ライフサイエンスコーパス: perfluorooctane

1 (perfluorooctanoic acid [PFOA]; 1H,1H,8H,8H-perfluorooctane-1,8-diol [FC8-diol]; 1H,1H,10H,10H-perfl

2 sed short-chain SFPs (FC-6 chemistry) and of perfluorooctane-based long-chain SFPs (FC-8 chemistry) w

3 ile the amide derivatives were precursors to perfluorooctane carboxylate (PFOA).

4 congeners under 10% of total PFASs, even for perfluorooctane carboxylic acid (PFOA, 6%).

5 Perfluorooctane caused significantly more toxic damage t

6 ids (including alkanes, alcohols, toluene, n-perfluorooctane, CCl(4), and DMSO) as a function of the

7 sformed a short chain alkane, n-octane, to n-perfluorooctane in stages.

8 Ss; e.g. perfluorooctanesulfonate (PFOS) and perfluorooctane (PFOA)].

9 In Brazil, the PFOS-precursor N-ethyl perfluorooctane sulfonamide (EtFOSA) is used in Sulflura

10 The ratio between perfluorooctane sulfonamide (FOSA) and its metabolite pe

11 tion to soils, while transformation products perfluorooctane sulfonamide (FOSA) and PFOS are sufficie

12 ied for PFOAAmS and three products including perfluorooctane sulfonamide (FOSA) for PFOSAmS through h

13 of 13 perfluorinated alkyl acids (PFAAs) and perfluorooctane sulfonamide (FOSA) in primiparous women

14 alkyl carboxylic acids (PFCAs, C(4-13)), and perfluorooctane sulfonamide (FOSA) were analyzed in plas

15 collected, perfluorooctane sulfonate (PFOS), perfluorooctane sulfonamide (FOSA), and C8-C14 perfluoro

16 tro metabolite from the pre-2002 product was perfluorooctane sulfonamide (FOSA), and coincident with

17 luorooctane sulfonamidoacetates (FOSAAs) and perfluorooctane sulfonamide (FOSA), including both branc

18 We observed significant temporal trends of perfluorooctane sulfonamide (FOSA), perfluorooctane sulf

19 ctane sulfonamido acetic acid (Et-FOSAA) and perfluorooctane sulfonamide (FOSA).

20 recent ten years for any substances, except perfluorooctane sulfonamide (FOSA).

21 ane sulfonic acids (PFSAs; C4,C6,C8,C10) and perfluorooctane sulfonamide (FOSA).

22 Perfluorooctane sulfonamide (PFOSA) is an immediate perf

23 sis by examining the isomer-specific fate of perfluorooctane sulfonamide (PFOSA), a known PFOS-precur

24 ecanoate (PFDeA), perfluorononanoate (PFNA), perfluorooctane sulfonamide (PFOSA), perfluorooctane sul

25 In the current work, concentrations of PFOS, perfluorooctane sulfonamide (PFOSA), PFOS isomer profile

26 erfluoroalkanesulfonic acids (PFSAs), methyl-perfluorooctane sulfonamide acetic acid (MeFOSAA, a PFSA

27 de ethanols (N-MeFOSE and N-EtFOSE); and two perfluorooctane sulfonamide acetic acids (N-MeFOSAA and

28 namides (PFOSA, N-MeFOSA, and N-EtFOSA); two perfluorooctane sulfonamide ethanols (N-MeFOSE and N-EtF

29 Legacy per- and polyfluoroalkyl acids and perfluorooctane sulfonamide in beluga whale liver were f

30 and 21% for PCB congeners 118, 167, 209, and perfluorooctane sulfonamide in females; and between 17%

31 DA), perfluorotridecanoic acid (PFTrDA)] and perfluorooctane sulfonamide precursors were estimated to

32 The biotransformation of perfluorooctane sulfonamide quaternary ammonium salt (PF

33 perfluorooctane sulfonate and its precursor perfluorooctane sulfonamide varied among tissues from 9

34 l (PCBs 138, 153, 167, 170, 195, and 209 and perfluorooctane sulfonamide) and paternal (PCBs 172 and

35 s, C(4), C(6), and C(8) perfluorosulfonates, perfluorooctane sulfonamide, and 6:2 and 8:2 fluorotelom

36 e, 8:2 fluorotelomer sulfonic acid, N-methyl perfluorooctane sulfonamide, and a previously unreported

37 cetate, N-ethyl perfluorooctane sulfonamide, perfluorooctane sulfonamide, and perfluorooctane sulfona

38 cid, perfluorooctane sulfonamidoacetic acid, perfluorooctane sulfonamide, and PFOS.

