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1 inopathy within 15 years (102 parafoveal, 23 pericentral).
2 Cs stimulated to migration is the buildup of pericentral actin clusters that prevent cell flattening
3 trally as fructose-1-phosphate and triggered pericentral adenosine triphosphate (ATP) depletion.
4  dendriform morphology were found within the pericentral and central region of the corneal stroma (20
5 actices may need to be adjusted to recognize pericentral and parafoveal hydroxychloroquine retinopath
6                                              Pericentral and periportal hepatocytes exhibited the mos
7 ries, also contributed to regeneration after pericentral and periportal injuries.
8                             Both the dorsal (pericentral) and the lateral (external) nuclei of the in
9                        Central, paracentral, pericentral, and the thinnest corneal thicknesses; anter
10 of three zones, periportal, mid-lobular, and pericentral, and zone-specific dysregulated gene express
11 CO concentrations may be elevated around the pericentral area in the liver after chronic alcohol inge
12 eously distributed with concentration in the pericentral area.
13  periportal regions were well oxygenated but pericentral areas became hypoxic.
14 sively in the liver and predominately around pericentral areas of the hepatic lobule, while there was
15 ixed (retinal changes in both parafoveal and pericentral areas).
16  before proceeding toward the periportal and pericentral areas.
17 ures correlated with birth weight (P < .05), pericentral axial curvature did not.
18 patial positioning across the periportal and pericentral axis.
19 ntify key differences between periportal and pericentral cells accounting for higher susceptibility t
20                           The descendants of pericentral cells differentiate into Tbx3-negative, poly
21                                        These pericentral cells express the early liver progenitor mar
22 d to a higher susceptibility to steatosis in pericentral cells in the model simulations.
23                          Furthermore, whilst pericentral cells tend to show higher lipid levels, vari
24  cells provide Wnt signals that maintain the pericentral cells, thereby constituting the niche.
25 ng damage is known to occur more severely in pericentral cells.
26                                 Furthermore, pericentral/centrilobular hepatocyte p50 nuclear translo
27 specific APR was evaluated in periportal and pericentral/centrilobular hepatocytes isolated using dig
28 ga, Hp, and Lbp expression being enriched in pericentral/centrilobular hepatocytes.
29 by splitting the sinusoid into periportal to pericentral compartments.
30                        With the exception of pericentral corneal thickness, all regions of corneal th
31 afoveal changes, 24 (12%) also had a zone of pericentral damage, and 24 (12%) had pericentral retinop
32                                 Finally, the pericentral expression of de novo lipogenesis contribute
33 s, whereas the CM projection also included a pericentral extension around the ventromedial and latera
34          In the 10-y biopsies, periportal or pericentral fibrosis was observed in 253 patients (51%),
35 nin in metabolic zonation where it regulates pericentral gene expression and in initiating liver rege
36 ion of hepatic stellate cells, and increased pericentral hepatic apoptosis following CCl(4) injury.
37 of asparagine can dampen hepatotoxin-induced pericentral hepatocellular death.
38             Furthermore, we demonstrate that pericentral hepatocytes also expand in number and size d
39 pstream effector of beta-catenin activity in pericentral hepatocytes and during LR.
40 L rats, ET-1 was localized in periportal and pericentral hepatocytes and hepatic sinusoidal cells.
41 tasis and regeneration, and identify Lgr5(+) pericentral hepatocytes as major cells of origin in HCC
42 an early peak of p21 expression occurring in pericentral hepatocytes at 6 h, prior to evidence of inj
43 mily members were predominantly localized in pericentral hepatocytes during liver injury, oval cell a
44 y, indicating that rapid induction of p21 in pericentral hepatocytes following CCl4 injection contrib
45 is only observed in a very limited number of pericentral hepatocytes in a pattern that is similar to
46 stem cells (ISCs) but find limited roles for pericentral hepatocytes in liver parenchyma homeostasis.
47 cytes in normal liver, whereas AAV5 targeted pericentral hepatocytes in steatotic liver.
48  enhancer 3 activity is highly restricted to pericentral hepatocytes in the adult liver.
49 ty acid beta-oxidation in the periportal and pericentral hepatocytes of AEG-1(DeltaMAC) livers.
