ライフサイエンスコーパス: peptide library

1 valuated by screening a combinatorial Tyr(P) peptide library.

2 from TMEV-infected mice using an overlapping peptide library.

3 through the screening of a combinatorial pY peptide library.

4 inding proteins by screening a combinatorial peptide library.

5 oma cell line, H2009, from a phage-displayed peptide library.

6 eptides were selected from the combinatorial peptide library.

7 natural protein library and a combinatorial peptide library.

8 pot mutations were matched to the neoantigen peptide library.

9 tro, using a filamentous phage display 7-mer peptide library.

10 isolate peptide mimics from a phage display peptide library.

11 atalyzed digestion of the best pools of each peptide library.

12 ions were confirmed with an ad-hoc synthetic peptide library.

13 rofiled using a positional scanning branched peptide library.

14 man memory T cell response using a synthetic peptide library.

15 e exchange to create a dynamic combinatorial peptide library.

16 pecific peptide ligands from random sequence peptide library.

17 y and binding kinetics of phages, displaying peptide libraries.

18 eening of structurally more diverse bicyclic peptide libraries.

19 atically profiled by screening combinatorial peptide libraries.

20 ts, using recombinant phages encoding random peptide libraries.

21 amenable to the in-cell production of cyclic peptide libraries.

22 pecificity of mTOR using positional scanning peptide libraries.

23 ion through adenovirus-displayed, semirandom peptide libraries.

24 e sequencing of hit beads from combinatorial peptide libraries.

25 explored using combinatorial chemistry based peptide libraries.

26 solated by screening synthetic combinatorial peptide libraries.

27 n situ click chemistry screens against large peptide libraries.

28 tions of phage display selection from 15-mer peptide libraries.

29 apid unambiguous sequencing of combinatorial peptide libraries.

30 ould be desirable to prepare and screen beta-peptide libraries.

31 and H-2K(d) was confirmed using recombinant peptide libraries.

32 tic for the creation and screening of cyclic peptide libraries.

33 ility for high-throughput screening of (RGD-)peptide libraries.

34 nds is usually approached by screening large peptide libraries.

35 sites using the collagen II and III Toolkit peptide libraries.

36 MHC alleles was determined using a synthetic peptide library (143 peptides of the core protein of hum

37 A genotype 3a peptide library (616 overlapping peptides spanning open

38 e conducted yeast two-hybrid screens of Brf1 peptide libraries against different TPR-containing Tfc4

39 ting colon cancer, we screened phage display peptide libraries against fresh human colonic adenomas f

40 After screening of the cyclic peptide library against a macromolecular target, the ide

41 Screening of a bicyclic peptide library against tumor necrosis factor-alpha (TNF

42 arallel synthesis of two small, focused beta-peptide libraries allowed us to identify relatively shor

43 The generation of a small peptide library allowed optimization of peptide sequence

44 ucted fluorogenic and standard combinatorial peptide libraries and analyzed them using fluorescence a

45 ich are typically developed from macrocyclic peptide libraries and are precisely epitope-targeted.

46 Using combinatorial peptide libraries and B cell lines expressing single HLA

47 such broad-spectrum AMPs from combinatorial peptide libraries and demonstrate that a simple in vitro

48 rculosis and S. coelicolor against synthetic peptide libraries and identified new substrate sequences

49 Here we screened phage-displayed peptide libraries and identified the 13-amino acid linea

50 Phage-displayed peptide libraries and in vitro affinity assays were used

51 positional scanning of biotinylated oriented peptide libraries and insights emerging from those deter

52 ection was developed using bacterial display peptide libraries and multiparameter flow cytometry (MPF

53 asin D and shewasin A using proteome-derived peptide libraries and observed remarkable similarities b

54 The convergence of phage-displayed peptide libraries and recombinant viral vectors launched

55 surface display screening from combinatorial peptide libraries and SPOT peptide array analysis--to el

56 Using a combinatorial peptide library and a cytotoxic T lymphocyte clone that

57 Here we utilize a peptide library and bioinformatic approach to predict li

58 was mapped by screening the Collagen Toolkit peptide library and by hydrogen/deuterium exchange.

