ライフサイエンスコーパス: pentapeptide

1 e (GlcNAc-MurNAc(pentapeptide)-GlcNAc-MurNAc(pentapeptide)).

2 pentapeptide and 1,6-anhydro-N-acetylmuramyl pentapeptide).

3 pproximately P, and is inhibited by the PhrC pentapeptide.

4 bly serve as a flexible tether for the NWETF pentapeptide.

5 y about half of the deuteriums of the parent pentapeptide.

6 tion and biogenesis of a cyclical AgrD-type, pentapeptide.

7 constant (Kd) of 11 microM observed with the pentapeptide.

8 inct from, its natural substrate, UDP-MurNAc-pentapeptide.

9 hosphate moiety of C35-P on bound UDP-MurNAc-pentapeptide.

10 onformational change when binding UDP-MurNAc-pentapeptide.

11 precursor UDP-N-acetylmuramic acid (MurNAc)-pentapeptide.

12 , its DNA operator, and repressor UDP-MurNAc-pentapeptide.

13 boxypeptidase, which hydrolyzes both di- and pentapeptide.

14 NRPSs is L-pHPG-L-Arg-D-pHPG-L-Ser-L-pHPG, a pentapeptide.

15 , in contrast to the other characterized Phr pentapeptides.

16 and AmiB either have no preference or prefer pentapeptides.

17 l wall proteins with tandemly repeated PPVYK pentapeptides.

18 nd tripeptides, and Fmoc-modified tetra- and pentapeptides.

19 vs. 71% of glutathione and up to 93% for the pentapeptides.

20 predict reliably the sensing ability of the pentapeptides.

21 e significantly more potent than the acyclic pentapeptide 1.

22 alasin D, zygosporin E, hirsutatin A, cyclic pentapeptides #1-2 and xylariotide A were also character

23 The tetrapeptide 1 and pentapeptide 2 are alpha-ketoamide-type HCV serine prote

24 Most significantly, the pentapeptides (21-23) were much better inhibitors (K(i)

25 t but with two hydrophobic residues made the pentapeptide a poor inhibitor.

26 involve the synthesis of UDP-n-acetylmuramyl pentapeptide, a key precursor molecule required for the

27 ically reacted with the lysine of UDP-MurNAc-pentapeptide, a peptidoglycan precursor used by the amin

28 phanamide (NATA), a tripeptide: AWA, and six pentapeptides: AAWAA, WVSGT, GYWHE, HEWTV, EAWQE, and DY

29 derived from the partitioning of host-guest pentapeptides (Ac-WLXLL) into the interfaces of phosphat

30 ide side chains of muropeptide subunits, and pentapeptides act as donors for cross-linking adjacent s

31 We hypothesized that the novel pentapeptide (ADH-1), which disrupts N-cadherin adhesion

32 The first two amino acids of the pentapeptide adopt a limited number of conformations.

33 The pentapeptide alpha-ketoamides of type 1 were weak HCV in

34 ium supplementation with the mature cyclical pentapeptide also inhibits bacterial growth.

35 The pentapeptide also interfered with prothrombin cleavage b

36 l-valyl-N-methylvalyl-prolyl-proline (P5), a pentapeptide also present in dolastatin 15 and cemadotin

37 transition states to form native tetra- and pentapeptide analogues was studied on S-acylcysteine pep

38 cetylglucosamine-1,6-anhydro-N-acetylmuramyl pentapeptide and 1,6-anhydro-N-acetylmuramyl pentapeptid

39 ounds increased, to a maximum of 95% for the pentapeptide and 56%, 57% and 45% for the dipeptide, rib

40 /M22K) exhibits enhanced HX within the CXXCH pentapeptide and a modest increase in Em (by 30 mV).

41 spectral signatures begin to converge at the pentapeptide and become almost the same for the octa- an

42 agments concomitantly with the appearance of pentapeptide and dipeptide peptidoglycan fragments and h

43 The pentapeptide and Hao-containing peptide strands are conn

44 ence enhancement using dansylated UDP-MurNAc-pentapeptide and heptaprenyl phosphate (C35-P, short-cha

45 xible arm allowing dual binding of enzyme to pentapeptide and modification site.