50 o that in males, but which then increased in pericentral hepatocytes resulting in a bowl-like distrib
51                     In contrast, AXIN2/LGR5+ pericentral hepatocytes show low proliferation rates des
52  method for the separation of periportal and pericentral hepatocytes that yields sufficiently pure fr
53            DTA-mediated ablation of AXIN2(+) pericentral hepatocytes transiently disrupts this zone,
54                   Increased proliferation of pericentral hepatocytes was demonstrated by 5-bromo-2'-d
55 and nuclear translocation of beta-catenin in pericentral hepatocytes with a concomitant increase in c
56 I and EII exhibit high levels of activity in pericentral hepatocytes with a gradual reduction in acti
57 n in the liver varies between periportal and pericentral hepatocytes(1-3), and in the intestine from
58 ynthesis in the periphery (including that in pericentral hepatocytes) and glutamine catabolism in (pe
59       Here, we found ASNS to be expressed in pericentral hepatocytes, a population of hepatic cells s
60  death of genomically damaged differentiated pericentral hepatocytes, and this may also prevent their
61 nerally more periportally restricted, toward pericentral hepatocytes, as was visualized using a fluor
62 bular gradient increasing from periportal to pericentral hepatocytes, claudin 3 is uniformly expresse
63 promoting pathways, mainly in periportal and pericentral hepatocytes, in AEG-1-C75S liver compared to
64  This results in a cycle of AA-enrichment in pericentral hepatocytes, membrane release of AA, and gen
65  V1a receptors are most heavily expressed on pericentral hepatocytes, or by using 2,5-di(tert-butyl)-
66 ause glucagon receptors are predominantly on pericentral hepatocytes, or by using dibutyryl cAMP, whi
67  the central vein with the weakest signal in pericentral hepatocytes, resulting in a hepatic lobular
68 er stem cell populations, including AXIN2(+) pericentral hepatocytes, that safeguard homeostasis and
69 ke from mainly periportal hepatocytes toward pericentral hepatocytes, thereby increasing exposure of
70 d invasion in the hepatocytes, especially in pericentral hepatocytes, were observed in AEG-1(DeltaMAC
71 tion of the enzyme, glutamine synthetase, in pericentral hepatocytes, where it converts potentially t
72 TLR4)-nuclear factor kB (NF-kB) signaling in pericentral hepatocytes.
73 ortal and mid-lobular hepatocytes but not in pericentral hepatocytes.
74 ory that dictates periportal, interzonal and pericentral human hepatocytes.
75 itially perfused at low-flow rates to induce pericentral hypoxia followed by a 40-minute reperfusion
76                            We postulate that pericentral induction of iNOS under ambient conditions o
77                                      A rapid pericentral inflammatory infiltrate enriched in F4/80(+)
78                                 After either pericentral injury with carbon tetrachloride or periport
79 n-negative epithelioid cells within zones of pericentral injury.
80 h enhanced keratin solubility; and prominent pericentral keratin network disruption.
81  injections into the lateral dorsal horn and pericentral laminae resulted in the largest number of li
82 eoplastic foci adjacent to portal tracts and pericentral large cell dysplasia.
83        Genetic lineage tracing revealed that pericentral Lgr5(+) hepatocytes have a long lifespan and
84 roscopically, Plg(0) livers had a pronounced pericentral linking, with accumulation of centrilobular
85 te-specific Asns deletion were more prone to pericentral liver damage than their control littermates
86 o administration revealed that Wnt-dependent pericentral liver gene expression involves multiple Fz s
87                  We find that periportal and pericentral mitochondria are morphologically and functio
88  while lipid synthesis is predominant in the pericentral mitochondria.
89 is, presumably autoimmune in nature, who had pericentral necrosis (zone 3) with relative sparing of t
90 at 60 minutes after reperfusion (P<0.05) and pericentral necrosis at 8 hours after reperfusion (P<0.0
91 er tumors but spared its orthodox pathway in pericentral normal hepatocytes.
92 nsion of the blind spot extending into large pericentral or other types of scotomata (64%).
93 utamine synthetase-positive, suggestive of a pericentral origin.
94  in a parafoveal (bull's eye) pattern, and a pericentral pattern of damage is especially prevalent am
95                            Patients with the pericentral pattern were taking hydroxychloroquine for a
96 ning studies and classified as parafoveal or pericentral pattern.
97 he CDE regimen, whereas TAA-treated mice had pericentral patterns of progressive injury and fibrosis,
98 s TCF/LEF DNA binding motif is restricted to pericentral (PC) hepatocytes in zone 3.