59 ughput screening of a phage-displayed random peptide library and classified the cell lines according

60 ha-chymase selects P1 Leu in a combinatorial peptide library and cleaves Ala-Ala-Pro-Leu-4-nitroanili

61 genetic selection, we have screened a random peptide library and identified a group of C-terminal mot

62 Herein, we generated and screened a peptide library and identified two short sequence amylin

63 d mAb as bait for screening of phage display peptide library and identifying those peptides with rand

64 tope mapping performed by screening a random peptide library and in silico docking modeling suggested

65 rofiled by screening against a combinatorial peptide library and kinetic analysis of individually syn

66 n and from 4 adults with celiac disease to a peptide library and measured T-cell receptor bias.

67 ires using a bacterial display random 12-mer peptide library and next-generation sequencing (NGS).

68 of pine nut, Pin p 1, were analyzed using a peptide library and sera from patients with clinical all

69 The inhibitory peptide library and the crystal structure of inhibitor-b

70 l mutations detected, we generated a virtual peptide library and used NetMHC to predict 149 unique ne

71 positional scanning synthetic combinatorial peptide libraries, and biometric data analysis.

72 k with S1 scanning peptides, phage-displayed peptide libraries, and S1 truncation/deletion variants w

73 crine-based screening of large combinatorial peptide libraries, and show that P5 promotes G-protein s

74 fluorescence resonance energy transfer-based peptide library approach in defining the substrate speci

75 ombining a positional scanning combinatorial peptide library approach with a peptide-HLA-I dissociati

76 ssessed in 15 kinases using a new degenerate peptide library approach.

77 Random-sequence peptide libraries are a commonly used tool to identify n

78 Phage-displayed peptide libraries are a powerful tool to identify peptid

79 orced" HDX approach in which MS/MS-confirmed peptide libraries are built via nano or standard ESI wit

80 To demonstrate this, phage-displayed peptide libraries are developed that contain a genetical

81 nd intracellular cytokine (ICC) assays using peptide libraries as antigens indicated that a significa

82 PLC-MS analyses of both a hydrophilic QPSSSR peptide library as well as common phosphopeptides.

83 mors by in vivo screening of phage-displayed peptide libraries, asking whether they too have distinct

84 Using a positional scanning peptide library assay, we determined the optimal phospho

85 dentified from a combinatorial phage display peptide library assemble preferentially to the edge or p

86 Using a focused peptide library based on a sequence derived from the in

87 Stimulation with an overlapping peptide library based on structural TBE virus proteins E

88 We constructed a combinatorial peptide library based on the BIV Tat ARM and identified

89 es from a 7776-member rational combinatorial peptide library based on the sequence of the natural por

90 signed a 9,604-member rational combinatorial peptide library based on the structural principles of kn

91 ons, we designed a 3888-member combinatorial peptide library based on the TM domain of Neu (ErbB2) as

92 brane-permeabilizing peptides, we screened a peptide library, based on the archetypal pore-former mel

93 nase substrate specificity using an unbiased peptide library-based approach with direct measurement o

94 g epitope of Bcl-2 could be identified via a peptide library-based membrane assay.

95 A global peptide library-based screening strategy revealed that t

96 ve displayed a 12-amino-acid (12-mer) random peptide library between the H and I sheets of the fiber

97 Using a specially designed peptide library, Biacore-detected protein-protein intera

98 e not only in competitive immunoscreening of peptide libraries but also as immunogenic carriers of al

99 decreased their degradation and that of the peptide libraries by 30-50%.

