ライフサイエンスコーパス: parental

1 Barriers to Guidelines use included parental (47.6%) and self (21.8%) concerns about allergi

2 her Europeans, and even after accounting for parental age and sequencing center.

3 n family age at onset, r=0.22 individual and parental age at death, and r=0.32 individual and mean fa

4 n family age at onset, r=0.38 individual and parental age at death, and r=0.40 individual and mean fa

5 age at onset, r=0.58 between individual and parental age at death, and r=0.69 between individual and

6 death was significantly correlated with both parental age at onset and at death and with mean family

7 ath) or the GRN group (r=0.22 individual and parental age at onset, r=0.18 individual and mean family

8 her the C9orf72 group (r=0.32 individual and parental age at onset, r=0.36 individual and mean family

9 he MAPT group (r=0.45 between individual and parental age at onset, r=0.63 between individual and mea

10 per base pair per generation (at an average parental age of 7.5 yr), much lower than found in direct

11 s that the male mutation bias is stable with parental ages and cast further doubt on the assumption t

12 : (1) cancer and mutation spectra along with parental ages were similarly distributed; (2) ascertainm

13 Genomic imprinting establishes parental allele-biased expression of a suite of mammalia

14 , Dot1l maternal deletion did not affect the parental allele-specific expression of imprinted genes,

15 nting is an epigenetic phenomenon leading to parental allele-specific expression.

16 hat involve transcriptional silencing of one parental allele.

17 ed by differences in DNA methylation between parental alleles at specific regulatory elements known a

18 discriminate methylation profiles in the two parental alleles.

19 based on a clear clonal relationship between parental and leukaemic cells.

20 a dynamic environment at the intersection of parental and nascent chromatin.

21 uplexes are packaged with an equal amount of parental and newly synthesized histones in the wake of t

22 Targeted cloning, mapping, and sequencing of parental and novel telomeric restriction fragments (TRFs

23 ns, disrupting previous correlations between parental and offspring environments, and interfering wit

24 monstrate the broad utility of using matched parental and transformed cells for small molecule inhibi

25 ng a series of genetic crosses that separate parental and zygotic contributions, we show that the H2A

26 Whether parental animals are intrinsically sensitive to neonatal

27 We posit that parental antagonism over embryonic growth drove the orig

28 Some parental antibodies yielded potent biparatopics with mul

29 ent, does not compromise the affinity of the parental antibody, and utilizes chemically stabilized si

30 Predicting future vision may avert parental anxiety and may optimize childhood development.

31 or more reactions in the past 12 months and parental anxiety significantly predicted higher levels o

32 at induced by the same doses of the virulent parental ASFV Georgia2010 isolate.

33 risk allergy cohort with comparable rates of parental atopy.

34 s a co-evolved system for credibly signaling parental attention to secondarily altricial infants.

35 or clpP2(-) knockdown strains but not in the parental bacteria, despite significant induction of hsp2

36 lly derived mimics of gliadin epitopes and a parental bacterial protein that is naturally processed b

37 on with an S aureus strain concordant with a parental baseline strain.

38 Offspring-induced parental behavior-related neuronal activation was found

39 hat parent-offspring conflict and associated parental benefits explain variation in fledging age amon

40 ight in children is strongly associated with parental body mass index (BMI) and overweight.

41 hysical presence of a co-parenting spouse on parental brain responses remains largely unknown.

42 Compared to parental bulk FG cells, PAWI-2 showed greater potency to

43 rmore, segregation analysis of F2 progeny of parental C57Bl/6N and Balb/C mice revealed that polymorp

44 ggs after male removal and further increased parental care after male and female removal.

45 portant role on the emergence of coordinated parental care and that considering environmental variabl

46 Here we show that the extent of parental care can determine whether siblings evolve to c

47 dy identified a number of nuclei involved in parental care in birds and suggests similar regulatory m

48 g, especially in animals that do not exhibit parental care such as reptiles.

49 ic adaptive contexts such as mate selection, parental care, coalition signaling, and group cohesion.

50 gdom, particularly in species with prolonged parental care, e.g., [8, 9].

51 ce-like preference evolved in the context of parental care, solitary species should not exhibit it.

52 ornamentation typically occurs in taxa with parental care, suggesting that selection arising from so

53 ecies of tortoises, solitary animals with no parental care.

54 rying beetles under two different regimes of parental care: Some populations were allowed to supply p

55 lication," a cell division that remodels the parental cell into two daughter cells.

56 on that circulating tumor cells resemble the parental cell line, but not lung-metastatic cells, sugge

57 odified cell lines compared to the Scrambled parental cell line.

