ライフサイエンスコーパス: partial hepatectomy

1 ed at different time points until 72 h after partial hepatectomy.

2 liver regeneration when applied 2 h prior to partial hepatectomy.

3 inistration of SB-258719 sixteen hours after partial hepatectomy.

4 nd 40 h (mitotic index in HE sections) after partial hepatectomy.

5 Male Wistar rats were subjected to 60-70% partial hepatectomy.

6 (Ad/BLOCK-iT/Nor-1(small hairpin RNA)) after partial hepatectomy.

7 iferative phases of liver regeneration after partial hepatectomy.

8 sing Cd39 are preferentially mobilized after partial hepatectomy.

9 support the selection of patients undergoing partial hepatectomy.

10 storation of liver volume and function after partial hepatectomy.

11 a, and its activation at 3 to 24 hours after partial hepatectomy.

12 in rat but not in regenerating livers after partial hepatectomy.

13 required for hepatocyte proliferation after partial hepatectomy.

14 at had undergone retrorsine pretreatment and partial hepatectomy.

15 erative than resident LSEC progenitors after partial hepatectomy.

16 a predictor of NAFLD and survival following partial hepatectomy.

17 ative chemotherapy treatments, and extent of partial hepatectomy.

18 ation, and increased the survival rate after partial hepatectomy.

19 d metabolism during liver regeneration after partial hepatectomy.

20 iated with decreased rates of survival after partial hepatectomy.

21 liver regeneration and mouse survival after partial hepatectomy.

22 e human blood clotting factor VIII, or after partial hepatectomy.

23 tic MMP-9 proteolytically cleaved VEGF after partial hepatectomy.

24 GPC3 TG mice during liver regeneration after partial hepatectomy.

25 tiation of liver regeneration in response to partial hepatectomy.

26 and had accelerated liver regeneration after partial hepatectomy.

27 hepatocytes in response to toxic injury and partial hepatectomy.

28 e progenitor cell niche following two-thirds partial hepatectomy.

29 nd sustain liver regeneration induced by 70% partial hepatectomy.

30 e liver after transplantation and two-thirds partial hepatectomy.

31 e proliferation and liver regeneration after partial hepatectomy.

32 ly inhibit liver proliferation in vivo after partial hepatectomy.

33 nderwent sham-operation or approximately 90% partial hepatectomy.

34 hour delay in hepatocyte proliferation after partial hepatectomy.

35 ssive accumulation of liver weight following partial hepatectomy.

36 atocyte fate during liver regeneration after partial hepatectomy.

37 ed capacity for liver regeneration following partial hepatectomy.

38 icantly accelerated liver regeneration after partial hepatectomy.

39 and endothelial cell proliferation following partial hepatectomy.

40 ced capacity to initiate DNA synthesis after partial hepatectomy.

41 /-) mice compared with control animals after partial hepatectomy.

42 generation following N-2-acetylaminofluorene/partial hepatectomy.

43 latory network driving the early response to partial hepatectomy.

44 injury with carbon tetrachloride exposure or partial hepatectomy.

45 osely followed liver function recovery after partial hepatectomy.

46 val of lymphocyte-deficient (Rag) mice after partial hepatectomy.

47 chronic hepatitis animal model and following partial hepatectomy.

48 )/M phase in Pbp(DeltaLiv) hepatocytes after partial hepatectomy.

49 s liver regeneration with low survival after partial hepatectomy.

50 iciency accelerates liver regeneration after partial hepatectomy.

51 tly impaired regeneration of the liver after partial hepatectomy.

52 did not compromise liver regeneration after partial hepatectomy.

53 d to 4-fold above baseline by 24 hours after partial hepatectomy.

54 id regeneration process following two-thirds partial hepatectomy.

55 he role of MMP-9 in liver regeneration after partial hepatectomy.

56 ase A (MMP-2) and gelatinase B (MMP-9) after partial hepatectomy.

57 row transplantation, ulcerative colitis, and partial hepatectomy.

58 regeneration and reduced steatosis following partial hepatectomy.

59 d in mice injected with Concanvalin A before partial hepatectomy.

60 , in the drinking water of mice subjected to partial hepatectomy.

61 iver regeneration in 157 patients undergoing partial hepatectomy.

62 tivation model of 2-acetylaminofluorene with partial hepatectomy.

