ライフサイエンスコーパス: peptidyl transferase center

1 r RNA 3'-CCA end is improperly docked in the peptidyl transferase center.

2 m to pause before allowing entrance into the peptidyl transferase center.

3 may generalize to other aaRS, as well as the peptidyl transferase center.

4 entified group thought to reside in the rRNA peptidyl transferase center.

5 to the E site but remains temporarily in the peptidyl transferase center.

6 re with another activity associated with the peptidyl transferase center.

7 n establishing the tertiary structure of the peptidyl transferase center.

8 ics on the scale of seconds at the ribosomal peptidyl transferase center.

9 is located in the immediate vicinity of the peptidyl transferase center.

10 is known to be a component of the ribosomal peptidyl transferase center.

11 ial for the successful assembly of ribosomal peptidyl transferase center.

12 via tertiary interactions to features of the peptidyl transferase center.

13 f the acceptor end of the A-site tRNA at the peptidyl transferase center.

14 the CCA end of deacyl-tRNA departs from the peptidyl transferase center.

15 within domains IV and V, which contains the peptidyl transferase center.

16 o position helices 77 and 78 relative to the peptidyl transferase center.

17 No hydrolytic water molecule was seen in the peptidyl transferase center.

18 o the polypeptide exit tunnel (PET) near the peptidyl transferase center.

19 egion is in close proximity to the ribosomal peptidyl transferase center.

20 from adopting an active conformation at the peptidyl transferase center.

21 interplay between the nascent chain and the peptidyl transferase center.

22 as a function of the distance away from the peptidyl transferase center.

23 e accommodation of decoding factors into the peptidyl transferase center.

24 the L27 N-terminus, which protrudes into the peptidyl transferase center.

25 oning the activated ends of tRNAs within the peptidyl transferase center.

26 f the A-tRNA from entering the A site of the peptidyl transferase center.

27 omal tunnel to the exit port, ~100A from the peptidyl transferase center.

28 S rRNA A-loop, an essential component of the peptidyl transferase center.

29 are elongated, one residue at a time, at the peptidyl transferase center.

30 he modern ribosome this remnant includes the peptidyl transferase center.

31 esidue was separated by 14 residues from the peptidyl transferase center.

32 l RNA (rRNA) that includes hairpin 92 of the peptidyl transferase center.

33 y conserved GGQ motif packs tightly into the peptidyl transferase center.

34 ents are normally performed in the ribosomal peptidyl transferase center.

35 23S ribosomal RNA, an important part of the peptidyl transferase center.

36 somal subunit in the cleft that contains the peptidyl transferase center.

37 the RNA-mediated catalysis of the ribosomal peptidyl transferase center.

38 3S rRNA at three sites, all located near the peptidyl transferase center.

39 inhibition of TnaC-tRNA(Pro) cleavage at the peptidyl transferase center.

40 he subunit interface, and junctions near the peptidyl transferase center.

41 f the ribosome such as the tRNA path and the peptidyl transferase center.

42 Nucleotide A2572 is in the ribosomal peptidyl transferase center.

43 binding sites of several antibiotics in the peptidyl transferase center.

44 that docks the catalytic GGQ motif into the peptidyl-transferase center.

45 s access to both the decoding center and the peptidyl-transferase center.

46 ment of the ribosome functional decoding and peptidyl transferase centers.

47 RNAs containing deleterious mutations in the peptidyl transferase center (25S NRD).

48 Thus, eIF5B interaction with the peptidyl transferase center A loop increases the accurac

49 ther universally conserved nucleotide in the peptidyl transferase center, A2451.

50 itionally, a nucleotide located close to the peptidyl transferase center, A2572, which was protected

51 All three are at or have been linked to the peptidyl transferase center according to the literature.

52 eptide exit tunnel at some distance from the peptidyl transferase center agrees with the proposed mod

53 ection between peptide bond formation at the peptidyl transferase center and chaperone-assisted de no

54 er resistance to antibiotics that target the peptidyl transferase center and exit tunnel of the ribos

55 contributes to the tertiary structure of the peptidyl transferase center and influences the conformat

56 he C-terminal domain of EF4 reaches into the peptidyl transferase center and interacts with the accep

57 alterations at every rRNA nucleotide of the peptidyl transferase center and isolating gain-of-functi

58 the protein that interacts with the ribosome peptidyl transferase center and mimics the 3'-acceptor s

59 omycin A (HygA) and macrolides, which target peptidyl transferase center and peptide exit tunnel, res

60 Both antibiotics bind at the peptidyl transferase center and sterically occlude the C

61 nterferes with eRF1's accommodation into the peptidyl transferase center and subsequent peptide relea

62 nd the subsequent expansions that shaped the peptidyl transferase center and the conserved core.

63 n of essential functional sites, such as the peptidyl transferase center and the decoding site.