46 rsor, Lipid I, from UDP-N-acetylmuramic acid-pentapeptide and the lipid carrier, undecaprenol phospha

47 ould be inhibited by an octanoylated ghrelin pentapeptide, and its potency was enhanced 45-fold when

48 the GLP-1 receptor might be mediated by the pentapeptide, and the previously reported nonapeptide (F

49 APS approach is first applied to the alanine-pentapeptide, and the results are tested against an expl

50 assembly line reconstitution of pacidamycin pentapeptide antibiotic scaffolds, bridging the primary

51 Pacidamycins are a family of uridyl tetra/pentapeptide antibiotics that act on the translocase Mra

52 Pacidamycins are a family of uridyl tetra/pentapeptide antibiotics with antipseudomonal activities

53 All exchangeable hydrogens on this pentapeptide are first deuterated by dissolving it in de

54 mixture in which the muramyl residue and the pentapeptide are modified singly and in combination.

55 Pentapeptides are linked to the conserved body of chemor

56 Pentapeptides are more effective than tetrapeptides.

57 Phr pentapeptides are produced by cleavage of their precurso

58 The Phr pentapeptides are secreted with a pro domain that is cle

59 flippases thought to shield the disaccharide-pentapeptide as it crosses the hydrophobic core of the m

60 taxis by Escherichia coli require a specific pentapeptide at the chemoreceptor carboxyl terminus.

61 additional amino acids extending beyond the pentapeptide at their carboxyl termini and assayed methy

62 -borne pentapeptide implied linker (i) makes pentapeptide available to modification enzymes by separa

63 Herein, we present a library of cyclic pentapeptides, based on our previously reported peptide

64 to afford peptidic derivatives for exploring pentapeptide-based hydrogels as potential biomaterials.

65 lic peptides that fold in water to present a pentapeptide beta-strand along one edge; the other edge

66 Pentapeptide binding enhances enzyme action, an enhancem

67 ion in T. maritima occurs independently of a pentapeptide-binding motif.

68 ganisms having MCPs that contain and/or lack pentapeptide-binding motifs identified key similarities

69 been inserted at positions i and i+3 of the pentapeptide Boc-(R)-Aic(NN)-(Ala)2-(R)-Aic(NN)-Ala-OMe

70 eight substrates, based on variation of the pentapeptide Boc-l-Ala-gamma-d-Glu-l-Lys-d-Ala-d-Ala, we

71 The pentapeptide branches in S. sciuri were composed of one

72 The assembly of PG requires disaccharide-pentapeptide building blocks attached to a polyisoprene

73 oteinogenic amino acids, proteolysis of this pentapeptide by trypsin yields two fragments from cleava

74 impact of properties of the Cys-X-X-Cys-His pentapeptide c-heme attachment (CXXCH) motif on heme red

75 pid I, indicating a strict specificity for a pentapeptide chain length.

76 binds the terminal d-alanine residue of the pentapeptide chain of bacterial peptidoglycan, resulting

77 I at the pyrophosphate and C-terminus of the pentapeptide chain.

78 nformation to the RGD sequence of the cyclic pentapeptide cilengitide when bound to integrin alpha(V)

79 We concluded, therefore, that pentapeptide CN-105 improved short- and long-term neurob

80 to the complete cytochrome c oxidase cyclic pentapeptide cofactor.

81 e-containing muramyl tetra- (compound 5) and pentapeptide (compound 6) showed that these compounds ha

82 P)-Ialpha with the lysine-containing muramyl pentapeptide (compound 6).

83 ompounds that contained only a stem peptide (pentapeptide, compound 1) and (DAP-PP, compound 2) as we

84 A truncated pentapeptide conjugated to 4-methyl hexanoic acid, havin

85 ic anti-dsDNA antibodies also recognizes the pentapeptide consensus sequence D/E W D/E Y S/G (DWEYS)

86 glycine generating enzyme (FGE) recognizes a pentapeptide consensus sequence, CxPxR, and it specifica

87 GOAT also transferred [(3)H]octanoyl to a pentapeptide containing only the N-terminal five amino a

88 and applied in the preparation of cyclic aza-pentapeptides containing the RGD (Arg-Gly-Asp) sequence.

89 The tumor-homing pentapeptide CREKA (Cys-Arg-Glu-Lys-Ala) specifically ho

90 cting cleavage of one of the B. subtilis Phr pentapeptides, CSF, from the proCSF precursor.

