ライフサイエンスコーパス: penetrant

1 receptor agonist) was a blood-brain barrier penetrant.

2 steosarcoma development, which remained 100% penetrant.

3 nducing peptides that are intrinsically cell-penetrant.

4 of agonist 4-fold, and the racemate is brain-penetrant.

5 as a means for rendering peptides more cell-penetrant.

6 Blebb was found to be highly brain penetrant.

7 ide range of mental disorders and are highly penetrant.

8 cases are underdiagnosed and/or incompletely penetrant.

9 ein] and is autosomal dominant and partially penetrant.

10 background but are unlikely to be completely penetrant.

11 ffected by diet and several are incompletely penetrant.

12 LK2 which are orally bio-available and brain-penetrant.

13 types, including those that are incompletely penetrant (2), automated identification of causative mut

14 , from birth resulted in spontaneous, highly penetrant AD with many of the major hallmarks of human A

15 harmacokinetics study, compound 9t was brain-penetrant after oral dosing, but exposure was limited by

16 the point of being permeable to normally non-penetrant agents without causing significant acute damag

17 a novel, highly potent, selective, and brain-penetrant ALK and ROS1 TKI with preclinical activity aga

18 valuation of PF-06463922, a potent and brain-penetrant ALK/ROS1 inhibitor.

19 t, selective, orally bioavailable, and brain-penetrant ALK2 inhibitors based on the lead compound LDN

20 K2V617F combined with Tp53 loss led to fully penetrant AML in vivo.

21 ) bone marrow cells rapidly develop a highly penetrant AML.

22 A selection of penetrant and "nonpenetrant" drugs were dosed to rats vi

23 a establish RBM20 cardiomyopathy as a highly penetrant and arrhythmogenic cardiomyopathy.

24 ozygous human mutations of NKX2-5 are highly penetrant and associated with varied congenital heart de

25 he rapid development of an aggressive, fully-penetrant and cell-autonomous myeloid leukaemia in mice,

26 11.2 deletion syndrome (22q11DS) is a highly penetrant and common genetic cause of neuropsychiatric d

27 Several examples are brain-penetrant and exhibit balanced multitargeted in vitro ac

28 This new model is highly penetrant and exhibits robust frequency of metastases to

29 32 is CNS-penetrant and highly effective in acute and latent mouse

30 er, telomerase variants are not always fully penetrant and in some families disease-causing variants

31 Thrombocytopenia is almost completely penetrant and is usually mild.

32 d i.c.v. administrations of SR11935, a brain-penetrant and JNK2/3 isoform-selective inhibitor, exerte

33 construct drug combinations that yield more penetrant and lasting responses in patients.

34 They are not fully penetrant and offer an opportunity to study their effect

35 d with the disease, most of which are highly penetrant and often cause early onset or atypical sympto

36 ction of NB-360, a novel blood-brain barrier penetrant and orally available BACE1 inhibitor, was veri

37 The highly penetrant and progressive AV block phenotype seen in hum

38 of 14 (PF-06447475), a highly potent, brain penetrant and selective LRRK2 inhibitor which has been f

39 (i.c.v.) administration of SR-3306, a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor, re

40 fication of new 1,4-benzodiazepines as brain penetrant and selective triple T-type calcium channel bl

41 Mouse models of fully penetrant and slowly evolving prostate tumorigenesis sho

42 -mediated female-to-male conversion was 100% penetrant and stable over many generations.

43 Hearing impairment was more penetrant and stapes malformations were more severe in E

44 rms for the logP and molecular weight of the penetrant and the refractive index of the vehicle mixtur

45 was developed to describe the effects of the penetrant and vehicle mixture properties on the mean dif

46 To study the complex relationship of penetrant and weaker polygenic risk variants to ASD, 'is

47 T-2102, a potent, orally bioavailable, brain penetrant, and selective mIDH1 inhibitor.

48 or suppressor gene, and they provide a fully penetrant animal model for the study of angiosarcoma dev

49 28-day treatment with S 38093, a novel brain-penetrant antagonist/inverse agonist of H3 receptors, on

50 ctivation, and this is alleviated by the CNS-penetrant antioxidant, indapamide.SIGNIFICANCE STATEMENT

51 tiple proliferation biomarkers, indicating a penetrant, arrested state.

