ライフサイエンスコーパス: pathobiology

1 g pathway has a well-described role in liver pathobiology.

2 s that reflect a deep knowledge of molecular pathobiology.

3 common and distinct underlying mechanisms of pathobiology.

4 ial boundaries of the current state of human pathobiology.

5 reduced iron availability contribute to the pathobiology.

6 eir specific contributions to nervous system pathobiology.

7 to the KD pot may better serve to understand pathobiology.

8 s lifetime, which can affect its biology and pathobiology.

9 ays an important role in viral bronchiolitis pathobiology.

10 rrent understanding of REM sleep biology and pathobiology.

11 relationships relevant to early valve lesion pathobiology.

12 naling as it relates to liver physiology and pathobiology.

13 a means for future studies addressing rabies pathobiology.

14 TH2 responses are implicated in asthma pathobiology.

15 a vital yet underdeveloped aspect of cancer pathobiology.

16 cidate previously unknown mechanisms of DIPG pathobiology.

17 wth factor 1 receptor (IGF1R) affects asthma pathobiology.

18 ine the association between FXIII and asthma pathobiology.

19 ation may play an important role in melanoma pathobiology.

20 sign of preventive strategies and inform CUA pathobiology.

21 play a central role in liver homeostasis and pathobiology.

22 ands, as well as new insights into glandular pathobiology.

23 and catabolism might be of importance in VKH pathobiology.

24 ich is suggestive of its diverse roles in PC pathobiology.

25 representing an early genetic lesion in CLL pathobiology.

26 aluate the function of pVir in Campylobacter pathobiology.

27 c disorders that may represent insights into pathobiology.

28 g to a poor mechanistic understanding of the pathobiology.

29 tant role for the miR-143/145 cluster in PAH pathobiology.

30 aches are often limited by a complex disease pathobiology.

31 ropagation that is intimately linked to KSHV pathobiology.

32 toxic oligomer species contributing to brain pathobiology.

33 ingly, blood pressure, shedding light on ALS pathobiology.

34 patients whose HF is driven by inflammatory pathobiology.

35 cell-cell fusion, a hallmark of the disease pathobiology.

36 e basis of biomarkers, advanced imaging, and pathobiology.

37 in the health-care system and interact with pathobiology.

38 and that inflammation may play a role in the pathobiology.

39 tabolite profile that would impinge on tumor pathobiology.

40 Cysteine proteases play important roles in pathobiology.

41 e association of IgG4 with APS, and possible pathobiology.

42 -CSC interactions in glioblastoma multiforme pathobiology.

43 ivated cellular signaling relevant to asthma pathobiology.

44 ominantly inherited provide insight into ALS pathobiology.

45 lead to medically actionable discoveries of pathobiology.

46 characterize a mouse model of papillomavirus pathobiology.

47 the master regulator of wall physiology and pathobiology.

48 s to test specific hypotheses on adventitial pathobiology.

49 ells (hiPSCs) that captures authentic cancer pathobiology.

50 t the roles of neurons and T cells in glioma pathobiology.

51 nical epidemiology, psychiatric nosology and pathobiology.

52 can provide an accessible window into asthma pathobiology.

53 switching, vascular inflammation and aortic pathobiology.

54 l space), which is crucially involved in the pathobiology.

55 n evolutionarily conserved key target in CIA pathobiology.

56 egulation of messenger RNA processing in MCL pathobiology.

57 onal treatment selection stemming from ccRCC pathobiology.

58 key pathways involved in fatty liver disease pathobiology.

59 D) is a heterogeneous disease with a complex pathobiology.

60 ultimately improve our understanding of SMZL pathobiology.

61 as central mechanisms in acute pancreatitis pathobiology.

62 oprotective drugs acting on different axonal pathobiologies.

