ライフサイエンスコーパス: paternal age

1 than female gametes and often increase with paternal age.

2 g habits, and they differed only slightly by paternal age.

3 no significant effects, after adjusting for paternal age.

4 ts (dnSNVs), that accumulate with increasing paternal age.

5 in males than in females and increases with paternal age.

6 y status, federal program participation, and paternal age.

7 psychiatric disorder (lifetime PD); and (3) paternal age.

8 s were de novo and associated with increased paternal age.

9 proportion of mutants, which decreases with paternal age.

10 enetic alterations associated with advancing paternal age.

11 al evidence for an increase in mutation with paternal age.

12 Much less is known about the impact of paternal age.

13 of autism risk with increasing maternal and paternal age.

14 tism associated with increasing maternal and paternal age.

15 no association with ASD after adjusting for paternal age.

16 n spectra between the sexes and at different paternal ages.

17 ce regarding the impact of both maternal and paternal ages.

18 DNMs in the offspring after controlling for paternal age (0.51 additional mutations per year, 95% CI

19 higher maternal age (1.13 [1.02-1.25]), and paternal age (1.12 [1.05-1.19]).

20 32; 95% CI: 0.11, 0.54; P < 0.01), and older paternal age (adjusted coefficient: 33.27; 95% CI: 4.10,

21 consisting of 9 clinical features: advanced paternal age, advanced maternal age, childhood maltreatm

22 may play an important role in accounting for paternal age-AH4 associations.

23 here was a strong, positive association with paternal age among participants without siblings.

24 en telomere length, child gender, ethnicity, paternal age and deprivation.

25 ction effects were observed between advanced paternal age and maternal age, as well as paternal alcoh

26 rved an inverse U-shaped association between paternal age and offspring AH4 score with the lowest sco

27 re established associations between advanced paternal age and offspring risk for psychiatric and deve

28 The association was similar for paternal age and present even among individuals older th

29 Through logistic regression adjusting for paternal age and race (and, in a subset, for maternal ag

30 c and educational backgrounds also varied by paternal age and race.

31 ant, monotonic association between advancing paternal age and risk of adult schizophrenia and schizop

32 cant monotonic association between advancing paternal age and risk of ASD.

33 association was also found between advancing paternal age and risk of autism in the offspring.

34 xamined the association between maternal and paternal age and subgroups of trisomy 21 defined by pare

35 Other variables, such as paternal age and subject's birth weight, were significan

36 anation for the association between advanced paternal age and various neurodevelopmental disorders bu

37 Odds ratios (ORs) for IF in relation to paternal age, and its interactions with maternal age, pa

38 story of psychiatric disorders, maternal and paternal age, and parental educational and employment st

39 Advanced paternal age (APA) has been shown to be a significant ri

40 Maternal and paternal ages are associated with neurodevelopmental dis

41 es as well as additional reports of advanced paternal age associated with paternal origin of three sp

42 We observed a paternal age association with AH4 but not RT, a measure

43 to better understand the association between paternal age at birth and hematological malignancies.

44 ication were verbal IQ for the ASD/ID genes, paternal age at birth for the DBE genes and adaptive fun

45 ippines, we first replicate the finding that paternal age at birth is associated with longer TL in of

46 Paternal age at birth was obtained for most of the cohor

47 (including sex, year of birth, maternal and paternal age at birth, and parity), for smoking 10 or mo

48 The effects of advancing paternal age at childbearing on offspring morbidity rema

49 est parental educational level, maternal and paternal age at childbirth, offspring birth year, offspr

50 In humans, the effect of paternal age at conception (PAC) on offspring leukocyte

51 We test for maternal (MAC) and paternal age at conception effects on offspring LTL in S

52 Studies in humans have revealed that the paternal age at conception explains most of the variatio

53 ial confounders (maternal age at conception, paternal age at conception, parental psychiatric history

54 positive causal effects of both maternal and paternal age at first birth on children's test scores at

55 identify the causal effects of maternal and paternal age at first birth on children's test scores ba

56 xposure or associated with both maternal and paternal age at Holocaust exposure were in the same dire

57 Paternal age at MI of <50, 50 to 59, 60 to 69, 70 to 79,

58 9, 1.64, 1.42, 1.16, and 0.92; in women, for paternal age at MI of <50, 50 to 59, and >/=60 years, th

59 The study examined the relation between paternal age at the time of birth and risk of schizophre

60 Advanced paternal age at the time of birth of the offspring may b

61 tribution to autism risk, and correlate with paternal age at the time of conception.