100 d ribosome display (RD) with the analysis of peptide libraries by next generation sequencing (NGS) of

101 Peptide mimics isolated from phage display peptide libraries by panning with self-tumor-associated

102 The development of peptide libraries by site-selective modification of a fe

103 A systematic screening of a Pex5 peptide library by ligand blot analysis revealed a novel

104 successful in screening a model solid-phase peptide library by showing the ability to select beads c

105 We recently demonstrated that phage peptide libraries can be an excellent source of immunore

106 ts indicate that virus-displayed, semirandom peptide libraries can be used to optimize targeting infe

107 motifs selected in vivo from a combinatorial peptide library can cross the BBB under normal and patho

108 The cyclic peptide library can potentially be of any size and the p

109 icrofluidic device to screen a combinatorial peptide library composed of 5 x 108 members displayed on

110 specificity of 3Clpro using fully degenerate peptide libraries consisting of all 160,000 possible nat

111 protein interactions of FXI, a large random peptide library consisting of 10(6) to 10(7) peptides wa

112 ntral to this process is the idea that small peptide libraries contain sequences that will bind to in

113 nitially identified from combinatorial phage peptide libraries, contain the sequence YPYF(I/L)P(L/I)

114 cetylase sequence specificity using oriented peptide libraries containing acetylated lysine.

115 synthesize and screen one-bead-one-compound peptide libraries containing free C-termini.

116 ter enzyme selectivity can be achieved using peptide libraries containing unnatural amino acids such

117 ike ligands from an mRNA-display macrocyclic peptide library containing >10(12) members.

118 A pY peptide library containing completely randomized residue

119 AMPs, including SMAP-29 and hRNase 7, from a peptide library containing crude mammalian cell lysates.

120 An inverted peptide library containing five random residues (theoret

121 A combinatorial peptide library containing four random residues at the N

122 obes, a feature that we show to be rare in a peptide library containing many members with species-spe

123 A 16,384-member rational combinatorial peptide library, containing peptides of 9-15 amino acids

124 We demonstrate here that composition-space peptide libraries coupled with function-based high-throu

125 ve alphaMI-domain binding sites, we screened peptide libraries covering the complete sequences of the

126 We developed an in vivo peptide library covering substrates of the ER Hsp70 syst

127 On the basis of matrices derived from the peptide library data, we identified and then confirmed t

128 with Reptin was localized using overlapping peptide libraries derived from the AGR2 protein sequence

129 internal agonist, we systematically screened peptide libraries derived from the ectodomain for agonis

130 Analysis of a synthetic peptide library derived from LL-37 showed that antimicro

131 With the use of a peptide library derived from Sema3F, C-1 residues that p

132 g, we examined PAR4-signaling responses to a peptide library derived from the canonical PAR4-agonist

133 We demonstrate the approach using a peptide library derived from the Escherichia coli proteo

134 by comparison of in vitro phosphorylation of peptide libraries differing by a single residue at that

135 ay of specific epitopes but are incapable of peptide library display and affinity selection.

136 Pools of disulfide-constrained random peptide libraries displayed on phage were selected for b

137 An improved binary tag system for encoding peptide libraries during synthesis was designed to facil

138 First, using overlapping peptide libraries encompassing the entire translated seq

139 By screening a combinatorial peptide library, followed by structure-activity relation

140 ariable cysteine-constrained phage-displayed peptide libraries for factor H-binding peptides.

141 itionally relied upon testing of overlapping peptide libraries for their reactivity with T cells in v

142 We screened a peptide library for mutations in SDF-1 that provide resi

143 We screened a phage-displayed peptide library for peptides that home to wounds in mice

144 this new system to screen a capsid-displayed peptide library for retargeted viral infection.

145 In this study, we used random peptide libraries from 7- to 13-mers and studied binding

146 Profiling its specificity with peptide libraries from Escherichia coli revealed a prefe

147 t will also allow the construction of random peptide libraries from which specific binding activities

148 ocks in the ribosomal synthesis of unnatural peptide libraries, from which functional, NRP-like molec

149 Capsid-displayed adenoviral peptide libraries have been a significant, yet unfeasibl

150 Peptides identified from combinatorial peptide libraries have been shown to bind to a variety o

151 Random bacteriophage (phage) display peptide libraries have traditionally been used for the s

152 Screening of the peptide library identified a lead substrate specifically

153 In addition, screening a combinatorial peptide library identified select amino acid substitutio

154 further expand the utility of combinatorial peptide libraries in biomedical research.