91 The largest response was obtained for the pentapeptides Cys-Ile-His-Asn-Pro and Cys-Ile-Gln-Pro-Va

92 ed a high-fat diet was accomplished with the pentapeptide cysteine-arginine-glutamic acid-lysine-alan

93 ce of two distinct classes of CheR proteins: pentapeptide-dependent and pentapeptide-independent meth

94 m is more common than the well-characterized pentapeptide-dependent methylation system.

95 A total of 6 of these 18 pentapeptide derivatives--1N, 2N, 3F, 3P, 3N, and 5P--fa

96 eratures, and that interaction with an MEEVD pentapeptide derived from Hsp90 stabilises a folded stru

97 vercrowding via the release of a fratricidal pentapeptide derived from the metabolic enzyme glucose-6

98 R, a transcription regulator that requires a pentapeptide derived from the papR gene product for bind

99 lic beta-sheet components 1a and 1b comprise pentapeptides derived from the N- and C-terminal regions

100 produce a fusion containing a zwitterionic, pentapeptide designed from Bax inhibiting peptide (Ku70)

101 In addition, cell permeable pentapeptides designed from Ku70, termed Bax-inhibiting

102 A pentapeptide, DFNKF, derived from human calcitonin and i

103 resulting naphthylalanine-substituted cyclic pentapeptides displayed variable mixed-efficacy profiles

104 t the concomitant binding of both UDP-MurNAc-pentapeptide-DNS and C35-P to the enzyme is required bef

105 ibodies to target antigens such as dsDNA and pentapeptide DWEYS.

106 We have also employed a synthetic sulfated pentapeptide (DY(SO(3)(-))DY(SO(3)(-))Q, designated D5Q1

107 Our data demonstrate that pentapeptide DYDYQ has opposing effects on membrane-boun

108 For the pentapeptides, EAWQE has a fluorescence intensity that i

109 th squaramate-RNA and unprotected UDP-MurNAc-pentapeptide efficiently inhibited FemXWv .

110 We have shown previously that a pentapeptide encompassing amino acid sequence 695-699 fr

111 for the approximately d-Ala-d-Ala moiety of pentapeptides engaged in cross-links in the bacterial ce

112 nstrated that an impermeable fluoresceinated pentapeptide enters the cytoplasm and nucleus of COS 7 c

113 exogenous enzymes were able to hydrolyse the pentapeptide epitopes effectively.

114 inidin concentration (P < 0.05), whereas the pentapeptide epitopes hydrolysis was influenced only by

115 luten peptides (synthetic 33-mer peptide and pentapeptide epitopes) under static simulated gastrointe

116 DGAT1 and DGAT2 contain a similar C-terminal pentapeptide ER retrieval motif, this motif alone is not

117 t of substrates: vitamin K hydroquinone, the pentapeptide FLEEL, and NaHCO(3), on the stability of th

118 Our rapidly assembling pentapeptides for injectable delivery (RAPID) hydrogels

119 ed on the His276-Pro277-Glu278-Val279-Tyr280 pentapeptide formed by the His-Tyr covalent linkage.

120 roposed to competitively displace UDP-MurNAc-pentapeptide from AmpR and convert it into an activator

121 by enzyme-linked immunosorbent assay using a pentapeptide from the human NMDA receptor.

122 We have shown that a pentapeptide from this region (DYDYQ) inhibits prothromb

123 Here we show that two complementary pentapeptides from a beta-sheet motif of a protein, bein

124 The separation of the parent MAbs and pentapeptides from their isomerization products was achi

125 ne (P), fluorene (F), or naphthalene (N)) to pentapeptides GAGAS (1), GVPVP (2), VPGVG (3), VTEEI (4)

126 pound 40 was 97% orally bioavailable, larger pentapeptides generally had low oral bioavailability.

127 etic PG fragment as substrate (GlcNAc-MurNAc(pentapeptide)-GlcNAc-MurNAc(pentapeptide)).

