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1 oligomeric states, KcsA (tetramer) and CorA (pentamer).
2 he gH/gL/UL128/UL130/UL131 (gH/gL/UL128-131) pentamer.
3 sts at least one alpha1-alpha1 interface per pentamer.
4 erized soluble forms of gH/gL, gH/gL/gO, and Pentamer.
5 h allowed the direct visualization of an SLN pentamer.
6 351 in gH/gL/gO and with UL128-Cys162 in the Pentamer.
7 the same as well as additional sites on the pentamer.
8 suggest that it functions as a tetramer or a pentamer.
9 tramer formation, as an E120A mutant forms a pentamer.
10 r C) relative to the first nucleotide of the pentamer.
11 on when compared with the isolated terminase pentamer.
12 ognition in the context of the phospholamban pentamer.
13 GFP or red autofluorescent protein and a GFP pentamer.
14 ins recapitulate the structure of the native pentamer.
15 elly-roll core) associate with a neighboring pentamer.
16 o that observed following depletion with the pentamer.
17 omeric PLN and storage of PLN as an inactive pentamer.
18 intrinsic signals to segregate into distinct pentamers.
19 ilt of 36.1-36.6 degrees between consecutive pentamers.
20 oups, with lower accumulation of trimers and pentamers.
21 assembled in vitro from bacterially produced pentamers.
22 otide, and multiple additions of GUCCA>p RNA pentamers.
23 is closed by incorporating 12 capsid-protein pentamers.
24 14S particles have long been presumed to be pentamers.
25 teraction sites along the interfaces between pentamers.
26 S particles are 488 kDa, confirming they are pentamers.
27 terminal domains of Npm2 and Np form similar pentamers.
28 served residues in the interface between two pentamers.
29 f replication by binding repeating G(A/G)GGC pentamers.
30 ectrostatic switch that favors hexamers over pentamers.
31 ctrostatic switch that favours hexamers over pentamers.
32 two GTPCH feedback regulatory protein (GFRP) pentamers.
33 viral epitope at the junction between capsid pentamers.
34 lattice of capsid protein (CA) hexamers and pentamers.
35 lpha-helix form salt bridges in hexamers and pentamers.
36 ly asymmetric structure made of hexamers and pentamers.
37 se that L1 protein is present in the form of pentamers.
38 hloroform) and a subsequent self-assembly of pentamer 1 into larger aggregates (in 80% methylcyclohex
39 synthetic protocol toward a merocyanine (MC) pentamer 1 which represents the first merocyanine oligom
43 n particular the noncovalent complexes up to pentamers (332 kDa) destroyed in FAIMS and not detected
44 A binding sequence is split into overlapping pentamers (5 base pairs) for calculating transcription f
45 As the arms of the stargate grow from the pentamer, a rough disk the diameter of a capsid thickens
49 ow that the Z-alpha1AT trimer, tetramer, and pentamer all form ring-like structures in strong support
50 by a 216S peak that was observed to contain pentamers among lipid debris in negatively stained grids
51 C heat-labile toxin (LTB) in lieu of the CTB pentamer and a donor strand truncation (dsc(14)) of CfaE
52 architectural element of the CA hexamer and pentamer and as a mechanistic element for generating lat
53 ce running along the 'top' surface of a DdrB pentamer and continuing down between two individual subu
55 ric organization of P1-P2 in the human stalk pentamer and functional non-equivalence of the individua
59 ates in intersubunit interactions in the CRP pentamer and is buried, to Gln resulted in a CRP mutant
62 l structure of Gemin2 bound to SmD1/D2/F/E/G pentamer and SMN's Gemin2-binding domain, a key assembly
63 mics simulations provided models for the SLN pentamer and the novel interaction between SERCA and an
66 cella spp. (BLS) is a highly stable dimer of pentamers and a scaffold with enormous plasticity on whi
67 hysiological partner locked Npm-N in ordered pentamers and counteracted the effects of phosphorylatio
70 ular interactions that allow CA to form both pentamers and hexamers and show how invariant pentamers
71 ns with variant single jelly-roll folds form pentamers and hexamers which assemble into a T = 43 icos
74 d, AIM is stabilized by association with IgM pentamers and maintains its high circulating levels.