63 MSCs supported survival after partial hepatectomy.

64 e (GH) signaling, was strongly induced after partial hepatectomy.

65 ver regeneration and clinical outcomes after partial hepatectomy.

66 rbol esters and the in vivo activation after partial hepatectomy.

67 difference to the 10-fold volume removal of partial hepatectomy.

68 difference to the 10-fold volume removal of partial hepatectomy.

69 nd a much higher rate of proliferation after partial hepatectomy.

70 fects the recovery of the living donor after partial hepatectomy.

71 eceptor blockade on liver regeneration after partial hepatectomy.

72 2-acetylaminofluorene treatment followed by partial hepatectomy (2-AAF/PH) by using rat genome 230 2

73 We addressed this question by performing 2/3 partial hepatectomy (2/3 PH) on mice with hepatocyte-spe

74 Liver regeneration after two-thirds partial hepatectomy (2/3 PH) results in synchronized pro

75 s during liver regeneration after two-thirds partial hepatectomy (2/3 PH).

76 ) cells that give rise to regeneration after partial hepatectomy, (3) cells responsible for progenito

77 Wild-type and Zip14(-/-) mice that underwent partial hepatectomy (70% of liver removed) were used as

78 ng regeneration was compared with that after partial hepatectomy (70%).

79 After 70% partial hepatectomy, albNS(cko) livers show increased DN

80 Moreover, liver regeneration after partial hepatectomy also depended upon the formation of

81 ) mice had impaired liver regeneration after partial hepatectomy and 50% mortality, indicating that N

82 -Fc (fragment, crystallizable) to mice after partial hepatectomy and acetaminophen intoxication, and

83 liver regeneration, which is required after partial hepatectomy and acute or chronic liver injury.

84 e proliferation and liver regeneration after partial hepatectomy and alters gene expression profiles

85 e two hours prior to and sixteen hours after partial hepatectomy and by intraperitoneal administratio

86 d experimental models of liver regeneration (partial hepatectomy and carbon tetrachloride treatment),

87 ranscriptional programs of adult liver after partial hepatectomy and contrasted these with developing

88 acid synthesis is reduced immediately after partial hepatectomy and during the early stage of liver

89 Regenerative growth was induced by partial hepatectomy and exposure to carbon tetrachloride

90 ety of hepatotrophic growth signals, such as partial hepatectomy and hepatocyte growth factor, can be

91 l liver regeneration can be induced upon 70% partial hepatectomy and is accompanied by an increase in

92 n vivo during mouse liver regeneration after partial hepatectomy and is strongly overexpressed in pre

93 signal, is activated in myeloid cells after partial hepatectomy and its conditional deletion results

94 We then performed a 70% partial hepatectomy and monitored postoperative survival

95 d (by SB-258719 and SB-269970) at 16 h after partial hepatectomy and peaked at 32 h ([(3)H]-thymidine

96 tomy (incidental tumors, 2 stage), including partial hepatectomy and portal LN dissection, with or wi

97 models of liver regeneration after extended partial hepatectomy and portal vein ligation for multipl

98 lectively augmented liver regeneration after partial hepatectomy and portal vein ligation, and increa

99 and/or Epac2 are deleted, were subjected to partial hepatectomy and the regenerating liver was analy

100 usoidal endothelial cell responses following partial hepatectomy and to dissect purinergic and growth

101 that CD81 levels also increased 2 days after partial hepatectomy and toward the end of regeneration.

102 sinophils stimulate liver regeneration after partial hepatectomy and toxin-mediated injury.

103 of hepatocyte proliferation (days 1-3 after partial hepatectomy) and subsequent reconstitution of th

104 s during mouse liver regeneration induced by partial hepatectomy, and DNA replication was determined

105 n the initiation of liver regeneration after partial hepatectomy, and new cytokines and receptors tha

106 hat follows CCl(4)-induced liver injury, 70% partial hepatectomy, and postnatal liver development wer

107 on, progression-free survival, conversion to partial hepatectomy, and viable HCC within the tumor spe

108 We used liver regeneration after partial hepatectomy as a physiological stress response m

109 Furthermore, applying two-thirds partial hepatectomy as a surgically induced liver regene

110 ed glycogen, and proliferated in response to partial hepatectomy, as neighboring native hepatocytes.