52 ans, the beta2AR agonist salbutamol, a brain-penetrant asthma medication, was associated with reduced

53 rmline variants were found in the moderately penetrant ATM and CHEK2 genes, where only truncating var

54 Here, we report brain-penetrant ATM inhibitors that have robust pharmacodynami

55 all molecule 7, a potent and selective brain-penetrant ATP-competitive mTOR inhibitor.

56 PF-06463922, a novel, orally available, CNS-penetrant, ATP-competitive small-molecule inhibitor of A

57 These new, cell-penetrant autophagy inducers and their molecular details

58 primary torsion dystonia (AOPTD) is a poorly penetrant autosomal dominant disorder; most gene carrier

59 ostic test was developed and confirmed fully penetrant autosomal recessive mode of inheritance.

60 idine analogues, have been found to be brain penetrant BACE-1 inhibitors.

61 nvestigated the effects of a potent nonbrain-penetrant BACE1 inhibitor, delivered directly to the bra

62 the discovery of orally bioavailable, brain-penetrant BACE1 inhibitors.

63 (Gt-ex13) heterozygotes exhibit incompletely penetrant BAV, CoA and PDA phenotypes similar to those i

64 explain aberrant structural connectivity and penetrant behavioral consequences in mice as well as hum

65 oup of syndromes are characterized by highly penetrant benign tumors.

66 al-specific splicing factor Esrp1 have fully penetrant bilateral cleft lip and palate.

67 poietic system, which phenocopied the highly penetrant bone marrow failure seen in Fanconi anaemia pa

68 potent (mGlu1 EC50 = 31.8 nM) and highly CNS penetrant (brain to plasma ratio (Kp) of 1.02) mGlu1 PAM

69 .4) variant associated with diabetes is <10% penetrant by the time an individual is 40 years old.

70 ort can enhance the overall permeance of the penetrant by up to an order of magnitude, but this gain

71 d the in vivo efficacy of nilotinib, a brain penetrant c-Abl inhibitor, in the acute MPTP-induced mod

72 bolism and retinoid signaling, exhibit fully penetrant CA.

73 gets in Li-Fraumeni syndrome (LFS), a highly penetrant cancer predisposition syndrome associated with

74 ls with Li-Fraumeni syndrome, a rare, highly penetrant cancer predisposition syndrome.

75 positive for pathogenic mutations in highly penetrant cancer susceptibility genes.

76 We investigate the genetic basis of highly penetrant cancer susceptibility in RF/J finding private

77 Specifically, using the brain penetrant catechol-O-methyl transferase (COMT) inhibitor

78 , with a large number of distinct and highly penetrant causal variants identified among a growing lis

79 is a relatively common monogenic and highly penetrant cause of autism spectrum disorder (ASD) and in

80 chiatric adverse effects observed with brain-penetrant CB1R blockers, ameliorate obesity and its mult

81 -55 (GSK232), a highly selective, cellularly penetrant CECR2 inhibitor with excellent physicochemical

82 the BBB spheroids to screen and identify BBB-penetrant cell-penetrating peptides (CPPs).

83 racterized adgra2 mutants and exhibit highly penetrant cerebrovascular defects.

84 smatch repair deficiency (bMMRD) is a highly penetrant childhood cancer syndrome often resulting in G

85 up15q syndrome is one of the most common and penetrant chromosomal abnormalities observed in individu

86 novel NFKB2 GOF mutations produce a nonfully penetrant CID phenotype through a different pathophysiol

87 distinct from UTX mutation, including fully penetrant cleft palate, mandible hypoplasia and deficits

88 d a palate elevation delay with incompletely penetrant cleft palate.

