ライフサイエンスコーパス: perhaps

1 produce and consume research conducted in 1, perhaps 2, species-and increasing pressure to reduce or

2 Old World monkeys diverged from apes perhaps 30 million years ago (Ma) according to molecular

3 I) species with mostly oxygen donor ligands, perhaps a few nitrogen donors, and probably no sulfur do

4 ly partially oxidized and thus redox-active, perhaps able to promote prebiotic chemical reactions.

5 rmation and remodeling of myelin sheaths and perhaps additional functions of oligodendrocytes and OPC

6 ly spread throughout the sub-Saharan region, perhaps aided by adaptation to alternate hosts and the a

7 ves, something in the brain, in the genes or perhaps all of these?

8 osage and protein quality control in C9, and perhaps all, ALS/FTD.

9 e important in the pathogenesis of many, and perhaps all, immune-mediated diseases.

10 f decay of activated phosphodiesterase, with perhaps also an increase in the rate of decay of light-a

11 the early stage of neural tube development, perhaps also contributing to caudal specific NTDs.

12 trimer-bearing nanoparticles in general and perhaps also for soluble Env proteins.IMPORTANCE Recombi

13 vans, Homo floresiensis, Homo luzonensis and perhaps also Homo heidelbergensis and Homo erectus(12) w

14 tivariate feedback networks in bone modeling-perhaps also in mammalian bones-and thus arguing for the

15 they require less metabolic change, and thus perhaps also less genetic change than other cross-feedin

16 of the effector enzyme phosphodiesterase and perhaps also of activated visual pigment.

17 ntext of nonskeletal cells, the osteocyte is perhaps among the least studied cells in all of vertebra

18 Although perhaps annoying in daily life, this can have severe con

19 function similarly to Xrn1 in transcription, perhaps as a complex, and that the decay factors Ccr4 an

20 the accessory olfactory bulb was indistinct, perhaps as a consequence of the altered architecture of

21 apid exchange between bone marrow and blood, perhaps as a means to optimize humoral immunity during d

22 ation in the parental life-history strategy, perhaps as a reliable signal of a chick's size or age.

23 gmentation standing out as a shared pathway, perhaps as a response to the high levels of ultraviolet

24 tact proviruses in vitro is extremely rapid, perhaps as a result of enhanced expression.

25 ample bias and skew in search query volumes, perhaps as a result of media coverage.

26 n of the domestic chicken in northern China, perhaps as early as 8,000 years ago.

27 y underappreciated role for GPCRs in cancer, perhaps as functional oncogenes, biomarkers, surface ant

28 their emergence, alternative energy sources, perhaps assisted by simple catalysts, must have mediated

29 se functions, and failure of RA signaling is perhaps associated with normal cognitive decline with ag

30 the loss or absence of histone acetylation, perhaps at stalled forks, may contribute to cell death i

31 r locus for targeted intervention of FXS and perhaps autism.

32 antly aerobic organoheterotrophic lifestyle, perhaps based on scavenging amino acids, nucleotides, an

33 Thus, intraislet diffusible factors should perhaps be considered as an alternate mechanism.

34 t the taste of food during consumption could perhaps be part of successful prevention and treatment o

35 ngevity more strongly in females than males, perhaps because inhibition of hepatic mTORC2 (mTOR Compl

36 EC/VCs) are able to control virus infection, perhaps because of host genetic determinants.

37 y of the anthracene-substituted derivatives, perhaps because of inter-arene torsions that emerge in t

38 ips with individual antioxidants were weaker perhaps because of small numbers.

39 reduced intensity conditioning PBSC h-HSCT, perhaps because of the combined effect of T and NK cell

40 oss-feeding are especially likely to evolve, perhaps because they require less metabolic change, and

41 commonly show the same fishing down response perhaps because time series are too short to witness ear

42 In spite of (or, perhaps, because of) their tremendous structural and fun

43 e that my trajectory will be of interest and perhaps beneficial to much younger women who are just ge

44 cardiac disease that accompanies CKD and is perhaps best characterized as diastolic dysfunction seen

45 ighly reduced form of the P-C-O unit that is perhaps best described as a uranium-stabilised OCP(2-.)

46 This effect is perhaps best exemplified by the risk of developing arter

47 as half of our global electricity needs and perhaps beyond.