62 Maternal and paternal age at the time of offspring's birth.

63 ) in offspring is positively correlated with paternal age at the time of the offspring conception.

64 rth cohort had prospective information about paternal age at the time of the offspring's birth.

65 dings suggest that variation in maternal and paternal ages at breeding could contribute substantially

66 We manipulated maternal and paternal ages at breeding over 2 generations in the neri

67 The paternal-age-at-conception (PAC) effect on TL is puzzlin

68 ational landscape in canids is determined by paternal age, body size, and CpG Islands recombination.

69 of DNMs in offspring increases not only with paternal age, but also with maternal age, and that some

70 Here, we show that paternal age can affect offspring longevity as strongly

71 2.32, and 2.74 among those of each increased paternal age category (27-<32, 32-<38, and > or =38 year

72 in (4:1 bias) and positively correlated with paternal age, consistent with the modest increased risk

73 Our data on advanced paternal age corroborates and extends previous clinical

74 n association with rare disorders related to paternal age (e.g., Apert syndrome, achondroplasia), thi

75 tant sperm over time-explaining the observed paternal age effect associated with these disorders-and

76 autosomal dominant disorders show a dramatic paternal age effect due to selfish mutations: substituti

77 ts age, and thus selection could explain the paternal age effect for Apert syndrome and other genetic

78 This identifies the biological basis of the paternal age effect for new mutations previously suggest

79 We found no paternal age effect for the overall population nor when

80 nces mutation rates, with a 1.5-fold greater paternal age effect in dogs compared to humans.

81 A paternal age effect in spermatogenic cells is recognized

82 Although it is assumed that the paternal age effect is the result of an increasing frequ

83 estes suggests that the common factor in the paternal age effect lies in the dysregulation of spermat

84 a statistically significant epidemiological paternal age effect of 6.3 years excess for fathers of M

85 n seven to eight times that of females and a paternal age effect of three mutations per year of fathe

86 syndrome (HRAS), which we collectively term "paternal age effect" (PAE) disorders, provides a good mo

87 deletions or rearrangements do not show the paternal age effect.

88 s are important in adequately explaining the paternal age effect.

89 A paternal-age effect and the exclusive paternal origin of

90 Therefore, contributing factors to the paternal-age effect may include selection and a higher n

91 Maternal and paternal age effects were seen in subgroups defined by r

92 gic mechanisms are suggested by maternal and paternal age effects.

93 for the lower offspring scores in the oldest paternal age group.

94 no such association was observed in younger paternal age groups.

95 interval: 1.1, 1.6; adjusted odds ratio for paternal age > or =40 years vs. 25-29 years = 1.4, 95% c

96 The AMCHS had demonstrated that paternal age >= 35 years elevates the risk of IF, with a

97 Among those with a paternal age >= 35, each additional year of smoking was

98 The risk of IF (n = 735) increased with paternal age >= 35, while it remained similarly lower am

99 n the second, third, and oldest quartiles of paternal age had 1.2, 1.3, and 1.7 times increased risk

100 comparison analyses indicated that advancing paternal age had a dose-response relationship with every

101 Advanced paternal age has been associated with an increased risk

102 While the impact of advanced paternal age has been documented, sociodemographic data

103 Advancing paternal age has been linked to autism.

104 crease in autism risk with both maternal and paternal age has potential implications for public healt

105 schizophrenia was associated with advancing paternal age in a population-based birth cohort of 87 90

106 The mutation rate increased with paternal age in all families, but the number of addition

107 dern humans and highlight a central role for paternal age in determining rates of mutation.

108 on in mutation rate: Each additional year of paternal age in humans leads to approximately 1.5 additi

109 on rates are a function of both maternal and paternal ages in humans.

110 Advancing paternal age is associated with increased genetic mutati

111 Advancing paternal age is associated with increased risk of psychi

112 Research has shown that higher maternal and paternal age is positively associated with children's ed

113 5.84) than did controls after adjustment for paternal age, low maternal education, race, residence, g

114 socioeconomic metrics, including maternal or paternal age <25 years, low education (9-10 years), unem

115 n-years among sons in the lowest quartile of paternal age (<27 years), to 2.00, 2.32, and 2.74 among

116 r female), race, and ethnicity; maternal and paternal age; maternal education; combined annual househ

117 ma over time; a similar effect of increasing paternal age may be due to the same selection process.