75 the relative quantities of monomers, dimers, pentamers and octamers in the C-S-H structure are measur
77 entamers and hexamers and show how invariant pentamers and structurally plastic hexamers associate to
79 cently determined structure of the human IgM pentamer, and how this interaction could affect parasite
80 active site of SubA is not occluded by the B-pentamer, and the B-pentamer does not enhance or inhibit
81 t does not bind Ca(2+) at low pH and forms a pentamer, and the transition from tetramer to pentamer i
83 ays that favor the rapid incorporation of CA pentamers, and leads to increased structural pleomorphis
85 at both Kmer-Sum and PWM stacking in the new pentamer approach along with a simplified integrative en
91 lexes gH/gL/gO and gH/gL/UL128/UL130/UL131A (Pentamer) are key targets of the human humoral response
93 gH-gL-gO trimer and gH-gL-UL128-UL130-UL131A pentamer), as well gH-gL and the fusion protein gB, whic
94 the periplasmic space of E. coli as soluble pentamers, as confirmed by multiangle light scattering a
95 he resulting receptors functionally resemble pentamers assembled with two copies of alpha4 and three
96 Structures of disulfide-linked hexamer and pentamer assemblies, as well as structures of the isolat
97 nicotine was present during, but not after, pentamer assembly and was caused by increased stability
98 We also show that a model of the hexamer/pentamer assembly can be readily generated with a single
100 sidues lining the 5-fold pore did not affect pentamer assembly or prevent association with the VP2 mi
101 ion in which higher-order assemblies of DdrB pentamers assist in the pairing of complementary ssDNA u
104 ures of two relevant complexes: a THO hetero-pentamer bound to Sub2 at 6.0 A resolution; and Sub2 ass
105 , the asymmetrical hexamer would appear as a pentamer by cryo-EM, a technology that acquires the aver
106 this vaccine did not express the gH/gL-based pentamer complex (PC) and failed to fully protect agains
107 ng the human cytomegalovirus (HCMV) envelope pentamer complex (PC) are thought to be important for pr
108 zing antibodies (NAb) targeting the envelope pentamer complex (PC) composed of the subunits gH, gL, U
109 tomegalovirus (GPCMV) encodes a glycoprotein pentamer complex (PC) for entry into non-fibroblast cell
111 he gH/gL/gO or the gH/gL/UL128/UL130/UL131A (Pentamer) complex has been found to fulfill this role, a
112 ll types, while the gH/gL/UL128/130/131a (gH-pentamer) complex imparts specificity in infecting epith
113 veals that the mAbs bind to gH-trimer and gH-pentamer complexes and identify the antibodies' epitope
114 The gH/gL/gO and gH/gL/UL128/UL130/UL131 (Pentamer) complexes play a key role in HCMV cell entry a
119 ed to coat-coat protein interactions between pentamers, constitute the primary lattice-forming contac
120 experimental support for the hypothesis that pentamers containing a central helical bundle, observed
121 n patterns established that sequence-defined pentamers containing imidazole or pyrrole groups in spec
124 the tetramer crystallized at neutral pH, the pentamer crystallized at low pH, suggesting that prefere
125 the well-studied raft marker cholera toxin B pentamer (CTxB) that binds up to five GM1 glycosphingoli
126 n several surfaces suggests that the octamer-pentamer defect motif acts as a flexible strain relief m
127 ization with epithelial cell-tropic DB or gH pentamer-deficient DB preparations, (v) UV-inactivated r
128 copies of the NFS1-ISD11-ACP-ISCU-FXN hetero-pentamer, delineates the interactions of FXN with other
129 nges of a short repeat, [VPGVG]5, an alanine pentamer, desmosine, and isodesmosine sites with and wit
130 the synthesis of the butadiyne-linked cyclic pentamer, despite the fact that the radii of their N5 do
133 is not occluded by the B-pentamer, and the B-pentamer does not enhance or inhibit the activity of Sub
134 e densities are crucial for the formation of pentamers, driven by cyclic hydrogen bonding between car
135 ave been able to directly visualize SV40 VP1 pentamers encapsidating short RNA molecules (500mers).