63 tions to examine pancreatic cell biology and pathobiology and could help screen for potential treatme

64 ystems biology description for understanding pathobiology and developing therapies, quantitative expe

65 w recent advances in our understanding of AD pathobiology and discuss current treatment strategies, h

66 raveling the factors that play a role in the pathobiology and epidemicity of K. pneumoniae is therefo

67 a The findings provide information about the pathobiology and epidemicity of Kpi(+) K. pneumoniae and

68 advance our molecular understanding of lung pathobiology and facilitate the development of new diagn

69 egulated RNP granules to myocardial cellular pathobiology and heart failure in gene-edited pigs and p

70 h the significance of SOX9 in gastric cancer pathobiology and heterogeneity, with implications for ta

71 rlap between FTD, AD and PD to assess shared pathobiology and identify novel genetic variants associa

72 eneity presents an opportunity to understand pathobiology and improve patient care.

73 thought to be a key aspect of chronic sepsis pathobiology and increasingly more prevalent after human

74 oundly altering our understanding of disease pathobiology and leading to the emergence of new biologi

75 contribute to a better understanding of COPD pathobiology and may open new therapeutic opportunities

76 enhances our understanding of RDS-associated pathobiology and our ability to design rational treatmen

77 ar regulators could provide new insight into pathobiology and possible new therapeutic strategies for

78 we discuss the current knowledge on dry AMD pathobiology and propose future research directions that

79 been implicated in interstitial lung disease pathobiology and proposed as a diagnostic and prognostic

80 could inform mechanistic studies of disease pathobiology and provide a framework to examine patient

81 phenotypes help to understand the underlying pathobiology and provide clinicians with directions for

82 chanisms of AKI, focusing on epithelial cell pathobiology and related cell-cell interactions, using i

83 als into subpopulations that differ in their pathobiology and response to treatment.

84 Our studies confirmed xenograft tumor-driven pathobiology and revealed early and late components of t

85 reinforce the importance of IL-13 in airway pathobiology and suggest that neutralization of IL-13 ma

86 yperdynamic contraction is essential for HCM pathobiology and that inhibitors of sarcomere contractio

87 should facilitate the study of human immune pathobiology and the development of targeted therapeutic

88 stuzumab, but the impact of d16HER2 on tumor pathobiology and therapeutic response remains uncertain.

89 and should provide important insight to both pathobiology and therapeutics.

90 l be a valuable tool in the study of ALS/FTD pathobiology and therapy.

91 eeded to examine the role of pSer-324 in tau pathobiology and to determine whether therapeutically mo

92 ltiple phenotypes that may differ in disease pathobiology and treatment response.

93 otential implications for understanding TNBC pathobiology and treatment.

94 ide hypotheses about potential mechanisms of pathobiology and underscore the utility of X. tropicalis

95 essing, which may have implications in viral pathobiology and vaccine design.

96 The authors review the pathophysiology, pathobiology, and emerging clinical perspectives on pulm

97 e cells (PASMCs), a major contributor of PAH pathobiology, and identified cyclin-dependent kinases (C

98 address a fundamental understanding of HFpEF pathobiology, and new diagnostic approaches and tools, a

99 ew light on our understanding of the disease pathobiology, and provide opportunities to design novel

100 d molecular mechanisms implicated in disease pathobiology are good therapeutic targets.

101 hese effector-host interactions and roles in pathobiology are incompletely understood.

102 e interactions and their roles in ehrlichial pathobiology are not well defined.

103 health, but their contribution in CM and its pathobiology are poorly understood.

104 through which HYAL2 dysregulation influences pathobiology are unclear.

105 been thought to be the central players in AA pathobiology, are not the only drivers of disease.

106 ghlight some aspects of macrodomain roles in pathobiology as well as their emerging potential as ther

107 ssociated with congenital cataracts, but the pathobiology awaits elucidation.

108 -chronic and aggressive-lack an unequivocal, pathobiology-based foundation.

