ライフサイエンスコーパス: pentasaccharide

1 saccharide, trisaccharides type 2 and 6, and pentasaccharide).

2 of AT in the absence and in the presence of pentasaccharide.

3 ning oligosaccharides, a trisaccharide and a pentasaccharide.

4 oaches to the synthesis of the core N-glycan pentasaccharide.

5 studied in both the absence and presence of pentasaccharide.

6 e P-helix formation and ATIII binding to the pentasaccharide.

7 ecific ionic and non-ionic contacts with the pentasaccharide.

8 ) only approximately 2-fold tighter than the pentasaccharide.

9 t (k(2)) in both the absence and presence of pentasaccharide.

10 is more buried and fits more snugly than the pentasaccharide.

11 ed in more hydrophobic interactions than the pentasaccharide.

12 had a 5-fold higher affinity for heparin and pentasaccharide.

13 hter complex with the trisaccharide than the pentasaccharide.

14 contacts with all the sugar residues of the pentasaccharide.

15 t (k(2)) in both the absence and presence of pentasaccharide.

16 ithrombin activated by high affinity heparin pentasaccharide.

17 is also established after exposing the core pentasaccharide.

18 interactions with high affinity heparin and pentasaccharide.

19 antibodies recognizing the C. difficile PS-I pentasaccharide.

20 n make contact with a single heparin-derived pentasaccharide.

21 ay or S-layer protein is glycosylated with a pentasaccharide.

22 inked lattices between SBA and four isomeric pentasaccharides.

23 ynthesize a comprehensive library of 32 PNAG pentasaccharides.

24 factor for the syntheses of oligomers beyond pentasaccharides.

25 isaccharides 17, 18, tetrasaccharide 23, and pentasaccharide 26.

26 antithrombin by a sequence-specific heparin pentasaccharide (300-500-fold), (ii) allosteric activati

27 by complexation with a high-affinity heparin pentasaccharide abolished the serpin's ability to inhibi

28 ated protein C mutant, similar to factor Xa, pentasaccharide accelerated the reaction 375-fold.

29 Blockwise coupling of the pentasaccharide acceptor with an alpha-(1->2)-linked man

30 A sequence-specific heparin pentasaccharide activates the serpin, antithrombin, to i

31 y wild-type reactivities with thrombin after pentasaccharide activation as well as normal full-length

32 However, heparin pentasaccharide activation increased the reactivity of t

33 up functions as a key determinant of heparin pentasaccharide activation of antithrombin both by contr

34 ts reactivity with these proteases following pentasaccharide activation.

35 Pentasaccharide addition elicited no further activation

36 The active AT-binding pentasaccharide also accelerated the inactivation rates

37 It was disclosed that the conjugate of the pentasaccharide analogue of Lewis Y antigen was more imm

38 R129H and R129Q antithrombins bound pentasaccharide and full-length heparins containing the

39 eparin and 33- to 70-fold in the presence of pentasaccharide and full-length heparins.

40 x D-sheet A interface, adjacent to the ATIII pentasaccharide and heparin cofactor-binding sites and s

41 Using pentasaccharide and hexasaccharide model compounds, we s

42 of the biologically important ATIII binding pentasaccharide and its precursors, which differ from ea

43 syl donors allowed for the completion of the pentasaccharide and provides a synthetic strategy that i

44 4Gal-T1) in complex with a GlcNAc-containing pentasaccharide and several GlcNAc-containing trisacchar

45 The serum binds both the defucosylated pentasaccharide and the fucosylated hexasaccharide witho

46 ) NMR of the complex consisting of the HNK-1 pentasaccharide and the HNK-1 412 antibody.