128 Undecaprenyl diphosphate-MurNAc-pentapeptide-GlcNAc (lipid II) is extracted from Escheri

129 Here we report the identification of a pentapeptide, GLP-1(32-36)amide (LVKGRamide), derived fr

130 A pentapeptide, Gly-Pro-Arg-Pro-Pro, with high affinity fo

131 tative catalytic triad (SDH) and a conserved pentapeptide (GXSXG) surrounding the nucleophilic serine

132 y stereochemistry, since five epimers of the pentapeptide, H2N-Gly-Leu-Ser-Phe-Ala-OH (GLSFA) all dis

133 The pentapeptide has an alternative binding mode that allows

134 -2, it was observed that the breakage of the pentapeptide has probably been taken place through H-bon

135 e that employs native chemical ligation of a pentapeptide (HCDLP) to recombinant S. coelicolor NiSOD

136 ation alter the mechanical properties of our pentapeptide hydrogels.

137 n, mediated by the nisin N-terminus-lipid II pentapeptide hydrogen bond.

138 ty is involved in the switch between di- and pentapeptide hydrolysis.

139 runcations on CheR binding to receptor-borne pentapeptide implied linker (i) makes pentapeptide avail

140 on of the third position residue in the stem pentapeptide in S. aureus MurE, the structure shows that

141 idoglycan precursor UDP-N-acetylmuramic acid-pentapeptide in the cytoplasm.

142 transition state to afford di-, tetra-, and pentapeptides in 78-95% yields.

143 DD-carboxypeptidase mutant that accumulates pentapeptides in its peptidoglycan, allowing us to visua

144 lso, inhibiting FtsZ increased the amount of pentapeptides in sacculi by about one-third.

145 namics (MD) simulations of Gly-Gly-X-Gly-Gly pentapeptides in water at 298 K with exhaustive sampling

146 -acetylmuramic acid-pentapeptide (UDP-MurNAc-pentapeptide) in the cytoplasm.

147 ively recent event in evolution and that the pentapeptide-independent methylation system is more comm

148 of CheR proteins: pentapeptide-dependent and pentapeptide-independent methyltransferases.

149 dividing cells, similarly to the PBPs and PG pentapeptides indicative of PG synthesis.

150 The whole C-terminal pentapeptide information is a determinant for modelling

151 The sulfated pentapeptide inhibited moderately both cleavages by beta

152 The pentapeptide inhibited weight gain, reduced fat mass wit

153 Ab) against LR (LR-Ab) or YIGSR, a synthetic pentapeptide inhibitor for LR, significantly attenuated

154 ng activator protein, HetR, and a diffusible pentapeptide inhibitor PatS-5 (RGSGR).

155 On the basis of an active pentapeptide inhibitor, 1, we envisioned that macrocycli

156 The pentapeptide inhibitors were very potent, with the C-ter

157 Enterostatin, an endogenous pentapeptide inhibits dietary fat intake when administer

158 The enzyme with a pentapeptide insertion between Leu(102) and Pro(103) was

159 -Glc PPase enzyme, we studied the effects of pentapeptide insertions at different positions in the en

160 he two classes of mutant HrpA proteins carry pentapeptide insertions in discrete regions, which are i

161 unctional HrpA derivatives that carry random pentapeptide insertions or single amino acid mutations,

162 The full pentapeptide intermediate, isolated following vancomycin

163 subsequent incorporation of the disaccharide-pentapeptide into PG.

164 Remarkably, COX-2 metabolized the pentapeptide into small fragments consisting mainly of d

165 The threading of pentapeptides into the beta-helical fold is interrupted

166 Our results suggest that the pentapeptide is an ideal starting point for the developm

167 A pentapeptide is attached to each of the lactyl units of

168 Information concerning the C-terminal pentapeptide is considered to describe the peptide struc

169 trol of the third position amino acid in the pentapeptide is crucial to maintain the fidelity of late

170 efensins, the third position of the lipid II pentapeptide is essential for effective copsin binding.

171 Thus, the mobility of the CXXCH pentapeptide is found to impact the His-Fe(III) interact

172 By mass spectroscopy, the pentapeptide is rapidly formed from GLP-1(9-36)amide, th

173 When this pentapeptide is replaced with alanines, as in EP20-24-24

174 on of mature cell wall precursor, UDP-MurNAc-pentapeptide, is inhibited by region 3.2 of sigma subuni

175 A proline-centered pentapeptide isoconformational to arachidonic acid, whic

176 When mixed with DNA, a pentapeptide KKRPK, but not KKKKK, is sufficient for DNA

177 ry structure appears to already occur at the pentapeptide level.