155 We discuss the contribution of phage display peptide libraries in determining dominant B-cell epitope

156 Direct screening of combinatorial peptide libraries in patients may allow the identificati

157 od for the rapid generation of combinatorial peptide libraries in sufficient purity to assay the prod

158 to synthesis and screening of combinatorial peptide libraries in the future.

159 Here, by selecting combinatorial random peptide libraries in tumor-bearing mice, we uncovered a

160 ypothesis that methods focusing on screening peptide libraries in vitro for members with the appropri

161 nds for therapeutic targets, phage-displayed peptide libraries in which cyclization is achieved by th

162 Here we screened a peptide library in cancer patients to uncover ligand-rec

163 Here we screen a combinatorial peptide library in mice and characterize a peptide (with

164 Screening of a combinatorial peptide library in positional scanning format led to the

165 was used to isolate mimotopes from a 12-mer peptide library in successive selection rounds.

166 tive of neighboring residues, as shown using peptide libraries incubated with recombinant CGEP and ma

167 one-bead, one-compound (OBOC) combinatorial peptide libraries is routinely carried out with the pept

168 Affinity selection of phage display peptide libraries is routinely used for isolating peptid

169 through screening and analysis of synthetic peptide libraries, ligand 1 has 7500-fold improved affin

170 d viremic KTR were stimulated using BK virus peptide libraries loaded or not on monocytes-derived den

171 rtoires were determined by identifying bound peptide library members for each specimen using cell sor

172 hod for the sequence determination of cyclic peptide library members has been developed.

173 we report the development of a combinatorial peptide library method for systematically profiling the

174 Here we describe a combinatorial peptide library method that allows rapid generation of p

175 tinct target sequences, we used a degenerate peptide library method to comprehensively characterize t

176 display, enabling the synthesis of unnatural peptide libraries of 10(14) unique members for the in vi

177 This report demonstrates that peptide libraries of defined character can serve as a re

178 e previously been delineated using synthetic peptide libraries of fixed length, or single protein cha

179 Recombinant FAP cleavage of peptide libraries of short amino acid sequences surround

180 In brief, phage-encoded combinatorial peptide libraries of the format X(m)CX(n)CX(o)CX(p) are

181 ribe a method for the biosynthesis of cyclic peptide libraries of up to 10(8) members in Escherichia

182 pproach that utilises human proteome-derived peptide libraries of varying length, termed Proteomic Id

183 and robust cyclization procedure to screen a peptide library of >10(13) different sequences and isola

184 A 5-mer OBOC peptide library of 104,907 unique sequences was construc

185 We first established a comprehensive peptide library of allergens from various commercial ext

186 expand the testable sequence space within a peptide library of approximately 100 members for CDK1, C

187 (2) An inventory-shared neoantigen peptide library of common solid tumors was constructed,

188 njugated alphaDEC205 with a linker-optimized peptide library of known CD8 T-cell epitopes from the mo

189 A peptide library of topographically segregated encoded re

190 his goal, we biopanned three phage-displayed peptide libraries on a series of well-defined human non-

191 struction of high-complexity random sequence peptide libraries on MS2 VLPs and that allow control of

192 sites compared to state-of-the-art synthetic peptide libraries or proteomics.

193 Here, phage-peptide library panning coupled with screening using nex

194 We use two distinct modified peptide-library platforms (beads and glass slides) to de

195 In vitro selection of chemically modified peptide libraries presented on phage, while a powerful t

196 uration through the screening of macrocyclic peptide libraries produced in E. coli cells.

197 of immunoprecipitation/mass spectrometry and peptide library profiling, we identified the eukaryotic

198 -I collagen as well as kinetic studies using peptide libraries randomized at P1 and P1', showed very

199 Combinatorial peptide libraries ranging in length between 9 and 12 ami

200 creening against trillion-member macrocyclic peptide libraries (RaPID system).

201 6 d of in vitro expansion using overlapping peptide libraries representing the whole viral protein.

