ライフサイエンスコーパス: paternal

1 e of the maternal haplotype, relative to the paternal.

2 such as low maternal (1.36 [1.28-1.46]) and paternal (1.38 [1.27-1.51]) education; and fetal growth

3 en telomere length, child gender, ethnicity, paternal age and deprivation.

4 re established associations between advanced paternal age and offspring risk for psychiatric and deve

5 In humans, the effect of paternal age at conception (PAC) on offspring leukocyte

6 Studies in humans have revealed that the paternal age at conception explains most of the variatio

7 xposure or associated with both maternal and paternal age at Holocaust exposure were in the same dire

8 tribution to autism risk, and correlate with paternal age at the time of conception.

9 ) in offspring is positively correlated with paternal age at the time of the offspring conception.

10 Here, we show that paternal age can affect offspring longevity as strongly

11 on in mutation rate: Each additional year of paternal age in humans leads to approximately 1.5 additi

12 We additionally investigated the role of paternal age on offspring sociability, a proxy for norma

13 Paternal age or body mass index (BMI) were not associate

14 mia and central nervous system tumors, older paternal age was not associated with risk of either type

15 Paternal age was not associated with TL in newborns.

16 (0.97, 0.98) per five years of maternal and paternal age, respectively).

17 ts (dnSNVs), that accumulate with increasing paternal age.

18 The paternal-age-at-conception (PAC) effect on TL is puzzlin

19 g data, we estimate the relationship between paternal-age-related dnSNVs and risk for five disorders:

20 We find that paternal-age-related dnSNVs confer a small amount of ris

21 dings suggest that variation in maternal and paternal ages at breeding could contribute substantially

22 We manipulated maternal and paternal ages at breeding over 2 generations in the neri

23 system-specific conditional deletion of the paternal allele (pat cKO) at the Cdkn1c locus resulted i

24 ain unrepaired, resulting in an undetectable paternal allele and, after mitosis, loss of one or both

25 ncoded by an imprinted gene Cdkn1c, with the paternal allele being silenced.

26 Mice with paternal allele deletion of Gnas (Gnas(+/p-)) have defec

27 maternal Igf2r allele expression exceeds the paternal allele due to imprinting (silencing).

28 f2r(I1565A/I1565A)) suggested that wild-type paternal allele expression attenuates the heterozygote p

29 Here we show that suppression of ALN paternal allele expression is imposed by non-canonical R

30 e cloning sequencing analysis shows that the paternal allele is hypermethylated while the maternal al

31 The c.913C>T variant on the paternal allele is predicted to result in a premature st

32 The possible expression and function of the paternal allele of Cdkn1c have remained little studied,

33 We now show that the paternal allele of the Cdkn1c gene is expressed at a low

34 Our results thus show that the paternal allele of the Cdkn1c locus plays a key role in

35 ernally inherited allele, which silences the paternal allele of UBE3A in cis However, the mechanism r

36 re expressed monoallelically from either the paternal allele or maternal allele as a result of epigen

37 pression on the maternal allele, but not the paternal allele, in the dorsomedial nucleus of the hypot

38 tarted expressing Plag1 ectopically from the paternal allele.

39 expression of maternal alleles and represses paternal alleles in response to excess paternal genomic

40 s, the level of expression from maternal and paternal alleles was not binary, instead supporting a di

41 nct epigenetic modifications on maternal and paternal alleles, correlating with parental-specific tra

42 l RNA-directed DNA methylation (RdDM) of the paternal ALN allele promoter.

43 The lack of a paternal ancestry effect suggests underlying mechanisms

44 from medical records including maternal and paternal ancestry, demographic factors, and reproductive

45 We aimed to assess the association between paternal and adolescent depressive symptoms in two large

46 Furthermore, few studies have investigated paternal and grandparental caffeine intake in relation t

47 No consistent associations were observed for paternal and grandparental caffeine intake.

48 in an offspring's genome increases with both paternal and maternal age.

49 ers of mutations per offspring increase with paternal and maternal age.

50 printing refers to the unequal expression of paternal and maternal alleles of a gene in sexually repr

51 methylation and H3K4me3 specifically marked paternal and maternal alleles, respectively.

