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1 ca patients (18.1% brainstem periventricular/periaqueductal, 32.7% periependymal along lateral ventri
2 rve nuclei, inferior and superior colliculi, periaqueductal and pontine gray matter, and the red nucl
4 periaqueductal gray (54%); and ventrolateral periaqueductal gray (52%) when compared with basal bindi
5 ); dorsal raphe nucleus (53%); dorsal medial periaqueductal gray (54%); and ventrolateral periaqueduc
6 her OT receptor activity in the ventrocaudal periaqueductal gray (cPAGv) contributes to mothers' redu
7 lating neuronal activity of the dorsolateral periaqueductal gray (dl-PAG) through excitatory and inhi
9 that VMHdm/c projection to the dorsolateral periaqueductal gray (dlPAG) induces inflexible immobilit
11 the ventromedial hypothalamus is the dorsal periaqueductal gray (dPAG), and stimulation of this stru
12 al gray (VPAG), or sympathoexcitatory dorsal periaqueductal gray (DPAG), differentially modulates CBF
13 e ventromedial hypothalamus (VMH) or lateral periaqueductal gray (lPAG) drives escape behaviors, wher
18 ceptors, acts by an unknown mechanism in the periaqueductal gray (PAG) and raphe magnus (RM) to stimu
19 could be mediated in part by actions in the periaqueductal gray (PAG) and the dorsal raphe nucleus (
20 IC and rACC exhibited opposite coupling with periaqueductal gray (PAG) and the mismatch between actua
21 CeL neurons directly project to the midbrain periaqueductal gray (PAG) and the paraventricular nucleu
22 se VMH efferents travel caudally through the periaqueductal gray (PAG) and then ventrally through the
24 The different subdivisions of the midbrain periaqueductal gray (PAG) are intricately (and different
25 attention or expectancy have identified the periaqueductal gray (PAG) as a key brainstem structure i
26 he generation of DRRs and stimulation of the periaqueductal gray (PAG) can induce the release of GABA
27 binds to mu-opioid receptors (MORs), and the periaqueductal gray (PAG) contains a dense population of
30 onnectivity fluctuations between the DMN and periaqueductal gray (PAG) dynamically tracked spontaneou
32 pothalamic nucleus (VMH) that project to the periaqueductal gray (PAG) form a crucial segment of the
33 NK(1)-Substance P receptors in the midbrain periaqueductal gray (PAG) in defensive rage behavior in
34 imulation in different parts of the midbrain periaqueductal gray (PAG) in the cat generates four diff
41 t.SIGNIFICANCE STATEMENT We demonstrate that periaqueductal gray (PAG) microglia contribute to the se
42 stablish the causal contributions of defined periaqueductal gray (PAG) neuronal populations in itch m
43 and spontaneous firings of rat ventrolateral periaqueductal gray (PAG) neurons, either mechanically d
44 tracellular Ca(2+) levels in dissociated rat periaqueductal gray (PAG) neurons, which express GPR55 m
46 ala by recording neurons in the amygdala and periaqueductal gray (PAG) of rats during fear conditioni
48 M), but not following co-injections into the periaqueductal gray (PAG) or into the spinal subarachnoi
49 by lesions of brainstem regions such as the periaqueductal gray (PAG) or the rostral ventromedial me
51 ances have motivated the hypothesis that the periaqueductal gray (PAG) participates in behaviors that
53 nal motor system, in which the mesencephalic periaqueductal gray (PAG) plays a central role, as demon
56 i, but theoretical advances suggest that the periaqueductal gray (PAG) should also be engaged during
57 beta-endorphin in the rVLM as well as in the periaqueductal gray (PAG) that are involved in EA-mediat
58 label and manipulate neurons in the midbrain periaqueductal gray (PAG) that are transiently active in
59 neurons that lie upstream of neurons in the periaqueductal gray (PAG) that gate the production of ul