58 s increased the binding to 53% +/- 3% of the parental cell line.

59 in all four MDR cell lines compared with the parental cell lines.

60 ion of the initial cell is determined in the parental cell, before the transition division.

61 internalized through integrins expressed in parental cells, in a tissue specific manner, as a key st

62 SR1 mutant cells were injected along with WT parental cells, tumor growth was enhanced with mutant ce

63 lls showed stronger E2F2 expression than the parental cells, while E2F2 inhibition sensitized the res

64 xel, and its downregulation desensitized the parental cells.

65 erexpression conferred resistance to MEKi in parental cells.

66 1 KO T cell lines, respectively, compared to parental cells.

67 SM-164-resistant BC cell growth, similar to parental cells.

68 -related transcription factors compared with parental cells.

69 This study indicates that parental characteristics, such as age, educational attai

70 that ornamented plumage is favored by strong parental choice for chicks with more extreme ornamentati

71 ism further emphasizes the important role of parental chromatin in development and could provide the

72 Meiotic pairing between parental chromosomes (homologs) is required for formatio

73 ocal exchange of genetic information between parental chromosomes and is essential for fertility.

74 The parental chromosomes come in contact through one of the

75 ajority of known epigenetic marks present in parental chromosomes during primordial germ cell develop

76 The exchange of genetic information between parental chromosomes in meiosis is an integral process f

77 e subtle morphological differences among the parental, circulating tumor cells, and lung metastatic c

78 ntative viruses of all three genotypes and a parental clade 2.3.2.1a strain (H5N1-R0) infected and re

79 gainst cancer cells and that activity of the parental clone, or functional avidity of selected gamma9

80 8% of the haploids in hybrids maintain their parental compartment status at B6/Cast divergent compart

81 found that, like GDNF, signaling through the parental compound Q121 is GFRa1-dependent.

82 h often display a higher toxicity than their parental compounds.

83 Parental concerns and lack of referrals are major identi

84 hange, the weight of evidence indicates that parental conditioning over generations is not a panacea

85 For many species, there were no benefits of parental conditioning.

86 Parental conflict may therefore be an important evolutio

87 in M. decorus, conform to the predictions of parental conflict: first, reciprocal F1s exhibit size di

88 self-fertilization may influence the rate of parental-conflict-driven evolution.

89 They had parental consanguinity and similarly affected, deceased

90 Parental consanguinity was noted in 11 children (31.4%).

91 gies to expand adolescent inclusion: waiving parental consent requirements, allowing adolescents to i

92 utions exhibiting higher expression than its parental construct (by a factor of 10) as well as the ab

93 SAMP and (parental control) AKR mice were assessed for baseline ga

94 parents; parental separation; bullying; and parental criminal conviction, with data collected on mul

95 ts, and interfering with the transmission of parental cues to offspring.

96 of hypoxia in human cancers compared to the parental cytotoxic agent and the vehicle groups.

97 pression or if the adoptive home experienced parental death or divorce during childhood/adolescence.

98 , and this effect is likely mediated both by parental depression and the continuity or disruption of

99 e broken/lost spectacles, forgetfulness, and parental disapproval.

100 t and resilience, female sex, and absence of parental divorce.

101 n forked DNA at 3.9 angstrom, revealing that parental DNA enters the ZF sub-ring and strand separatio

102 results complete the DNA path from entry of parental DNA into CMG to exit of daughter DNA from PCNA.

103 During replication, hemi-methylation on parental DNA strands guides symmetric CG methylation on

104 s (28%), reduction in open defecation (13%), parental education (10%), maternal nutrition (5%), econo

105 , economic improvement (19.5%), increases in parental education (14.9%), and better piped water acces

106 ed change in HAZ, with key factors including parental education (24.7%), maternal nutrition (19.3%),

107 , length of follow-up (mean, 4.3 years), and parental education (mean, 14.3 years).

108 red environmental variation of height in low parental education families.

109 Parental education mostly showed a positive association

110 Increased parental education was also a strong predictor of improv

111 ation on height at ages 1 to 69 years and on parental education were pooled allowing the analyses at

112 sts that the SES inequalities, in particular parental education, are related to global aspects of cor

113 with persistent differences across levels of parental education, household income, and household food

114 maternal and newborn health care, increased parental education, migration to urban areas, and reduce

115 height did not show a consistent relation to parental education.

116 , we evaluate the potential for sex-specific parental effects in a freshwater population of three-spi

117 Intergenerational plasticity or parental effects-when parental environments alter the ph

118 associated with suicidal ideation, and that parental emotional support may be protective; (c) Adhere

119 rational plasticity or parental effects-when parental environments alter the phenotype of future gene

120 nisms cope with environmental stressors when parental environments are highly predictive of offspring

121 s (loading), in part shaped by the inherited parental epigenome.