89 les with ASD were more likely to have highly penetrant CNVs (p = 0.017) and were also overrepresented

90 runcating fat1a mutations exhibit completely penetrant coloboma, recapitulating the most consistent d

91 variability between treatments (vehicle and penetrant combinations) as well as noise within treatmen

92 l-3-pyridincarboxamides, including the brain-penetrant compound 14G: [5-(4-chlorophenyl)-6-(cycloprop

93 esulted in a highly potent, selective, brain penetrant compound 71 (PF-05085727) that effects in vivo

94 nts in genetic analyses, particularly highly penetrant contributors to severe Mendelian disorders.

95 toderm (NNE) and Grhl2 loss results in fully penetrant cranial neural tube defects (NTDs) in mice.

96 x3(-/-) mutant mouse embryos display a fully-penetrant cranial NTD.

97 l that includes genes associated with highly penetrant CRCP syndromes in addition to Lynch syndrome g

98 genes and other genes associated with highly penetrant CRCP syndromes led to an average increase of 0

99 ated pexacerfont, an orally available, brain penetrant CRH1 antagonist for its ability to suppress st

100 ned and synthesized a highly selective brain-penetrant CSF1R inhibitor (PLX5622) allowing for extende

101 bryos lacking this enhancer display variably penetrant defects in anterior-posterior axis orientation

102 l patterns of inheritance and contain highly penetrant deleterious variation in specific genes.

103 ho are buffering the effects of rare, highly penetrant, deleterious mutations.

104 Psychotic illness in this highly penetrant deletion was associated with similar neuroanat

105 We did not find a highly penetrant detrimental impact of lifelong very low levels

106 or (GR)50 during development caused a highly penetrant developmental arrest, while post-developmental

107 and infection underlie FSGS; however, highly penetrant disease genes have been identified in a small

108 thmogenic cardiomyopathy (ACM) is a variably penetrant disease increasingly identified in young patie

109 stargeting alleles caused more severe (fully penetrant) disease.

110 BCL11A erythroid enhancer results in highly penetrant disruption of this motif, reduction of BCL11A

111 ests that achieving high affinity for a cell-penetrant druglike inhibitor might be challenging.

112 nary potential, however, relatively few anti-penetrant drugs have been developed to control fungal di

113 AD, who were affected carriers of the fully penetrant E280A mutation in the presenilin-1 (PSEN1) gen

114 ssion and loss of PHF6 combined caused fully penetrant early-onset leukemia.

115 , seip-1 Homozygous seip-1 mutants displayed penetrant embryonic lethality, which is caused by the di

116 c deficiency in mice resulted in a partially penetrant embryonic or perinatal lethal phenotype, with

117 We also discovered penetrant enhanced synaptic plasticity across mouse mode

118 until metaphase I but then display a highly penetrant failure to transition to anaphase I.

119 e mutation in titin as the cause of a highly penetrant familial cardiomyopathy with features of left

120 Z1-null mice, although viable, display fully penetrant female-specific lymphoproliferative disorder.

121 ms that are downstream targets of highly ASD-penetrant FMR1 and CHD8 genes are also heavily affected

122 sources in the brain when triggered by brain-penetrant focused ultrasound (FUS) through intact scalp

123 haploinsufficiency in these genes is highly penetrant for ASD and intellectual disability (ID).

124 1.2 microdeletions, a genetic variant highly penetrant for schizophrenia.

125 inding domain) missense mutations are highly penetrant for varied congenital heart defects, including

126 els in cells that lack centrioles led to the penetrant formation of de novo centrioles that gained th

127 tify healthy individuals resilient to highly penetrant forms of genetic childhood disorders.

128 neage-restricted progenitors to induce fully penetrant GBM using CNS progenitor-specific inducible Cr

129 3T-SNCA mouse model) were exposed to a brain-penetrant GCS inhibitor, GZ667161.