178 an from the dacA-1 mutant contained elevated pentapeptide levels in standard and low salt media, and

179 Nonfluorogenic tetrapeptide and pentapeptide libraries were synthesized and analyzed to

180 Based on protein folding considerations, a pentapeptide ligand, CALNN, which converts citrate-stabi

181 peptide (Park's nucleotide) to prenyl-MurNAc-pentapeptide (lipid I), the first membrane-anchored pept

182 observation suggests that 1,6-anhydroMurNAc-pentapeptide may convert AmpR into an activator of ampC

183 the extreme carboxyl terminus important for pentapeptide-mediated enhancement of adaptational modifi

184 l three carboxyl-terminal extensions reduced pentapeptide-mediated enhancement of rates of adaptation

185 ale liposomal formulation (NLF) contains the pentapeptide mimic 1,4-Bis (9-O dihydroquinidinyl) phtha

186 nce on Asp isomerization was evaluated using pentapeptide models of the MAbs, which included the labi

187 of a larger-sized peptidoglycan monomer, the pentapeptide monomer, and an increased release of peptid

188 We find that a pentapeptide motif (FQKLL) within the Htt protein regula

189 sp2 homologues identified a highly conserved pentapeptide motif (Gly-X-Ser(362)-X-Gly) typical of mos

190 cognate 71 kDa protein (HSC70) recognizing a pentapeptide motif (KFERQ-like motif) in the protein seq

191 Deletion of a C-terminal pentapeptide motif of PipB2, LFNEF, prevents its periphe

192 creasing the binding affinity of a consensus pentapeptide motif toward the beta subunit of Escherichi

193 posed of tandemly repeated Pro-Hyp-Val-X-Lys pentapeptide motifs, is found primarily in the Leguminos

194 hereby producing cells with higher levels of pentapeptides, mutants carrying only AmiC produced a hig

195 A pentapeptide (N-formyl-Met-Ile-Val-Ile-Leu (fMIVIL)) fro

196 ecaprenyl pyrophosphate-N-acetylmuramic acid(pentapeptide)-N-acetylglucosamine (lipid II), which is r

197 re as determined by NMR of the 2-kDa NAG-NAM(pentapeptide)-NAG-NAM(pentapeptide) synthetic fragment o

198 lycan substrate fragment containing the full pentapeptide, NAM-(L-Ala-D-isoGlu-L-Lys-D-Ala-D-Ala).

199 but not, or only marginally, the UDP-MurNAc pentapeptide nucleotide precursor as acceptor substrates

200 gate the competence and sporulation factor-a pentapeptide of amino acid sequence ERGMT-within intact

201 add the cross-bridge amino acids to the stem pentapeptide of cell wall precursors, and vanK is essent

202 otensin(8-13), an analogue of the C-terminal pentapeptide of neuropeptide Y, and a neuropeptide FF an

203 ich add the branch amino acid(s) to the stem pentapeptide of peptidoglycan precursors.

204 e signals for communication, such as the Phr pentapeptides of Bacillus subtilis.

205 ct ions for a series of histidine-containing pentapeptides of both non-tryptic (AAHAL, AHAAL, AHADL,

206 of the tetrapeptide intermediate yielding a pentapeptide on the thio-templated nonribosomal peptide

207 ow only three deuteriums are attached on the pentapeptide, one on each of the amide nitrogens of Y, I

208 catalyzes the transformation from UDP-MurNAc-pentapeptide (Park's nucleotide) to prenyl-MurNAc-pentap

209 In contrast, for certain pentapeptides patterned on fibrin B knobs, the delay in

210 n of lipid II, the undecaprenyl-disaccharide pentapeptide peptidoglycan precursor, remains mysterious

211 F (Spo0F approximately P), and its inhibitor pentapeptide, PhrA, was analyzed in part by generating c

212 edicted to encode five modules pointing to a pentapeptide precursor in nocardicin A biosynthesis, unl

213 The isolated UDP-linked N-acylmuramyl-pentapeptide precursor molecules also contain a mixture

214 ng the AmpR.DNA tetramer bound to UDP-MurNAc-pentapeptide predicts that the UDP-MurNAc moiety of the

215 e nonnaturally occurring D form of the DWEYS pentapeptide prevents these antibodies from depositing i

