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1 of West Nile virus (WNV) genomic RNA form a penultimate 16-nt small stem-loop (SSL) and an 80-nt ter
4 rtion of Nox2 domains, we show here that the penultimate 22 amino acids of Nox4 are involved in const
5 in gpD is essential for the packaging of the penultimate 8-10 kb (15-20%) of the viral genome; virtua
8 The overhang residues are looped out and the penultimate adenines of the two residues at the top end
9 he presence of a D-methyl substituent on the penultimate alanine residue of the cell wall peptide.
10 as the potential to truncate proteins with a penultimate alanine, proline, or other selective amino a
12 surface of TBP, which in turn positions the penultimate alpha helix of NC2beta to block recognition
16 ase (CF1) is quenched when cysteine 322, the penultimate amino acid of the gamma subunit, is specific
17 structural basis for the contribution of the penultimate amino acid of the peptide ligand to the affi
21 nteractions involving the side chains of the penultimate amino acids of the peptide ligands, whereas
22 tional homodimeric enzyme that catalyzes the penultimate and final steps of de novo purine nucleotide
23 hat are responsible for the catalysis of the penultimate and final steps of the purine de novo synthe
24 lkylamine N-acetyltransferase (AANAT) is the penultimate and key regulatory enzyme in the melatonin b
25 cin and also of L-gulonolactone oxidase, the penultimate and last (also rate-limiting) steps in the s
26 en accounting for the combined influences of penultimate and LIG deglaciation on glacial isostatic ad
27 extensive folding cooperativity between the penultimate and terminal base pair, which is independent
28 the pointed end, unique contacts between the penultimate and terminal subunits are consistent with ex
29 rmation and cooperativity arises because the penultimate and the ultimate folding transitions in the
30 een N-terminal aspartates and the C-terminal penultimate arginine as well as N-terminal hydrogen-bond
32 ase encounters an abasic site, we varied the penultimate base pairs (PBs) adjacent to the abasic site
33 ealed a new Pd catalyst system to effect the penultimate borylation chemistry using simple monodentat
34 he penultimate instar caused a repeat of the penultimate br expression patterns, and the formation of
36 eactive indolenine C2 oxidation state from a penultimate C21 functionalized Aspidosperma-like pentacy
40 leaving enzyme 1 (BACE1) is required for the penultimate cleavage of the amyloid-beta precursor prote
41 position and positioning of the ultimate and penultimate codons of the tmRNA ORF play a crucial role
45 lated by reversible glutathionylation of the penultimate cysteine mediated by growth factor stimulati
47 der multimers (via disulfide bonding between penultimate cysteine residues) resulted in proteins havi
49 pimelate (DAP) moiety of one peptide and the penultimate D-alanine of another peptide or between two
50 rejection of the D-methyl substituent of the penultimate D-alanine residue of the DD-peptidase substr
52 nvolves acyl-transfer chemistry in which the penultimate (D)Ala first acylates the active-site serine
53 mate both successful wound closure (based on penultimate debridement biomarker data) and the necessar
55 e consistent with such an early date for the penultimate deglaciation are either the variability of t
56 the longer period of reduced AMOC during the penultimate deglaciation can explain the more-rapid sea-
57 of fossil corals, that sea level during the penultimate deglaciation had risen to ~85 meters below t
61 or sediment mixing, the midpoint age for the penultimate deglaciation is determined to be 135 +/- 2.5
64 brupt changes in tropical climate during the penultimate deglaciation, coincident with North Atlantic
68 ic herbicide that inhibits competitively the penultimate enzyme 5-enolpyruvylshikimate 3-phosphate sy
69 lamine N-acetyltransferase (Aanat) mRNA, the penultimate enzyme in melatonin synthesis, and it exhibi
70 is controlled by cAMP through actions on the penultimate enzyme in melatonin synthesis, arylalkylamin
73 l-3-Hydroxyacyl-CoA dehydrogenase (HAD), the penultimate enzyme in the beta-oxidation spiral, reversi
75 lalkylamine N-acetyltransferase (AANAT), the penultimate enzyme in the melatonin pathway (serotonin -
76 ere, we describe the characterization of the penultimate enzyme in the pathway, hispidin 3-hydroxylas
80 underwent alternative splicing, although the penultimate exon deleted variant appeared mainly in cell
81 nucleotides (nt) of exon 22 in mouse and the penultimate exon in both human (exon 21) and mouse (exon