137 lations show that hIAPP forms from trimer to pentamer exhibit high structural stability with well-pre
138 in cells compared to a BTA monomer, with the pentamer exhibiting a 65-fold improvement in efficacy co
139 rinsically disordered tail domains of two NP pentamers, facing each other through their distal face,
140 omer at its alpha-helical conformation and a pentamer fibril fragment of Abeta(42) peptide with or wi
141 transient low oligomeric states of receptor pentamers, followed by partial unfolding of helical part
145 These data are consistent with gH/gL/gO and Pentamer forming mutually exclusive cell entry complexes
147 ily of histone chaperones is identified by a pentamer-forming domain and multiple acidic tracts that
148 tameric TSP-4, but neither TSP-5/COMP of the pentamer-forming subgroup B nor TSP-2 of the trimer-form
153 fied CyPs facilitated the dissociation of L1 pentamers from recombinant HPV11 L1/L2 complexes in a pH
155 ingle polycistronic vector encoding the five pentamer genes separated by "self-cleaving" 2A peptides
160 results reveal a regulatory role of the PLN pentamer in calcium homeostasis, going beyond the previo
163 re-fibrillar tetramer form and the fibrillar pentamer in the Abeta40 aggregation landscape disappears
164 or understanding the important role of the B-pentamer in the assembly and the intracellular trafficki
165 constructed in total nine different receptor pentamers in at least two different ways and expressed t
166 long with increased alpha2beta1gamma1 GABAAR pentamers in hippocampal slices using cell-surface cross
167 tein products, and assembly of protomers and pentamers in infected M1-D macrophages did not differ fr
170 n type 3A (5-HT3A) ICD assembles into stable pentamers in solution in the absence of the other two do
174 en followed to synthesize a second series of pentamers in which the Tz group is used as a pi-conjugat
175 ion, Gemin2 wraps around the crescent-shaped pentamer, interacting with all five Sm proteins, and gri
177 ivated catalytic site and confirmed that the pentamer interactions are essential for productive catal
179 u15(SR)13 model features a cyclic [Au(I)-SR] pentamer interlocked with one staple trimer motif protec
180 ex vivo used human leukocyte antigen class I pentamers, intracellular cytokine staining, and fine map
181 ade of elongation reactions in which one VP1 pentamer is added at a time, with a rate of approximatel
182 ilt angle difference between the monomer and pentamer is approximately 13 degrees , showing that intr
183 amily; (iv) a molecular docking model of the pentamer is compatible with the location of the identifi
184 nfection of fibroblasts, and the gHgLpUL128L pentamer is required for infection of endothelial, epith
185 mains associated with SERCA and that the PLN pentamer is required for the regulation of cardiac contr
187 We find that when Mg(2+) is present, the pentamer is stabilized by the putative gating sites (M1/
189 A is also demonstrated, and the formation of pentamers is shown to be highly sensitive to local curva
190 ns and restoration of gH/gL/UL128-UL131A (gH pentamer), (iv) equivalent neutralizing antibody titers
191 ts core, the CCD of human strain ST3 forms a pentamer lacking the bound Ca(2+) despite the residues (
195 Here, we demonstrate that both trimer and pentamer NAbs are frequently found in human transplant p
196 p)UL128, pUL130, and pUL131 (the gHgLpUL128L pentamer) neutralized HCMV infection with high potency.
198 e, three-fourths-complete capsid lacking one pentamer of capsomers and a free, stable pentamer were o
199 ds missing one capsomer, capsids missing one pentamer of capsomers, and free pentamers of capsomers)
200 sults reveal a stoichiometry consisting of a pentamer of ExbB, a dimer of ExbD, and at least one TonB
201 ugh it is generally accepted that eIF2B is a pentamer of five non-identical subunits (alpha-epsilon),
202 astest and most powerful packaging motors, a pentamer of gp17 that translocates DNA at a rate of up t
209 ascent Shigella T3SA needle is topped with a pentamer of the needle tip protein invasion plasmid anti
212 amer that sandwiches DNA between two helical pentamers of ATP-associated AAA+ domains, sharply bendin
213 quentially added to the growing capsid, with pentamers of building blocks and incomplete capsids miss
214 missing one pentamer of capsomers, and free pentamers of capsomers) had been predicted in theoretica
215 atalytic large subunits (LSu) assembled into pentamers of dimers, (L2)5, and differs from Rubiscos fr
217 rimentally tested this prediction, using the pentamers of SH3 domains and proline-rich motifs (SH3(5)
218 formed by approximately 250 hexamers and 12 pentamers of the CA protein is delivered to the cytoplas
219 psid is an icosahedral lattice comprising 72 pentamers of the major capsid protein (L1) and the assoc
222 iruses with capsids composed primarily of 72 pentamers of the viral VP1 protein, which forms the oute
223 ent decamer in solution, consistent with the pentamer-of-dimers assembly seen crystallographically.
224 l-atom models for the hexamer-of-hexamer and pentamer-of-hexamer elements as well as for the entire c
225 ed stable complexes of crenezumab with Abeta pentamer (oligomer model) and 16-mer (fibril model).