216 Extracellular Phr pentapeptides produced by gram-positive, spore-forming b

217 Their activity is inhibited by specific Phr pentapeptides produced from the product of phr genes thr

218 stal structure of Cbl(TKB) in complex with a pentapeptide, pYTPEP, revealed that the PEP region adopt

219 Macrocycle 1b containing the pentapeptide QIVYK shows little inhibition, suggesting t

220 The PhrF C-terminal pentapeptide, QRGMI, inhibits RapF activity.

221 Enterostatin is a pentapeptide released from its precursor protein procoli

222 NA foci and translation of repeat-associated pentapeptide repeat (PPR) proteins, consistent with obse

223 ss of synthetic repeat proteins based on the pentapeptide repeat family of beta-solenoid proteins.

224 The expression of MfpA, a member of the pentapeptide repeat family of proteins from Mycobacteriu

225 A unique CD spectrum for the pentapeptide repeat fold is described.

226 The pentapeptide repeat is a recently discovered protein fol

227 The pentapeptide repeat protein (PRP) family has more than 5

228 uberculosis MfpA is a founding member of the pentapeptide repeat protein (PRP) family that confers re

229 QnrB1 is a plasmid-encoded pentapeptide repeat protein (PRP) that confers a moderat

230 DNA-binding domain, and PatL (All3305) is a pentapeptide repeat protein.

231 Of these, the pentapeptide repeat-containing (PRP) Qnr proteins are be

232 At2g44920 from Arabidopsis thaliana is a pentapeptide-repeat protein (PRP) composed of 25 repeats

233 s two domains, a beta-helix domain formed by pentapeptide repeats and a bilobed catalytic domain remi

234 The structure revealed that the pentapeptide repeats encode the folding of a novel right

235 Formation of the peptidoglycan stem pentapeptide requires the insertion of both L and D amin

236 effector-binding domain bound to UDP-MurNAc-pentapeptide revealed that the terminal D-Ala-D-Ala moti

237 c) consists of a heme covalently linked to a pentapeptide segment (Cys-X-X-Cys-His), which provides a

238 e investigated the effects of relamorelin (a pentapeptide-selective agonist of the ghrelin receptor t

239 action between the CheR beta-subdomain and a pentapeptide sequence (NWETF or NWESF) at the C-terminus

240 both substrate sites and a carboxyl-terminal pentapeptide sequence carried by certain receptors.

241 ndance receptors carry the carboxyl-terminal pentapeptide sequence NWETF that enhances adaptational c

242 by either enzyme is dependent on a conserved pentapeptide sequence, NWETF or NWESF, present at the ex

243 investigated the relative importance of each pentapeptide side chain for the two enhancing interactio

244 PBP 5 removes the terminal D-alanine from pentapeptide side chains of muropeptide subunits, and pe

245 ts are recognized by SrtC proteins through a pentapeptide sorting signal, and while previous studies

246 We investigated the molecular basis for pentapeptide specificity using peptide analog inhibitors

247 es: the well-known peptidoglycan D-Ala-D-Ala pentapeptide stem terminus and the pentaglycyl bridging

248 fragments with reduced cross-linking with a pentapeptide stem that terminated in d-Ala-d-Lac.

249 We believe that most of the few pentapeptide stems ending in d-Ala- d-Ala occur in the t

250 anied by a dramatic accumulation of unlinked pentapeptide stems with no change in the tetrapeptide po

251 nhanced without altering the sequence of the pentapeptide strand.

252 a-turn conformation that develops within the pentapeptide structural repeats above the phase transiti

253 alization of PBP2 was also observed when its pentapeptide substrate was eliminated by addition of d-c

254 uced increase in reactivity of fIXa toward a pentapeptide substrate.

255 ncoded library (130,321 compounds) of lysine pentapeptide substrates of TGase, synthesized using the

256 ired enzyme activity and the availability of pentapeptide substrates.