47 Multiple pentasaccharide and trisaccharide side chains are O link

48 s of h-M340H-beta4Gal-T1 in complex with the pentasaccharide and various trisaccharides at 1.9-2.0A r

49 ut the total syntheses of heparosan tri- and pentasaccharides and heparin di-, tetra-, hexa-, and oct

50 d antD resulted in the disappearance of BclA pentasaccharides and the appearance of a tetrasaccharide

51 This is demonstrated for two isomeric pentasaccharides and two isomeric hexasaccharides, each

52 Both short (pentasaccharide) and relatively long (eicosasaccharide)

53 The H-type II pentasaccharide, Le(x) pentasaccharide, and Le(y) hexasaccharide were prepared

54 tols, 3,6-disubstituted mannitol-terminating pentasaccharides, and 2-mono- and 2,6-disubstituted mann

55 , four isomeric trisaccharides, two isomeric pentasaccharides, and two isomeric hexasaccharides) as t

56 gest that PAA binds antithrombin in both the pentasaccharide- and the extended heparin-binding sites,

57 These enzymes are the target of the pentasaccharide antibiotic moenomycin as well as the pro

58 structure with that of the complex with the pentasaccharide antigen [-->2)-alpha-L-Rha-(1-->2)-alpha

59 ues implicated in the binding of the heparin pentasaccharide (Arg47, Lys114, Lys125, Arg129) provides

60 ith biomedical importance, i.e., polyanionic pentasaccharide Arixtra and polycationic peptide protami

61 ch chemokine pair was mixed with the heparin pentasaccharide, Arixtra, and assayed by ESI-FTICR mass

62 de, sucrose octasulfate, and an octasulfated pentasaccharide, Arixtra.

63 This S-layer is glycosylated with the same pentasaccharide as that of Hfx. volcanii, but the intact

64 The key building block, a pentasaccharide-Asn analogue containing two thiol residu

65 binding of the terminal Gal residues of the pentasaccharides at identical sites in each monomer, wit

66 lution of smaller glycans (tri-, tetra-, and pentasaccharides) at low organic solvent content hampers

67 nicellular eukaryotes, Skp1 is modified by a pentasaccharide attached to a hydroxyproline near its C

68 ther protists, Skp1 is regulated by a unique pentasaccharide attached to hydroxylated Pro-143 within

69 ylation at the internal GalNAc unit of a Gb5 pentasaccharide backbone that furnishes a Neu5Acalpha(2,

70 Skp1 hydroxyproline is modified by a similar pentasaccharide, based on mass spectrometry, and that as

71 found the complex-type N-linked glycan core pentasaccharide beta-GlcNAc-(1-->2)-alpha-Man-(1-->3)-[b

72 ng-end residue D produced variable losses in pentasaccharide binding energy of approximately 15-75% b

73 The salt dependence of pentasaccharide binding showed that the binding defect o

74 , the designed activators do not bind in the pentasaccharide binding site in antithrombin resulting i

75 nd Lys139, which are outside of the putative pentasaccharide binding site, play pivotal roles in the

76 haride ligand that binds antithrombin in the pentasaccharide binding site, while it competes with ful

77 ion for R132 and K133 peripheral to the main pentasaccharide binding site.

78 to 24%) and in the association constant for pentasaccharide binding to antithrombin [(2.6 +/- 0.3)-f

79 Pentasaccharide binding ultimately results in a conforma

80 f the combining site groove much better than pentasaccharide binding.

81 indicate that sulfated DHPs bind to both the pentasaccharide-binding site and extended heparin-bindin

82 n native ATIII and then becomes exposed when pentasaccharide binds to the inhibitor and activates it.

83 The results show a pentasaccharide bound across the catalytic site of MalP

84 n a native-like state in spite of having the pentasaccharide bound in the normal fashion.

85 roduce type/group-specific Shigella flexneri pentasaccharide bricks from a single lightly protected n

86 composed of up to 15 monosaccharides using a pentasaccharide building block equipped with four orthog

87 ed non-natural disaccharide acceptor, into a pentasaccharide building block suitable for chain elonga

88 sugar that can be subsequently extended to a pentasaccharide by novel glycosyltransferases.

89 at contributes the 2nd and 3rd sugars of the pentasaccharide cap formed on Skp1 hydroxyproline.

90 1000- and 2-fold faster, respectively, than pentasaccharide-catalyzed rates.

91 On the other hand, the pentasaccharide-catalyzed reactivity of antithrombin wit

92 at proline 143, which is then modified by a pentasaccharide chain.