52 Paternal and maternal epigenomes undergo marked changes

53 nt rhinitis was associated with male gender, paternal and maternal history of atopy, eczema, and hous

54 zygote transition in mice and is distinct in paternal and maternal nuclei within single-cell zygotes.

55 According to the results, paternal and maternal transmission of the mutant allele

56 rapidly with the spatial separation between paternal and maternal trees.

57 imating associations of transmitted maternal/paternal and non-transmitted maternal GRS with child ove

58 y underlines the importance of investigating paternal and secondhand smoking in addition to maternal

59 etiology of several disorders, the impact of paternal and/or maternal metabolic syndrome on the clini

60 ransplantation in that the fetus, possessing paternal antigens, is a semi-allogeneic graft that can s

61 se in DNA methylation on the X chromosome of paternal as compared to maternal origin.

62 Maternal and paternal ASD-PGSs were explored in relation to BAP trait

63 Maternal (but not paternal) ASD-PGSs were related to the pragmatic languag

64 38-1.49); there was a weaker association for paternal asthma (OR 1.17, 95% CI 1.11-1.23).

65 tigated the association between (a) maternal/paternal asthma and offspring ASD, and (b) prenatal expo

66 Among their maternal/paternal aunts and uncles, 1744 (0.24%) and 1374 (0.18%)

67 omic and circuit-level mechanisms underlying paternal behaviour and the ways in which the subcortical

68 The emergence of paternal behaviour in a male animal has been shown to be

69 We find a statistically significant paternal bias in Alu retrotransposition.

70 primarily arose de novo without maternal or paternal bias.

71 In contrast, paternal birth season predicted offspring HAZ at 24 mo (

72 In contrast, higher paternal BMI (P < 0.001), maternal prepregnancy BMI (P <

73 Maternal and paternal BMI (standard deviation (SD) units) had a stron

74 ions were present for maternal compared with paternal BMI across these associations; however, there w

75 was collected at 15 weeks of gestation, and paternal BMI was assessed when the child was 18 months o

76 rolling for gestational age and maternal and paternal BMIs.

77 progeny up to the F(4) generations and that paternal, but not maternal, exposure is most important f

78 tics, socioeconomic status, and maternal and paternal cardiovascular disease.

79 A low protein diet had minimal effects on paternal cardiovascular function or renin-angiotensin sy

80 Given the evolutionary importance of paternal care and heightened cooperation to human life h

81 Humans are rare among mammals in exhibiting paternal care and the capacity for broad hyper-cooperati

82 maternal behavior and also promoted unusual paternal care in rats, as measured by pup-retrieval test

83 date, and is linked to territorial defense, paternal care, and courtship.

84 iological mechanisms underlying maternal and paternal care, especially in rodents, and discuss the re

85 Some genes are unique to different stages of paternal care, some genes are shared across stages, and

86 derstanding of the neural basis of mammalian paternal care, the genomic and circuit-level mechanisms

87 understanding the mechanisms and effects of paternal care.

88 nse to a territorial challenge versus during paternal care.

89 ioural, neural and molecular consequences of paternal caregiving for offspring are becoming increasin

90 Across the animal kingdom, paternal caregiving has been found to be a highly mallea

91 PSR prevents the paternal chromatin from forming chromosomes during the f

92 In mammals, paternal chromatin is extensively reprogrammed through t

93 double-strand break (DSB) introduced on the paternal chromosome at the EYS locus, which carries a fr

94 De novo mutations arising on the paternal chromosome make the largest known contribution

95 ernal UPD14 or epimutations/deletions on the paternal chromosome, whereas KOS most frequently arises

96 Patient P7 carried the mutation in the paternal chromosome.

97 Reductional meiosis I, where maternal and paternal chromosomes (homologs) segregate, is followed b

98 which premature segregation of maternal and paternal chromosomes in the fertilized oocyte can produc

99 d whole-genome sequence analyses reveal that paternal cognition improvement is inherited by the offsp

100 as 1) a vector to carry any signal from the paternal compartment to the maternal reproductive tract

101 We also see paternal continuity through time, including the same Y-c

102 for all Malagasy individuals with a limited paternal contribution from Europe and the Middle East.