60 ng emotions and projects to the amygdala and periaqueductal gray (PAG) to modulate emotional response
61 ult of increased microglia activation in the periaqueductal gray (PAG), a central locus mediating the
62 state functional connectivity (rs-fc) of the periaqueductal gray (PAG), a key region in the descendin
63 We found that pain PEs were encoded in the periaqueductal gray (PAG), a structure important for pai
64 havior in the cat elicited from the midbrain periaqueductal gray (PAG), and that such effects are blo
65 halamus, the amygdala, the hypothalamus, the periaqueductal gray (PAG), and the brainstem reticular f
66 ciation between the brainstem areas, such as periaqueductal gray (PAG), and the headache phase of mig
68 ere densest in the lateral and ventrolateral periaqueductal gray (PAG), lateral parabrachial nucleus
69 d 81, 96, 106, and 82 tolerance genes in the periaqueductal gray (PAG), prefrontal cortex, temporal l
70 ministered systemically or directly into the periaqueductal gray (PAG), produces a significantly grea
71 stent with the location of areas such as the periaqueductal gray (PAG), rostral ventral medulla, and
72 We show that BDNF-containing neurons in the periaqueductal gray (PAG), the central structure for pai
73 ctions to the rostral midbrain including the periaqueductal gray (PAG), the deep layers of the superi
74 lowing administration into the ventrolateral periaqueductal gray (PAG), the dorsal PAG, and the rostr
75 otropic glutamate receptor 5 (mGluR5) in the periaqueductal gray (PAG), the key area of endogenous pa
76 or-expressing neurons (LepRb neurons) in the periaqueductal gray (PAG), the largest population of Lep
77 lateral and the upper lateral portion of the periaqueductal gray (PAG), the Su3 and PV2 nuclei of the
78 nduced connectivity between the amygdala and periaqueductal gray (PAG), which statistically mediated
79 teral amygdala (BLA)-prefrontal cortex (PFC)-periaqueductal gray (PAG)-spinal cord pathway was identi
92 sis that neurons in the rostral ventromedial periaqueductal gray (rvmPAG) are a source of inhibitory
93 resynaptic GABA release in the ventrolateral periaqueductal gray (vlPAG) activates the descending ant
94 ulatory regions, including the ventrolateral periaqueductal gray (vlPAG) and locus ceruleus (LC).
96 een shown that the ventrolateral part of the periaqueductal gray (VLPAG) and the adjacent dorsal deep
100 een central amygdala (CeA) and ventrolateral periaqueductal gray (vlPAG) is implicated in several dis
102 n (PG) E2 signaling within the ventrolateral periaqueductal gray (vlPAG) is pronociceptive in naive a
106 hat the ventrolateral column of the midbrain periaqueductal gray (vlPAG) region mediates the hypotens
107 y estimates are relayed to the ventrolateral periaqueductal gray (vlPAG) to organize fear output.
108 ed IS induces DeltaFosB in the ventrolateral periaqueductal gray (vlPAG), and levels of the protein a
109 ory synapses on neurons in the ventrolateral periaqueductal gray (vlPAG), and photostimulation of the
110 utamatergic projections to the ventrolateral periaqueductal gray (vlPAG), which contains diverse cell
114 la (17%), midline raphe (40%), ventrolateral periaqueductal gray (VLPAG, 15%), lateral hypothalamic a
115 croinjecting morphine into the ventrolateral periaqueductal gray (vPAG) develops with repeated admini
116 vity of dopamine (DA) neurons in the ventral periaqueductal gray (vPAG) tracks with arousal state, an
117 istration of morphine into the ventrolateral periaqueductal gray (vPAG), a key structure contributing
118 of neurons of the sympathoinhibitory ventral periaqueductal gray (VPAG), or sympathoexcitatory dorsal
120 in structures involved in vocal production (periaqueductal gray and anterior hypothalamus) was signi
122 as well as in discrete cells in the lateral periaqueductal gray and in the central gray nucleus.