93 Recent determination of the structure of the pentasaccharide complex found a glycosidic linkage psi t

94 -ray cocrystal structure of the antithrombin-pentasaccharide complex shows that Trp49 does not contac

95 a recent X-ray structure of the antithrombin-pentasaccharide complex, suggested that the majority of

96 While the 2,4-, 3,6-, and 2,6-pentasaccharide complexes possess a common P6422 space g

97 No activation was observed, even at a pentasaccharide concentration 10 times higher than that

98 ictyostelium, Skp1 is modified by an unusual pentasaccharide containing a Galalpha1-Fuc linkage, whos

99 Lactoseries tetrasaccharide c (LSTc), a pentasaccharide containing a terminal alpha2,6-linked si

100 olysaccharide, which consists of a repeating pentasaccharide containing d-mannose, d-glucose and l-rh

101 ytic site of dGMII led to the synthesis of a pentasaccharide containing the alpha(1,6)-linked Man of

102 Lacto-N-fucopentaose III (LNFPIII) is a pentasaccharide containing the Lewis(x) trisaccharide th

103 n of antA resulted in the appearance of BclA pentasaccharides containing anthrose analogs possessing

104 e the synthesis of unnatural 6-O-sulfated CS pentasaccharides containing either a 6-O-sulfo-2-azidoga

105 ractions, suggesting that Arg(129) binds the pentasaccharide cooperatively with other residues.

106 ruption ofmanBcoregives rise to a deep-rough pentasaccharide core (beta-d-Glcp-(1-->4)-alpha-Kdop-(2-

107 iantennary structures with a common N-linked pentasaccharide core (mannose3-N-acetylglucosamine2), mo

108 y removing sugars outside the N-glycopeptide pentasaccharide core with exoglycosidases.

109 serpin allosterically activated by a heparin pentasaccharide could be enhanced as much as 55-fold by

110 The 2, 3-pentasaccharide cross-linked complex, on the other hand,

111 vation of the serpin antithrombin by heparin pentasaccharide DEFGH was previously shown to involve tr

112 de unit DEF of the sequence specific heparin pentasaccharide DEFGH.

113 molecules devoid of the antithrombin-binding pentasaccharide DEFGH.

114 al saccharide residues of a specific heparin pentasaccharide, denoted DEFGH, in the allosteric activa

115 ents heparin binding to FXa, the heparin and pentasaccharide dependence of FXa inactivation by AT in

116 pentasaccharide with negligible transfer to pentasaccharides derived from hyaluronan or heparan.

117 ions in an AglB-dependent manner by the same pentasaccharide detected on H. volcanii flagellins.

118 B-pentamer with the ganglioside GM1 receptor pentasaccharide diffract to near-atomic resolution.

119 This pentasaccharide drives Th2-type responses in vivo and in

120 N-sulfoglucosamine (GlcNS) and the synthetic pentasaccharide drug fondaparinux demonstrate the broad

121 nally activating antithrombin with a heparin pentasaccharide enhanced the affinity of the serpin for

122 n contrast to thrombin, an active AT-binding pentasaccharide enhanced the inhibition of des-PPW appro

123 Competitive binding studies with heparin pentasaccharide, epicatechin sulfate, and full-length he

124 In all three complexes the pentasaccharide exhibits an altered conformation across

125 Antithrombin binds to specific pentasaccharides expressed on heparin, glycosaminoglycan

126 ectroscopic studies on the 1:1 adduct of the pentasaccharide Fondaparinux (FPX) and the substitution-

127 Frequently, the pentasaccharide fondaparinux is used off-label.

128 lar-weight heparin, and none formed with the pentasaccharide fondaparinux sodium.

129 low-molecular-weight heparin (LMWH), and the pentasaccharide fondaparinux.