103 Italian Queen Breeders and Bee Producers the paternal contribution is mostly unknown.

104 l characteristics (e.g., fecundity), whereas paternal contribution is often considered limited to gen

105 , suggesting that MED30 is important for the paternal control of early embryo development.

106 Pathogenic variants in the paternal copy of MAGEL2 cause Schaaf-Yang syndrome (SHFY

107 WS) is caused by deficient expression of the paternal copy of several contiguous genes on chromosome

108 larval lipid consumption rates varied among paternal crosses, which is consistent with the presence

109 ted with increased rate of maternal, but not paternal, death before the age of 50 across all parent b

110 atient carrying a maternal duplication and a paternal deletion in the UBE2T loci displayed normal per

111 djustments, a 1 SD (three-point) increase in paternal depressive symptoms was associated with an incr

112 Finally, paternal diet modified the expression profiles of centra

113 s affected than individuals with uniparental paternal disomy (UPD); of those with UBE3A pathogenic va

114 s present in 6% of captured molecules of the paternal DNA sample, also indicating mosaicism.

115 Thus, paternal drug exposure induces a protective phenotype in

116 ded poverty (61%), maternal nutrition (14%), paternal education (6%), fertility (6%), maternal age (3

117 R, 3.1, P = .02; African American, P < .001; paternal education less than college (OR, 1.4, P = .05);

118 vels, including improvements in maternal and paternal education, household socioeconomic status, sani

119 gnificant effects on exposure estimates were paternal education, maternal race/ethnicity, and materna

120 very, Apgar score at 5 minutes, maternal and paternal educational levels, annual taxable household in

121 Here, we establish a paternal effect model based on nicotine exposure in mice

122 For each species, we observed a profound paternal effect of foliage supplements on fitness.

123 e Coccinellini, and that this was entirely a paternal effect.

124 Furthermore, maternal and paternal effects on offspring survival were non-additive

125 transmit information regarding stress in the paternal environment to sperm, potentially altering feta

126 Paternal environmental conditions can influence phenotyp

127 m roles in intergenerational transmission of paternal environmental experience.

128 Paternal environmental perturbations including exposure

129 d induce offspring phenotypes that relate to paternal environmental stressors.

130 However, the form in which paternal epigenetic information is transmitted to offspr

131 ogether, we uncover a conserved mechanism of paternal epigenetic information transmission to the embr

132 Paternal epigenetic inheritance is gaining attention for

133 Precisely how the paternal epigenome is reprogrammed in flowering plants h

134 differentiate male gametes and reprogram the paternal epigenome.

135 is sufficient to determine the viability of paternal excess Arabidopsis (Arabidopsis thaliana) seeds

136 and lethal (diploid x tetraploid) and viable paternal excess crosses (diploid x tetraploid nrpd1).

137 etraploid fathers represses seed abortion in paternal excess crosses.

138 Endosperms from both lethal and viable paternal excess seeds share widespread transcriptional a

139 recent studies focusing on the influence of paternal experience before conception have implicated ge

140 embryo; 2) a molecular signal, encoded by a paternal experience, to carry this memory and enact down

141 dently and jointly manipulating maternal and paternal experiences and separately evaluating their phe

142 The effect of paternal exposure during pregnancy and infancy on infect

143 cific responses to particular aspects of the paternal exposure history, or a generic response to pate

144 us chemicals on germline epigenetics and how paternal exposure may impact the health of future genera

145 In mice, paternal exposure to cigarette smoke condensate (CSC) ca

146 Paternal exposure to dLAN decreased splenic endocrine re

147 Paternal exposure to MPA did not increase the risk of ad

148 Here, using a mouse model of paternal exposure to traumatic stress, we identify circu

149 stral to extant octoploid strawberries and a paternal, extinct Fragaria iinumae-like diploid progenit

150 Finally, we explore the possibility that paternal extracellular vesicles could themselves serve a

151 e is the best-established way to reconstruct paternal family history in humans.

152 al family history of AD (UK Biobank), and 3) paternal family history of AD (UK Biobank).