202 In this report, we screened a peptide library representing the SARS-CoV S protein sequ

203 13 patients who performed shared neoantigen peptide library, respectively.

204 ompatibility; incorporation into a synthetic peptide library resulted in the identification of all se

205 pitope mapping with a phage-displayed random peptide library revealed that one of these mAbs (2A5) co

206 fluorescence resonance energy transfer-based peptide library revealed that the I144A, I144C, and I144

207 Epitope mapping, using a phage display peptide library, revealed that cAb29 binds the 2alpha(1)

208 Peptide library scanning showed consistent binding in th

209 Previously, a phage display peptide library screen identified SM1, a peptide that bi

210 Here we describe a peptide library screen to identify sequence requirements

211 An iterative mixture-based random doedecamer peptide library screen with Edman sequencing of MMP-20 c

212 554W), was identified using an intracellular peptide library screen, and subsequently shown to both i

213 ing kinase phosphorylation motifs than older peptide library screening approaches based on Edman sequ

214 We performed combinatorial peptide library screening in vivo on a novel human prost

215 this reaction, we have used a combinatorial peptide library screening platform as a method to explor

216 We used combinatorial peptide library screening to design an optimal peptide s

217 Finally, we used combinatorial peptide library screening to determine that PASK prefers

218 rected mutagenesis, pegylation of molecules, peptide library screening, and gene transfer) have resul

219 ifs through integration of bacterial display peptide library screening, next-generation sequencing (N

220 Through peptide library screening, we identified ADAMTS-like pro

221 ion site sequence, which we verified through peptide library screening.

222 this study demonstrate that phage-displayed peptide library screens on lipid membranes result in the

223 peaklists accommodating, in MS/MS-confirmed peptide library searches, ambiguous mass-hits to non-tar

224 dria, and that an internalizing-phage random peptide library selects for peptide motifs that localize

225 roof of concept, we produced phage-displayed peptide libraries Ser-[X]4-Gly-Gly-Gly, with Gly and Ser

226 Experiments with random-sequence peptide libraries show the single-chain dimer to be high

227 y diverse T cells specific for CMV lysate or peptide libraries spanning pp65 and immediate early (IE)

228 althy donors by stimulation with overlapping peptide libraries spanning the entire coding sequence of

229 By screening peptide libraries spanning the sequence of the alphaIIb

230 Using an overlapping peptide library spanning each of the RSV-derived protein

231 pectrometry and screening of a 413,611 human peptide library spanning the entire human proteome ident

232 Using a peptide library spanning the entire LMP2 sequence, 25 CT

233 icial antigen-presenting cells loaded with a peptide library spanning the entire PRAME protein and co

234 Using a peptide library spanning the entire sequence of the hexo

235 nse, using for the first time an overlapping peptide library spanning the entire viral genome.

236 re investigated by positional scanning using peptide libraries that substituted its leucine core with

237 iously identified ligands from combinatorial peptide libraries that target tumor vasculature after in

238 echnology was demonstrated for two synthetic peptide libraries that were used to screen and optimize

239 Here, we developed an A(b)-peptide library that enabled unbiased screening of pepti

240 Kv1.3 channel blockers from a natural venom peptide library that was formatted for autocrine-based s

241 de novo sequencing followed by a search in a peptide library that we created.

242 A peptide library (that was displayed on phage) was positi

243 y to specify the amino acid frequency in the peptide library; these frequencies often differ signific

244 Here, we screened degenerate peptide libraries to deduce the optimal ULK1 substrate m

245 ct with P. falciparum PKG (PfPKG) and tested peptide libraries to identify its phosphorylation site p

246 rface biomarkers, emphasizing the utility of peptide libraries to probe the surface of a cell.

247 Here we use assembly assays with peptide libraries to show that high-expressing B15 class

248 en developed to screen one-bead-one-compound peptide libraries to systematically profile the sequence

249 ere, we extended the ProteomeTools synthetic peptide library to 550,000 tryptic peptides and 21 milli

250 enesis, homology modeling, and assays with a peptide library to characterize the structural determina

251 four rAbs to probe a random phage-displayed peptide library to determine if epitopes within the MV n

252 gonal high-throughput screen of an iterative peptide library to identify peptide sequences that have

253 es, we screened computationally designed BH3 peptide libraries using bacterial surface display to ide

254 erties were identified from a Zealand Pharma peptide library using pharmaceutical profiling, establis

255 0-1) substrates, were selected from a random peptide library using the phage display technique.