122 gene expression profiles were influenced by parental experience.

123 the nematode Caenorhabditis elegans and that parental exposure of animals to P. vranovensis promotes

124 Parental exposure to pathogens can prime offspring immun

125 dity involves transmission of the effects of parental exposure to the offspring through epigenetic ch

126 exposure with differential effects based on parental exposure-related factors.

127 Of 2288 children with parental face-to-face interviews and/or skin prick testi

128 ns and their associations with childhood and parental factors.

129 assess their associations with childhood and parental factors.

130 ses and controls, the two other studies used parental family history of Alzheimer's disease to define

131 Compared to parental FCF, these analogs are more effective in decrea

132 adaptively and cause hybrids to fall between parental fitness peaks, with potential consequences for

133 Compared to the parental FL3#2 strain, the DH6 strain shows stronger fem

134 ediates antitumor efficacy comparable to the parental FOLR1-TCB whereas a noncleavable control Prot-F

135 OLR1 expression is prevented compared to the parental FOLR1-TCB.

136 al trends and for psychiatric history in the parental generation did not alter the results.

137 onse and avoided H/L ratio alteration in the parental generation exposed to high environmental temper

138 y repressed by supplying tetracycline to the parental generation.

139 ASD was ascertained in both the child and parental generations.

140 Here we map genomic interactions for each parental genome (including the X chromosome), using an o

141 After fertilization, parental genomes are enclosed in two separate pronuclei.

142 isms, when the two pronuclei first meet, the parental genomes are separated by four pronuclear membra

143 na disassembly and subsequent merging of the parental genomes into a single nucleus after mitosis.

144 synchronized reorganization program in both parental genomes.

145 lterations are being examined in relation to parental gonadal dose, reconstructed using questionnaire

146 ncies, but the potential impact of assessing parental gonadal mosaicism has not been considered.

147 We identified tetrads and reconstructed parental haplotypes, which revealed the inbred ancestry

148 e oncogene arising in parallel from distinct parental haplotypes.

149 consensus sequences that lack information on parental haplotypes.

150 I.4 HuNoV in STAT1-knockout HIEs compared to parental HIEs.

151 Individuals with parental history of atopic disease had increased odds of

152 Parental history of atopic disease is a well-established

153 We sought to determine the association of parental history of atopic disease with AD in offspring.

154 t differ between subjects with and without a parental history of dementia, but were significantly cor

155 yopia with age, sex, grade level, ethnicity, parental history of myopia and severity.

156 After adjusting for PRSs, parental history still strongly predicted progression to

157 however, the effects are small compared with parental history, particularly for bipolar disorder.

158 s (DEGs) were identified in association with parental Holocaust exposure (FDR-adjusted p < 0.05); mos

159 some of these genes mediating the effects of parental Holocaust exposure on C-reactive protein.

160 Moreover, the DEGs associated with parental Holocaust exposure were enriched for glucocorti

161 and immune-related genes in association with parental Holocaust exposure with differential effects ba

162 ed memory B cells than those inoculated with parental immunogens.

163 brids were inferred in silico based on their parental inbred lines using single nucleotide polymorphi

164 al for a more comprehensive understanding of parental influences on child development.

165 n of pregnancy, the most specialized form of parental investment among vertebrates, is the rejection

166 indicative of an adaptive seasonal shift in parental investment in response to a deteriorating offsp

167 Using parental investment theory, we derived several predictio

168 otypes differed from 2n = 28 chromosomes for parental Ixodes spp. ticks, and both increase and decrea

169 ng morphological resemblance with one of its parentals (K. daigremontiana).

170 ha/170 mRNA and protein levels compared with parental K562 cells.

171 ants are 6, 10, and 14 mo of age can enhance parental language input and whether this, in turn, chang

172 Parental language input is one of the best predictors of

173 ng a role for the chick ornamentation in the parental life-history strategy, perhaps as a reliable si

174 Parental lineages and genomic data both revealed demogra

175 xation rates and photosynthetic induction in parental lines of a soybean nested association mapping (

176 show a significant difference between M4 and parental lines.

177 levels compared to the binding levels of the parental m1 protein.

178 In comparison to the parental m1 VacA protein, a chimeric protein (designated

179 n chalk was validated using a segregating bi-parental mapping population.