111 les collected from 55 patients who underwent partial hepatectomy at the Royal Infirmary Edinburgh bet

112 cy underwent retrorsine treatment and either partial hepatectomy before transplantation or carbon tet

113 However, after partial hepatectomy, BM LSEC progenitor proliferation an

114 After partial hepatectomy, BM SPCs provide hepatocyte growth f

115 nic mice accelerate liver regeneration after partial hepatectomy but are not protected from hepatocyt

116 ice exhibited accelerated regeneration after partial hepatectomy but no signs of neoplastic or preneo

117 atocyte proliferation and survival following partial hepatectomy, but also acts in concert with other

118 for an efficient early cytokine response to partial hepatectomy, but is inhibitory to later growth f

119 a critical role in liver regeneration after partial hepatectomy, but their role in TCPOBOP-induced d

120 ibition accelerated liver regeneration after partial hepatectomy by 40%, whereas systemic MMP inhibit

121 n important role in liver regeneration after partial hepatectomy by affecting matrix remodeling, as w

122 irst round of hepatocyte proliferation after partial hepatectomy by preventing increases in growth ho

123 ocytes, p38gamma induces proliferation after partial hepatectomy by promoting the phosphorylation of

124 n of the hepatovascular mass (days 4-8 after partial hepatectomy) by inhibiting upregulation of the e

125 Despite improvements, major partial hepatectomy can be associated with considerable

126 Partial hepatectomy causes a transient increase in p21 i

127 n animals preconditioned with retrorsine and partial hepatectomy, cell transplantation after ETN pret

128 dly inhibited hepatocyte proliferation after partial hepatectomy, confirming its pivotal role in cell

129 that accumulate in regenerating livers after partial hepatectomy, contributes to this process by regu

130 In rats, after 70% partial hepatectomy, daily administration of 1K1 for 5 d

131 In response to partial hepatectomy, deletion of Epac1 and/or Epac2 led

132 Thus, after two-thirds partial hepatectomy, DeltaEGFR livers displayed lower an

133 proliferation in p21 null mice subjected to partial hepatectomy, establishing the functional signifi

134 e previously reported that mice subjected to partial hepatectomy exhibit rapid development of hypogly

135 at liver by applying the 2-acetaminofluorene/partial hepatectomy experimental model.

136 After partial hepatectomy, expression of the vascular ectonucl

137 F15/19 levels improve survival of mice after partial hepatectomy, FGF19 mitogenic activity is associa

138 , respectively; whereas liver radiation plus partial hepatectomy followed by cell transplantation pro

139 ced in response to loss of liver mass due to partial hepatectomy followed by regeneration.

140 rategy to stimulate liver regeneration after partial hepatectomy for colorectal liver metastases (CRL

141 tabase, we identified 192 patients who had a partial hepatectomy for HCC from 1985 to 2002.

142 encouraging results have been reported with partial hepatectomy for solitary metastases, with percut

143 n the liver of wild type mice in response to partial hepatectomy, further supporting a role for these

144 ice to deplete hepatocyte alphavbeta8, after partial hepatectomy, hepatocyte proliferation and liver-

145 rmous regenerative capacity such that, after partial hepatectomy, hepatocytes rapidly replicate to re

146 omic analysis of seven time points following partial hepatectomy identified the epigenetic regulator

147 d HCC model) that underwent RF ablation, 35% partial hepatectomy (ie, left lobectomy), or a sham oper

148 We performed partial hepatectomies in mice with hepatocyte-specific d

149 eration in normal and steatotic livers after partial hepatectomy in a rodent model.

150 and 8.6-fold during liver regeneration after partial hepatectomy in adults.

151 calcineurin, were also accelerated following partial hepatectomy in BI-1-deficient hepatocytes.

152 exposure on liver regeneration following 70% partial hepatectomy in mice lacking the Cip/Kip inhibito

153 cell proliferation, were assessed following partial hepatectomy in mice that do not express CD39, th

154 ion and accelerated liver regeneration after partial hepatectomy in mice.

155 ed H4) at the Foxo3 p53RE was detected after partial hepatectomy in mice.

156 et internalization also occurred following a partial hepatectomy in mice.