130 es for two GAG model compounds, a heparin/HS pentasaccharide (fondaparinux sodium; FX) and enzymatica

131 ude low-molecular-weight heparins (LMWHs); a pentasaccharide (fondaparinux); oral anticoagulants: vit

132 r results showed that GAG model compounds, a pentasaccharide (fondaparinux, FX) and an octasaccharide

133 anti-FXa activity compared with those of the pentasaccharide, fondaparinux, and low molecular weight

134 w molecular weight heparin and the synthetic pentasaccharide, fondaparinux, had similar platelet-pote

135 afts were continuously infused with alphaGal pentasaccharide for 4-5 hr, maintaining the serum oligos

136 The pentasaccharide fragment alpha-d-Man-(1 --> 5)-[alpha-d-

137 formation unless it is activated by a unique pentasaccharide fragment of heparin (H(5)).

138 It has been demonstrated that a unique pentasaccharide fragment of heparin (H5) activates AT by

139 A unique pentasaccharide fragment of heparin can enhance the reac

140 A unique pentasaccharide fragment of high-affinity heparin activa

141 s of two novel tetrasaccharide and two novel pentasaccharide fragments of the Le(a)Le(x) TACA: the te

142 t the synthesis of a tetrasaccharide and two pentasaccharide fragments of the Le(a)Le(x) tumor-associ

143 cs, we report the synthesis of eight tri- to pentasaccharide fragments of these oligosaccharides.

144 It was unexpected that pentasaccharide fragments were also detected among the d

145 y steps in the total synthesis of a branched pentasaccharide from a saponin natural product.

146 ate that the nonreducing-end residues of the pentasaccharide function both to recognize the native lo

147 n that is post-translationally modified by a pentasaccharide, Gal alpha1,Gal alpha1,3Fuc alpha1,2Gal-

148 isaccharide (Galalpha1-3Galbeta1-4GlcNAc) or pentasaccharide (Galalpha1-3Galbeta1-4GlcNAcbeta1-3Galbe

149 Dictyostelium, Skp1 is modified by a linear pentasaccharide, Galalpha1-6Galalpha1-Fucalpha1-2Galbeta

150 ata to determine the solution structure of a pentasaccharide, GalNAc6S(beta1-4)GlcA(beta1-3)GalNAc4S(

151 The oligosaccharides used were: pentasaccharide GlcNAcbeta1,2-Manalpha1,6 (GlcNAcbeta1,2

152 binding interactions among CCL7, Arixtra (a pentasaccharide glycosaminoglycan [GAG] analog), and dis

153 nd comparable to the affinity of soluble GM1 pentasaccharide (GM1(os)).

154 The syntheses of the targeted pentasaccharide have been performed with both three- and

155 mic data demonstrate that the native tri- to pentasaccharides have free energies of binding in the ra

156 on sites are modified with covalently linked pentasaccharides having the same mass as that modifying

157 interaction with the negatively charged GD2-pentasaccharide headgroup.

158 parin enoxaparin (Lovenox) and the synthetic pentasaccharide heparin analog fondaparinux (Arixtra), w

159 The binding of pentasaccharide heparin to antithrombin induces a confor

160 iant) inhibits thrombin 17 times faster than pentasaccharide heparin-activated antithrombin.

161 ed and derivatized with a potentially linear pentasaccharide, Hex-->Hex-->Fuc-->Hex-->HexNAc-->(HyPro

162 3)-galactose epitopes were prepared, and the pentasaccharide HNK-1 required incorporation of a 3-O-su

163 In contrast, the fifth sugar of the pentasaccharide, identified as mannose in this study, is

164 The fully protected antithrombotic pentasaccharide idraparinux was synthesized in 23 steps

165 ently assembled the antithrombin III-binding pentasaccharide in just 6 steps, in contrast to the appr

166 he extent of the rate-accelerating effect of pentasaccharide in the AT inhibition of the mutants was

167 tacts (approximately 75) with the Fab as the pentasaccharide, including the same number of hydrogen b

168 es are similar to the value measured for GM1 pentasaccharide, indicating that neither the ceramide mo

169 Binding of GSG4 is identical to the natural pentasaccharide, indicating that the inactive thio compo

170 or activation of factor Xa inhibition is the pentasaccharide-induced conformational change, with appr

171 loss in binding energy for the antithrombin-pentasaccharide interaction due to the disruption of a c

172 inding partner of this group on antithrombin-pentasaccharide interactions by equilibrium binding and

173 eover, we describe the successful use of the pentasaccharide intermediate in the [5 + 5] synthesis of

174 xcept for the ultimate stage, where a single pentasaccharide intermediate is converted into a set of

175 ,6-mannosylation, to form the first branched pentasaccharide intermediate of the pathway.