130 One-fourth of the non-penetrant gene carriers showed abnormalities on MRI.

131 ns of 269 symptomatic individuals and 19 non-penetrant gene carriers were assessed.

132 Because of the highly penetrant gene mutation and clinical features consistent

133 We thus used a CNS-penetrant generic medication used in hypertension, indap

134 he excess of inherited risk resides in lower-penetrant genes.

135 Specific highly penetrant genetic causes can often be shared by a subset

136 ed variants in BRCA2 as the most common high-penetrant genetic factor associated with pancreatic canc

137 py number variants are among the most highly penetrant genetic risk variants for developmental neurop

138 igation of neuroimaging biomarkers in highly penetrant genetic syndromes represents a more biological

139 ence can serve as a model to identify highly penetrant genetic variants in closely related individual

140 tudies enable researchers to identify highly penetrant genetic variants too rare to be tested in conv

141 g individuals with highly, but incompletely, penetrant genetic variants.

142 tified the first orally bioavailable and CNS penetrant glucagon-like peptide-1 receptor (GLP-1R) nonc

143 sought to identify structurally novel, brain penetrant, GluN2B-selective inhibitors suitable for eval

144 dings have resulted in an efficacious, brain-penetrant GPR52 agonist as a valuable pharmacological to

145 s-of-function alleles causes an incompletely penetrant, haploinsufficiency disorder.

146 harbors in-frame exon deletions in partially penetrant hereditary retinoblastomas and is known to imp

147 Highly penetrant hereditary thyroid cancer manifests as familia

148 ferin pairs emit light that is poorly tissue penetrant, hindering efforts to visualize targets in dee

149 Brain-penetrant histone deacetylase 6 inhibitors increase Hsp9

150 discovery of our first neuroprotective brain penetrant hit compound MPAQ (5c).

151 The fully penetrant homozygous mutant showed termination of cardia

152 cognised functional class that contribute to penetrant human disease, and demonstrate the power of la

153 ery of the highly potent and selective brain-penetrant hV1a antagonist RO5028442 (8) suitable for hum

154 In addition, we observed highly penetrant hydrocephalus, white spotting and soft tissue

155 ions in glioma highlights the need for brain-penetrant IDH1 mutant-selective inhibitors as an alterna

156 rst time the effect of a blood-brain barrier-penetrant IMPase inhibitor on human central nervous syst

157 auses embryonic defects, which are partially penetrant in an inbred strain but fully lethal in non-in

158 drug targets, and was bioavailable and brain-penetrant in mice.

159 esirable to advance a molecule which was CNS penetrant in order to treat brain metastases.

160 gene disruption, the phenotype appeared very penetrant in stable F1 fish.

161 ately selective, orally available, and brain-penetrant in wild-type mice, and confirmation of target

162 In the whole animal, ZCZ011 is brain penetrant, increased the potency of these orthosteric ag

163 ion levels to be significantly higher in the penetrant individuals.

164 Our model demonstrates that penetrant-induced plasticization of polymer chains parti

165 phyxiating thoracic dystrophy with partially penetrant inheritance.

166 t, highly selective, orally available, brain-penetrant inhibitor of LRRK2.

167 kout mice with a new, highly specific, brain-penetrant inhibitor of MAP kinase-interacting kinases re

168 hat disruption of 2-HG production with brain-penetrant inhibitors in IDH1 mutant gliomas may have sub

169 t for the design of a class of potent, brain penetrant inhibitors of T. brucei NMT.

170 al and DMPK properties to afford the non-CNS penetrant inverse agonist 22 (AZ-GHS-22) and the CNS pen

171 t inverse agonist 22 (AZ-GHS-22) and the CNS penetrant inverse agonist 38 (AZ-GHS-38).

172 d a novel series of aryl sulfonamides as CNS-penetrant, isoform-selective Na(V)1.6 inhibitors, which

173 heterozygous condition exhibited a partially penetrant late lethality.