257 hemical assays, caspase-2 uniquely prefers a pentapeptide (such as VDVAD) rather than a tetrapeptide,

258 R of the 2-kDa NAG-NAM(pentapeptide)-NAG-NAM(pentapeptide) synthetic fragment of the cell wall.

259 he(7)/D-Nal(2')(7)-Arg(8)-Trp(9)-Lys(10)-NH2 pentapeptide template lead to nanomolar range and select

260 ibe truncation and SAR studies to identify a pentapeptide that binds Cbl tyrosine kinase binding doma

261 Residues 549-553 comprise the NWETF pentapeptide that binds the CheR methyltransferase and C

262 Cilengitide (CGT) is a cyclic pentapeptide that demonstrated efficacy for GBM treatmen

263 ADH-1 is a cyclic pentapeptide that disrupts N-cadherin adhesion complexes

264 are different but share a carboxyl-terminal pentapeptide that enhances adaptational covalent modific

265 The PG building block is a disaccharide-pentapeptide that is synthesized as a lipid-linked precu

266 undecaprenyl diphosphate and a disaccharide-pentapeptide that PG-synthesizing enzymes use to build t

267 A phr gene encoding a secreted pentapeptide that regulates the activity of its associat

268 tracellular death factor is a quorum-sensing pentapeptide that relays cell density information to an

269 the nonapeptide bradykinin and of two globin pentapeptides that are potential in vivo substrates.

270 cer of AmpC, the quantities of both the stem pentapeptide (the substrate for the dd-carboxypeptidase

271 For pentapeptides, the constraint gives rise to inaccessible

272 s have been developed to synthesize tri- and pentapeptide thioesters containing one or more p-(hydrox

273 f excess Q7, APN quantitatively converts the pentapeptides Thr-Gly-Ala-X-Met into the dipeptides X-Me

274 f the peptidoglycan precursor phospho-MurNAc-pentapeptide to the lipid carrier undecaprenyl phosphate

275 by comparing the fragments generated from a pentapeptide to those obtained on a commercial tandem ma

276 tylglucosamine disaccharides cross-linked by pentapeptides to form a tight mesh barrier.

277 ne bound and soluble forms of PBP5 converted pentapeptides to tetrapeptides in vitro and in vivo, and

278 , aromatic-aromatic interactions promote the pentapeptides transform from alpha-helix to beta-sheet c

279 Phospho-MurNAc-pentapeptide translocase (MraY) catalyzes the synthesis

280 One such target is phospho-MurNAc-pentapeptide translocase (MraY), an essential integral m

281 ecific inhibitor of MraY, the phospho-MurNAc-pentapeptide translocase that catalyzes the synthesis of

282 MraY (phospho-MurNAc-pentapeptide translocase) catalyses the first and an ess

283 MraY (phospho-MurNAc-pentapeptide translocase) is an integral membrane enzyme

284 e nanomolar inhibitors of Mtb phospho-MurNAc-pentapeptide translocase, the enzyme responsible for the

285 nd VanY acting on dipeptide (D-Ala-D-Ala) or pentapeptide (UDP-MurNac-L-Ala-D-Glu-L-Lys-D-Ala-D-Ala),

286 idoglycan precursor UDP-N-acetylmuramic acid-pentapeptide (UDP-MurNAc-pentapeptide) in the cytoplasm.

287 ; 2.32 +/- 0.55%ID/g), a low-affinity cyclic pentapeptide under clinical development.

288 e macrocyclic beta-sheet peptides comprise a pentapeptide "upper" strand, two delta-linked ornithine

289 and hydrophilicity that matches that of the pentapeptide "upper" strand.

290 pH-dependent partitioning of the host-guest pentapeptide variants AcWL-X-LL-NH(2) and WL-X-LL-NH(2)

291 of suitably functionalized tri-, tetra- and pentapeptides via Suzuki-Miyaura cross-coupling has been

292 Macrocycles 1 containing the pentapeptide VQIVY in the "upper" strand delay and suppr

293 or epoxidation activity when the small FLEEL pentapeptide was used as a substrate, suggesting that N-

294 ons of DYDYQ, whereas high concentrations of pentapeptide were required to inhibit cleavage of rP2-II

295 ved when Y* was generated by photolysis in a pentapeptide, which matched the primary sequence surroun

296 tle activity against muropeptides containing pentapeptides, which typically characterize newly synthe

297 owed that the enhanced binding observed with pentapeptides with carboxyl-terminal tyrosine, compared

298 e length of their peptides (tri-, tetra-, or pentapeptides with or without mono- or dipeptide branch)

299 MOR and DOR, we have synthesized a series of pentapeptides with the goal of developing a MOR agonist/

300 -Ala-Trp-Ala-Ala-amide (AAWAA), and the five pentapeptides with the same sequence as the Trp substitu