82 ed to pursue direct Sanger sequencing of the penultimate exon of DVL1 and its paralogs DVL2 and DVL3
83 racterized by being uniformly located in the penultimate exon of DVL1 and resulting in a -1 frameshif
85 nse variant (c.2737C>T [p.Arg913Ter]) in the penultimate exon of ZSWIM6 who have severe-profound inte
86 All mutations were located in the last or penultimate exon, suggesting escape from nonsense-mediat
87 5-azacytidine inhibited the deletion of the penultimate exon, whereas two indolocarbazole-derived in
88 o truncating PPM1D mutations in the last and penultimate exons cause syndromic ID, which provides add
89 re termination codons within the terminal or penultimate exons that are not subject to nonsense-media
91 -methylglucuronate moiety linked to a xylose penultimate from the reducing terminal xylose and some n
92 ade by the glycosidic oxygen and 4-OH of the penultimate galactose, that is complementary to the hydr
93 remarkable patterns of variability since the penultimate glacial period (140 ka), but the seasonality
95 ch age control has been lacking for even the penultimate glacial termination (T-II), which culminated
96 nd eMed hydrographic variability through the penultimate glacial termination (TII) and last interglac
97 a sedimentary archive from the lake over the penultimate glacial-interglacial transition (MIS 6-5) an
99 , reversible tyrosination and removal of the penultimate glutamate from alpha-tubulin, and phosphoryl
102 s cotranslationally via an amide bond to the penultimate glycine residue within the canonical motif (
103 rong activators: the former with an aromatic penultimate Hb residue and the latter with the HbYX moti
104 on and enhanced methane emissions during the penultimate Heinrich event, the Bolling and Allerod inte
105 that include the extended loop prior to the penultimate helix, the extended Omega-loop, and a beta-h
108 e intein N-terminus and the conserved intein penultimate His are absent in the KlbA family of inteins
109 arose by mutation from ancestors in which a penultimate His facilitated splicing, (ii) that loss of
115 However, substitution of an alanine for the penultimate histidine residue, with either asparagine or
116 h can cleave methionine from substrates with penultimate histidine, asparagine, glutamine, leucine, m
119 1348 The Carboniferous, the time of Earth's penultimate icehouse and widespread coal formation, was
120 ive isoforms are weakly expressed during the penultimate instar and highly expressed during the prepu
121 prene, a juvenile hormone analog, during the penultimate instar caused a repeat of the penultimate br
122 engineering substitutions at both the +1 and penultimate intein positions, we have further characteri
125 h-latitude stadials and interstadials of the penultimate interglacial and the last deglaciation.
127 ting groups were removed by treatment of the penultimate intermediate 65 with TAS-F (tris(dimethylami
128 l fluoride 3, and the global desilylation of penultimate intermediate 77 mediated by in situ generate
131 transfer of this acyl moiety by CouN7 to the penultimate intermediate in coumermycin A1 assembly comp
132 H(2) bound to FeMo-co and corresponds to the penultimate intermediate of N(2) hydrogenation, the stat
133 d the utility of functionalized boronates as penultimate intermediates in the synthesis of diverse co
135 ng read the paper by Oikarinen et al. in the penultimate issue of Insights into Imaging, the author d
137 regulatory grammars are best learned in the penultimate layer of the ResNets, and the proposed metho
139 ucylblasticidin S (LBS) was suggested as the penultimate metabolite with 20-fold less inhibitory acti
140 thermore, we show that a substitution in the penultimate MftA Val-29 position causes the accumulation
142 toward styrene is greatly improved when the penultimate monomer on the growing polymer chain is styr
143 lactose, which is the most commonly observed penultimate monosaccharide to SA, may mediate AAV9 trans
144 nd various small amino acids residues at the penultimate N-terminal position were prepared via solid-
145 tures, it is, owning an alanine (A) as their penultimate N-terminal residue (e.g. NAPNPR, YACSVR) wer
151 cate that side chains that interact with the penultimate nucleotide (Q419, N420, and Y423) are import
152 erminants that allows the positioning of the penultimate nucleotide at the polymerization active site
158 e relative importance of sialic acid and the penultimate oligosaccharide sequence on binding affinity
161 olpyruvate synthase intein improved when its penultimate Phe was changed to His, but splicing of the
163 of gene 5 protein, and an oxygen atom on the penultimate phosphate diester of the primer strand.