109 ared to uninflamed tissues, revealing shared pathobiology between COVID-19 and inflammatory bowel dis

110 Methamphetamine (Meth) exacerbates HIV-1 pathobiology by increasing virus transmission and replic

111 have emerged as a testing platform for HIV-1 pathobiology by reflecting natural human disease process

112 ow that miR410 plays a potential role in PAH pathobiology by targeting a modulator of pulmonary vascu

113 rable advances have since been made into the pathobiology (changes in organ function, morphology, cel

114 Our understanding of asthma onset, pathobiology, classification, and management has evolved

115 task force (n = 19) with expertise in sepsis pathobiology, clinical trials, and epidemiology was conv

116 However, ZIKV's unique pathobiology demands an explanation of how its structure

117 hese studies extend our understanding of CLL pathobiology, demonstrating that reduced differentiation

118 tion, prevalence, clinical significance, and pathobiology derived from animal studies will likely pro

119 vant for other autoimmune disorders in which pathobiology, ectopic MHC class I expression, and IP col

120 Notably, similar endosomal-lysosomal pathobiology emerges early in sporadic AD, where neurona

121 nowledge are identified regarding how sickle pathobiology evokes pain, pathways specific to chronic a

122 Consequently, exploring PAX-related pathobiology generates insights into both normal develop

123 ng of some key aspects of multiple sclerosis pathobiology has allowed the identification of character

124 nding of human exocrine pancreas biology and pathobiology has been hampered by a lack of suitable pre

125 pediatric acute lymphoblastic leukemia (ALL) pathobiology has led to dramatic improvements in patient

126 ugh advances in the understanding of the PAH pathobiology have been seen in recent years, molecular p

127 opportunities) in existing knowledge of COPD pathobiology, how systems biology and network medicine c

128 ecular features of the underlying aggressive pathobiology in -7 AML patients.

129 a component of corticosteroid nonresponsive pathobiology in adults with SA that may differ in childr

130 ll (VSMC) phenotypic switching, an important pathobiology in arterial disease.

131 t cancer, which suggests a new concept of ER pathobiology in breast cancer.

132 alterations in collagen V expression in the pathobiology in classic Ehlers-Danlos syndrome.

133 xclusively targeting these aspects of axonal pathobiology in patients with secondary progressive mult

134 been shown to regulate normal functions and pathobiology in the digestive system.

135 e these strategies into the discovery of RNA pathobiology in this disease.

136 designed small molecules that target the DM1 pathobiology in vitro in three distinct ways by acting s

137 functionally connect them to alpha-synuclein pathobiology in yeast, worms, and mouse.

138 ucidating cancer biology do not recapitulate pathobiology including tumor heterogeneity, an inherent

139 ational processing of proteins central to AD pathobiology, including tau, amyloid-beta (Abeta), and t

140 ge amounts of IFN-gamma, might also drive AA pathobiology independent of classical, autoantigen-depen

141 yet-undescribed early manifestations of tau pathobiology, independent of neurodegeneration, and prov

142 The defining pathobiology is an imbalance between the metabolic deman

143 JMML pathobiology is characterized by constitutive activation

144 generation (AMD); however, its impact on AMD pathobiology is unresolved.

145 le of B cell receptor (BcR) signaling in CLL pathobiology, it is notable that IkappaBepsilon loss was

146 eptides, does not require prior knowledge of pathobiology, it may be broadly useful for de novo disco

147 a pressing need to better understand how the pathobiology leads to severe disease in some patients ve

148 es a critical appraisal of the epidemiology, pathobiology, neuropathology, and neuroimaging of vascul

149 d to iPSC disease models to recapitulate the pathobiology of a broad spectrum of human maladies, incl

150 Cytokine-driven inflammation underlies the pathobiology of a wide array of infectious and immune-re

151 strates the importance of UDP-GalNAcA in the pathobiology of A. baumannii.

152 these modifiers may provide insight into the pathobiology of AD and potential therapeutic measures.

153 nt implications for our understanding of the pathobiology of age-associated diseases and may guide ta

154 sregulated inflammation is implicated in the pathobiology of aging, yet platelet-leukocyte interactio

155 The pathobiology of AL in the setting of a technically optim

156 ALL-MSC communication gives insight into the pathobiology of ALL and opens new avenues to develop mor

157 ls and their receptors may contribute to the pathobiology of Alzheimer disease.