48 reversibility will require fresh approaches, perhaps borrowed from other fields.

49 duced depressive-like behavior in male mice, perhaps by altering alpha-amino-3-hydroxy-5-methyl-4-iso

50 enance in ways other than just through Amo1, perhaps by constraining a looped domain through pairing.

51 rically modulate Ca(2+) activation of force, perhaps by controlling the troponin I switching mechanis

52 , at least in part by an indirect mechanism, perhaps by increasing steady state levels of APP, while

53 ther biochemical modifications are revealed, perhaps by other members of the large FMO family in this

54 X4L4 can largely reverse the Ku inhibition, perhaps by pushing the Ku inward to expose the overhang

55 te a requirement for the inhibition of Polo, perhaps by sequestering Polo to the microtubules during

56 ced in the presence of citrate and tartrate, perhaps by the activity of a divergent histidine kinase-

57 evaluating group differences after CSDS and perhaps can be applied to other mouse models of psychiat

58 mbrane substrates, suggesting that multiple, perhaps combinatorial, determinants are involved in subs

59 e based on optimising the dose and schedule, perhaps combined with other targeted agents that might p

60 However, the existence of altered and perhaps compensatory neural dynamics, sub-serving audito

61 xts or does it play a more specialized role, perhaps contributing only when initiation is less depend

62 e tau protein in vivo have remained elusive, perhaps contributing to the lack of disease-modifying th

63 erature and BAT thermogenic gene expression, perhaps contributing to their obesity.

64 8.2 is subject to adjustment by distinct and perhaps coordinated mechanisms for its localization and

65 interactions at particle-cell interfaces and perhaps correlates with the local Hg-S coordination stat

66 or earth's biogeochemical fluxes of C and N, perhaps costing 4-7% of forest fixed photosynthetic C in

67 Perhaps counter-intuitively, the tangible clinical needs

68 Perhaps counter-intuitively, we find that even when the

69 While D2R decreased (perhaps counterintuitively) with exercise, there was no

70 t damage segregation and division asymmetry, perhaps counterintuitively, are not necessarily benefici

71 axis may play an important role in EndMT and perhaps CVD.

72 e genome information, is a long-standing but perhaps deceptive mystery.

73 ajectories of depressive symptoms over time, perhaps differentially by sex and race.

74 g types of arrhythmia result from direct and perhaps distinct effects of hypokalemia on cardiomyocyte

75 pressors, yet remained higher in metastases, perhaps driven by cell cycle regulatory gene variants.

76 ave been hindered by contradictory findings, perhaps due in part, to a recent discovery that two isof

77 iant depletion from foetal muscle enhancers, perhaps due to divergent selection for higher muscle mas

78 ker well-resolved shoulder 4.8% more mobile, perhaps due to empty (genome-free) particles.

79 on is the mutagenic activity of these foods, perhaps due to generation during cooking [e.g., heterocy

80 occurred within the last 1.1 million years, perhaps due to global glaciation oscillations during the

81 less clear than that of laboratory findings, perhaps due to high night-to-night sleep variation.

82 d HS::AXR3-NT:GUS were also observed in tni, perhaps due to inefficient polyubiquitin hydrolysis and

83 e-directed medical therapy of heart failure, perhaps due to interventricular differences in their mol

84 ted in a mutant that lacked both chaperones, perhaps due to misfolding or instability.

85 anetary materials, suggesting the existence, perhaps ephemeral, of transitional objects with a layere

86 Perhaps equally staggering is the fact that as many as 2

87 several recent studies have suggested that, perhaps especially, within the striatum, neuronal popula

88 gest therapeutic potential in modulating and perhaps even enhancing TLR9 signals in B cells.

89 s and their interactions might relate to, or perhaps even explain, human cognitive capacities.

90 enerating better understanding, support, and perhaps even infrastructure for the academic NDA.

91 A secondary effect, perhaps even more important, is that the unequal segrega

92 It is possible that many, perhaps even most, psychiatrists will be incorporating s

93 ell at the protein, secondary structure, and perhaps even side-chain levels.

94 ng alternative due to their very similar and perhaps even superior semiconductor characteristics.

95 ses in plant leaves and animal epithelia and perhaps even the formation of human fingerprints.