153 BP [beta(GSMR) = -0.10, p = .05]) and to the paternal family history of AD UK Biobank dataset (SBP [b

154 ference in the likelihood of maternal versus paternal family history of epilepsy.

155 rnal dispensations before pregnancy and with paternal first-trimester dispensations were consistent w

156 ybp, suggests it to be one of the Ashkenazi paternal founders; to have expanded as part of the overa

157 terns, resulting from predominantly European paternal gene flow.

158 nicotine exposure induced depression in the paternal generation, but reduced depression and promoted

159 ritance of DNA methylation patterns from the paternal generation.

160 We find little evidence for a maternal (or paternal) genetic effect of birthweight associated varia

161 ide data set supports the concept of delayed paternal genome activation in plant embryos.

162 se findings strongly suggest that PSR causes paternal genome elimination by disrupting at least three

163 thesized to aid in the ordered exodus of the paternal genome following fertilization.

164 Overrepresentation of the paternal genome in sporadic hydatidiform moles (purely a

165 erm telomere length as a potential marker of paternal genome integrity and leukocyte telomere length

166 e postimplantation stage, methylation of the paternal genome is consistently lower than that of the m

167 ucture from a condensed maternal and a naive paternal genome to generate a totipotent embryo.

168 The paternal genome undergoes a massive exchange of histone

169 Transcription of the paternal genome was highly restricted but unexpectedly i

170 entical but chimerically shared 78% of their paternal genome, which makes them genetically in between

171 arental differentiation, we showed the known paternal-genome preference for placental contribution, r

172 to parental dosage, with excess maternal or paternal genomes creating reciprocal phenotypes.

173 esses paternal alleles in response to excess paternal genomic dosage.

174 Paternal genomic excess frequently results in extensive

175 ver, our analysis suggests that maternal and paternal genomic imprinting are equally rare events in A

176 th relevant data on maternal, offspring, and paternal genotype are required to obtain more precise (a

177 pective human cohorts to identify changes in paternal germ cell epigenetics in association with offsp

178 f the chromatin regulator Kdm6a (Utx) in the paternal germ line results in elevated tumor incidence i

179 Selective maternal or paternal germline recombination is showcased with sample

180 to F1 daughters to F2s), a predator-exposed paternal grandfather (i.e. predator-exposed F0 males to

181 When their paternal grandfather was exposed to predation risk, fema

182 sex-specific way down the male lineage, from paternal grandfathers to F2 males.

183 evalence of myopia at age 7 was lower if the paternal grandmother had smoked in pregnancy, an associa

184 Paternal grandmothers smoking in pregnancy showed no ass

185 ified all twins, full siblings, maternal and paternal half siblings, and cousins.

186 adjusting for shared familial factors among paternal half-siblings (OR 1.20, 95% CI 0.80-1.81), full

187 rs as maternally or paternally related-e.g., paternal half-siblings-using the locations of autosomal

188 CI = 1.2-2.9) for cousins whose parents were paternal half-siblings.

189 al half-siblings; 1.3 (95% CI = 0.9-2.1) for paternal half-siblings; 1.7 (95% CI = 1.4-2.0) for cousi

190 Many such technologies could use in vivo paternal haploid induction (HI), which occurs when doubl

191 #159550) inferring that they lie on the same paternal haplotype.

192 n assessing the intergenerational impacts of paternal health.

193 singly recognized as an additional source of paternal hereditary information beyond DNA.

194 ial CENTROMERIC HISTONE (CENH3) gene induces paternal HI in Arabidopsis(4-6).

195 Here we report a commercially operable paternal HI line in wheat with a ~7% HI rate, identified

196 Maternal or paternal high fat (HF) diet can modify the epigenome in

197 Independent studies have observed that a paternal history of stress or trauma is associated with

198 The effect of maternal and paternal history was comparable for all atopic diseases.

199 hared DEGs associated with both maternal and paternal Holocaust exposure or associated with both mate

200 printing in humans by generating exclusively paternal human androgenetic embryonic stem cells (aESCs)

201 he upper panel of Figure 2 incorrectly read 'paternal imprinting' and should have read 'maternal impr

202 In humans, most germline mutations are paternal in origin and numbers of mutations per offsprin

203 hich was more elevated (p < .001) than after paternal infections (n = 350,835; HR, 1.01; 95% CI, 0.98

204 ntly (p = .08) different from the risk after paternal infections (n = 8559; HR, 1.07; 95% CI, 0.95-1.