166 cent transcript stimulates hydrolysis of the penultimate phosphodiester bond by providing active grou
167 n is through the association of Shc with the penultimate phosphotyrosine within the TPO receptor, Mpl
168 ratified by ancestry, time to progression on penultimate platinum, and response to most recent platin
169 status, progression-free interval after the penultimate platinum-based regimen, and best response to
170 status, progression-free interval following penultimate platinum-based regimen, and best response to
171 system, stratified by time to progression on penultimate platinum-based regimen, response to the most
172 Placing the C-terminal phenylalanine in the penultimate position also results in loss of function.
173 eaves selected amino acids at the N-terminal penultimate position and has the potential to alter the
175 rtant, and the charged residue (R227) in the penultimate position in the mouse hepatitis coronavirus
176 strictly conserved cysteine (Cys111) at the penultimate position in the sequence forms an intramolec
180 terminal position or, alternatively, in the penultimate position with galactose in the terminal posi
182 nd serves multiple functions in cleaving the penultimate positioned prolyl bonds at the NH(2) terminu
183 ion of two residues (Glu-145 and Ser-146) at penultimate positions in this chain rescued dimer format
184 an additional step beyond production of the penultimate precursor GA9 mediated by the homologous ope
185 uced by methylseleninic acid (MSeA), a novel penultimate precursor of the putative critical anticance
187 efficient large-scale synthesis of acid 1, a penultimate precursor to the HCV NS5A inhibitor BMS-9860
188 r/Phe is positioned between the terminal and penultimate primer bases and (b) the phenolic OH group i
191 tion of 6, 7-dimethyl-8-ribityllumazine, the penultimate product in the synthesis of riboflavin.
195 gradation, the present results indicate that penultimate proline residues also are an important means
196 of a neuropeptide database that illustrates penultimate proline residues are frequently found in neu
197 ugh it is commonly proposed that the role of penultimate proline residues is to protect peptides from
198 ere performed on two model peptides in which penultimate proline residues were known to be important
199 e second position from the N-terminus (i.e., penultimate proline) frequently adopt multiple conformat
201 roteins with substitutions in the N-terminal penultimate residue as well as deletion of the CP "gate"
202 e removal of the initiator methionine if the penultimate residue has a small radius of gyration (glyc
203 n bound to nucleosomes, and suggest that the penultimate residue in the CTD (K195) is juxtaposed betw
204 Here, we have examined mutations at the penultimate residue of eIF1, G107, that produce Sui(-) p
207 ump by lysophospholipids did not involve the penultimate residue, Thr-947, which is known to be phosp
209 ift from thoracic-like to lumbar-like at the penultimate rib-bearing level, rather than the ultimate
210 ty is strictly dependent on the 2'-OH of the penultimate ribose, it is indifferent to a 2'-OH versus
215 the most recent sample before diagnosis, the penultimate sample before diagnosis, and the oldest samp
216 ibition was due to a Michael addition of the penultimate selenocysteine residue of TrxRs to the QMs.
217 e been identified in mammals: both contain a penultimate selenocysteine residue that is essential for
219 pite the presence of an N-terminal Ala and a penultimate Ser, the KlbA inteins splice efficiently usi
220 ns, using an appropriately modified powerful penultimate single-step vindoline-catharanthine coupling
222 s also stabilize the "barbell shapes" of the penultimate stage in platelet production, because additi
224 feature of normal development, including the penultimate stage of anther development, leading to dehi
227 isk of in situ breast cancer, the postulated penultimate stage preceding invasive breast cancer.