96 lar solvents, but it is possible to find and perhaps evolve polymers that are functional in such phas

97 lants show growth and developmental defects, perhaps explaining previous unsuccessful attempts at the

98 genes in Capsella compared with Arabidopsis, perhaps explaining the essential role of Pol IV in polle

99 terfering RNAs in exosome-deficient mutants, perhaps explaining why plants have evolved mechanisms to

100 r vertebrates also nested in the same place, perhaps exploiting the presence of the large bird colony

101 l supplementary food source for zooplankton, perhaps extending survival during low phytoplankton peri

102 enes involved in uptake of sugar and peptide perhaps for heterotrophic lifestyle.

103 reductive carboxylation in glutamine usage, perhaps for production of biosynthetic intermediates.

104 he jet for long periods (e.g. overnight, and perhaps for several hours early in the morning).

105 intestinal development and pathophysiology, perhaps for therapeutic discovery.

106 s elevated in DeltahRpn13 and trRpn13 cells, perhaps from cell stress.

107 tributions from the intergalactic medium and perhaps from other galaxies(2).

108 revalence of aerial dispersal in AM fungi is perhaps greater than previously indicated and a hypothes

109 eoples of the island distinctly more recent, perhaps > 1500 years ago.

110 er than lophs suggests frugivorous diets and perhaps hard object feeding.

111 VTA(Vgat) neurons help set an animal's (and perhaps human's) mental and physical activity levels.

112 r of archaeological sites globally, totaling perhaps hundreds of thousands of culturally and paleoenv

113 to the higher uptake into the cytoplasm and perhaps importantly lower efflux of HgII by the cells, t

114 arch is needed to refine strategies that may perhaps improve survival if mechanical ventilation is pu

115 ecreased ClC-5:R345W membrane trafficking is perhaps in a fully functional form.

116 ggesting increased mitochondrial efficiency, perhaps in compensation for reduced access to glutamate.

117 Perhaps in no other biomedical field have naturally occu

118 children with rapid-onset OCD symptoms, and perhaps in other conditions.

119 that mTORC1 appears to regulate cell growth, perhaps in part through AKAP8L.

120 d during slower-paced or stopover movements, perhaps in part to access carrion produced by vehicle co

121 tes to the arthritogenicity in SKG mice, and perhaps in patients with RA.

122 er a kilometre from the nearest known canal, perhaps in response to greater aeration of surface peat.

123 njunctival injection and tearing (SUNCT) and perhaps in short lasting unilateral neuralgiform headach

124 decreased VRE colonization and infection and perhaps, in turn, decreased daptomycin prescribing.

125 Thus, perhaps inattention to behavioral state leads to failure

126 ution of forebrain regions to this behavior, perhaps including motor learning regions abutting the co

127 y of domestication than previously supposed, perhaps including multiple domestication events, hybridi

128 waters, but is less prominent below 8000 m, perhaps indicating a preference to store DMSP in the dee

129 improved performance in all measured traits, perhaps indicating an absence of trade-offs at least in

130 s express low levels of MHC class I (MHC I), perhaps influencing the ability of CD8(+) T cells to eff

131 e PfEMP1 present ICAM-1 at different angles, perhaps influencing the ability of neighboring PfEMP1 do

132 neuromechanics and exoskeleton performance; perhaps informing future 'muscle-in-the loop' exoskeleto

133 d where specific genotypes can be amplified, perhaps initially by cellular proliferation but further

134 ion by limiting the inflammatory process and perhaps initiate the healing and regeneration process of

135 led neurons do not appear to be nociceptors, perhaps insinuating a role for them in discriminative to

136 s; and 3) promoting, experimenting with, and perhaps institutionalizing both reproducible research st

137 dy considered as a bounded portion of space, perhaps instrumental to drive newborns' attention toward

138 l activity in any of the sensory modalities, perhaps integrating across them.

139 lie outside the visualized interactions, and perhaps involve quaternary assembly or membrane-interact

140 We propose that experiential factors, perhaps involving associative or episodic memory, can ex

141 s with minimal impact on animals and humans, perhaps leading to the development of new non-toxic herb

142 Perhaps less familiar to clinicians is the fact that dru

143 whereas a history of severe hypoglycaemia is perhaps less injurious.

144 avirus disease of 2019 has direct short- and perhaps long-term effects on flavor perception.

145 collapse, might reflect a complementary, and perhaps longer lasting, devolatilization history by sola

146 the virus to others for an extended period, perhaps longer than 14 days.