123 central roles in pain and affect, including periaqueductal gray and nearby dorsal raphe and nucleus
124 ncreased functional connectivity between the periaqueductal gray and rostral anterior cingulate, as h
126 m and also expressed at much lower levels in periaqueductal gray and spinal cord, structures known to
128 ucleus, Kolliker-Fuse nucleus, ventrolateral periaqueductal gray area, central nucleus of the amygdal
130 signaling is modulated in the ventrolateral periaqueductal gray by persistent inflammation different
131 tween the ventromedial prefrontal cortex and periaqueductal gray correlated with somatosensory decrea
133 m activity in surrounding nuclei such as the periaqueductal gray due to technological and methodologi
134 rojections from the ARC to the ventrolateral periaqueductal gray during EA at P5-P6 contribute to inh
135 (vmPFC), insula, amygdala, hypothalamus, and periaqueductal gray emerge as central brain structures u
136 hibition-of avBST input to the ventrolateral periaqueductal gray impaired consolidation, whereas neit
137 fralimbic prefrontal cortex, hippocampus and periaqueductal gray in extinction learning, while mainta
138 dies in the midbrain reticular formation and periaqueductal gray in four clinically documented and ge
139 rect evidence supporting the notion that the periaqueductal gray is a site for higher cortical contro
140 f the projections from the ICx to the dorsal periaqueductal gray is sufficient for provoking flight b
141 ned the role of eNOS within the dorsolateral periaqueductal gray mater (dlPAG) on cardiovascular resp
142 bnormal in hippocampus ( approximately 10%), periaqueductal gray matter ( approximately 13%), fimbria
145 al cortex, the lateral hypothalamus, and the periaqueductal gray matter (PAG) are involved in these c
146 ase in the total phosphatase activity in the periaqueductal gray matter (PAG) from morphine-pelleted
147 roinjection of dipyrone (metamizol) into the periaqueductal gray matter (PAG) in rats causes antinoci
148 orsal horn (DH) by brain regions such as the periaqueductal gray matter (PAG) plays a critical role i
150 nervate various targets, including thalamus, periaqueductal gray matter (PAG), and lateral parabrachi
152 r ibotenic acid lesions of the ventrolateral periaqueductal gray matter (vlPAG) attenuated antinocice
153 -immunoreactive (TH-ir) cells in the ventral periaqueductal gray matter (vPAG) expressed Fos protein
154 reased gray matter in the midbrain including periaqueductal gray matter and nucleus cuneiformis, wher
155 e right amygdala and decreased activation in periaqueductal gray matter and the rostral anterior cing
156 rodents, that deep brain stimulation in the periaqueductal gray matter can rapidly and reversibly ma
157 mygdala, prefrontal cortex, hippocampus, and periaqueductal gray matter to the control of conditioned
159 sterior hypothalamic nuclei), and brainstem (periaqueductal gray matter, dorsal and central superior
160 more modest, but labeling was strong in the periaqueductal gray matter, dorsal raphe nucleus, and la
161 tions to lateral hypothalamus, dorsal raphe, periaqueductal gray matter, pericerulear region, rostrov
162 rea, Edinger-Westphal nucleus, ventrolateral periaqueductal gray matter, reticular formation, peduncu
166 from identified spino-parabrachial and spino-periaqueductal gray neurons indicated the presence of pa
167 ggest that the ventromedial hypothalamus and periaqueductal gray play distinct roles in the control o
168 al cortex, lateral orbitofrontal cortex, and periaqueductal gray relative to controls but showed grea
170 of AT(2)R-eGFP(+) neurons projecting to the periaqueductal gray revealed AT(2)R-eGFP(+) neuronal pro
171 amic nucleus, and to aspects of the midbrain periaqueductal gray that coordinate passive defensive be
172 und no evidence that neurons of the midbrain periaqueductal gray that project to the RVM are postsyna
173 ual anterior cingulate cortex (sgACC) to the periaqueductal gray to the rostral ventromedial medulla
176 ircuitry implicated in retaliation (amygdala/periaqueductal gray) in youths with DBD and low levels o
177 measured in the dorsal central gray matter (periaqueductal gray), the locus coeruleus, the ventromed
179 g paraventricular nucleus, and ventrolateral periaqueductal gray); hypothalamic visceromotor pattern
180 m the medial prefrontal cortex to the dorsal periaqueductal gray, a brainstem area vital for defensiv
181 (+) neuronal projections from the CeM to the periaqueductal gray, a key brain structure mediating fea
186 tal cortex, ventral striatum, temporal lobe, periaqueductal gray, and cerebellum in eight inbred stra
191 rway motor control (i.e., the Kolliker-Fuse, periaqueductal gray, and intermediate reticular nuclei).