158 To better understand the pathobiology of Alzheimer's disease we measured levels o

159 Our results support a more complex pathobiology of aspirin hypersensitivity.

160 ssociated with differences in the underlying pathobiology of asthma.

161 -depth mechanistic knowledge of the cellular pathobiology of atherosclerosis can lead to new ideas fo

162 sculature is an important contributor to the pathobiology of atherosclerotic cardiovascular disease.

163 Therefore, here, we investigated the pathobiology of B. neotomae infection in the BALB/c mous

164 Greater insights into the pathobiology of BPD will provide a better understanding

165 gesting that early PVD may contribute to the pathobiology of BPD.

166 rway microbiome, host systemic response, and pathobiology of bronchiolitis.

167 or protein SUMOylation in the life cycle and pathobiology of C. glabrata.

168 our data provide valuable insights into the pathobiology of C. jejuni sheep abortion clone and stron

169 tial applications in vesicle physiology, the pathobiology of cancer and other diseases, diagnostics u

170 putational modeling to better understand the pathobiology of cancer and to better affect its cure.

171 munity-governed inflammatory cascades in the pathobiology of chemoradiotherapy-induced OM and the dev

172 MMPs may play a role in the pathobiology of children with ARDS.

173 roducts (RAGE) is critically involved in the pathobiology of chronic inflammatory diseases.

174 ether, our findings provide insight into the pathobiology of CLL to suggest a more complex relationsh

175 It aims to help researchers understand the pathobiology of collagen-related diseases and create nov

176 lar angiogenesis distinguished the pulmonary pathobiology of Covid-19 from that of equally severe inf

177 ution of specific cellular components to the pathobiology of diabetic retinopathy remains to be defin

178 Progress has been made to understand the pathobiology of disease mechanisms for myotonic dystroph

179 damental to development, homeostasis and the pathobiology of diseases such as cancer.

180 is Review, we discuss the latest data on the pathobiology of each oxidase component, the complex cros

181 The pathobiology of early squamous lung cancer is poorly und

182 ecific region of the protein critical to the pathobiology of EKC syndrome and to DSP function in the

183 With a better understanding of the pathobiology of events following acute SCI, developing i

184 t into an unexpected role for FXIII-A in the pathobiology of familial dermatofibroma.

185 tantial progress in our understanding of the pathobiology of fibrosis, a translational gap remains be

186 Food-specific IgE is central to the pathobiology of food allergy, but not sufficient to indu

187 s, which are strongly implicated in the root pathobiology of GBM.

188 function, all of which are implicated in the pathobiology of heart failure (HF).

189 ency renal nerve denervation (RF-RDN) on the pathobiology of HF and the interaction between the renal

190 cal and molecular alterations underlying the pathobiology of HPV-associated OPSCC (designated HPV(+)

191 etworks can enhance our understanding of the pathobiology of human periodontitis and, after appropria

192 To better understand the pathobiology of hydrosalpinx, we compared the proteome o

193 entists are elucidating the pathogenesis and pathobiology of individual cardiomyopathies.

194 s on alterations in hematopoietic TFs in the pathobiology of inherited platelet defects.

195 To understand the pathobiology of interactions between the bacterium and h

196 The pathobiology of IPNB demonstrates geographic variation.

197 In this article, we review the pathobiology of liver disease in HCV-HIV coinfected pati

198 plementing the limited data available on the pathobiology of lung capillaries and small arteries; 3)

199 central role of the SRF/MRTF pathway in the pathobiology of lung fibrosis and suggest that its inhib

200 Here, we assessed the pathobiology of LZTR1-mediated bleeding disorders.

201 Because these cells are implicated in the pathobiology of many allergic and immunologic diseases,

202 as greatly expanded our understanding of the pathobiology of many SCAs, revealing that they occur via

203 cross-talk between secretion systems in the pathobiology of medically relevant Acinetobacter species

204 The indeterminate pathobiology of MGZL has led to uncertainty regarding th

205 Diaphanous formins and add insights into the pathobiology of microcephaly.

206 this mouse line impractical for studying the pathobiology of mitochondrial optic neuropathies.