157 We have shown that partial hepatectomy in multidrug resistance 2 knockout (

158 e implantation of 2-acetylaminofluorene with partial hepatectomy in rats or on feeding a 3,5-diethoxy

159 ivation models of 2-acetylaminofluorene with partial hepatectomy in rats, and 3,5-diethoxycarbonyl-1,

160 ive proliferation that can be observed after partial hepatectomy in rats.

161 role in stimulating liver regeneration after partial hepatectomy in rodents and humans.

162 into wild-type (WT) rats that had undergone partial hepatectomy in the presence of 2-acetylaminofluo

163 nd liver regeneration was impaired following partial hepatectomy in these animals.

164 ming factors are also up-regulated after 70% partial hepatectomy in vivo.

165 We performed partial hepatectomy in WT and liver-specific Sirt1-defic

166 compare liver regeneration upon partial hepatectomy in young and adult mice.

167 is study utilizing surgical liver resection (partial hepatectomy) in various complement-deficient mic

168 st that the hypoglycemia that develops after partial hepatectomy induces systemic lipolysis followed

169 Liver regeneration triggered by two-thirds partial hepatectomy is accompanied by elevated hepatic l

170 so suggests that AhR functionality following partial hepatectomy is dependent on a p21(Cip1)-regulate

171 Liver regeneration in response to partial hepatectomy is dependent on the efficiency of gr

172 Liver regrowth following partial hepatectomy is enabled by proliferation of hepat

173 well tolerated, and liver regeneration after partial hepatectomy is not impaired, indicating that reg

174 Liver regeneration after partial hepatectomy is one of the most studied models of

175 s no obvious consequences for normal livers, partial hepatectomy leads to severe liver necrosis and r

176 Following liver regeneration after partial hepatectomy, liver grows back precisely to its o

177 When irradiated rats underwent partial hepatectomy, liver regeneration was compromised,

178 We investigated these mechanisms using the partial hepatectomy model in mice given standard or 10%

179 were subjected to the 2-acetylaminofluorene/partial hepatectomy model of oval cell-mediated liver re

180 The retrorsine-partial hepatectomy model was used for liver repopulatio

181 atocyte RXRalpha in liver regeneration using partial hepatectomy model.

182 y increased liver repopulation in retrorsine/partial hepatectomy model.

183 After two-thirds partial hepatectomy, mutant mice (n = 5) displayed incre

184 Partial hepatectomy of the adult mammalian liver activat

185 Partial hepatectomy of Uhrf1(HepKO) livers resulted in e

186 We performed partial hepatectomy of wild-type mouse liver and induced

187 We performed partial hepatectomies on wild-type C57BL/6, CD45.1, Tcrd

188 More specifically, we have performed partial hepatectomy on mice with genetic deficiency in C

189 1-Fc increased innate immunity in mice after partial hepatectomy or acetaminophen-induced injury, wit

190 e injury, such as rodent LR after two-thirds partial hepatectomy or administration of damaging chemic

191 e liver regeneration/repair after either 70% partial hepatectomy or carbon tetrachloride-induced live

192 n exceptional replicative capacity following partial hepatectomy or chemical injuries.

193 ant hepatocyte proliferation following liver partial hepatectomy or damage resulting from carbon tetr

194 cetylaminofluorene-treated rats subjected to partial hepatectomy or in D-galactosamine-treated rats.

195 Thirty-nine patients undergoing partial hepatectomy or liver transplantation for HCC wer

196 ing Med1 did not regenerate following either partial hepatectomy or treatment with certain nuclear re

197 Following partial hepatectomy, p53(-/-) hepatocytes exhibited earl

198 generated a TSP-1-deficient mouse model of a partial hepatectomy (PH) and explored TSP-1 induction, p

199 ncreased in young livers proliferating after partial hepatectomy (PH) and in human liver tumors.

200 Recent studies using partial hepatectomy (PH) and other experimental models o

201 during liver regeneration in rats after 70% partial hepatectomy (PH) at early and mid time points to

202 CcnE2, and Cdk2 for liver regeneration after partial hepatectomy (PH) by generating corresponding dou

203 Partial hepatectomy (PH) consistently results in an earl

204 Mice subjected to partial hepatectomy (PH) develop hypoglycemia, followed

205 the wave of cell proliferation that follows partial hepatectomy (PH) identified approximately 1,400

206 rowth during embryonic development and after partial hepatectomy (PH) in adults is characterized by t

207 nor (30%), standard (60%), or extended (80%) partial hepatectomy (PH) in mice with and without liver

208 Liver regeneration is impaired following partial hepatectomy (PH) in mice with genetic obesity an

209 expression is induced 40-fold at 24 h after partial hepatectomy (PH) in mice.