39 4 perfluoroalkyl sulfonic acids (PFSAs), and perfluorooctane sulfonamide, in livers of 50 otters whic

40 perfluorooctane sulfonamidoacetate, N-ethyl perfluorooctane sulfonamide, perfluorooctane sulfonamide

41 about the stability of high-molecular-weight perfluorooctane sulfonamide-based substances such as the

42 forming an important intermediate precursor (perfluorooctane sulfonamide: FOSA), into a prevalent com

43 s (FTMACs), fluorotelomer acrylates (FTACs), perfluorooctane sulfonamides (FOSAs), and perfluorooctan

44 ances [e.g., fluorotelomer alcohols (FtOHs), perfluorooctane sulfonamides (FOSAs), and perfluorooctan

45 s (FTMACs), fluorotelomer acrylates (FTACs), perfluorooctane sulfonamides (FOSAs), and perfluorooctan

46 nd 8:2 fluorotelomer sulfonates (FTS); three perfluorooctane sulfonamides (PFOSA, N-MeFOSA, and N-EtF

47 nd numerous PFAA-precursors (i.e., (N-alkyl) perfluorooctane sulfonamides and fluorotelomer carboxyli

48 rmation of precursors ((N-alkyl substituted) perfluorooctane sulfonamides; FOSAMs).

49 observed between SAmPAP diester and N-ethyl perfluorooctane sulfonamido acetate (an anticipated degr

50 dominant, alongside precursors such as ethyl perfluorooctane sulfonamido acetic acid (Et-FOSAA) and p

51 .39), with a strong correlation for N-methyl perfluorooctane sulfonamido acetic acid (r(sp) = 0.68).

52 landfill leachates and N-methyl and N-ethyl perfluorooctane sulfonamido acetic acid assisted in that

53 w molecular weight substances (e.g., N-ethyl perfluorooctane sulfonamido ethanol (EtFOSE)) in wastewa

54 ric concentrations of PFOA, PFNA, and methyl perfluorooctane sulfonamido ethanol (MeFOSE) (p <= 0.05)

55 uorohexanesulfonate (PFHxS), and 2-(N-methyl-perfluorooctane sulfonamido) acetate (Me-PFOSA-AcOH) wer

56 Six PFCs [2-(N-methyl-perfluorooctane sulfonamido) acetate (Me-PFOSA-AcOH), pe

57 N-ethyl perfluorooctane sulfonamidoacetate, perfluorooctane sulfonamidoacetate, N-ethyl perfluorooct

58 ed to a suite of products, including N-ethyl perfluorooctane sulfonamidoacetate, perfluorooctane sulf

59 Perfluorooctane sulfonamidoacetates (FOSAAs) and perfluo

60 he observed metabolites in fish were N-ethyl perfluorooctane sulfonamidoacetic acid, perfluorooctane

61 thyl perfluorooctane sulfonamidoacetic acid, perfluorooctane sulfonamidoacetic acid, perfluorooctane

62 rrestrial invertebrates, and PFOS, PFDA, and perfluorooctane sulfonamidoacetic acids (FOSAAs) bioaccu

63 s mitigated in polyfluoroalkyl betaines, yet perfluorooctane sulfonamidoalkyl betaine (PFOSB) showed

64 Perfluorooctane sulfonamidoethanol based phosphate diest

65 Perfluorooctane sulfonamidoethanol-based phosphate (SAmP

66 In particles, perfluorooctane sulfonamidoethanols (FOSEs) dominated, w

67 ), perfluorooctane sulfonamides (FOSAs), and perfluorooctane sulfonamidoethanols (FOSEs).