256 nd BT2) were selected from a phage-displayed peptide library via binding to tetragonal BaTiO3 powder.

257 When the peptide library VVWXTA (where X represents all 20 common

258 degradation in the extracts and that of the peptide libraries was completely blocked by o-phenanthro

259 First, a human anti-peptide library was constructed by diversifying a scaffo

260 A random peptide library was expressed on the surface of a mammal

261 A yeast-displayed cystine-knot peptide library was generated by substituting a six amin

262 A phosphotyrosyl (pY) peptide library was screened against the SH2 domains, an

263 A combinatorial phosphotyrosyl (pY) peptide library was screened to determine the amino acid

264 This peptide library was subsequently used to evolve an inhib

265 In this work, a cyclic peptide library was synthesized and screened against the

266 performed using high-resolution MS, and the peptide library was then used to identify prototypic and

267 An acetyl-histone peptide library was used to determine the thermodynamic

268 Next, the generated peptide library was used to develop a targeted proteomic

269 A peptide library was used to map the binding site and def

270 nel of single-substitution analogs and large peptide libraries, we derived novel detailed binding mot

271 Using peptide libraries, we determined if this frequently iden

272 Using peptide libraries, we found that in PTN the alphaMI doma

273 Using combinatorial peptide libraries, we functionally measured broad T-cell

274 By screening HMGB1 peptide libraries, we identified a tetramer (FSSE, desig

275 Probing phage-displayed peptide libraries, we identified and characterized mimet

276 pared with Mamu-E and Qa-1(b) Using extended peptide libraries, we identified and refined the peptide

277 tility in genetically encoded, combinatorial peptide libraries, we report a simple and robust method

278 Using phage display peptide libraries, we screened for ligands that bound to

279 fusion assays, biolayer interferometry, and peptide libraries, we show that SIRPalpha, which, simila

280 Using a phage-displayed peptide library, we determined that 24B11 binds an epito

281 sing dendritic cells pulsed with a cyclin-A1 peptide library, we generated T cells against several cy

282 Using a combinatorial peptide library, we identified a consensus binding seque

283 mia cells with a combinatorial phage display peptide library, we isolated a peptide motif, sequence P

284 nship (SAR) study, two highly focused cyclic peptide libraries were further designed, synthesized, an

285 Bacterial cell-displayed peptide libraries were quantitatively screened for binde

286 The FAIMS approach identified 35% of the peptide library, whereas LC-MS/MS alone identified 8% an

287 e reactivity of these compounds with a model peptide library, which collectively contained all 20 nat

288 By scanning synthetic combinatorial peptide libraries with each enzyme, we compared the pref

289 Preparation of support-bound combinatorial peptide libraries with free C-termini has been challengi

290 ening of small porous beads from solid-phase peptide libraries with high sensitivity and specificity,

291 Panning of phage display peptide libraries with mAb 763.74 and mAb GH786 resulted

292 long natural protein and short combinatorial peptide libraries with much higher complexities.

293 By screening a 13-mer peptide library with a diversity of 10(8), we have ident

294 using a one-bead, one-compound (OBOC) acetyl-peptide library with a quantum dot tagging strategy and

295 trate consensus, we screened a combinatorial peptide library with active MRK.

296 motope of GD2, isolated from a phage display peptide library with anti-GD2 mAb 14G2a, induces MHC cla

297 ular mimicry was sought by screening a phage peptide library with anti-GPIIIa49-66 antibody as bait f

298 med an external correction using a synthetic peptide library with known peptide relative abundance.

299 Screening of the X(15) phage display peptide library with the anti-GD2 monoclonal antibody (m

300 We screened a random peptide library within the receptor-binding domain of a