64 end in tRNA interactions with the ribosomal peptidyl transferase center and the elongation factor Tu

65 ubunit along the path it follows between the peptidyl transferase center and the exit site on the dis

66 Two hydrophobic crevices, one at the peptidyl transferase center and the other at the entranc

67 a catalytic water can be coordinated in the peptidyl transferase center and, together with previous

68 d helix 44 of 18S rRNA, domain 4 is near the peptidyl-transferase center and its helical subdomain co

69 omain V (which is known to be a component of peptidyl transferase center) and a loop of the helix 35

70 the A loop and P loop, respectively, of the peptidyl transferase center, and G1735A, mapping near a

71 , including the neighborhood surrounding the peptidyl transferase center, and stable association of r

72 Proposed catalytic mechanisms at the peptidyl transferase center are based on structures of m

73 d that the ribosome dynamics detected at the peptidyl transferase center are highly inhomogeneous.

74 The tRNAs in the peptidyl transferase center are in the A/A site and the

75 es of tRNA substrate located in the ribosome peptidyl transferase center around the 2-fold axis, we h

76 oRNA binding causes little distortion of the peptidyl transferase center but do provide suggestive ev

77 fined to the nascent peptide residues in the peptidyl transferase center but not to the peptide segme

78 e ribosome is catalyzed in the large subunit peptidyl transferase center by release factors on recogn

79 ons of two other nucleotide positions in the peptidyl transferase center, C2471 and U2519 (C2452 and

80 al subunit bL27m to provide stability to the peptidyl-transferase center during elongation.

81 centers in the large subunit, including the peptidyl-transferase center, for unnatural polymer synth

82 confirm the topographical separation of the peptidyl transferase center from the E site domain.

83 S rRNA nucleotides in the 2585 region of the peptidyl transferase center, G2583A and U2584C, were obs

84 bosomal subunits and the conformation of the peptidyl transferase center in the context of the intact

85 Cryo-EM analysis revealed a malformed peptidyl transferase center in the misassembled 50S subu

86 nd peptidyl-D-aa-tRNA can trap the ribosomal peptidyl-transferase center in a conformation in which p

87 onstruct that comprises much of the 23S rRNA peptidyl transferase center, including the central loop

88 Classic peptidyl transferase center inhibitor chloramphenicol (C

89 ce of these results for the structure of the peptidyl transferase center is considered.

90 s to block assembly at a late stage when the peptidyl transferase center is formed, indicating a poss

91 The ribosomal peptidyl transferase center is responsible for two funda

92 gest that the positioning of Pro-tRNA in the peptidyl transferase center is the major determinant for

93 nity for CCdApPuro comparable to that of the peptidyl transferase center itself (Kd approximately 10

94 Three additional sites were at the peptidyl transferase center itself.

95 -bound tRNAs, whose 3' termini reside in the peptidyl transferase center, label primarily nucleotides

96 ntly, Nog1 eviction from the pre-60S permits peptidyl transferase center maturation, and allows Yvh1

97 in 23S rRNA, which is situated close to the peptidyl transferase center, may participate in one or m

98 class I release factor (RF) protein and the peptidyl transferase center of a large subunit rRNA.

99 to interact with nucleotide residues in the peptidyl transferase center of domain V.

100 to pseudouridine (Psi) in a stem-loop at the peptidyl transferase center of Escherichia coli 23S rRNA

101 lmN and Cfr, both methylate A2503 within the peptidyl transferase center of prokaryotic ribosomes, yi

102 ance of pseudouridine formation (Psi) in the peptidyl transferase center of rRNA was examined by depl

103 These findings directly implicate the peptidyl transferase center of the 50S subunit in the me

104 on and peptidyl release are catalyzed at the peptidyl transferase center of the 50S subunit of the 70

105 on binding sites of the 30S subunit with the peptidyl transferase center of the 50S subunit via rRNA-

106 , inhibit protein synthesis by targeting the peptidyl transferase center of the bacterial ribosome.

107 has been implicated as a constituent of the peptidyl transferase center of the Escherichia coli 50 S

108 (BlaS) targets translation by binding to the peptidyl transferase center of the large ribosomal subun

109 h the accommodation corridor en route to the peptidyl transferase center of the large ribosomal subun

110 The action of the peptidyl transferase center of the large ribosomal unit

111 ffectively an unbranched tube connecting the peptidyl transferase center of the large subunit and the

112 or interaction localized in proximity to the peptidyl transferase center of the large subunit of the

113 lation of an adenosine nucleotide within the peptidyl transferase center of the ribosome mediated by

114 gyl anisomycin binds to the highly conserved peptidyl transferase center of the ribosome similar to t

115 ired for introducing specific changes in the peptidyl transferase center of the ribosome that activat

116 This nucleotide is positioned within the peptidyl transferase center of the ribosome, which is a

117 of domain V, which forms a major part of the peptidyl transferase center of the ribosome.

118 catalytically productive orientation in the peptidyl transferase center of the ribosome.

119 o acids are polymerized into peptides in the peptidyl transferase center of the ribosome.