210 herapy would impair liver regeneration after partial hepatectomy (PH) in mice.

211 Extended partial hepatectomy (PH) in patients is leading to porta

212 ined the intrinsic hepatic innervation after partial hepatectomy (PH) in rats and the presence and pa

213 Liver regeneration after surgical partial hepatectomy (PH) in retrorsine-exposed rats is a

214 ver NK cells undergo phenotypic changes post-partial hepatectomy (PH) in vivo, including increased cy

215 BACKGROUND & AIMS: Liver regeneration after partial hepatectomy (PH) increases the protein folding b

216 gnaling during liver regeneration (LR) after partial hepatectomy (PH) is observed in several species.

217 wild-type (WT) littermates were used in the partial hepatectomy (PH) model for compensatory regenera

218 ty during liver regeneration using the mouse partial hepatectomy (PH) model.

219 We developed a partial hepatectomy (PH) protocol in zebrafish and inves

220 Partial hepatectomy (PH) rapidly and transiently induced

221 ays are involved in liver regeneration after partial hepatectomy (PH) to initiate growth, protect liv

222 We performed partial hepatectomy (PH) to transgenic mice that overexp

223 e the role of PXR in liver regeneration, 2/3 partial hepatectomy (PH) was performed on wild-type and

224 3 (HFD groups) weeks of treatment with G49, partial hepatectomy (PH) was performed, and all mice wer

225 atocyte DNA and prevents proliferation after partial hepatectomy (PH), allowing selective expansion o

226 lysis of murine liver regeneration after 70% partial hepatectomy (PH), an established model of adult

227 in initiating liver regeneration (LR) after partial hepatectomy (PH), by regulating expression of Cy

228 When subjected to partial hepatectomy (PH), dramatic increases in the numb

229 Different surgical procedures, including partial hepatectomy (PH), intraoperative portal vein lig

230 ays are involved in liver regeneration after partial hepatectomy (PH), to initiate growth, protect li

231 In conjunction with partial hepatectomy (PH), transplanted stem/progenitor c

232 2-KO mice display delayed regeneration after partial hepatectomy (PH).

233 l role early in liver regeneration following partial hepatectomy (PH).

234 ubjected to retrorsine treatment followed by partial hepatectomy (PH).

235 eling potentials of cholangiocytes after 70% partial hepatectomy (PH).

236 for hepatocyte proliferation in response to partial hepatectomy (PH).

237 per control of the regulation of SIRT1 after partial hepatectomy (PH).

238 nd impaired liver mass restitution following partial hepatectomy (PH).

239 small grafts and the remaining livers after partial hepatectomy (PH).

240 during liver regeneration after a two-thirds partial hepatectomy (PH).

241 chymal cells during liver regeneration after partial hepatectomy (PH).

242 appropriate regenerative response following partial hepatectomy (PHTx) compared to wildtype controls

243 t liver injury and regeneration induced by a partial hepatectomy (PHx) could have different effects o

244 on in the remnant liver of the rat after 70% partial hepatectomy (PHx) during the early phase respons

245 ogen) deposition was recently reported after partial hepatectomy (PHx) in mice, but the role of fibri

246 s were compared with those of standard (68%) partial hepatectomy (pHx) in mice.

247 Liver regeneration after a two-thirds partial hepatectomy (PHx) is a complex process requiring

248 Liver regeneration after partial hepatectomy (PHx) is orchestrated by multiple si

249 the rat 2-acetylaminofluorene (2AAF) and 2/3 partial hepatectomy (PHx) liver regeneration model.

250 L-2Rgamma(-/-) (NSG) mice that had undergone partial hepatectomy (PHx) represented the best combinati

251 ut (DeltaKlf6), cell proliferation following partial hepatectomy (PHx) was increased compared to cont

252 ver regeneration in rat following two-thirds partial hepatectomy (PHx) was investigated using RNA int

253 Seventy percent partial hepatectomy (PHx) was performed in C57Bl/6 mice

254 In the present study, partial hepatectomy (PHx) was used to study liver regene

255 hepatocytes in culture, rat liver following partial hepatectomy (PHx), and hepatoma cell lines.