180 ol achievement and resilience, and an intact parental marriage can substantially buffer these adverse

181 genotypes from this study can be targeted as parental materials to improve existing common bean germp

182 nvasive, and adhesive in vitro compared with parental MCF7 cells, and this phenotype was mediated by

183 gs, liver, and bone marrow, all derived from parental MDA-MB-231 triple-negative breast cancer cells.

184 monomineralic anorthosites appear to require parental melts saturated in plagioclase only but where a

185 emotional neglect; parental substance abuse; parental mental illness or suicide attempt; violence bet

186 ed by offspring sex and presence of reported parental mental illness, with adjustment for covariates.

187 We report that parental metabolic syndrome epigenetically reprograms me

188 ndividual mediators of this association were parental monitoring and involvement (indirect effect = 1

189 Positive parenting, parental monitoring and supervision, and food security a

190 gned protective factors (positive parenting, parental monitoring and supervision, food security at ho

191 representing the pairwise combination of 11 parental monoclonal antibodies against CD73 was generate

192 Experimental down-regulation of Bsnd in the parental mouse strain phenocopied the severe cystic kidn

193 e first time, we show that CIMVs-MSCs retain parental MSCs phenotype (Sca-1(+), CD49e(+), CD44(+), CD

194 economic background, usage of eyeglasses and parental myopia was assessed by a questionnaire before v

195 Considering environmentally-induced parental or developmental legacies in ecological and evo

196 divergent stress-induced mortality based on parental origin in mice with equivalent dystrophin expre

197 We were able to identify the parental origin of each copy of chromosome 10 in the mat

198 ant to embryonic reprogramming, resulting in parental origin-specific monoallelic gene expression.

199 Associations of parental overweight status at age 8 years, puberty, and

200 persistence of POE varies between different parental pairs, perduring for at least 10 generations in

201 inantly cis controlled and largely reflected parental patterns, providing a genetic basis for inherit

202 mprove the anti-inflammatory activity of the parental peptides.

203 s the quality of life (QOL) of children from parental perspective but little is known about the child

204 ing communities that faithfully re-establish parental phenotype.

205 However, both the parental phenotypic and the GRS associations may depend

206 ' incorporation did not adversely impact the parental polymer.

207 h after further mapping and validation in bi-parental populations will be useful for development of s

208 pression data and were validated in three bi-parental populations.

209 variables (i.e., sex of the exposed parent, parental posttraumatic stress disorder, age at Holocaust

210 tween families, to understand the context of parental preference and to determine whose fitness inter

211 vely easily via the inheritance of alternate parental premating isolating genes and barriers.

212 of alternate alleles at genes that determine parental premating isolation.

213 The mechanisms that control how the two parental pronuclei fuse in the first mitosis of the embr

214 In addition, by inheriting parental properties, hybrid tumours were found to mimic

215 We measured parental provisioning rates and estimated the amount of

216 Parental psychiatric disorders accounted for 40% of the

217 Parental psychiatric illness explains almost half of the

218 the 5A2 interval 10 Mbp shorter than the bi-parental QTL mapping interval.

219 cohort based was undertaken using an online parental questionnaire, clinical visits including struct

220 Co-crystallization of the parental rabbit mAb in complex with the human ROR2 kring

221 hods: The rituximab-resistant Raji2R and the parental Raji cell lines were used.

222 Although bi-parental rearing is a common occurrence in humans, the i

223 lates with activity similar to that of their parental recombinant mAbs.

224 ight eye was seen for a second opinion after parental refusal of enucleation.

225 induces cell death with faster kinetics than parental reoviruses.

226 2-month) visits were evaluated together with parental report of AD diagnosis by a health care provide

227 nea index and any aggregation parameter, but parental report of snoring was positively associated wit

228 Based on parental reports, 2,518 (25.9%) had been exposed to alco

229 ld employment configuration was derived from parental reports: both parents full-time, male-breadwinn

230 sex (typically males) commonly require more parental resources, these sex differences are not curren

231 nd III interferons in IPEC-DQ cells than the parental rPEDV.

232 posure in childhood/adolescence consisted of parental self-reports of smoking and participants' serum

233 r suicide attempt; violence between parents; parental separation; bullying; and parental criminal con

234 used Cre driver lines, in most cases with a parental sex bias related to Cre expression in sperm or

235 1.6-log higher setpoint viral loads than the parental SHIV-325c stock.

236 ibited a similar replicative capacity to the parental SHIV-AE16 stock.

237 1/- plants were gametophyte lethal, although parental single homozygous plants were viable.

