vinblastine (CPD100) which converts to the parent compound only in the presence of lower oxygen lev

226 or no quantifiable systemic exposure to the parent compound or a presumed metabolite.

227 alt avoids isolation or concentration of the parent compound or HCl salt and will facilitate the use

228 The parent compound, oxybenzone, was also present in all sam

229 5c) were synthesized in four steps from the parent compound p-tert-butyldihomooxacalix[4]arene and o

230 of DSBFNPC show a strong resemblance to the parent compound, PC, and the ECL spectrum produced via r

231 rrow this gap we investigated the fate of 20 parent compounds (PCs) and 11 characteristic TPs in four

232 improved metabolic stability compared to the parent compound, PG648 (6).

233 Parent compound plus its metabolites resveratrol-3-O-glu

234 philic metabolites were identified, with 20% parent compound present at 90 min after injection in bab

235 However, their parent compound, protocatechuic acid, did not show this

236 Concentrations of parent compounds ranged from <10 to 3830 ng/L (gemfibroz

237 The resulting DT50s of parent compounds ranged from 0.5 (fluoxetine) to 306 day

238 f Na(+) channel and IKr blockade by both the parent compound ranolazine and its active metabolites, w

239 e bloodstream, with 25% of the (11)C-labeled parent compound remaining 30 min after injection.

240 pheral metabolism, with approximately 40% of parent compound remaining at 30 min after injection.

241 Therefore, focusing solely on parent compound removal for contaminants of higher relat

242 (Ni(1-x)Fe(x)OOH) over their pure Ni and Fe parent compounds, resulting in one of the most active cu

243 eliminary photophysical investigation of the parent compound revealed a pronounced sensitivity of its

244 e presence of the specific inhibitor and its parent compound revealed novel binding sites for this ch

245 These active metabolites may prolong the parent compound's psychotropic and physiological effects

246 of these active metabolites may prolong the parent compound's psychotropic and physiological effects

247 difluoro-GABA with that of the fluorine free parent compound showed that introduction of each fluorin

248 e most active derivatives and the unmodified parent compounds showed up to 6-fold higher activity in

249 MT dual epigenetic inhibitory profile of the parent compound, some analogues, notably 4a (UVI5008), a

250 Indeed, compared to the halogen free parent compounds, some 7-halogenated derivatives exhibit

251 In addition to these parent compounds, some transformation products have also

252 SMX metabolites were also conjugates of the parent compound, such as pterin-SMX and methyl salicylat

253 1,029 inactive chemicals to detect possible parent compounds that might have active metabolites.

254 enoids in SRFA and provided insight into the parent compounds that must be diagenetically modified on

255 Like the parent compound, the cyclic derivative irreversibly acti

256 Similar to the parent compound, the new microporous materials are stabl

257 For the parent compounds, the amniotic fluid concentrations of s

258 siderably lower affinities compared to their parent compounds, the bivalent ligand approach led to si

259 rder of magnitude higher than those of their parent compounds, their future preparation and isolation

260 Parent compound tissue concentrations for both species c

261 in acidic urine, leading to delivery of the parent compounds to bladder.

262 First, rate constants for transformation of parent compounds to metabolites were correlated to those

263 re correlated to those for transformation of parent compounds to NER, leading to degradation half-liv

264 DCF-M403 is less toxic than its parent compound toward H. azteca, which may be linked to

265 is of pharmaceutical metabolites back to the parent compound, treatment systems should be designed ba

266 ) resulting from partial dissociation of the parent compound [U2F](-).

267 nt and their potential to retransform to the parent compound, underlines the importance of including

268 bic structural transitions of "122" SrFe2As2 parent compound using combined high resolution synchrotr

269 -) mouse livers perfused with the respective parent compounds using a cassette dosing approach.

270 he interdimer interface when compared to the parent compound vinblastine.

271 Metabolism of this prodrug to the active parent compound was confirmed in rat kidney homogenates,

272 ooxygenase (BMO) that was oxidized after the parent compound was consumed.

273 The decay of the parent compound was monitored with HPLC/ITMS, and the co

274 similar studies using solution dosing of the parent compound was observed in the in vivo studies in b

275 ion, only less than 5% and approximately 10% parent compound was present in blood, respectively.

276 rface water samples, median concentration of parent compounds was 110 ng/L reaching up to 6 mug/L for

277 50% current decrease) of individually tested parent compounds was 2.7 g/L for FF, 3.0 g/L for HMF, 1.

278 The extent of the metabolism of all three parent compounds was dependent on the microsomal prepara

279 were detected in 47% of the cases where the "parent-compound" was applied.

280 The ratios of biotransformation products to parent compound were 12-17 for DCF-M403 and 0.01-0.7 for

281 The parent compounds were active in all transactivation assa

282 Selected prodrugs and parent compounds were also tested for their cytotoxicity

283 The highest concentrations of parent compounds were measured in effluent that was not

284 ymatic oxidation of the 2-butyl group of the parent compound, were synthesized from 6-chloro-2-iodo-9

285 es reduced the antimicrobial activity of the parent compound when conjugated to the xanthone scaffold

286 However, the parent compounds, when tested below their respective non

287 emperature (T (c)), light hole-doping to the parent compound, which is an antiferromagnetic Mott insu

288 the substitution of a carbonyl group in the parent compound with a sulfonyl in the PDK inhibitors.

289 by FVP methods and also by reactions of the parent compound with electrophiles, leading to a range o

290 Unlike its parent compound with low water solubility, intraperitone

291 Thus, for the parent compound with R = H, i.e., [(bipy)Au(mu-O)(2)Au(b

292 netic data were collected for the respective parent compounds with a pent-4-enyl and a pent-4-enoyl c

293 entified that improve on the activity of the parent compound, with IC(50) values for induction of cel

294 minor role in elimination of the respective parent compound, with the exception of prochloraz.

295 o 175-fold higher activity than the monoaryl parent compounds, with encouraging improvements in solub

296 Detecting metabolites and parent compound within a cell type is now a priority for

297 In contrast to what happens in the parent compound x = 0.0 as a function of pressure, we fi

298 ase inhibition studies demonstrated that the parent compound (ZJ-43) exhibited potent inhibitory acti

299 d to both the mono-ester (PGI-02749) and the parent compound (ZJ-43) in both blood and brain.

300 load, which is ~17% higher than that of its parent compounds, ZrB(12) and YB(12), with hardness valu