205 e similarly increased risks for maternal and paternal infections before and after pregnancy.

206 Exposure included all maternal and paternal infections treated with anti-infective agents o

207 bsence of the father and the transmission of paternal influences across generations may allow researc

208 RNA) populations vary in response to diverse paternal insults.

209 We find that greater paternal investment and lower frequency of extramarital

210 us for p.Leu206His and the third patient had paternal isodisomy for chromosome 19 and was homozygous

211 re reduced in hypothalami of fasted Snord116 paternal knockout (Snord116p-/m+) mice.

212 genomes mitigates mutational erosion, while paternal leakage exacerbates the ratchet effect.

213 own, and that homologous recombination under paternal leakage might not be needed.

214 Paternal leakage provides opportunity for recombination

215 ntury have drawn strong associations between paternal life experiences and offspring health and disea

216 de strong evidence for the impact of diverse paternal life experiences on offspring neurodevelopmenta

217 Paternal lineage F3 DEHP males exhibited decreased ferti

218 genes had altered expression patterns in the paternal lineage males.

219 ng in postnatal day 15 F2 descendants on the paternal lineage of ancestral male and female T3-overexp

220 ion males that were descendants of F1 males (paternal lineage) and those from F1 females (maternal li

221 e conserved across three generations via the paternal lineage, which was independent of sperm methylo

222 re mediated to only male descendants via the paternal lineage.

223 ion transect of the dynamics of maternal and paternal lineages in France as well as of autosomal geno

224 We detected four different paternal lineages of domestic sheep and resolved, at the

225 eny, coalescing similarly to other Ashkenazi paternal lineages, 1,743 ybp, suggests it to be one of t

226 omic diversity (including maternal lineages, paternal lineages, and genome-wide data) across 257 vill

227 establish the significance of a sup-optimal paternal low protein diet for offspring vascular homeost

228 onverting enzyme activity were programmed by paternal low protein diet in a sperm and/or seminal plas

229 Paternal low protein diet modified F1 male offspring tes

230 Paternal low protein diet modified F1 neonatal and adult

231 eport in this issue of Molecular Cell that a paternal low-protein diet elevates ROS in the testicular

232 in mammalian cells and for the clearance of paternal mitochondria after embryonic fertilization in C

233 s such as active degradation and dilution of paternal mitochondria ensure maternal mitochondrial inhe

234 ental inheritance at two levels, eliminating paternal mitochondrial genomes or destroying mitochondri

235 In both species we observe a paternal mutation bias, a parental age effect, and a hig

236 novel data reveal the impact of sub-optimal paternal nutrition on offspring cardiovascular well-bein

237 Moreover, maternal and paternal obesity predispose offspring to poor cognitive

238 Paternal obesity was also associated with higher risk of

239 ephales promelas), a species exhibiting sole paternal offspring care, by examining endocrine-associat

240 rticularly influential in species exhibiting paternal offspring care.

241 Both maternal and paternal older ages were associated with risk of lymphom

242 essed UBE3A gene and biallelic expression of paternal-only genes.

243 Maternal antenatal, but not paternal or grandparental, caffeine intake is associated

244 by CTCF and cohesin are only present in the paternal or maternal chromosomes, respectively, in the z

245 bility that our findings reflect the role of paternal or postnatal nicotine exposure, as opposed to m

246 rolling for age, sex, enrollment period, and paternal origin (adjusted HR, 3.2; 95% confidence interv

247 eep and resolved, at the global level, their paternal origins and differentiation.