147 istinct clade of siphoviruses infecting, and perhaps lysogenizing, filamentous cyanobacteria.

148 It was perhaps mandatory if the appearance of aldosterone as a

149 the eyestalk ablation is still necessary to perhaps manipulate the female endocrine of the black tig

150 of these cells in regenerative medicine that perhaps may solve several problems inherent in the use o

151 rmine whether the patient is unresponsive or perhaps minimally conscious(1), and to predict whether t

152 eak sea levels during MIS G7 (~2.75 Ma) and, perhaps, MIS G1 (~2.63 Ma) are also suggestive of EAIS i

153 psychiatric and neurological conditions, and perhaps modulate common presentations and pathophysiolog

154 the first synapse of the visual pathway and perhaps more broadly in the nervous system.

155 e for a low value, 1-2 kPa, in frog eggs and perhaps more generally.

156 Perhaps more importantly in the context of psychiatry, m

157 the reported results ultimately indicate or, perhaps more importantly, what they do not indicate.

158 Perhaps more in parallel with the subtler manifestations

159 Although perhaps more primitive in some respects, quantitative an

160 e discovery of aptamers that adopt novel and perhaps more protein-like folds with hydrophobic cores t

161 tes of clinical trials in neurodegeneration, perhaps most apparent in recent high-profile failures of

162 Perhaps most important for 3D imaging is that the distan

163 Perhaps most important, the Medicaid expansion extended

164 l fine-tuning of activity and stability and, perhaps most importantly, provide "matrix isolation" tha

165 xhibit marked sensitivity to familiar music, perhaps most readily revealed by popular "name that tune

166 Perhaps most significantly, I draw attention to the surp

167 Perhaps most strikingly, the advances that transformed m

168 Perhaps most strikingly, we show that white matter chang

169 Perhaps my reflections will help an aspiring scientist s

170 implicated as a key structure involved in or perhaps necessary for the learning of statistical regula

171 Perhaps no other group is more closely associated with t

172 e plausible concern that what is measured is perhaps not an oscillator but is instead a sequence of e

173 never change, and of how some new ideas are perhaps not as new as we would like to think.

174 ropose our approach as a proof-of principle, perhaps not only applicable to the anti-Leishmania vecto

175 Perhaps not surprisingly, many other organ systems are a

176 is possibility suggests that these PPIs, and perhaps not the individual chaperones themselves, could

177 l-to-novel platforms are producing, although perhaps not unsurprisingly, compelling results suggestin

178 care and reduce waste in the United States, perhaps now is an important moment to reconsider the ben

179 Recognising that pushing-from-below perhaps occurs with thorium as well as uranium, and with

180 role for mitochondrial release of EndoG, and perhaps of apoptosis itself.

181 xploit the "CDK6 dependence" of Ph+ ALL and, perhaps, of other hematologic malignancies.

182 ining P recovery with energy conservation is perhaps one of the greatest challenges of this century.

183 lly guided routes in complex environments is perhaps one of the most spectacular pieces of evidence f

184 Could any new approach to terpene synthesis, perhaps one patterned on biosynthesis, enable a divergen

185 ausing complete loss of function account for perhaps one-third of cases, largely detected through WES

186 have enabled the synthesis of nucleic acids, perhaps opening a way into the RNA world.

187 protein underlie chemoresistance in HCC and perhaps other cancers and point to an important role for

188 ribute differently to risk for psychosis and perhaps other classes of psychiatric symptoms.

189 ce: first, we demonstrate that tenovins, and perhaps other compounds that activate p53, may activate

190 ing histone H3 tails, SAM concentration, and perhaps other effectors.

191 the proper folding of Wnt3a, BAFF, IL-7, and perhaps other factors produced by the extra-hematopoieti

192 utritional and aesthetic value of citrus and perhaps other fruit crops.

193 premature to conclude that centrosomes, and perhaps other membraneless organelles, are necessarily b

194 d help block refractory or recurrent RMS and perhaps other neoplasms and other cancer as well.