120 This modification is located in the peptidyl transferase center of the ribosome.

121 ndividual point mutations, in either the 25S peptidyl transferase center or 18S decoding site, that a

122 aphic structures of antibiotics bound to the peptidyl transferase center or the exit tunnel of archae

123 crystallography and reveals it to occupy the peptidyl transferase center P-site of the ribosome.

124 Such placement, near the peptidyl transferase center, provides a rationale for th

125 ibosomes are limited by the lack of complete peptidyl transferase center (PTC) active site mutational

126 r: rotation of the 5S RNP, maturation of the peptidyl transferase center (PTC) and the nascent polype

127 e ribosomal RNA segments that constitute the peptidyl transferase center (PTC) and those that connect

128 beling, and mutational analyses revealed the peptidyl transferase center (PTC) as the focal point of

129 nucleotide rearrangements that suppress the peptidyl transferase center (PTC) catalytic activity sti

130 The ribosome's peptidyl transferase center (PTC) catalyzes peptide bond

131 its peptide-bond formation in the ribosome's peptidyl transferase center (PTC) during its own transla

132 The effect of AAP and Arg on ribosome peptidyl transferase center (PTC) function was analyzed

133 ribosomal exit tunnel and the A-site of the peptidyl transferase center (PTC) in halting translation

134 the CCA-end of the A-site tRNA away from the peptidyl transferase center (PTC) is functionally signif

135 Here we demonstrate that the ribosomal peptidyl transferase center (PTC) is supported by a fram

136 The catalytic peptidyl transferase center (PTC) is targeted by the bro

137 x RNA helicase specifically activated by the peptidyl transferase center (PTC) of 23S rRNA.

138 we visualize the formation of the conserved peptidyl transferase center (PTC) of the human mitochond

139 Peptide bond formation is catalyzed at the peptidyl transferase center (PTC) of the large ribosomal

140 es, thereby participating in structuring the peptidyl transferase center (PTC) of the large ribosomal

141 protein synthesis inhibitors that target the peptidyl transferase center (PTC) on the large subunit o

142 nding of neither nucleotide (ATP or ADP) nor peptidyl transferase center (PTC) RNA, the presumed phys

143 ribosomal RNA (rRNA) helix 89 of the nascent peptidyl transferase center (PTC) through Nsa2.

144 tion axes for both subunits pass through the peptidyl transferase center (PTC), indicating a tendency

145 cific insertion in HflX reaches far into the peptidyl transferase center (PTC), such that it would ov

146 oteins are essential for the function of the peptidyl transferase center (PTC).

147 of the large ribosomal subunit known as the peptidyl transferase center (PTC).

148 and catalyzing peptide bond formation at the peptidyl transferase center (PTC).

149 none molecule within its binding site in the peptidyl transferase center (PTC).

150 l differences are in the conformation of the peptidyl-transferase center (PTC) and the interface betw

151 the sarcin/ricin loop (SRL) and A2531 in the peptidyl-transferase center (PTC) has adverse effects on

152 e tunnel of the ribosome, extending into the peptidyl-transferase center (PTC).

153 owing a disruption of the A-site side of the peptidyl-transferase center (PTC).

154 rnate secondary structure within the nascent peptidyl-transferase-center (PTC).

155 A), especially in the catalytic active site (peptidyl transferase center; PTC), are often functionall

156 discovered near the decoding center and the peptidyl transferase center, respectively.

157 ethylates an adenosine nucleotide within the peptidyl transferase center, resulting in the C-8 methyl

158 es specific nucleotides within the ribosomal peptidyl transferase center that appear to be essential

159 mes, and their effect on conformation in the peptidyl transferase center, the GTPase-associated cente

160 erichia coli 23S rRNA, 14 are located in the peptidyl transferase center, the main antibiotic target

161 iary interactions between nucleotides in the peptidyl transferase center, the SRD, and the GTPase-ass

162 rmB is unperturbed by SrmB deletion, but the peptidyl transferase center, the uL7/12 stalk, and 30S c

163 , nascent polypeptide chains travel from the peptidyl transferase center through the nascent polypept

164 e essential macromolecular components of the peptidyl transferase center to 23S rRNA and ribosomal pr

165 s a hydrolytic reaction in the large subunit peptidyl transferase center to release the finished poly

166 subunit surface, connecting the tRNA in the peptidyl transferase center to the distally located nasc

167 -helices inside the ribosome tunnel near the peptidyl transferase center under specific conditions.

168 changes occur at several nucleotides in the peptidyl transferase center upon alterations in pH, temp

169 es of 8 rRNA-modifying enzymes targeting the peptidyl transferase center were individually inactivate

170 reates a free tryptophan-binding site in the peptidyl transferase center, where bound tryptophan inhi

171 econd, their acceptor stems are bound by the peptidyl transferase center, which aligns the 3'-aminoac

172 tRNAs for binding in the A-site cleft in the peptidyl-transferase center, which is universally conser

173 rom the back of the 50 S particle toward the peptidyl transferase center within the 50 S subunit.

174 ming the three- dimensional structure of the peptidyl transferase center within the ribosome.