68 ), perfluorooctane sulfonamides (FOSAs), and perfluorooctane sulfonamidoethanols (FOSEs)] have suffic

69 ), perfluorooctane sulfonamides (FOSAs), and perfluorooctane sulfonamidoethanols (FOSEs)].

70 In cloth, perfluorooctane sulfonamidoethanols (i.e., MeFOSE and Et

71 were detected regularly in peat samples with perfluorooctane sulfonate (85-655 ng kg(-1)), perfluoroo

72 idence interval (CI): 0.69, 0.96) for linear perfluorooctane sulfonate (n-PFOS), 0.84 (95% CI: 0.69,

73 atio = 1.36; 95% CI: 1.12, 1.64), 37% higher perfluorooctane sulfonate (PFOS) (GM ratio = 1.37; 95% C

74 Perfluorooctane sulfonate (PFOS) accounted for 75% of th

75 Elevated levels of perfluorooctane sulfonate (PFOS) and elevated detection

76 covered microplastic fibers (BMFs) to adsorb perfluorooctane sulfonate (PFOS) and lead (Pb) at enviro

77 ch concentrations either remained unchanged (perfluorooctane sulfonate (PFOS) and perfluorocarboxylat

78 Perfluorooctane sulfonate (PFOS) and perfluorohexane sul

79 Perfluorooctane sulfonate (PFOS) and perfluorooctanoate

80 Perfluorooctane sulfonate (PFOS) and perfluorooctanoate

81 Polyfluoroalkyl chemicals (PFCs) such as perfluorooctane sulfonate (PFOS) and perfluorooctanoate

82 e association between early life exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic a

83 ether umbilical cord blood concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoic a

84 urbed production of legacy compounds such as perfluorooctane sulfonate (PFOS) and perfluorooctanoic a

85 prior toxicity evaluations on PFAS, such as perfluorooctane sulfonate (PFOS) and perfluorooctanoic a

86 Perfluorooctane sulfonate (PFOS) and perfluorooctanoic a

87 The results of a study on levels of perfluorooctane sulfonate (PFOS) and perfluorooctanoic a

88 Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are compounds that do n

89 Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) are persistent environm

90 Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) are persistent, synthet

91 c dose-response data and PBPK modeling using perfluorooctane sulfonate (PFOS) as a case study.

92 ct aqueous perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) at concentrations of mu

93 ely detect perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) at concentrations of ng

94 The environmental occurrence of perfluorooctane sulfonate (PFOS) can arise from its dire

95 and 0.91 ng g(-1) ww, respectively, whereas perfluorooctane sulfonate (PFOS) concentrations did not

96 Of the 36 target PFASs, perfluorooctane sulfonate (PFOS) dominated in all but on

97 sories for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) in 2016.

98 (e.g., ~62 PVs versus ~12 PVs predicted for perfluorooctane sulfonate (PFOS) in loamy sand).

99 onship between perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) in plasma versus milk a

100 st concentrations in the earthworms were for perfluorooctane sulfonate (PFOS) in the AFFF-impacted So

101 oning parameters of both linear and branched perfluorooctane sulfonate (PFOS) in unsaturated soils.

102 Perfluorooctane sulfonate (PFOS) is an environmental con

103 Perfluorocarbon chain of perfluorooctane sulfonate (PFOS) is not only hydrophobic

104 Great variability exists in perfluorooctane sulfonate (PFOS) isomer patterns in huma

105 Serum perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) levels have been shown

106 circumvents the use of water scavengers and perfluorooctane sulfonate (PFOS) ligands.

107 Exposure to perfluorooctane sulfonate (PFOS) may arise directly, fro

108 h suggests perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) may be associated with

109 ia staff or contractors with serum levels of perfluorooctane sulfonate (PFOS) of 5 ng/mL or more who

110 Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) persist in the environm

111 2.7 and 1440 mug/L and the concentration of perfluorooctane sulfonate (PFOS) plus perfluorooctanoic

112 -ng/mL increase in simulated cord plasma for perfluorooctane sulfonate (PFOS) was 2.72 g (95% CI: -3.