256 6(-/-) ), we challenged liver function after partial hepatectomy (PHx), inducing acute proliferative

257 Following partial hepatectomy (PHx), mice with a liver-specific IL

258 Liver regeneration, following partial hepatectomy (PHx), occurs through precisely cont

259 y also impaired liver regeneration following partial hepatectomy (PHx), the effect of CR2-Crry in thi

260 esbsiella pneumoniae or Escherichia coli) or partial hepatectomy (PHx).

261 icant inhibition of liver regeneration after partial hepatectomy (PHX).

262 delayed proliferative response to two-thirds partial hepatectomy (PHX).

263 tically involved in liver regeneration after partial hepatectomy (PHX).

264 ats with 2-acetylaminofluorine and two-third partial hepatectomy (PHX).

265 ced by 2-acetylaminofluorene (2-AAF) and 70% partial hepatectomy (PHx).

266 d impaired proliferation of hepatocytes upon partial hepatectomy (PHx).

267 d during liver regeneration after two-thirds partial hepatectomy (PHx).

268 Partial hepatectomy (PHx, 70% resection) was performed i

269 ds are currently used in preclinical models: partial hepatectomy, portal ligature or embolization, an

270 e expression, within 1 hour after two-thirds partial hepatectomy (post-PH) in C57BL/6J mice.

271 After partial hepatectomy, residual liver vasculature remains

272 Partial hepatectomy results in an increase in tumor grow

273 severely inhibited in DeltaEGFR livers after partial hepatectomy, revealing a new function for EGFR k

274 cle progression and liver regeneration after partial hepatectomy, suggesting that DBC1/DN-DBC1 transi

275 che may play a smaller role in recovery from partial hepatectomy than BM LSEC progenitors, but, when

276 When subjected to two-thirds partial hepatectomy, the Ctnnb1(loxp/loxp); Alb-Cre(+/-)

277 Following partial hepatectomy, the liver initiates a regenerative

278 Following partial hepatectomy, the liver initiates a regenerative

279 We performed partial hepatectomies to test liver regeneration and the

280 ithin a milieu of chronic inflammation links partial hepatectomy to accelerated hepatocarcinogenesis;

281 Concanvalin A was injected 4 days before partial hepatectomy to natural killer T cells- deficient

282 d in bile ducts and oval cells in retrorsine/partial hepatectomy-treated liver, and this correlated w

283 In mice, partial hepatectomy up-regulated expression of CCL20 and

284 We studied a murine model of partial hepatectomy using immunodeficient mice to determ

285 oung mice inhibits liver proliferation after partial hepatectomy via the cyclin D3-C/EBPalpha pathway

286 Most important, LR after partial hepatectomy was impaired in caNrf2-transgenic mi

287 Partial hepatectomy was performed in C57BL/6 wild-type,

288 ative capacity of Ercc1(-/Delta) liver after partial hepatectomy was significantly reduced.

289 A model of liver regeneration after 70% partial hepatectomy was used, followed by examination of

290 Using a model of liver regeneration after partial hepatectomy, we found that DN-DBC1 is down-regul

291 k2, cyclin A2/Cdk2, and cyclin B1/Cdk1 after partial hepatectomy were altered in regenerating RXRalph

292 adical pancreaticoduodenectomy, subtotal and partial hepatectomy were analyzed.

293 tocyte proliferation that occurred following partial hepatectomy were not observed in Zip14(-/-) mice

294 , and a dramatic reduction in survival after partial hepatectomy, whereas additional global deletion

295 ped hepatocellular carcinomas 6 months after partial hepatectomy, whereas Nemo(Deltahepa) mice fed th

296 n contrast to the regenerative process after partial hepatectomy, which is driven by the replication

297 ted kinases and AKT activation 3 hours after partial hepatectomy, which, however, is alleviated by te

298 A total of 124 patients underwent partial hepatectomy with cyst fenestration, 10 underwent

299 ed bi-1(+/+) and bi-1(-/-) mice subjected to partial hepatectomy with respect to the kinetics of live

300 dramatically impedes tumorigenesis following partial hepatectomy without compromising survival or liv