176 Deprotection of the pentasaccharide intermediate to give the hexyl and amino

177 ative glycosylation to obtain the key tetra-/pentasaccharide intermediates, which was followed by ste

178 Herein, the GM1 pentasaccharide is dissected into smaller fragments to d

179 Although distortion of the pentasaccharide is significant, the principal factor in

180 The resulting pentasaccharide is suitably protected for further chain

181 ide as that of Hfx. volcanii, but the intact pentasaccharide is synthesized on a single carrier molec

182 alpha-1,6-linked-fucose to the N-glycan core pentasaccharide, is an abundant protein modification tha

183 in chains, including the minimal AT-specific pentasaccharide, is mediated exclusively through the all

184 tiation of Co(2+)-adducted tri-, tetra-, and pentasaccharide isomers, while CID, HCD, and ETD were in

185 s the additional 6 arm GlcNAc present in the pentasaccharide, it does not serve as a key recognition

186 matic synthesis of the dolichylpyrophosphate pentasaccharide, it was thus possible to define the bioc

187 JCPyV infection of host cells requires the pentasaccharide lactoseries tetrasaccharide c (LSTc) and

188 The H-type II pentasaccharide, Le(x) pentasaccharide, and Le(y) hexasa

189 high-affinity heparin, high-affinity heparin pentasaccharide, long-chain low-affinity heparin, and de

190 nalogues with distinct topological profiles, pentasaccharides LSTa (alpha-2,3 linkage) and LSTc (alph

191 s of epimeric disaccharides and the branched pentasaccharide Man3 glycan, demonstrating that this tec

192 stal structures of MVL free and bound to the pentasaccharide Man3GlcNAc2 at 1.9- and 1.8-A resolution

193 hat the alpha-linked mannose residues in the pentasaccharide Man3GlcNAc2 core was essential to mainta

194 onality could be readily introduced at the N-pentasaccharide (Man3GlcNAc2) core by use of azido-conta

195 and meanwhile preserving the natural, core N-pentasaccharide (Man3GlcNAc2) structure in the resulting

196 Sulfated pentasaccharide may be sufficient to bind to CTX.

197 stitution at lysine 139 had no effect on the pentasaccharide-mediated activation of ATIII toward fact

198 nstrate a pivotal role for lysine 114 in the pentasaccharide-mediated activation of ATIII.

199 e potential role(s) of these residues in the pentasaccharide-mediated activation of ATIII.

200 GAGs heparin, heparan sulfate (HS), and its pentasaccharide mimetic Fondaparinux (FPX).

201 tion of antithrombin was not affected by the pentasaccharide modifications.

202 tion mechanism was investigated with variant pentasaccharides modified in the GH disaccharide.

203 radation system to recognize the common core pentasaccharide motif (Man3GlcNAc2) of N-linked glycopro

204 O-sulfated alpha-methyl glycoside of heparin pentasaccharide motif known to interact with the antithr

205 ts comprising the first four subunits of the pentasaccharide N-linked to the S-layer glycoprotein, a

206 of the polymer was identified as a branched pentasaccharide of the structure shown.

207 viously investigated the binding of tri- and pentasaccharides of N-glycan with a GlcNAc at their nonr

208 or the fucose at the Le(x) reducing end; the pentasaccharides only lack the galactose residue at the

209 n factor Xa specificity due to activation by pentasaccharide or bridging heparins.

210 an important role in the binding of heparin pentasaccharide or in the mechanism of heparin activatio

211 The four pentasaccharides possess the common structure of (beta-L

212 All variant pentasaccharides produced a normal enhancement of antith

213 nformational preorganization of the branched pentasaccharide rather than through the effect of cooper

214 Concise syntheses of the acidic pentasaccharide, related to the O-antigenic polysacchari

215 th 9V and 9A PS are composed of an identical pentasaccharide repeat unit, as reported previously.