113 Perfluorooctane sulfonate (PFOS) was not significantly a

114 Perfluorooctane sulfonate (PFOS) was the compound found

115 n of serum perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) with self-reported preg

116 rends of perfluorooctane sulfonamide (FOSA), perfluorooctane sulfonate (PFOS), and perfluoroalkyl car

117 ulfonate (PFHxS), perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), and perfluorononanoic

118 PFAAs), including perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), and perfluorononanoic

119 (PFNA), perfluorooctane sulfonamide (PFOSA), perfluorooctane sulfonate (PFOS), and perfluorooctanoic

120 ulfonate (PFHxS), perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), and perfluoroundecanoa

121 advisories are primarily being developed for perfluorooctane sulfonate (PFOS), but this work reinforc

122 nyls (OH-PCBs), pentachlorophenol (PCP), and perfluorooctane sulfonate (PFOS), compete with thyroxin

123 Legacy PFAS, including perfluorooctane sulfonate (PFOS), have been regularly de

124 Some substituted C8 PFSAs [keto-perfluorooctane sulfonate (PFOS), hydrogen-PFOS, and uns

125 nd polyfluoroalkyl substance used to replace perfluorooctane sulfonate (PFOS), mainly in aircraft hyd

126 This is the first report of PFOA, perfluorooctane sulfonate (PFOS), perfluorohexane sulfon

127 ) prenatal plasma perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), perfluorohexane sulfon

128 rations of PFASs [perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoate (PF

129 entrations of perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid

130 We measured serum creatinine, PFOA, perfluorooctane sulfonate (PFOS), perfluorononanoic acid

131 s the 147 biota samples (18 taxa) collected, perfluorooctane sulfonate (PFOS), perfluorooctane sulfon

132 Previously measured median concentrations of perfluorooctane sulfonate (PFOS), perfluorooctanoate (PF

133 ciations of prenatal serum concentrations of perfluorooctane sulfonate (PFOS), perfluorooctanoate (PF

134 cross a range of relevant concentrations for perfluorooctane sulfonate (PFOS), perfluorooctanoate (PF

135 ted TSH values were higher among the highest perfluorooctane sulfonate (PFOS), perfluorooctanoic acid

136 degradation of two contaminants-nitrate and perfluorooctane sulfonate (PFOS)-in four source waters w

137 gations into the biodegradation potential of perfluorooctane sulfonate (PFOS)-precursor candidates ha

138 FBS), perfluorohexane sulfonate (PFHxS), and perfluorooctane sulfonate (PFOS).

139 As), including perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS).

140 l blue and the persistent organic pollutant, perfluorooctane sulfonate (PFOS).

141 te (PFOA) and 140 ng/L (median 850 ng/L) for perfluorooctane sulfonate (PFOS).

142 of the PFAS in AFFF-affected surface waters: perfluorooctane sulfonate (PFOS, 40%), perfluorohexane s

143 Concomitantly, levels of FOSA (22%/y), perfluorooctane sulfonate (PFOS, 8.4%/y), perfluorodecan

144 g(dw,soil))(-1)] but to a lesser extent than perfluorooctane sulfonate (PFOS: BSAF ~ 21-29).

145 5% CI: 0.69, 1.00) for sum of branched-chain perfluorooctane sulfonate (Sm-PFOS), 0.79 (95% CI: 0.66,

146 tanoate [PFOA] RR = 0.95; 95% CI, 0.77-1.18; perfluorooctane sulfonate [PFOS] RR = 0.98; 95% CI, 0.87

147 1.7 (95% confidence interval: 1.0, 2.8) for perfluorooctane sulfonate and 2.1 (95% confidence interv

148 The concentration ratios (+/-SE) between perfluorooctane sulfonate and its precursor perfluorooct

149 sk in boys per quartile of maternal level of perfluorooctane sulfonate and perfluorooctanoic acid (P