192 tudies conducted in the 1960s identified the periaqueductal gray, and its descending projections to t
195 descending pain modulatory system (amygdala, periaqueductal gray, and rostral-ventromedial medulla),
196 BGluM increases in the ipsilateral striatum, periaqueductal gray, and somatosensory cortex, and in co
197 and/or downregulation in cerebellum, caudal periaqueductal gray, and spinal cord and attenuated tole
198 sencephalic nucleus, the lateral part of the periaqueductal gray, and the medial vestibular nucleus t
199 minalis, along with their projections to the periaqueductal gray, are strongly implicated in freezing
200 nucleus, median eminence, infundibular stem, periaqueductal gray, area postrema, pontine raphe nucleu
201 nucleus, retrochiasmatic area, ventrolateral periaqueductal gray, Barrington's nucleus), hypothalamic
202 areas), bed nucleus of the stria terminalis, periaqueductal gray, Barrington's nucleus, Kolliker-Fuse
203 tex, anterior cingulate, the cerebellum, and periaqueductal gray, brain areas that mediate task perfo
204 vidence for substantial dual labeling in the periaqueductal gray, caudal portions of the zona incerta
205 the ventral tegmental area (VTA), habenula, periaqueductal gray, cerebellum, hypothalamus, and hippo
206 to predict arm and leg stimulation from the periaqueductal gray, control regions (e.g., white matter
207 l motor nucleus of the vagus), ventrolateral periaqueductal gray, dorsal parabrachial nucleus, perive
208 amus (LH), mediolateral septum, dorsolateral periaqueductal gray, dorsal raphe, ventral tegmental are
209 hese subdivisions included the ventrolateral periaqueductal gray, dorsomedial hypothalamus, dorsolate
211 ygdala, bed nucleus of the stria terminalis, periaqueductal gray, hippocampus, and dorsal anterior ci
212 idus nucleus, nucleus of the solitary tract, periaqueductal gray, hypothalamic paraventricular nucleu
213 ervation of the parabrachial nucleus and the periaqueductal gray, important nociceptive structures.
214 ar and posterior hypothalamus, zona incerta, periaqueductal gray, intermediate layers of the contrala
215 sal lateral hypothalamic area, ventrolateral periaqueductal gray, lateral parabrachial nucleus and ca
216 terminalis, central nucleus of the amygdala, periaqueductal gray, lateral parabrachial nucleus, nucle
217 scle tone such as those in the ventrolateral periaqueductal gray, lateral pontine tegmentum, locus ce
218 ulomotor nucleus, red nucleus, raphe nuclei, periaqueductal gray, locus coeruleus, trigeminal nucleus
219 he hypothalamus; and ventral tegmental area, periaqueductal gray, medial and posterior pretectal nucl
220 ptive tolerance, receptor desensitization in periaqueductal gray, nor a super-sensitization of adenyl
221 ial longitudinal fasciculus, supraoculomotor periaqueductal gray, nucleus of the optic tract, the inf
222 oidance) dependent on the extended amygdala, periaqueductal gray, or septum, all regions that project
223 he substantia nigra, ventral tegmental area, periaqueductal gray, parabrachial nucleus, and dorsal va
224 sal lateral hypothalamic area, ventrolateral periaqueductal gray, parabrachial nucleus, and nucleus o
225 ei, hippocampus, amygdala, substantia nigra, periaqueductal gray, paratrochlear nucleus, paralemnisca
226 the two fiber types was also observed in the periaqueductal gray, particularly in the vicinity of the
227 n the Kolliker-Fuse and parabrachial nuclei, periaqueductal gray, pedunculopontine nucleus (PPT) and
228 d nucleus of the stria terminalis, amygdala, periaqueductal gray, raphe and parabrachial nuclei) and
229 gdala, hypothalamus, zona incerta, thalamus, periaqueductal gray, raphe nuclei, lateral parabrachial
230 olaminergic and cholinergic cell groups, the periaqueductal gray, several brainstem reticular nuclei,
231 formation, cerebellum, parabrachial nucleus, periaqueductal gray, thalamus, hypothalamus, amygdala, b
232 inalis, the medial and central amygdala, the periaqueductal gray, the dorsal raphe, and the locus coe
233 amic nuclei, the medial geniculate body, the periaqueductal gray, the ventral tegmental area, the sup
234 and lateral nuclei of the hypothalamus; and periaqueductal gray, ventral tegmental area, substantia
237 ption of the projection to the ventrolateral periaqueductal gray, where the GABAergic contribution ap
238 CG and OFC, mPFC, LHA, VMN, hippocampus, and periaqueductal gray, with largest effect sizes in mPFC a
239 radycardia, midbrain activity (including the periaqueductal gray-PAG) and PAG-amygdala connectivity.