238 ts, cotinine <1.0 ng/mL); and 3) nonhygienic parental smoking (1-2 smoking parents, cotinine >=1.0 ng

239 g parents, cotinine <1.0 ng/mL); 2) hygienic parental smoking (1-2 smoking parents, cotinine <1.0 ng/

240 e persistent negative influences of prenatal parental smoking and youth substance use as they are mod

241 We aimed to assess the associations of parental smoking during pregnancy, specifically of quitt

242 ons of this study include the self-report of parental smoking information and the possibility of resi

243 Population strategies should focus on parental smoking prevention before or at the start, rath

244 exposed, participants exposed to nonhygienic parental smoking were at higher risk of poor (lowest qua

245 re observed at both time points for prenatal parental smoking, life events, and negative affect and s

246 ors, such as early testosterone exposure and parental socialization, work together in the development

247 age at conception, maternal education level, parental socio-economic status, gestational age, breast-

248 hy participants matched for age, gender, and parental socio-economic status.

249 polygenic scores were inferior to those from parental socioeconomic factors.

250 RNA-Seq analyses were conducted on hexaploid parental species (S. alterniflora and S. maritima), thei

251 urally occurring hybrids as well as in their parental species and explore links between migratory tra

252 classical and molecular cytogenetics of both parental species and hybrids.

253 aches to analyze the differences between the parental species and the hybrids, and determined the ori

254 uch species hybridize, migratory traits from parental species can combine maladaptively and cause hyb

255 Hybrid isolates that differ from their parental species in infection-relevant traits have been

256 two distinct peaks that overlapped with the parental species' averages.

257 reduce genetic variation in daughter versus parental species, a common pattern is the recurrence of

258 lake and stream habitats as compared to both parental species.

259 These early parental-specific domains correlate with gene repression

260 We also find TADs that arise in a non-parental-specific manner during a second wave of genome

261 development (score on the Wolke scale), and parental stimulation (Home Observation for Measurement o

262 protected when challenged with the virulent parental strain ASFV-G.

263 aureus strain that was the same strain as a parental strain at time of screening.

264 gher levels of asp23/SigB when compared with parental strain HU-14.

265 eric proteins in which VacA m1 segments of a parental strain were replaced by corresponding m2 sequen

266 ivotal to assess the fitness consequences of parental strategies.

267 The questions of whether parental structures can be inherited in the newly formed

268 ical, or emotional abuse; emotional neglect; parental substance abuse; parental mental illness or sui

269 , including ACEs, socioeconomic deprivation, parental substance use, and mental health.

270 activation of EMT-related gene networks than parental Suit2 cells, and forced overexpression of ST6Ga

271 Herein we report results of parental surveys of these domains from the second Newbor

272 In comparison to the parental T3D strain, we found that this mismatched virus

273 exual RNA replication mechanisms involve one parental template, whereas sexual RNA replication mechan

274 A replication mechanisms involve two or more parental templates.

275 We assessed parental transmitted and non-transmitted genetic contrib

276 In conclusion, parental transmitted GRSs, based on adult BMI, contribut

277 udied participants, examined associations of parental trauma-related variables (i.e., sex of the expo

278 ell lines was concordant with the respective parental tumor and characteristic for the respective tum

279 cancer cell able to propagate/phenocopy the parental tumor and recapitulate tumor heterogeneity.

280 pe and genotype closely recapitulating their parental tumor.

281 and genomic profiles of their corresponding parental tumors is crucial when analyzing their biologic

282 The chromosomal aberration patterns of the parental tumors were largely maintained in the cell line

283 These cross react against parental, unmodified tumors and lead to a high rate of c

284 hat replicates with faster kinetics than the parental virus and forms larger plaques.

285 ng a steeper transcription gradient than the parental virus and generation of defective interfering R

286 timized, SHIV-AE16W proved comparable to the parental virus, and SHIV-325cH demonstrated markedly enh

287 increased avidity for JAM-A relative to the parental virus, mimicking properties of ISVPs.

288 imilar in corneas from HSV-CD80-infected and parental virus-infected mice.

289 reduced replicative fitness compared to the parental virus.

290 anced replicative capacity compared with the parental virus.

291 loping ASF after challenge with the virulent parental virus.

292 ity, cell tropism, and neuropathology of the parental virus.

293 efects in growth and in competition with the parental virus.

294 eased inhibitory activity over that of their parental viruses.

295 ges of L420A, G64(Fix) L420A, and G64S L420A parental viruses.

296 During development, the amount of parental vocal feedback experienced influences the rate

297 Ps, genes, and pathways that interacted with parental warmth (PW) on EF.

298 ergo successful sexual reproduction with the parental wild-type strain.

299 f SHM that was reduced by half compared with parental WT Ramos B cells, demonstrating that the CTNNBL

300 fferences in gene expression relative to the parental (WT) line.