207 hts into conserved mechanisms and the shared pathobiology of mRNA dysregulation in disease.

208 ow antibiotic resistance mutations shape the pathobiology of multidrug-resistant infections has the p

209 development is crucial for understanding the pathobiology of multiple developmental disorders.

210 on has also been shown to play a role in the pathobiology of myriad cancers, one of which is glioblas

211 cal amyloid fold, play a central role in the pathobiology of neurodegenerative diseases.

212 the tumor suppressor NF1 contributes to the pathobiology of neurofibromatosis type 1, but a related

213 nding of both the normal development and the pathobiology of ocular neovascularization.

214 ve direct implications for understanding the pathobiology of other hormone-receptor-driven cancers an

215 ver the past decades, knowledge of the basic pathobiology of PAH and its natural history, prognostic

216 tral role of the vascular endothelium in the pathobiology of PAH.

217 ate developments in our understanding of the pathobiology of pain in SCD.

218 nt, or stroma, is of major importance in the pathobiology of pancreatic ductal adenocarcinoma (PDA),

219 nt for understanding the role of sENG in the pathobiology of PE and other cardiovascular diseases.

220 orted pegiviruses, which sheds lights on the pathobiology of pegivirus.

221 l processes with possible involvement in the pathobiology of periodontal disease.

222 ese findings expand our understanding of the pathobiology of PH in HF.

223 Emerging concepts are also relevant to the pathobiology of PH, including a role for bone marrow and

224 le metabolite alterations are germane to the pathobiology of PTEN-related CS and BRRS, as well as gen

225 important implications for understanding the pathobiology of renal disease.

226 This may have implications for the pathobiology of respiratory virus-induced airway disease

227 This review addresses the pathobiology of SA and discusses the current limitations

228 uggest that any role of glycosylation in the pathobiology of SARS-CoV-2 will lie beyond its immediate

229 The following review focuses on the evolving pathobiology of SCD, how various complications of SCD ca

230 1C isoforms among phenotypes relevant to the pathobiology of schizophrenia.

231 rain development, has been implicated in the pathobiology of schizophrenia.

232 The pathobiology of sepsis is becoming increasingly well und

233 ysregulated leukocyte responses underlie the pathobiology of sepsis, which is a leading cause of deat

234 t NK and CD8(+) T lymphocytes facilitate the pathobiology of septic shock.

235 ks alterations in cellular metabolism to the pathobiology of several common respiratory diseases.

236 GLI1 oncogene has been implicated in the pathobiology of several neoplasms including diffuse larg

237 lial cell-secreted factors contribute to the pathobiology of squamous cell carcinoma (SCC) by enhanci

238 r transport across the peritoneum and of the pathobiology of structural and functional changes in the

239 a relevant platform to investigate both the pathobiology of such infections as well as novel approac

240 protein changes could negatively affect the pathobiology of the 2010 derivative, its virulence defec

241 are discussed, including the immunology and pathobiology of the complex relationship between ageing

242 number of persons at risk of infection, the pathobiology of the disease is unknown, and no effective

243 tion about how these cells contribute to the pathobiology of the disease.

244 symptom frequency, suggesting a role in the pathobiology of the late-onset phenotype.

245 provide important insights pertinent to the pathobiology of the P vivax infection.

246 These results suggest a tissue specific pathobiology of the Q141K variant, support an important

247 de a strong foundation for understanding the pathobiology of the relapse.

248 Even though the pathobiology of the resulting retinal degeneration has b

249 ntly, exciting insights into the biology and pathobiology of these cell type-specific niches are bein

250 vealing signatures consistent with the known pathobiology of these lesions, our observations provide

251 To demonstrate the involvement of UPR in the pathobiology of these lesions, we employed chemical chap

252 dels have led to better understanding of the pathobiology of these neuropathies, there continues to b

253 at broaden evidence-based approaches and the pathobiology of these novel events.