118 Advanced paternal age may play a role in non-Hodgkin lymphoma eti

119 age, maternal body mass index, maternal age, paternal age, newborn sex, newborn ethnicity, season of

120 46 195 453 births, with an overall mean (SD) paternal age of 31.5 (6.8) years and 484 507 (1.1%) invo

121 nal age of 30.2 (18.6) years and a mean (SD) paternal age of 32.8 (13.1) years; 51.1% of offspring we

122 the OR for IF was 1.50 (95%CI 1.16-1.93) at paternal age of 35-<40 years, 2.06 (1.34-3.16) at 40-<45

123 We explored paternal age-offspring cognition associations in 772 par

124 nd a much larger effect of maternal age than paternal age on mutation rates in the aye-aye.

125 We additionally investigated the role of paternal age on offspring sociability, a proxy for norma

126 The effect of increased paternal age on prostate cancer risk may operate through

127 valuated independent effects of maternal and paternal age on risk of autism spectrum disorder.

128 no evidence to show an effect of maternal or paternal age on the frequency of nondisjunction.

129 here are independent effects of maternal and paternal age on the risk of autism.

130 Paternal age or body mass index (BMI) were not associate

131 rter telomeres than children from the U.S.A. Paternal age (P = 0.019) was positively associated with

132 ed for calendar year, age, sex, maternal and paternal age, place of residence at birth, and somatic c

133 observed to arise in fathers, and increasing paternal age positively correlates with the risk of new

134 d not differ in distributions of maternal or paternal age, previous livebirths, maternal smoking, or

135 c risk for schizophrenia was associated with paternal age (R(2) = 0.002; P = 1e-04), and offspring ed

136 (AMCHS) interviewed 1910 infertile couples (paternal age ranged 22-57 years) to look for risk factor

137 g data, we estimate the relationship between paternal-age-related dnSNVs and risk for five disorders:

138 We find that paternal-age-related dnSNVs confer a small amount of ris

139 (0.97, 0.98) per five years of maternal and paternal age, respectively).

140 nt with the clinical observation of advanced paternal age resulting in new cases of achondroplasia an

141 trend by adjusting for birth year, advanced paternal age showed no association with offspring IQ; ho

142 Parental age, especially paternal age, strongly influences mutation rates, with a

143 droplasia have been associated with advanced paternal age, suggesting that these mutations occur pref

144 ber of DNMs increases at a constant rate for paternal age, the contribution from the mother increases

145 academic morbidity associated with advancing paternal age using several quasi-experimental designs, i

146 oportional hazards regression, we found that paternal age was a strong and significant predictor of t

147 rval: 1.32, 1.44), and a 10-year increase in paternal age was associated with a 22% increase (odds ra

148 Advanced paternal age was associated with increased risk of ASD.

149 In the study population, advancing paternal age was associated with increased risk of some

150 Increased paternal age was associated with significant increases i

151 perinatal factors, every 10-year increase in paternal age was consistently associated with greater us

152 ternal age (> or =40 years) became null when paternal age was included in the statistical model.

153 In separate analyses, paternal age was modeled as a continuous variable and as

154 mia and central nervous system tumors, older paternal age was not associated with risk of either type

155 Paternal age was not associated with TL in newborns.

156 Advanced paternal age was noted for the fathers of patients with

157 Paternal age was positively associated with non-Hodgkin

158 Paternal age was significantly correlated with the sex r

159 radic AS births increases exponentially with paternal age, we hypothesized that the frequency of AS m

160 ion, and other covariates, both maternal and paternal age were independently associated with autism (

161 Associations with paternal age were strongly, but not completely, attenuat

162 The mechanism(s) linking paternal age with epigenetic changes in sperm remain unk

163 ether there is an independent association of paternal age with implantation failure (IF) in couples u

164 There was a joint effect of maternal and paternal age with increasing risk of ASD for couples wit

165 le is known about the interactive effects of paternal age with maternal age, paternal smoking and alc

166 We then show that this association of paternal age with offspring TL is cumulative across mult

167 The association of older paternal age with risk of early-onset prostate cancer (<