248 k factors included maternal prepregnancy and paternal overweight, excessive gestational weight gain,

249 he maternal parent (HA maps) compared to the paternal parent (AH maps), suggesting that 509022 had ov

250 A methylation (RdDM) pathway activity in the paternal parent is sufficient to determine the viability

251 ith incorrect relationship types or maternal/paternal parent sexes, five of which we confirmed as mis

252 nhancement through the germline, pointing to paternal physical activity as a direct factor driving of

253 ion between female tissues of the pistil and paternal pollen tubes imposes hybridization barriers in

254 de novo H3K9 trimethylation (H3K9me3) in the paternal pronucleus after fertilization is catalysed by

255 (5fC), and 5-carboxylcytosine (5caC) in the paternal pronucleus.

256 Paternal provisioning among humans is puzzling because i

257 and conditions associated with emergence of paternal provisioning in the hominin lineage.

258 hared DEGs associated with maternal PTSD and paternal PTSD were in opposite directions, while fold ch

259 l exposure history, or a generic response to paternal 'quality of life'.

260 oth kin and non-kin, many group members were paternal rather than maternal relatives, and unrelated a

261 egulation, and its repression by the loss of paternal RdDM is associated with only modest gene expres

262 toward production of female offspring while paternal relationship to sex allocation was the reverse.

263 characteristics, and behavior, PCBs inhibit paternal reproductive success and have the potential to

264 In contrast, how PCBs affect paternal reproductive success is largely unknown, but co

265 ndicated selective expression of the mutated paternal SGCE allele.

266 o earlier Neolithic lineages, whereas on the paternal side a Steppe ancestry is clearly visible.

267 y history of epilepsy on the maternal versus paternal side.

268 uitting or reducing smoking and maternal and paternal smoking combined, with preterm birth, small siz

269 ated that effective interventions to prevent paternal smoking in the presence of children would reduc

270 Paternal smoking seems to be associated, independently o

271 Among nonsmoking mothers, paternal smoking was associated with childhood overweigh

272 rnal smoking, and 16 also had information on paternal smoking.

273 regression models adjusted for maternal and paternal sociodemographic and lifestyle-related characte

274 a higher signal on the maternal (state M) or paternal (state P) allele.

275 Transmission of preconception paternal stress exposure is associated with changes in e

276 strates the influence that both maternal and paternal stress exposures have in changing the course of

277 Little data exists on effects of paternal tetrahydrocannabinol (THC) exposure prior to re

278 Paternal tobacco smoking independently increased the ris

279 while adjusting for pregnancy, maternal, and paternal traits, first-trimester antidepressant exposure

280 occurs through direct binding of TET3 to the paternal transcribed allele of the imprinted gene Small

281 ive epigenetic networks between maternal and paternal transcripts at the Ube3a locus.

282 mtDNA heteroplasmy, but find no evidence of paternal transmission of mtDNA in humans.

283 The paternal transmitted birth weight score was significantl

284 Both maternal and paternal transmitted BP scores were negatively associate

285 Maternal and paternal transmitted GRSs (SD-units) increased odds for

286 Both maternal and paternal transmitted height haplotype scores were highly

287 Furthermore, we showed that loss of the paternal Ube3a antisense transcript resulted in both uni

288 Here we sought to examine maternal and paternal Ube3a expression in DRGs neurons and to evaluat

289 p-regulation of UBE3A-ATS without repressing paternal UBE3A However, increasing expression of UBE3A-A

290 t Cas9 can be used to activate ('unsilence') paternal Ube3a in cultured mouse and human neurons when

291 This early treatment unsilenced paternal Ube3a throughout the brain for at least 17 mont

292 ndary element resulted in full repression of paternal UBE3A, demonstrating that UBE3A imprinting requ

293 ome, whereas KOS most frequently arises from paternal UPD14 or epimutations/deletions on the maternal

294 ong boys, maternal waist circumference (WC), paternal WC and TV viewing mediated 16%, 11.5% and 13% o

295 Among girls, maternal and paternal WC mediated 20% and 14% of the association betw

296 n by investigating structural changes to the paternal X chromosome before and during X chromosome ina

297 ADs are lost as genes become silenced on the paternal X chromosome but linger in regions that escape

298 ne during spermatogenesis in mosquitoes, the paternal X chromosome is shredded and only Y chromosome-

299 e expression from the maternal X compared to paternal X chromosome, revealing that these parent-of-or

300 In mice, transcriptional repression of the paternal X-chromosome (Xp) and enrichment in epigenetic