254 that might broaden our understanding of the pathobiology of this aggressive sarcoma.

255 Fowler syndrome model therefore defined the pathobiology of this disease and provided new insights i

256 he understanding of the genetic etiology and pathobiology of this disease.

257 aise the profile of NTHi and to document the pathobiology of this microbe.

258 as been made in understanding the causes and pathobiology of this often life-threatening condition.

259 spective validation to further elucidate the pathobiology of this phenomenon.

260 kin and may improve our understanding of the pathobiology of tissue inflammatory diseases.

261 iers and oncogenic pathways that reflect the pathobiology of tumor cells and their microenvironment w

262 othesis provides a useful perspective on the pathobiology of uraemic syndrome.

263 system maturation, myelin stability, and the pathobiology of various de- and dys-myelinating disorder

264 ulation of iron has been associated with the pathobiology of various disorders of the central nervous

265 Although the underlying pathobiology of vision limiting processes in RD is not f

266 a framework for the genetic architecture and pathobiology of vitiligo, highlight relationships with o

267 r telomerase and telomere dysfunction in the pathobiology of XP by comparing Xpc(-/-)-mutant mice and

268 However, the pathobiology of ZIKV transmission through the rectal rou

269 pping and to assess the relationship between pathobiology/pathophysiology and prognosis.

270 from an incomplete understanding of disease pathobiology, phenotypic heterogeneity, and natural hist

271 nd ischemic stroke, which may reflect shared pathobiology predisposing to small vessel arteriopathy.

272 Heterogeneity in sepsis-related pathobiology presents a significant challenge.

273 Understanding the pathobiology related to the autoreactive T-cell and micr

274 ro However, the relevance of MIOX to tubular pathobiology remains enigmatic.

275 nd the role of astroglial TDP-43 loss to ALS pathobiology remains to be clarified.

276 fections) morbidities in young children, the pathobiology remains uncertain.

277 uence of host systemic metabolism on disease pathobiology remains unclear.

278 t factor H (CFH); however, its impact on AMD pathobiology remains unresolved.

279 ed frontiers in current alopecia areata (AA) pathobiology research, with an emphasis on potential "ne

280 ultured human ALCL cells, a key tool in ALCL pathobiology research.

281 critical component in reflecting such human pathobiology rests in defining the tissue and cellular s

282 and they provide evidence of organ-specific pathobiology resulting from different mutations within G

283 controls, suggesting that some aspect of MS pathobiology retards the accumulation of beta-amyloid bu

284 exosomes as a potential target to attenuate pathobiology signals.

285 e definitive understanding of the underlying pathobiology, studies linking pathology to molecular mar

286 an emphasis on potential "new" players in AA pathobiology that deserve more systematic exploration an

287 these disorders, and insights into molecular pathobiology that have potential for clinical translatio

288 gger a version of ischemia/reperfusion (I/R) pathobiology that is singular in its origin, cyclicity,

289 ied for complementary targets to inhibit the pathobiology that is specific to inflammatory breast can

290 lecular level about ischemia and reperfusion pathobiology that may be translated into future new ther

291 n ELN disruptions as not only the antecedent pathobiology that underlies beta-amyloidogenesis but als

292 torial introduces this month's special Liver Pathobiology Theme Issue, a series of reviews that encom

293 n patient subsets sharing similar underlying pathobiology, therefore increasing the likelihood of cli

294 multiple NLR inflammasomes attenuate disease pathobiology through modulating IL-1beta and IL-18 level

295 alization of REEP1 and further elucidate the pathobiology underlying REEP1 mutations in patients.

296 We examined mutation pathobiology via expression of mutant GNA14 or GNA11 in

297 hitherto underappreciated aspects of keloid pathobiology, we took a laser capture microdissection-ba

298 I to assist clinicians' understanding of its pathobiology, when to deploy the diagnosis, and its asso

299 hypersensitivity pneumonitis suggest shared pathobiology with IPF, and might help to stratify risk.

300 is based on histologic grade and underlying pathobiology with low-grade disease hypothesized to be i