195 Thus, administration of flagellin, and perhaps other pathobiont antigens, may confer some prote

196 hemical assays, it rationalizes how SMG1 and perhaps other PIKKs specifically phosphorylate Ser/Thr-c

197 transmission dynamics of this bacterium and perhaps other rickettsial pathogens from medically impor

198 ts influenza virus at the nuclear stage (and perhaps other stages) of the viral life cycle, based on

199 These findings argue that in fishes (and perhaps other vertebrates), nonosteocytic skeletal cells

200 therapeutic targets for treatment of NS and perhaps other, more common, congenital HCM disorders.

201 as a substantial impact on the HPA axis and, perhaps, other stress-mediating systems.

202 efficacious antiviral immune interventions, perhaps paired with more effective latency reversal, mus

203 Perhaps paradoxically, certain forms of mitochondrial dy

204 efit from resective or ablative therapy, and perhaps prevent invasive interventions in those unlikely

205 n the same tasks used previously [2,3], then perhaps prior studies primarily found unidirectional BE

206 than male rats suggest that female rats are perhaps protected against the more pronounced changes in

207 duced and therapy-induced stress factors and perhaps providing an evolutionary advantage.

208 SCZ classification performance of cognition, perhaps providing another target for refining early iden

209 ly; treatment-by-time interaction P = .005), perhaps reflecting a longer carryover effect of tamoxife

210 s become more distinct as the brain matures, perhaps reflecting increased utilization of nuclear rete

211 responses of geckos differ across ontogeny, perhaps reflecting life-history stages prioritising grow

212 sual stimuli entrained oscillations in vLGN, perhaps reflecting shared strategies for visuomotor proc

213 plying a top-down regulation of carbon loss, perhaps reflecting the higher carbon costs of nutrient a

214 However, perhaps reflecting the specificity and generally high af

215 hed from low to high open probability, which perhaps reflects occasional binding of CaM despite the p

216 Perhaps related to this, the audiogenic seizure (AGS) is

217 tional toolbox or does it await development, perhaps relying on language acquisition?

218 homologous recombination intermediates, and perhaps remove unhooked ICLs.

219 ed resistance to ICIs is remarkably limited, perhaps restraining effective development of next-genera

220 cognition is largely phasic (milliseconds to perhaps seconds), and unlikely to be volume-transmitted.

221 physiological results implicate a direct and perhaps selective role of DAGL-alpha in the integration

222 t this disease has multiple contributors and perhaps several distinct aetiologies.

223 capes differ markedly between normal tissues-perhaps shaped by differences in their structure and phy

224 Our results suggest that Dnmt3b3 and perhaps similar Dnmt3b isoforms facilitate de novo DNA m

225 o make RNA molecules, some of which possess (perhaps slight) catalytic activity.

226 r Markov models have been used with caution, perhaps sparingly, primarily because of the lack of enou

227 hanistic aspects of these reactions that are perhaps specific to peptide-based catalysts and their in

228 hibition, which is a positive indication and perhaps suggests that the unsaturated spiroketal fragmen

229 recent advances in this important subset, or perhaps superset, of aging clocks that have been develop

230 Perhaps surprisingly for immunologists, the Krebs cycle

231 Perhaps surprisingly given its multiple origins, sex det

232 e, or maximal latency of the first stage or, perhaps surprisingly, at least one unstable evolutionari

233 Thus, perhaps surprisingly, inter-specific differences in the

234 Perhaps surprisingly, our extensive spatiotemporal searc

235 c principle also applies to mate choice and, perhaps surprisingly, pregnancy.

236 rent from the larger unilateral projections, perhaps synchronizing activity on the two sides of the a

237 ed hearing in African mole-rats is adaptive, perhaps tailoring hearing to eusocial and subterranean l

238 Although we attempt to plan the way we live, perhaps the best description of life is from the words o

239 Anopheles gambiae and Aedes aegypti are perhaps the best studied mosquito species and important

240 oceanic pacemaker of the Atlantic Ocean and perhaps the entire Earth's climate.

241 Perhaps the greatest challenge to expanded use of MPAs i

242 Of any pathogen, HIV provides perhaps the greatest challenge to successful vaccine dev

243 cyanotoxins is challenging to forecast, and perhaps the least understood exposure route is via inhal

244 Perhaps the most advantageous characteristic of PARP inh

245 Postfertilization growth is perhaps the most dramatic event during fruit morphogenes

246 ng graphene to break its lattice symmetry is perhaps the most efficient approach toward realizing ban

247 l relevance, and prophylactic treatments are perhaps the most efficient strategy.