174 ns in Tet2 and Flt3, which resulted in fully penetrant, lethal AML.

175 induced myeloid transformation, with a fully penetrant, lethal chronic myelomonocytic leukemia (CMML)

176 ic expression of TLX3 alone caused partially penetrant leukemia.

177 Aquaporin 4, EAAT2b), while others are quite penetrant (lipophilic molecules, Cx30, ZO-1, Occludin).

178 t LXR-623, a clinically viable, highly brain-penetrant LXRalpha-partial/LXRbeta-full agonist selectiv

179 low-clearance, orally bioavailable, and CNS-penetrant M1-selective PAM with minimal agonist activity

180 bolic infection state responsible for highly penetrant male-restricted hepatic carcinogenesis.

181 and that PDE4 inhibitors that are not brain-penetrant may have an improved safety profile.

182 Peripheral administration of the brain penetrant MC3/4R receptor peptide agonist, Melanotan II

183 erties, we selected the antihypertensive CNS-penetrant medication indapamide for investigation.

184 Atoh1 transgene expression developed highly penetrant medulloblastoma at a young age with extensive

185 deletion of Pten and Trp53 resulted in fully penetrant medulloblastoma originating from the perivascu

186 he SHH receptor gene Ptch1 resulted in fully penetrant medulloblastomas.

187 s in this model led to accelerated and fully penetrant melanomagenesis and synchronous tumor formatio

188 illness are not exclusively caused by highly penetrant Mendelian mutations, but can also be contribut

189 covery of a new, orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 (mGlu(7)) ne

190 murine intestinal epithelium leads to highly penetrant metastasis (100% metastasis; with >80% liver m

191 These studies describe a potent brain penetrant mGluR2 positive allosteric modulator (PAM), SA

192 lecular mechanisms of the most prevalent and penetrant microdeletion associated with neurodevelopment

193 t agonist delivered by a blood-brain barrier penetrant microglia-specific targeting nanocarrier we pr

194 inal epithelium and the effective killing of penetrant microorganisms, while suppressing the activati

195 Consistent with a fully penetrant model for these genes, we found no significant

196 With a CNS penetrant molecule, kinase selectivity is a key consider

197 loinsufficiency of the Shank3 gene (a highly penetrant monogenic autism risk factor), which exhibits

198 domains 3 (SHANK3) gene represents a highly penetrant, monogenic risk factor for autism spectrum dis

199 As brain-penetrant MT-stabilizing agents have proven effective ag

200 tly, administration of Epothilone D, a brain-penetrant MT-stabilizing natural product, was found to r

201 y is sufficient for the development of fully-penetrant, multifocal carcinomas, closely mimicking huma

202 nd elucidate mechanisms through which highly penetrant, multigene copy number variants contribute to

203 rs, a heterozygous, nonsynonymous, and fully penetrant mutation (p.

204 on because affected individuals, but not non-penetrant mutation carriers, have a greater reduction of

205 ease caused by an autosomal dominant, highly penetrant mutation in the presenilin-1 (PSEN1) gene, and

206 Rare fully penetrant mutations in AKT2 are an established cause of

207 ic disorders - whether caused by rare highly penetrant mutations or sporadic forms - and holds promis

208 e of these families there may be rare highly penetrant mutations that segregate with illness.

209 chments in genes known to harbor rare highly penetrant mutations.

210 n that AIRAPL-deficient mice develop a fully-penetrant myeloproliferative neoplastic process.

211 Existing strategies that use tissue-penetrant near-infrared light for the targeted treatment

212 d succumb to a rapidly progressing and fully penetrant neonatal myeloid disease.

213 d delivers neurotensin, an otherwise non-BBB-penetrant neuropeptide, at levels capable of modulating

214 n CDH1 mutation-positive families, including penetrants, non-penetrants or non-carriers for NSCLP.