99 es with a gradual reduction in activity in a pericentral-periportal direction.
100 sual symptoms corresponded to focal areas of pericentral photoreceptor disruption in all cases.
101 cytes throughout the liver, rather than by a pericentral population.
102  abnormality of spikes or sharp waves in the pericentral region (centroparietal, centrofrontal, or ce
103 detaldehyde adduct was located mainly in the pericentral region of the liver.
104 ed increases in NADH autofluorescence in the pericentral region, leukocyte adherence, and nonperfused
105 ed increment in NADH autofluorescence in the pericentral region, relative to control mice.
106 ) after I/R in these mice, especially in the pericentral region.
107 on (indicating hypoxia), particularly in the pericentral region.
108 essed in the liver that is pronounced in the pericentral region.
109 creased, predominantly in hepatocytes in the pericentral region.
110 oximately 5% of hepatocytes clustered in the pericentral region.
111  of adherent leukocytes in both midzonal and pericentral regions after gut I/R was elevated.
112 s, detected immunochemically, accumulated in pericentral regions in liver.
113 ay account for increased oxidative damage in pericentral regions in NASH.
114  Calretinin immunoreactivity was high in the pericentral regions of the IC, but the central nucleus w
115 tly, juniper berry oil reduced cell death in pericentral regions of the liver lobule by 75%.
116 obule has its reactivity enhanced in hypoxic pericentral regions where the pH is lower.
117 tochondrial phenotypes in the periportal and pericentral regions, linking nutrient gradients across t
118 thetase gene is also active, specifically in pericentral regions.
119 d X antigens in the liver, especially in the pericentral regions.
120 ld increase in nitrotyrosine accumulation in pericentral regions.
121 dal space surrounding the periportal and the pericentral regions.
122 Detachment of the posterior hyaloid from the pericentral retina exerts anterior traction on the foveo
123                                              Pericentral retina with normal lamination showed a thinn
124 of ONL in the superior-temporal and temporal pericentral retina.
125 hanges 2 degrees -6 degrees from the fovea), pericentral (retinal changes >/= 8 degrees from the fove
126                                              Pericentral retinopathy alone was seen in 50% of Asian p
127                            The likelihood of pericentral retinopathy was higher among Asian patients
128 zone of pericentral damage, and 24 (12%) had pericentral retinopathy without any parafoveal damage.
129                            In some families, pericentral RP or macular dystrophy were found in family
130       A key feature of partial epilepsy with pericentral spikes is a characteristic encephalogram abn
131 his distinctive encephalogram abnormality of pericentral spikes unites these several seizure types in
132 ily epilepsy syndrome, partial epilepsy with pericentral spikes, which we map to chromosome 4p15.
133 ared to increase the subjective intensity of pericentral staining of iNOS.
134 ession of de novo lipogenesis contributed to pericentral steatosis when additionally simulating the i
135 ells accounting for higher susceptibility to pericentral steatosis.
136 emand, without zonal dominance by a putative pericentral stem cell population.
137 ed disease in all three families showed more pericentral than peripheral field dysfunction.
138 n the predominant location of steatosis from pericentral to pan-sinusoidal or azonal.
139 tion of the zonated metabolic functions from pericentral to periportal hepatocytes, which is orchestr
140 orrespond to their acinar position of either pericentral vein or periportal vein.
141  pattern in the TAA model as driven from the pericentral vein region.
142 one, which is reestablished by conversion of pericentral vein-juxtaposed glutamine synthetase (GS)(-)
143  mice exhibit a stark loss of high levels of pericentral viral biosynthesis.
144 tasis, cells from both periportal zone 1 and pericentral zone 3 contracted in number, whereas cells f
145 ve TCF/LEF transcription are confined to the pericentral zone and are not increased in number during
146 pecially beta2SP, from the periportal to the pericentral zone as regeneration nears termination via i
147                                   However, a pericentral zone of preserved architecture was present,
148 omoting fibrogenic EV release in the hepatic pericentral zone, which represents a potential therapeut
149 gulation of EV-related pathways in the liver pericentral zone, which was abrogated by glycolysis gene
150 compared between the periportal (zone 1) and pericentral (zone 3) regions of the rat liver during reg
151 is-associated changes between periportal and pericentral zones.

 
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