248 ALDH16 is perhaps the most enigmatic member of the superfamily, ow

249 Perhaps the most exciting examples are multiple instance

250 Perhaps the most fertile area for discovery has been the

251 Looking forward, perhaps the most fruitful marriage of the advances in mo

252 The efficacious dose of a drug is perhaps the most holistic metric reflecting its therapeu

253 Cassava is perhaps the most important crop in Africa for smallholde

254 Perhaps the most important goal of such vaccines is not

255 Proteins are perhaps the most important yet frustratingly complicated

256 the primary determinant of high Tac IPV and perhaps the most modifiable risk factor.

257 peRATOR, present several potential benefits, perhaps the most notable being de facto O-glycosite loca

258 However, perhaps the most notable finding of this study was that

259 Perhaps the most obvious way this occurs is when predato

260 de is a leading cause of death worldwide and perhaps the most puzzling and devastating of all human b

261 ensure survival in harsh environments, with perhaps the most robust method being the formation of a

262 Of the variants studied, perhaps the most severe assembly defects are associated

263 e rapid global spread of COVID-19 represents perhaps the most significant public health emergency in

264 Nipponia nippon), an endangered bird that is perhaps the most successful example of how conservation

265 iscovery of the Ser-His-Asp catalytic triad, perhaps the most unusual variation on the textbook class

266 on gas-filled hollow-core fibers constitute perhaps the most viable solution towards ultrafast, comp

267 Perhaps the most well established candidate signature is

268 tic inactivation of NF2 is the principal and perhaps the only driver of tumor initiation; and that tu

269 al or star-forming galaxies, suggesting that perhaps the repeating and apparently non-repeating sourc

270 , the results thus far have been mixed, with perhaps the strongest responses observed in relapsed/ref

271 AKI on proteinuria, although proteinuria is perhaps the strongest risk factor for future loss of ren

272 Perhaps the trilobite was translucent.

273 Of these, the latter is, perhaps, the cardinal test of integrated function along

274 d by GRASP55 and GRASP65 trans-oligomers and perhaps their binding partners.

275 hanisms behind nociceptive sensitization and perhaps their contribution to chronic pain.

276 observed in these neuroplasticity paradigms, perhaps thereby contributing to metaplasticity in the ad

277 Perhaps this capacity evolved in stem Crocodylomorpha, d

278 Perhaps this paradigm shift is no more apparent than in

279 Perhaps, this situation is about to change with developm

280 d folding of the TCRs reduces glycosylation, perhaps through conformational stabilization that restri

281 of how delirium may cause cognitive decline, perhaps through evidence of contemporaneous neuronal inj

282 ould have avoided substantial gas accretion, perhaps through gap opening or late formation(6).

283 endent functions contribute to B2 induction, perhaps through ORF36 targeting of proteins involved in

284 on channel subfamily M member 4 (TRPM4), and perhaps TRPM5, Na(+) channels to control Ca(2+)-mediated

285 per cent (420-580 gigatonnes CO(2))(5), and perhaps two-thirds of the remaining carbon budget if mea

286 missense variants were functionally neutral, perhaps unexpectedly in light of its evolutionary conser

287 Furthermore, and perhaps unexpectedly, e2 significantly increased risk of

288 vioral context; that tonality is widespread, perhaps universal; that music varies in rhythmic and mel

289 However, despite a perhaps unparalleled understanding of links between zebr

290 Perhaps unsurprisingly, we previously found that KSHV us

291 19 disruption looks likely across the world, perhaps until 2021, contingency plans are evolving in ca

292 catastrophe frequency with microtubule age, perhaps via tip structure remodeling.

293 Perhaps we need additional investigation, analysis, and

294 to be more "tightly wound" than others, or, perhaps, we are the ones marveling at others' ability to

295 her the fossils are transported from afar or perhaps were not benthic.

296 tween forward and reverse locomotion states, perhaps when both forward (PVC) and reverse (including R

297 s have resulted in improved human health and perhaps will encourage the development of new therapeuti

298 when combined with AR or CHI3L1 inhibition, perhaps with the addition of immunotherapy.

299 wing the transmission of a gorilla parasite, perhaps within the last 10,000 years, while Plasmodium v

300 During this pandemic and for months, perhaps years, to come, it is critical to reconsider the