216 The synthetic PS-I pentasaccharide repeating unit as well as the Rha-(1-->3

217 PS A2 consists of a pentasaccharide repeating unit containing mannoheptose,

218 genes are involved in sialic acid synthesis, pentasaccharide repeating unit formation, and oligosacch

219 approach for the first total synthesis of a pentasaccharide repeating unit of Acinetobacter baumanni

220 mproved chemical synthesis protocols for the pentasaccharide repeating unit of PS-I and oligosacchari

221 Chemical synthesis of the pentasaccharide repeating unit of the O-antigen from Esc

222 CPS of 35B is composed of pentasaccharide repeating units that are linked through

223 -antithrombin and alpha-antithrombin+heparin pentasaccharide reported to date (2.6A and 2.9A resoluti

224 ithrombin, we studied the effect of deleting pentasaccharide residues on this activation.

225 tion and previously assigned roles in adding pentasaccharide residues one to four, the composition of

226 a tetrasaccharide comprising the first four pentasaccharide residues.

227 rombin induced by binding a specific heparin pentasaccharide result in very large increases in the ra

228 al activation of the chimeras with a heparin pentasaccharide resulted in normal approximately 100-300

229 t with the altered affinities of the variant pentasaccharides resulting mostly from perturbed interac

230 ite this affinity loss, the 3-O-desulfonated pentasaccharide retained the ability to induce tryptopha

231 s two complexes with two antigen segments (a pentasaccharide Rha A-Rha B-Rha C-GlcNAc D-Rha A' and a

232 e strongly associated to the presence of the pentasaccharide sequence AGA*IA (A(NAc,6S)-GlcUA-A(NS,3,

233 antithrombin, by binding through a specific pentasaccharide sequence containing a critical 3-O-sulfo

234 it mechanism to bind with high affinity to a pentasaccharide sequence found in about one-third of hep

235 Activation occurs upon binding of a specific pentasaccharide sequence found in heparin that results i

236 s establish an important role of the heparin pentasaccharide sequence in preferential binding and sta

237 AT-III binding to a specific heparin pentasaccharide sequence, containing an unusual 3-O sulf

238 alized sensor for the physiologically active pentasaccharide sequence.

239 tope becomes larger across the tri-, tetra-, pentasaccharide series, entropy contributions to the fre

240 ical evidence for conventional Hbonds in the pentasaccharide sialyl Lewis-X (sLe(X)-5) between 5 and

241 The nonreducing terminal residue of the pentasaccharide side chain is the unusual sugar anthrose

242 llagen-like region with multiple copies of a pentasaccharide side chain.

243 rase that attaches the fourth residue of the pentasaccharide side chain.

244 or cooperative interactions with the heparin pentasaccharide so as to lock the serpin in the activate

245 onstrated through analysis of three isomeric pentasaccharide species and the small protein ubiquitin.

246 yltransferase, the K(M) value obtained for a pentasaccharide substrate was 1.23 0.08 mM.

247 ng oligosaccharide acceptors indicate that a pentasaccharide, such as N-glycans with GlcNAc at their

248 P1 is variably modified by an unusual linear pentasaccharide, suggesting the localization of a novel

249 The pentasaccharide terminates with the unusual deoxyamino s

250 To that end, we describe a core pentasaccharide that at potential branching positions is

251 se III (LNFPIII) is a biologically conserved pentasaccharide that contains the Lewis(x) trisaccharide

252 cinetobacter baumannii 17978 revealed that a pentasaccharide that decorates glycoproteins is formed o

253 ) is a structurally homogeneous ULMW heparin pentasaccharide that is synthesized through a lengthy ch

254 st to unfractionated heparin, this synthetic pentasaccharide that mimics the unique Antithrombin III

255 ires modification of the hydroxyproline by a pentasaccharide that, in Dictyostelium, influences Skp1

256 complex of beta4Gal-T1 with I-antigen analog pentasaccharide, the beta1-6-branched GlcNAc moiety is b