150 Perfluorooctane sulfonate and perfluorooctanoic acid are

151 Perfluorooctane sulfonate and perfluorooctanoic acid wer

152 Although perfluorooctane sulfonate hazard index decreased by 72%

153 The percentage of branched perfluorooctane sulfonate increased with depth, consiste

154 (EDI) of C8-PFAS (perfluorooctanoic acid and perfluorooctane sulfonate) (0.023 nanograms per kilogram

155 id), PFBS (perfluorobutane sulfonate), PFOS (perfluorooctane sulfonate), and PFOA (perfluorooctanoic

156 (PFCs), including perfluorooctanoic acid and perfluorooctane sulfonate, are manmade chemicals that ha

157 born to mothers in the lowest quartiles: for perfluorooctane sulfonate, beta = -0.18 (95% confidence

158 cept for March-April, when concentrations of perfluorooctane sulfonate, perfluorooctanoate, and numer

159 We measured concentrations of perfluorooctane sulfonate, perfluorooctanoate, perfluoro

160 A novel PFAS, unsaturated perfluorooctane sulfonate, was detected in >80% of water

161 (F-53B), a commonly utilized alternative for perfluorooctane sulfonate, was detected in pregnant wome

162 f PFCs, including perfluorooctanoic acid and perfluorooctane sulfonate, were positively associated wi

163 terval: 1.01, 3.27; P for trend = 0.019) for perfluorooctane sulfonate.

164 ulfonamide, perfluorooctane sulfonamide, and perfluorooctane sulfonate.

165 d; PFOA) and suppression of immune response (perfluorooctane sulfonate; PFOS).

166 ) concentrations in breast milk, we measured perfluorooctane sulfonic (PFOS) and perfluorooctanoic ac

167 A doubling in perfluorooctane sulfonic acid (PFOS) and perfluorodecano

168 s with the highest serum concentrations were perfluorooctane sulfonic acid (PFOS) and perfluorooctano

169 /perfluoroalkyl substances (PFASs) including perfluorooctane sulfonic acid (PFOS) and perfluorooctano

170 ng studies have shown that concentrations of perfluorooctane sulfonic acid (PFOS) in men are higher t

171 Perfluorooctane sulfonic acid (PFOS) is one of the most

172 Exposure to perfluorooctane sulfonic acid (PFOS) or to perfluoroocta

173 ns ranged from undetected to 36.1 pg/mL, and perfluorooctane sulfonic acid (PFOS) ranged from undetec

174 Perfluorooctane sulfonic acid (PFOS) was the dominant co

175 Perfluorooctane sulfonic acid (PFOS) was used as a repre

176 Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) were previously det

177 reactivities of perfluorooctanoic (PFOA) and perfluorooctane sulfonic acid (PFOS) with hydrated elect

178 Electrochemical fluorination manufacture of perfluorooctane sulfonic acid (PFOS), one of the most st

179 s), including perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane su

180 Cs, including perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorononanoic

181 Perfluorohexane sulfonic acid (PFHxS), perfluorooctane sulfonic acid (PFOS), perfluorooctanoic

182 PFAA: Perfluorohexane sulfonic acid (PFHxS), perfluorooctane sulfonic acid (PFOS), perfluorooctanoic

183 the predominant route for human exposure to perfluorooctane sulfonic acid (PFOS).

184 Associations between plasma perfluorooctane sulfonic acid and perfluorononanoate (PF

185 before sampling, while inputs of the legacy perfluorooctane sulfonic acid had decreased.

186 fluorooctanoic acid and a 20-34% increase in perfluorooctane sulfonic acid in drinking water.

187 ances (PFAS) like perfluorooctanoic acid and perfluorooctane sulfonic acid is critical due to their e

188 PFOS (perfluorooctanesulfonate, or perfluorooctane sulfonic acid) is an anthropogenic fluor

189 safety limits (e.g., 70 ng/L for the sum of perfluorooctane sulfonic acid, PFOS and perfluorooctanoi

190 ture for commonly monitored compounds (e.g., perfluorooctane sulfonic acid, PFOS).

191 ~5.4) by inherently implanting Cu sites with perfluorooctane to create interfacial noncovalent intera