215 s regard, we evaluated the effect of a brain-penetrant, novel multifunctional dopamine D2/D3 agonist,

216 entify a significant cellular effect of rare penetrant NRXN1 mutations in human neurons, which was fo

217 ntral motor neurons, resulting in completely penetrant NT defects, while excision after embryonic day

218 Mutant embryos develop partially penetrant NTDs while surviving mice exhibit post-natal f

219 ead to give 18 (SBI-553), a potent and brain penetrant NTR1 allosteric modulator.

220 orders that are also characterized by highly penetrant obesity, a major additional risk factor, is un

221 disease, heterozygous mutations cause highly-penetrant obesity.

222 positive families, including penetrants, non-penetrants or non-carriers for NSCLP.

223 CNS targets and classified as either "brain penetrant" or "peripherally restricted" on the basis of

224 eries of highly potent, selective, and brain-penetrant oxazole-4-carboxamide-based inhibitors of glyc

225 yridines that are potent and selective brain penetrant P2X7 antagonists are described.

226 BKM-120 is a CNS-penetrant pan-class I phosphatidyl-inositol-3 kinase (PI

227 Over 200 rare and fully penetrant pathogenic mutations in amyloid precursor prot

228 per eye compared with those with known high-penetrant pathogenic variants and are more likely to rem

229 Over 200 highly penetrant pathogenic variants in the genes APP, PSEN1, a

230 autosomal genes as well as into the variably penetrant pathophysiological spectrum of phenotypes obse

231 ceptor-mediated transcytosis using the brain-penetrant peptide Angiopep-2 (An2), which targets LDL re

232 the anterior hypothalamus results in a fully penetrant phenotype characterised by a complete arrest o

233 These mice displayed a fully penetrant phenotype characterized by growth enhancement

234 deletion of ZFP57 in mice presents a highly penetrant phenotype with no animals surviving to birth.

235 oid for Pals1) in nephrons developed a fully penetrant phenotype, characterized by cyst formation and

236 ghts into the genetic mechanism for a highly penetrant phenotype.

237 d micrognathia, thus recapitulating the most penetrant phenotypes of the syndrome.

238 NA loss-of-function rarely results in highly penetrant phenotypes, but rather, influences cellular re

239 Our data suggest the CNS-penetrant PI3K inhibitor BKM-120 may have anti-invasive

240 ockin model, in which we demonstrated highly penetrant, pleiotropic cardiac anomalies.

241 These phenotypes lead to nearly 100%-penetrant pollen degeneration upon anther maturation.

242 t-specific deletion of Lkb1 results in fully penetrant polyposis in mice.

243 Dicer1 (S1836D/S1836D) mice display highly penetrant postnatal lethality, and the few survivors dis

244 MYC activation results in highly penetrant pRCC tumours (MYC), while MYC activation, when

245 isease [KD]), a central nervous system (CNS)-penetrant protective agent rescued myelin and oligodendr

246 dominant-negative) form of a rare but highly penetrant psychiatric risk factor, Disrupted-In-Schizoph

247 Following the discovery of cell penetrant pyridine-4-carboxylate inhibitors of the KDM4

248 We identify highly penetrant rare mutations in 16% of familial CRC.

249 In addition to well known, highly penetrant rare mutations that cause mendelian disorders

250 A fully penetrant recessive 4-bp deletion was identified in the

251 eveloped more severe pyelonephritis and 100% penetrant renal abscess (a complication that is rare in

252 MCRPE is an autosomal dominant, fully penetrant retinal dystrophy with a preclinical stage, an

253 ions contribute to the etiology of partially penetrant retinoblastomas.

254 utations in established moderately or highly penetrant risk genes for breast cancer (BC) and/or ovari

255 Rare, highly penetrant risk genes such as the 22q11.2 microdeletion a

256 Individuals with rare and more penetrant risk variants are often intellectually disable

257 This extreme phenotype likely harbors highly penetrant risk variants, making it primed for discovery

258 essing (Myf5-expressing) cells develop fully penetrant sarcomagenesis, suggesting skeletal muscle pro

259 xplored the impact of one of the most highly penetrant schizophrenia risk genes, DISC1, upon the medi

260 hosphoinositide 3-kinase (PI3K), have highly penetrant secretion of autoreactive IgM antibodies.