228 downstream sequence or DS) with the 16S rRNA penultimate stem (anti-DS or ADS region) enhances protei
229 ptidyl (P) site, the functional relay of the penultimate stem helix of SSU rRNA, and other structures
230 functional relay is centered around the long penultimate stem of 16S rRNA at the subunit interface, i
231 ty between the DB sequences and the 16S rRNA penultimate stem resulted in increased protein accumulat
233 droxyl of a tetracycline intermediate in the penultimate step during biosynthesis of the anticancer n
235 ssential hexameric enzyme that catalyzes the penultimate step in coenzyme A (CoA) biosynthesis and is
236 ine adenylyltransferase (PPAT) catalyzes the penultimate step in coenzyme A (CoA) biosynthesis: the r
239 acylglycerol to diacylglycerol, which is the penultimate step in one pathway for triacylglycerol synt
240 rly, glycerol 3-phosphate, necessary for the penultimate step in phosphatidylglycerol production, dec
242 to L-histidinol and inorganic phosphate, the penultimate step in the biosynthesis of L-histidine.
243 sferase (GNAT) superfamily and catalyzes the penultimate step in the biosynthesis of melatonin; a lar
244 e compelling evidence that AsbA performs the penultimate step in the biosynthesis of petrobactin, inv
248 ndent O-methyltransferase that catalyzes the penultimate step in the biosynthesis of the aminocoumari
249 e phenoxazinone synthase (PHS) catalyzes the penultimate step in the biosynthesis of the antibiotic a
251 A ribosyltransferase-isomerase catalyzes the penultimate step in the biosynthesis of the hypermodifie
252 ine adenylyltransferase (PPAT) catalyzes the penultimate step in the coenzyme A (CoA) biosynthetic pa
253 adenylyltransferase (PPAT) regulates the key penultimate step in the essential coenzyme A (CoA) biosy
254 ependent aminotransferase that catalyzes the penultimate step in the production of dTDP-Quip3NAc.
257 se in Saccharomyces cerevisiae catalyzes the penultimate step in the synthesis of triacylglycerol (i.
258 osphatidate phosphatase, which catalyzes the penultimate step in the synthesis of triacylglycerol and
259 hosphatidate phosphatase (PAP) catalyzes the penultimate step in the synthesis of triacylglycerol and
260 ylacetoacetate to fumarylacetoacetate is the penultimate step in the tyrosine/phenylalanine catabolic
261 phosphatidate phosphatase that catalyzes the penultimate step in triacylglycerol synthesis and plays
262 oded phosphatidate phosphatase catalyzes the penultimate step in triacylglycerol synthesis, and the d
265 oposed Plm biosynthetic pathway in which the penultimate step is hydroxylation of the cyclohexanecarb
266 rom shikimic acid via a pathway in which the penultimate step is the isomerization of 2-cyclohexenylc
267 he meristematic region and indicate that the penultimate step of GA biosynthesis, GA 20-oxidation, is
269 s adduct resembles the intermediate from the penultimate step of the carboligation reaction between b
270 de transformylase isozymes that catalyze the penultimate step of the de novo purine biosynthesis path
271 olase) and is responsible for catalyzing the penultimate step of the de novo purine biosynthetic path
273 methyl-but-2-enyl diphosphate (HMBPP) in the penultimate step of the methyl-erythritol phosphate (MEP
275 e-3-phosphate synthase (EPSPS) catalyzes the penultimate step of the shikimate pathway and is the tar
277 c acid phosphatase (PAP) responsible for the penultimate step of triglyceride synthesis and dephospho
279 (DTBS) catalyze the antepenultimate and the penultimate steps, respectively, of biotin synthesis.
281 erminal subunit make the partially flattened penultimate subunit accessible for binding monomers.
283 In Toxoplasma, the presence of a contrasting penultimate sugar assembled by a different glycosyltrans
285 eomycins (PLMs) are BLM analogs in which the penultimate thiazolium ring of the bithiazole tail is re
286 ows the importance of phosphorylation of the penultimate Threonine (ERalpha-T(594)) for high-affinity
287 d the requirement for phosphorylation of the penultimate threonine, which is found in most members of
293 ls of TRAP family members harbor a conserved penultimate tryptophan, which is essential for aldolase
294 n the significance of phosphorylation of the penultimate tyrosine for maintenance and processing of t
295 it binding pocket residues in HifB or at the penultimate tyrosine in HifA abolished formation of HifB
297 Phosphorylation of p97's highly conserved penultimate tyrosine residue, which is the main phosphor
298 In the case of the PAN and 19S activators, a penultimate tyrosine/phenylalanine residue contacts the