257 antithrombin in the absence and presence of pentasaccharide, the difference in reactivity was increa

258 In the case of the 3,6- and 2,6-pentasaccharides, the symmetry of their cross-linked lat

259 old when the serpin was activated by heparin pentasaccharide, thereby transforming antithrombin into

260 22 and Phe-121 make minimal contact with the pentasaccharide, they play a critical role in heparin bi

261 he targets included one tetrasaccharide, one pentasaccharide, three octasaccharides, and two nonasacc

262 esC) but was fully stabilized by the heparin pentasaccharide (Tm 71.8, normal 71.0 degreesC), indicat

263 Global deprotection afforded the target pentasaccharide to be used for the conversion into neogl

264 sulfo group affected both the ability of the pentasaccharide to recognize native antithrombin and its

265 ng geometry of the sequence-specific heparin pentasaccharide to within 2.5 A.

266 Three pentasaccharides, two tetrasaccharides, and a trisacchar

267 The pentasaccharide unit -Man3GlcNAc2- lies at the protein-j

268 l transferases needed to build the repeating pentasaccharide unit of the inflammatory glucorhamnan.

269 We created a compound, SN7-13, from pentasaccharide units and tested it in a range of assays

270 The type 9V capsule consists of repeating pentasaccharide units linearly arranged, with an average

271 protected H-type II blood group determinant pentasaccharide utilizing glycosyl phosphate and glycosy

272 The synthesis of the core pentasaccharide was also accomplished using an high-perf

273 imulation and modeling, a pertussis-LPS-like pentasaccharide was chemically synthesized for the first

274 The pentasaccharide was conjugated with a powerful carrier,

275 cells grown in low salt, substantially less pentasaccharide was detected.

276 ority of the enhanced affinity of the latter pentasaccharide was due to direct electrostatic and hydr

277 (-1) while that for binding to soluble GM(1)-pentasaccharide was found to be approximately 4 x 10(6)

278 The protected chlorohexyl glycoside pentasaccharide was the precursor to the hexyl glycoside

279 peptides carrying two N-linked core tri- and pentasaccharides was achieved.

280 rinux, an excellent anticoagulant heparinoid pentasaccharide, we demonstrated that l-iduronic acid ca

281 132M and K133M variants to the high affinity pentasaccharide were weakened only 2.3- and 4.5-fold res

282 Pentasaccharides were more stable to heat treatment than

283 tamide was fully reduced to an acetamide the pentasaccharides were obtained in four and five steps, r

284 type 2 tetrasaccharide, and the GM1 and GD2 pentasaccharides were screened against the family 51 CBM

285 All of these pentasaccharides were well-resolved and characterized by

286 Fondaparinux is a synthetic pentasaccharide, which binds to antithrombin, thereby in

287 hrombin in a manner identical to the natural pentasaccharide, while a novel hexasaccharide bound the

288 oprotein Asn-13 and Asn-83 are modified by a pentasaccharide, while dolichol phosphate is modified by

289 structure, common to all chloroviruses, is a pentasaccharide with a beta-glucose linked to an asparag

290 affected the preferential interaction of the pentasaccharide with activated antithrombin.

291 unts of GlcA residues to chondroitin-derived pentasaccharide with negligible transfer to pentasacchar

292 w significant binding to the singly branched pentasaccharide with the structure alpha-L-Rhap(1-->2)al

293 In Dictyostelium, Skp1 is modified by a pentasaccharide with the type I blood group H antigen (F

294 glycosidic linkages extending from the core pentasaccharide with thioethers amenable to construction

295 This structure is a pentasaccharide with two beta-xylulofuranose residues; u

296 We also detected di-, tri-, and pentasaccharides with one sulfate group.

297 ates as a pentamer with a series of divalent pentasaccharides with terminal LacNAc residues.

298 short polyanions (synthetic heparin-mimetic pentasaccharide), with the majority of the protein molec

299 Each tetramer accommodates up to six pentasaccharides, with at least three such ligands requi

300 optimal lipid moiety and the GM1 ganglioside pentasaccharide yielded affinities similar, within a fac