261 portion); ventromedial hypothalamus; lateral periaqueductal gray; and medial, central, and basolatera
262 pramammillary nuclei; ventrolateral midbrain periaqueductal gray; rostral and midlevel ventrolateral
263 ation of neurons in the lateral/dorsolateral periaqueductal grey (l/dlPAG) produces increases in hear
264 tial activation in individual columns of the periaqueductal grey (PAG) during breathlessness and its
267 ed from the rostral ACC (rACC), thalamus and periaqueductal grey (PAG) of CCI and sham-operated mice.
268 mol (250 pmol) into the caudal ventrolateral periaqueductal grey (PAG), but not at other sites in the
269 , deep layers of superior colliculus (DLSC), periaqueductal grey (PAG), or caudal pontine reticular f
270 or region (subthalamic nucleus, STN) and the periaqueductal grey (PAG), which have now been recorded
271 s originating in the brainstem ventrolateral periaqueductal grey (VL-PAG), which control the spinal p
273 ed connectivity to the left anterior insula, periaqueductal grey and hypothalamus among other areas.
274 with overactive projections to the amygdala, periaqueductal grey and striatum, and an underactive med
275 he greatest neural changes were found in the periaqueductal grey area (PAG) where anticipation of exe
276 natomical tracing methods to define midbrain periaqueductal grey circuits for specific defensive beha
277 s freezing by disinhibition of ventrolateral periaqueductal grey excitatory outputs to pre-motor targ
278 f activity within dorsal anterior cingulate, periaqueductal grey matter (PAG) and superior temporal g
279 t to various brain areas including thalamus, periaqueductal grey matter (PAG), lateral parabrachial a
280 1 nucleus was found to project mainly to the periaqueductal grey matter (PAG), predominantly ipsilate
281 EM-off neurons (located in the ventrolateral periaqueductal grey matter (vlPAG) and lateral pontine t
282 have identified increased activity with the periaqueductal grey matter associated with stimulation o
283 inated release of 2-AG and anandamide in the periaqueductal grey matter might mediate opioid-independ
284 ockade of cannabinoid CB(1) receptors in the periaqueductal grey matter of the midbrain prevents non-
285 G concentrations and, when injected into the periaqueductal grey matter, enhances stress-induced anal
287 nucleus of the amygdala to the ventrolateral periaqueductal grey that produces freezing by disinhibit
289 n secondary within-group analyses, increased periaqueductal grey volume was associated with role limi
292 s of the anterior cingulate cortex (ACC) and periaqueductal grey, areas involved in pain processing,
293 teral hypothalamus, midbrain tegmental area, periaqueductal grey, dorsal pons and various cortical ar
294 ased in the bilateral substantia nigra, left periaqueductal grey, right posterior cingulate cortex an
295 rtex, dentate gyrus, thalamus, hypothalamus, periaqueductal grey, superior colliculus, locus coeruleu
298 The findings suggest the thalamo-cortico-periaqueductal network associated with the experience of
299 01, eta(p)(2)=0.35) within a thalamo-cortico-periaqueductal network that has previously been associat