226 cages from a previously favored trimer to a pentamer or hexamer, and another from a trimer to a much
228 cerevisiae Fpr4, share the NPL fold and form pentamers, or a dimer of pentamers in the case of HD2.
229 c MC subunits (in chloroform) up to the full pentamer pai-stack (in 75% methylcyclohexane/25% chlorof
230 c strength or temperature to form 5.8-MDa 12-pentamer particles, indistinguishable from native empty
231 sidues 69-71 and 193-197 of VP3 spanning the pentamer-pentamer interface, and another region incorpor
233 ow how the hydrophobic patch on top of the B-pentamer plays a dominant role in binding the A-subunit.
234 ial lines, in that gH/gL/UL128/UL130/UL131A (pentamer)-positive strains can infect and replicate, whi
235 8(+) epitopes were defined, with peptide-MHC pentamer-positive cells displaying the central and effec
236 structure observed in the four copies of the pentamer present in the asymmetric unit has been used to
237 iometry to low sensitivity (alpha4)3(beta2)2 pentamers primarily through this interaction in the endo
238 nd are arranged in the capsid in consecutive pentamers related by a translation along the main viral
239 ssembly of the quasi-equivalent hexamers and pentamers requires remarkably subtle rearrangements in s
241 The X-ray crystal structure of an Ns1tbe pentamer revealed an all-cis PPI helix, and the CD curve
243 Interestingly, alpha2 was crystallized as a pentamer, revealing the intersubunit interactions in a w
246 through a novel RNA motif consisting of the pentamer sequence AGCCC with sequence restrictions at po
247 H(R)-CH2-NH-CO- residue in a model oligourea pentamer sequence was replaced by guest units bearing va
248 of CD3/CD8/PD-1/Tim-3, HSV-1, CD8(+) T cell pentamer (specific for a peptide derived from residues 4
251 orrelation between the titers of trimer- and pentamer-specific NAbs and transmission of HCMV from mot
253 e overall location of gH/gL-, gH/gL/gO-, and Pentamer-specific neutralizing antibody binding sites.
254 bilizing annulus was seen, instead the intra-pentamer stability comes from the interaction of VP4C an
256 ke other viruses of Picornavirales, no intra-pentamer stabilizing annulus was seen, instead the intra
257 CS) (CD107a, IFN-gamma, TNF-alpha and IL-2), pentamer staining and T-cell phenotyping were used to di
260 (V49A) had particularly large effects on PLB pentamer structure and PLB-SERCA regulatory complex conf
261 time frame, gamma peptides derived from the pentamer subunits are produced and are organized in a ve
262 to gB or gH/gL but also by antibodies to the pentamer, suggesting a potential role for the pentamer i
263 e, the first structural view of gH/gL/gO and Pentamer supporting the development of vaccines and anti
264 utively secreting high levels of recombinant pentamer that displayed the functional antigenic sites t
266 esent ideas on the possible positions in the pentamer that may be occupied by the alpha5 subunit, and
268 rfacing array of capsid protein hexamers and pentamers that are recognized by numerous cellular prote
270 llection of oligomers, including trimers and pentamers, that ultimately matures into amorphous aggreg
271 le the closed state structure is a symmetric pentamer, the open state displayed unexpected asymmetric
273 xperiments, we then demonstrate that, in the pentamer, three anaesthetic-sensitive rho1 subunits are
274 forming LS from Aquifex aeolicus (AaLS) into pentamers through a small number of rationally designed
276 ced an antibody immune response to the viral pentamer to enhance virus neutralization on non-fibrobla
277 Higher-order oligomeric models (ranging from pentamer to octamer), built by incremental addition of p
278 as been that the studies did not compare the pentamer to the other major form of gH/gL, the gH/gL/gO
286 TM protein structures ranging from dimers to pentamers, we show that our method predicts structures t
289 ncluding glycoprotein B (gB), gH/gL, and the pentamer, were evaluated for their effects on viral entr
290 asmic loop is vital for the integrity of the pentamer when Mg(2+) is absent from the M1/M2 sites.
291 red over its prefibrillar counterpart in the pentamer where an interconversion bottleneck appears.
293 al or human sera were found to recognize the pentamer, which mediates HCMV entry into endothelial and
294 forms highly unusual cyclic hydrogen-bonded pentamers, which combine with simultaneously formed FcCO
295 etry showed that nicotine favors assembly of pentamers with (alpha3)2(beta4)3 stoichiometry; these ar
298 mer of E1/E2 may be further assembled into a pentamer, with 12 pentamers comprising a single HCV viri