261 Systemic administration of a brain-penetrant selenopeptide activates homeostatic transcript

262 s neurodegenerative disorder caused by fully penetrant single gene mutations in a minority of cases,

263 ed risk stratification utility of common low penetrant single nucleotide polymorphisms (SNPs) and epi

264 onditional gene targeting to develop a fully penetrant small animal model of this disease that recapi

265 ological stabilization of p53 with the brain-penetrant small molecule idasanutlin resulted in synthet

266 There is an urgent need for new, brain penetrant small molecules that target the central nervou

267 ize the discovery of highly selective, brain-penetrant, small molecule p38alphaMAPK inhibitors that a

268 issing exon 3, suggestive of an incompletely penetrant splice defect.

269 ammatory gene expression, and enabled highly penetrant spontaneous pulmonary metastasis.

270 e common risk variants and rarer more highly penetrant submicroscopic chromosomal deletions and dupli

271 tors, although orally bioavailable and brain-penetrant, suffer from unfavorable off-target binding to

272 t disease-causing BMPR2 mutation is only 20% penetrant, suggesting that genetic variation provides mo

273 terozygous embryos exhibited an incompletely penetrant syndrome of CHDs with heterotaxy.

274 ng the basis of microcephaly in AS, a highly penetrant syndromic feature with early postnatal onset,

275 hin 6 mo, Nbn (-/mid8) mice developed highly penetrant T cell leukemias.

276 Minocycline, a centrally-penetrant tetracycline antibiotic, inhibits microglial a

277 h longer half-life and to be much more brain penetrant than SKA-121, not only lowered blood pressure

278 scribed, many of which are likely to be less penetrant than the currently known genes.

279 ive on ALK-dependent cell lines, efficiently penetrant the blood-brain barrier (BBB) in different ani

280 source for rational development of new brain-penetrant therapeutics and for advancing understanding o

281 roliferation as well as invasion, with brain penetrant therapies.

282 Lorlatinib is a potent, brain-penetrant, third-generation tyrosine kinase inhibitor (T

283 Free-volume of polymers governs transport of penetrants through polymeric films.

284 gesting that molecules do not need to be CNS-penetrant to block these receptors.

285 es are nonimmunogenic, are freely and deeply penetrant to human OA cartilage, and persist in chondroc

286 ies of PQR620 (52), the first-in-class brain penetrant TORKi showing efficacy in a TSC mouse model.

287 o identify a highly potent, selective, brain penetrant TORKi.

288 ence that systemic administration of a brain-penetrant TrkB antagonist (tat-cyclotraxin-B) reduces se

289 show that systemic administration of a brain-penetrant TrkB antagonist leads to brain region-specific

290 The completely penetrant tumors were indistinguishable from human ASPS

291 Remarkably, the mice develop highly penetrant tumours with OCCC-like histopathology, culmina

292 al triplications cause a frequent and highly penetrant type of autism linked to increased gene dosage

293 Here we used brain penetrant tyrosine kinase inhibitors (TKIs), including n

294 discovery of a potent, selective, and brain-penetrant V1a receptor antagonist, which was not suitabl

295 m of frequency and effect, from rare, highly penetrant variants to common risk alleles with small eff

296 al appearances, but may still represent less penetrant variants.

297 e sequencing to probe for other rare, highly penetrant variants.

298 c for evaluating vaccine responses to highly penetrant viruses with cross-reactive serotypes.

299 4 aa) that are proteolytically stable, brain penetrant when administered intraperitoneally, neuroprot

300 It is orally bioavailable and brain penetrant with robust preclinical efficacy.